ABSTRACT
Breast tumor has become one of the malignant tumors with the highest incidence, and is a serious threat to human health, especially to women. Chemotherapy is an important anti-breast tumor therapy, which can be used in almost every stage of breast tumor therapy alone or in the combination with surgery and radiation therapy. Alkaloids are a kind of ubiquitous natural products, and important active components of various medicinal plants. A large number of studies have shown that alkaloids could exert an anti-breast tumor effect by inhibiting proliferation, metastasis and angiogenesis, resisting mitosis, promoting apoptosis and autophagy, and triggering cell cycle arrest. The extensive anti-breast tumor effect makes alkaloids an important candidate drug source. This paper reviews the anti-breast tumor mechanism of natural products of alkaloids.
Subject(s)
Female , Humans , Alkaloids/pharmacology , Apoptosis , Autophagy , Breast Neoplasms/drug therapy , Cell Cycle Checkpoints , Cell Line, Tumor , Cell ProliferationABSTRACT
Objective To evaluate and summarize the best available evidence of effects of physical exercise on fall prevention in community-dwelling elderly people.Methods We searched Cochrane Library,JBI Library,Registered Nurses' Association of Ontario (RNAO),National Guideline Clearinghouse (NGC),PubMed,EMbase,Scottish Intercollegiate Guideline (SIGN),British Medical Journal Best Practice,British Medical Journal Best Practice,CBM,Wanfang Database and CNKI,to collect literatures including guideline,evidence summary(ES),best practice information sheet (BPIS),recommend practice (RP),system review(SR) and original research.Three authors independently evaluated quality of literatures and extracted data.Results Ten articles were enrolled,including four guidelines,two SRs,one RP,one ES,and two randomized controlled trials.Best evidence included:exercises should aim to provide moderate or high balance function training.Tai Chi and yoga were effective in fall prevention.Multifactorial assessment,group-based or home-based exercises were able to prevent falls.Conclusion Community should provide physical exercise recommendations for the elderly and satisfy the corresponding conditions.Available best evidence is recommended to use according to individual situation of the elderly.
ABSTRACT
Objective To evaluate and summarize the best available evidence of effects of physical exercise on fall prevention in community-dwelling elderly people.Methods We searched Cochrane Library,JBI Library,Registered Nurses' Association of Ontario (RNAO),National Guideline Clearinghouse (NGC),PubMed,EMbase,Scottish Intercollegiate Guideline (SIGN),British Medical Journal Best Practice,British Medical Journal Best Practice,CBM,Wanfang Database and CNKI,to collect literatures including guideline,evidence summary(ES),best practice information sheet (BPIS),recommend practice (RP),system review(SR) and original research.Three authors independently evaluated quality of literatures and extracted data.Results Ten articles were enrolled,including four guidelines,two SRs,one RP,one ES,and two randomized controlled trials.Best evidence included:exercises should aim to provide moderate or high balance function training.Tai Chi and yoga were effective in fall prevention.Multifactorial assessment,group-based or home-based exercises were able to prevent falls.Conclusion Community should provide physical exercise recommendations for the elderly and satisfy the corresponding conditions.Available best evidence is recommended to use according to individual situation of the elderly.