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1.
China Pharmacy ; (12): 263-270, 2022.
Article in Chinese | WPRIM | ID: wpr-913081

ABSTRACT

OBJECTIVE To compare and study the supporting policies for the filing man agement system of traditional Chinese medicine preparation prepared by traditional technology (hereinafter referred to as “TCM preparation ”)in medical institutions issued by the state and various provinces ,and their development ,so as to provide reference for the improvement of the follow-up supervision and management of the filing works. METHODS According to Announcement on the Filing Management of TCM Preparations Prepared by Medical Institutions Using Traditional Processes issued by former National Food and Drug Administration (hereinafter referred to as the Announcement)as well as notices and specific implementation rules issued by provincial bureaus ,the filing work data of 10 provinces in recent 3 years were selected for comparison ,sorting,statistics,classification and induction. The policy characteristics and progress of filing work were studied. RESULTS & CONCLUSIONS According to the local actual situation,some provinces had refined or expanded the contents of several parts of the Announcement,such as the scope of TCM preparations,the situation not allowed to record ,the filing process and working time requirements ,the disclosure ,change and cancellation of filing information ,and the implementation of supervision and management. The statistical results of filing data in 10 provinces showed that compared with 2019,the number of TCM preparation declared for filing and medical institutions declared for filing had increased with growth rate of 91.0% and 48.8% respectively in 2020. There is still room for improvement in the supporting policies for the filing of TCM preparations ,which can be optimized by referring to the features of some provinces ’ implementation policies ,refining the construction of norms and standards ,and strengthening the construction of regulatory system platform. It is necessary to optimize policy and strengthen the capacity building of reporting institutions in advance ;carry out daily supervision and control risk based on risk during the filing management ;emphasize follow-up supervision ,strengthen the construction of ADR monitoring system in medical institutions ,and carry out life cycle supervision and management constructively afterwards,in order to promote the further development of TCM preparations in medical institutions.

2.
Chinese Journal of School Health ; (12): 372-377, 2022.
Article in Chinese | WPRIM | ID: wpr-923108

ABSTRACT

Objective@#To evaluate the effectiveness of aerobic exercise, resistance exercise, and aerobic combined resistance exercise on body composition among overweight and obese children and adolescents, to provide more comprehensive and effective evidences for overweight/obesity intervention research and practice in children and adolescents.@*Methods@#Randomized controlled trials (RCTs) regarding exercises on body composition among children and adolescents with overweight and obesity published before December 31th, 2020 were searched in databases of CNKI, Wanfang, PubMed, Web of Science. Two reviewers independently screened literature, extracted data and assessed risk of bias of included studies. Stata 15.1 and RevMan 5.0 were used for statistical analysis.@*Results@#A total of 38 RCTs were included. The effectiveness of exercise on BMI reduction among overweight/obese children and adolescents were in the following rankings: combined exercise [ MD =-1.25(-1.76--0.74), P <0.05], aerobic exercise [ MD =-0.87(-1.23--0.52), P <0.05], resistance exercise [ MD =-0.58(-1.06--0.10), P <0.05]. The effectiveness of exercise on body fat percentage reduction among overweight/obese children and adolescents were in the following rankings: combined exercise [ MD =-4.02(-5.60--2.44), P <0.05], resistance exercise [ MD =-2.89(-4.62--1.16), P <0.05], aerobic exercise [ MD =-1.88(-3.14--0.62), P <0.05].@*Conclusion@#Aerobic training combined with resistance training is the most effective exercise to improve body composition for children and adolescents with overweight and obesity. When formulating exercise prescription,atrobic combined with resistance exercise can be used as the first choice for overweight and obese children and adolescents.

