ABSTRACT
BACKGROUND@#Patients with lung cancer are often accompanied by anxiety, which affects postoperative recovery. The aim of this study is to explore the effects of preoperative anxiety on early prognosis in patients after thoracoscopic lung cancer resection.@*METHODS@#A total of 100 patients undergoing thoracoscopic resection of lung cancer were divided into 2 groups by hospital anxiety and depression scale (HADS): 44 in anxiety group (anxiety score>8) and 56 in control group (anxiety score<8). The primary endpoint: length of postoperative hospital stay. The secondary endpoint: length of hospital stay, visual analogue scale (VAS), the incidence of nausea and vomiting as well as postoperative new arrhythmia and the consumption of postoperative analgesic and rescue antiemetic.@*RESULTS@#Compared with the control group, the length of postoperative hospital stay and hospital stay in the anxiety group were both significantly longer [(5.1±2.5) d vs (4.0±1.3) d, P<0.01; (10.9±4.0) d vs (9.1±4.1) d, P<0.05)], the VAS score and the incidence of nausea as well as arrhythmia were significantly increased [(4.7±1.9) vs (2.6±1.8), P<0.001; 40.9% vs 16.1%, P<0.01; 36.4% vs 20.7%, P<0.05], and the consumption of postoperative analgesic and rescue antiemetic were also significantly increased [(72.5±8.9) mL vs (68.2±9.4) mL, P<0.05; (2.1±2.9) mg vs (0.9±1.9) mg, P<0.05].@*CONCLUSIONS@#Preoperative anxiety can affect the early prognosis of patients after thoracoscopic lung cancer resection, prolong hospitalization time, increase the postoperative pain score and the incidence of postoperative nausea and new arrhythmia as well as the consumption of postoperative analgesic and rescue antiemetic.
ABSTRACT
Objective To investigate the effects of different concentrations of botulinum toxin type A on hypertrophic scar fi-broblasts ,and to explore the molecular mechanism of botulinum toxin type A in the treatment of scar and prevention of postopera-tive scar hyperplasia .Methods Different concentrations of botulinum toxin A (0 .01 ,0 .1 ,1 U/L and 10 U/L) were used on hyper-trophic scar fibroblasts for 24 hours ,to observe the changes of cell adhesion and cytoskeleton under laser confocal microscopy .MTT and flow cytometry were used to detect the proliferation ,apoptosis and cycle of change ,at the same time real time fluorescence quantitative PCR and Western blot were conducted to detected the expression of TGF-β,matrix metalloproteinase MMP-1 ,MMP-2 and MMP-9 gene and protein expression changes .Results With the increase of botulinum toxin A dose ,the number of cell adhesion and cytoskeletal fluorescence intensity decreased ,cell proliferation ability decreased and mainly blocked at G0-G1 phase ,and the ap-optosis also increased with the dose increased .The results of qPCR and Western blot showed that MMP-1 and MMP-9 gene and protein were highly expressed with the increase of botulinum toxin A dose ,while TGF-βand MMP-9 showed low expression .Con-clusion Botulinum toxin A can inhibit the proliferation of hypertrophic scar fibroblasts and inhibit the expression of MMP-1 and MMP-2 ,which can inhibit scar formation .It plays a positive role in the treatment of scar .
ABSTRACT
OBJECTIVE:To observe the clinical effects of Sanqi shengji ointment (SQSJO) preventing skin flap necrosis. METHODS:75 cases of local flap transfer in head and facial operation were randomly divided into blank group,treatment group, control group and with 25 cases in each group. After surgery,except for conventional treatment,treatment group was coated with SQSJO additionally;control group was additionally treated with rh-bFGF. The dressing was changed with iodophor in blank group conventionally till the wound healed. The skin flap necrosis,healing course,local skin temperature,swelling disappearance time and wound healing time were observed and compared among 3 groups after surgery. RESULTS:Compared with blank group,the incidence of skin flap necrosis decreased significantly in other 2 groups,there was statistical significance(P0.05);the flap swelling disappearance time and wound healing time of treatment group were significantly shorter than those of control group and blank group;there was statistical significance (P<0.05). CONCLU-SIONS:SQSJO can prevent skin flap necrosis accurately after flap transfer,and has no significant difference from rh-bFGF in pre-vention effect. Moreover,it is better than rh-bFGF in improving local swelling and shortening wound healing.