3.
Article in Chinese | WPRIM | ID: wpr-911303

ABSTRACT

Objective:To evaluate the effect of paravertebral nerve block (PVNB) combined with general anesthesia on intraoperative regional cerebral oxygen saturation (rScO 2) in elderly patients undergoing thoracoscopic lobectomy. Methods:Seventy American Society of Anesthesiologists physical status Ⅱ or Ⅲ patients of both sexes, aged 60-85 yr, with body mass index of 18-25 kg/m 2, were divided into 2 groups ( n=35 each) using a random number table method: general anesthesia group (group G) and PVNB combined with general anesthesia group (group PG). PVNB was performed at T 4 and T 6 with 0.5% ropivocaine 10 ml for each site under ultrasound guidance before induction of anesthesia in group PG.After induction of anesthesia, anesthesia was maintained with IV propofol and remifentanil, and a patient-controlled intravenous analgesia pump was connected at the end of operation.The maximum and minimum rScO 2 and cumulative time of rScO 2 below the baseline value were recorded.The rScO 2 was recorded before anesthesia (T 0), at 5 min before one-lung ventilation (T 1), at 5 min after one-lung ventilation (T 2) and at tracheal extubation (T 3). The length of postoperative hospital stay and complications within 30 days after operation were recorded. Results:Compared with group G, the minimum rScO 2 and rScO 2 at T 2 and T 3 were significantly increased, the incidence of postoperative cognitive dysfunction was reduced ( P<0.05), and no significant change was found in the other parameters mentioned above in group PG ( P>0.05). Conclusion:PVNB combined with general anesthesia can improve intraoperative rScO 2 and reduce the development of postoperative cognitive dysfunction in elderly patients undergoing thoracoscopic lobectomy.

4.
Chinese Journal of Geriatrics ; (12): 1425-1428, 2021.
Article in Chinese | WPRIM | ID: wpr-911032

ABSTRACT

Objective:To study the influence of patients' ages on average medical expenses under the diagnosis related group and prospective payment system(DRG-PPS)model.Methods:Medical records of 52 987 selected patients at a third-tier general hospital in Beijing were collected from January 1 to December 31, 2019, and were then divided into three age groups based on age, the elderly group, the middle-aged group and the young group, and one-way ANOVA was used to determine differences in medical expenses between the same DRG group and different age groups.Related-sample nonparametric tests and linear regression were carried out for the three age groups to estimate the influence of the age factor on the medical expenses of different DRG groups.Results:First, the data of the three age groups in the same DRG group were analyzed by one-way ANOVA.The P values of the DRG groups were less than 0.05, except for the cb39 crystal surgery DRG group; Then, the data of the three age groups in different DRG groups were analyzed with the nonparametric test( P=0.021, less than 0.05); Finally, linear regression analysis was also used to analyze the case data of the three age groups.The p value was less than 0.05, and the standardized influence coefficient was 0.173, suggesting age was positively correlated with hospitalization expenses. Conclusions:Age affects average hospitalization expenses.After the implementation of the DRG-PPS model, the payment of DRG patients should be standardized with the inclusion of the age factor.

5.
Article in Chinese | WPRIM | ID: wpr-910869

ABSTRACT

Objective:To explore the association between different paths of diabetic progression and dyslipidemia in a Nanjing adult population.Methods:From January 2017 to June 2018, 61, 098 local residents aged ≥18 years were selected from the Chronic Disease and Risk Factor Surveillance database in Nanjing using a five-stage stratified cluster random sampling method. Data were collected through interview surveys, physical measurements, and laboratory examinations. The relationship between different rates of diabetic progression and dyslipidemia was analyzed using complex weighting and multilevel models.Results:In all, 60, 283 participants were finally enrolled in the study. The weighted proportions of normal glucose regulation, pre-diabetes, and diabetes were 71.2%, 17.9%, and 10.9%, respectively. The overall weighted prevalence, awareness, treatment, and control of dyslipidemia were 29.8%, 41.6%, 28.9%, and 22.9%, respectively. The weighted proportion of patients with dyslipidemia combined with diabetes was 52.9%. The weighted prevalence of dyslipidemia in adults with normal glucose regulation, pre-diabetes, and diabetes was 24.0%, 38.8%, and 52.9%, respectively (all P<0.001). Compared to the normal glucose regulation group, subjects with pre-diabetes ( OR = 2.04, 95% CI: 1.95-2.13) or diabetes ( OR= 3.87, 95% CI: 3.66-4.10) had possibly gradually increased risks of dyslipidemia (all P<0.001). In addition, there was an increasing trend toward awareness, treatment, and control of dyslipidemia with increasing levels of glucose (all P<0.001). The weighted awareness of dyslipidemia in adults with normal glucose regulation, pre-diabetes, and diabetes was 36.3%, 42.8%, and 56.2%, respectively; the corresponding rates of treatment and control were 23.7%, 29.2%, and 43.7%, and 20.4%, 22.6%, and 30.1%, respectively. Conclusion:Diabetes and dyslipidemia have become the main chronic diseases in the Nanjing population.

6.
Chinese Journal of Endemiology ; (12): 660-663, 2021.
Article in Chinese | WPRIM | ID: wpr-909073

ABSTRACT

Objective:To investigate the correlation between thyroid function index and serum visfatin in patients with acute pancreatitis (AP).Methods:Using a prospective design, 65 patients with AP treated in Binzhou People's Hospital from December 2017 to December 2019 were selected as the research subjects. They were divided into mild acute pancreatitis (MAP) group ( n = 35) and severe acute pancreatitis (SAP) group ( n = 30) according to the acute physiology and chronic health Ⅱ (APACHE Ⅱ) score ( < 8, ≥8 scores). At the same time, 40 healthy people were selected as the control group. The serum levels of free thyroxine (FT 4), free triiodothyronine (FT 3) and thyrotropin (TSH) were measured by chemiluminescence immunoassay. Radioimmunoassay was used to measure serum reverse triiodothyronine (rT 3) level, and enzyme-linked immunosorbent assay was used to measure serum visfatin level. Pearson method was used to analyze the correlation between thyroid function index and serum visfatin in patients with AP. Results:The FT 4 [(14.02 ± 3.63), (15.68 ± 3.05) pmol/L], FT 3 [(2.34 ± 0.80), (3.66 ± 0.65) pmol/L], and TSH levels [(2.78 ± 0.85), (3.10 ± 0.57) mU/L] in SAP and MAP groups were significantly lower than those in control group [(17.03 ± 3.96), (6.04 ± 1.55) pmol/L, (4.88 ± 2.30) mU/L, P < 0.05], but the rT 3 levels [(1.63 ± 1.12), (1.23 ± 0.26) nmol/L] were significantly higher than that in control group [(0.97 ± 0.28) nmol/L, P < 0.05]. There was significant difference in serum FT 3 levels between SAP and MAP groups ( P < 0.05). The serum visfatin levels of SAP, MAP and control groups were (10.75 ± 2.92), (3.70 ± 1.73), (2.30 ± 1.31) ng/ml, the difference between the three groups was statistically significant ( F = 67.174, P < 0.05). The serum visfatin levels in SAP and MAP groups were higher than that in control group, and that in SAP group was higher than that in MAP group ( P < 0.05). There were negative correlations between serum FT 3 level and visfatin level in SAP and MAP groups ( r = - 0.672, - 0.610, P < 0.05). Conclusions:The serum visfatin level and thyroid function index of AP patients are abnormal. The levels of FT 3 and visfatin are correlated with the severity of AP patients, and there is a negative correlation between the levels of FT 3 and visfatin. Detection of thyroid function index is helpful to judge the AP patient's condition.

7.
Article in Chinese | WPRIM | ID: wpr-906430

ABSTRACT

Objective:To observe the clinical efficacy of Yishen Tongluofang in treating oligosperm type male infertility with kidney deficiency and blood stasis syndrome and explore its effect on serum sex hormones and seminal plasma microenviro. Method:One hundred and four patients were randomly divided into observation group and control group with 52 cases each. Patients in control group took compound Xuanju capsules orally, 3 capsules/time, 3 times/day. Patients in observation group took Yishen Tongluofang, 1 dose/day. Treatment courses continued three months and followed up for three months in both groups. The pregnancy situations of spouses within six months were recorded. Examination of semen parameters before and after treatment and score of kidney deficiency and blood stasis syndrome were conducted. The levels of seminal plasma zinc, fructose, elastase, acid phosphatase and <italic>α</italic>-glucosidase, serum follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRT) and testosterone (T) were detected before and after treatment. Result:During the observation period of six months, the pregnancy rate of spouses in the observation group was 22.00%, higher than 10.00% in the control group, but the difference was not statistically significant (<italic>χ</italic><sup>2</sup>=2.678,<italic>P</italic>>0.05). The clinical efficacy in the observation group was better than that of the control group (<italic>Z</italic>=2.326,<italic>P</italic><0.01). Sperm concentration, sperm motility, sperm motility, normal morphological sperm and linear movement speed of the observation group were all superior to those of the control group<italic> </italic>(<italic>P</italic><0.01). The levels of zinc and fructose in seminal plasma of the observation group were higher than those of the control group (<italic>P</italic><0.01), and the score of kidney deficiency and blood stasis syndrome was lower than that of the control group (<italic>P</italic><0.01). Serum FSH, LH and PRT levels in the observation group were lower than those in the control group (<italic>P</italic><0.01), and the T level was higher than that in the control group (<italic>P</italic><0.01). The seminal plasma elastase of the observation group was lower than that of the control group, while the levels of acid phosphatase and <italic>α</italic>-glucosidase were higher than those of the control group (<italic>P</italic><0.01). Conclusion:Yishen Tongluofang can significantly improve sperm parameters, regulate the level of sex hormones and seminal plasma environment in patients with oligosperm type male infertility, and improve the tendency of spouse pregnancy. Its clinical efficacy is better,so it is worthy of further research and application.

8.
Article in Chinese | WPRIM | ID: wpr-906373

ABSTRACT

Codonopsis Radix, one of the bulk commodities, has been commonly used for tonification in clinical practice. Apart from the medicinal purpose, it can also be utilized as food. Among the multiple local varieties, the ones called "Luduiduoji" in Tibetan medicine cannot be neglected, which have frequently been adopted for diminishing inflammation and swelling, invigorating spleen and stomach, and tonifying Qi, etc. Considering its complex origins and frequent substitution by or confusion with other medicinal materials, this paper reviewed the Si Bu Yi Dian, Jingzhu Bencao, ministerial and local standards, modern literature on Tibetan medicine, and the results of field investigation in major Tibetan medicine hospitals and medicinal material markets of Sichuan, Qinghai and Tibet to figure out the name, original plants, medicinal parts, effects, and local varieties of Codonopsis Radix in Tibetan medicine. The results showed that the names of local varieties were diverse, many of which were transliterated into Tibetan, with "Luduiduoji" being most well-known. It was derived from 14 species in genus Codonopsis and one in Adenophora of family Campanulaceae, with Codonopsis foetens subsp. nervosa, C. thalictrifolia var. mollis, C. canescens, C. alpina, and C. pilosula being the main species. According to literature records, the roots, aerial parts, and whole plants could all be employed as medicine, but there were certain differences in their clinical applications. At present, in order to protect the medicinal resources, Tibetan medical workers mostly collect the aerial parts, which are applicable to patients with yellow water, rheumatism, Gamba disease, and leprosy. This literature review of local varieties for Codonopsis Radix and textual research on their original plants are of great significance for elevating the standard, accelerating the pharmacodynamic research, expanding the sources and promoting the rational use of Codonopsis Radix.

9.
Article in Chinese | WPRIM | ID: wpr-906302

ABSTRACT

Objective:To observe the clinical effect of modified Zengyetang in treating slow transit constipation (STC) due to Qi-Yin deficiency and its effect on gastrointestinal function. Method:One hundred and thirty eligible patients were randomly divided into a control group (<italic>n</italic>=65, 6 cases dropped out or were lost to follow-up and 59 completed the trial) and a treatment group (<italic>n</italic>=65, 3 cases dropped out or were lost to follow-up and 62 completed the trial). Patients in the control group received oral mosapride citrate dispersible tablets, 5 mg per time, three times per day, while those in the treatment group were treated with modified Zengye Tang, one bag per day, for four successive weeks. The main symptom constipation, the Patient Assessment of Constipation Symptoms (PAC-SYM), and traditional Chinese medicine (TCM) syndrome scores, colonic transit, as well as motilin (MTL), vasoactive intestinal peptide (VIP), and substance P (SP) levels before and after treatment were recorded, together with the frequency of spontaneous complete bowel movements (SCBMs) per week and STC recurrence during treatment. Result:The clinical efficacy (95.16%) of the treatment group was higher than that (81.36%) of the control group (<italic>χ</italic><sup>2</sup>=5.631 4, <italic>P</italic><0.05), whereas the recurrence rate (30.65%) of the treatment group was significantly lower than that (57.63%) of the control group (<italic>χ</italic><sup>2</sup>=8.941 1, <italic>P</italic><0.01). After treatment, the main symptom constipation, three sub-scale and total PAC-SYM, and TCM syndrome scores in the treatment group were obviously decreased as compared with those in the control group (<italic>P</italic><0.01). The proportions of residual markers at 24, 48, and 72 h in the treatment group declined in contrast to those in the control group (<italic>P</italic><0.01). The frequency of SCBMs per week in the 2<sup>nd</sup>, 3<sup>rd</sup>, and 4<sup>th</sup> weeks of the treatment group was higher than that in the control group (<italic>P</italic><0.01). Compared with the control group after treatment, the treatment group exhibited significantly elevated MTL and SP but lowered VIP (<italic>P</italic><0.01). Conclusion:Modified Zengyetang relieves the clinical symptoms, regulates gastrointestinal hormone secretion, increases the frequency of SCBMs, enhances colonic transit, and decreases the recurrence of patients with STC due to Qi-Yin deficiency.

10.
Article in Chinese | WPRIM | ID: wpr-906290

ABSTRACT

Plantaginis Semen is a traditional Chinese medicine (TCM) commonly used in China, which is one of the authentic medicinal materials in Jiangxi. It has great development prospects. However, the current research on Plantaginis Semen is not in-depth enough, mainly involving chemical components and pharmacological activities. There are few researches on processing and variety of Plantaginis Semen. In order to further develop and utilize the resources of Plantaginis Semen, we summarized 4 varieties that have been studied more at present, the processing contents of Plantaginis Semen in ancient and modern literature were consulted and sorted out, and its processing historical evolution were summarized. The influences of different processing technologies and methods on the chemical composition and pharmacological effects of Plantaginis Semen were analyzed, the possible processing mechanism was discussed. Meanwhile, and the quality evaluation methods of Plantaginis Semen varieties included in the 2020 edition of Chinese Pharmacopoeia were summarized. The author mainly analyzed the researches status of Plantaginis Semen and its decoction pieces in the three aspects of variety, processing and quality evaluation, and summarized its current major problems such as insufficient use and development of varieties, unclear processing mechanisms, and undetermined quality evaluation standards. And combined with the national standardization project of TCM to carry out the prospect and analysis for it, in order to solve the problems in the actual production and use of Plantaginis Semen, and provide reference for its further development, production of the high-quality decoction pieces, analysis of the processing mechanism, and establishment of the quality control system.

11.
Article in Chinese | WPRIM | ID: wpr-906042

ABSTRACT

Cells in the arterial wall are constantly subjected to the shear stress generated by the blood flow. Shear stress plays a pivotal role in the formation of atherosclerosis. The endothelial cells located between the blood and the vessel wall have a unique response to the shear stress of the blood flow, which can convert mechanical stimulation into intracellular signals, thereby affecting the pathological process of atherosclerosis. Endothelial function is not only regulated by hormones, growth factors and other biochemical substances, but also affected by mechanical forces such as blood flow shear stress. Physiologically, shear stress can play an anti-atherosclerotic role in maintaining the homeostasis of endothelial cells. Pathological shear stress will lead to endothelial dysfunction and promote the progression of atherosclerosis. Under the mediation of different shear stress, the endothelial function can be regulated through epigenetic pathways or mechanically sensitive cation channels. Therefore, it is necessary to understand how various signal transduction pathways are affected by pathological shear stress, so as to cause endothelial dysfunction and atherosclerosis. Traditional Chinese medicine(TCM) has been increasingly recognized for its curative effect in treating atherosclerosis, with the advantages of few side effects, multiple targets and multiple mechanisms. In recent years, the understanding of the anti-atherosclerosis mechanism of TCM mediated by shear stress has gradually deepened. This review will take endothelial function as the breakthrough point, systematically sort out the influence of shear stress on the pathological process of atherosclerosis and the related molecular mechanisms. Meanwhile, it is the first time to summarize the latest research progress of Chinese medicine against shear stress damage by sorting out the existing literature. This article mainly clarify the relationship between shear stress, endothelial function, atherosclerosis and TCM, in order to provide a theoretical basis for the clinical treatment and pathological mechanism of atherosclerosis.

12.
Article in Chinese | WPRIM | ID: wpr-905079

ABSTRACT

Objective:To study the resources and medicinal use of Tibetan medicine Codonopsis canescens,analyze its suitable habitat,and protect its wild resources,in order to provide an important reference basis for further rational development and utilization. Method:Combined investigation methods of literature textual research,visiting investigation and on-the-spot investigation were adopted. Result:In this paper,we investigated the resources and medicinal use of C. canescens in 27 cities and counties of Sichuan,Qinghai and Tibet. Compared with historical records of C. canescens,the results showed that there was no obvious change in the distribution range,and the distribution was uneven in different places. Ganzi Prefecture, Sichuan, boasts rich resources; in particular, Luhuo county has as high as 90-120 plants/100 m2, it is estimated that the reserves per unit area of root C. canescens in this area were 3 445.32 g·m-2,which totaled 1 279.18 ton(1 ton=1 000 kg). In history,the root is the main medicinal part. However, in recent years,in order to protect resources,the aboveground part is frequently used. The clinical efficacy of Tibetan medicine is mainly to tonify Qi and activate blood circulation. It can be combined with other drugs to treat rheumatism,sores,furuncle,carbuncle and other diseases. However,the plants of Codonopsis are mixed with C. canescens in each Tibetan area,and the mixed varieties are determined according to the growing varieties of the same genus in this area. Conclusion:The reserves of wild resources of C. canescens are decreasing with the increase of clinical use and market demand of Tibetan medicine. There is serious mixture of Codonopsis plants in Tibetan areas. It is suggested paying attention to resource protection,carrying out artificial planting,establishing the standard for the medicinal use of Tibetan medicine,and promote rational and sustainable utilization of resources.

13.
Journal of Medical Biomechanics ; (6): E560-E567, 2021.
Article in Chinese | WPRIM | ID: wpr-904438

ABSTRACT

Objective To study the influence of skull thickness on intracranial biomechanical parameters by finite element method. Methods The female head at 5th percentile was selected for CT scanning to construct finite element model of the head with high biofidelity,and the model was verified by reconstructed cadaver test. The finite element model of the head with different skull thickness was established, and multiple groups of tests were carried out to compare the intracranial mechanical parameters. Results The negative value of intracranial pressure was significantly affected by the decrease in skull thickness under the same head size, while the negative value of intracranial pressure was slightly affected, with an increasing trend. The shear stress and von Mises stress of brain tissues were significantly increased with skull thickness increasing. Conclusions Under the same head size, the skull thickness will affect head injury to a certain extent, and people with small skull thickness are more likely to be injured than those with large skull thickness.

14.
Journal of Medical Biomechanics ; (6): E290-E296, 2021.
Article in Chinese | WPRIM | ID: wpr-904400

ABSTRACT

Objective Based on the existing clinical drainage device, two novel mechanisms were designed for the connection between the drainage tube of the patient and the drainage tube of the drainage bag, so as to compare such two mechanisms and validate whether the mechanisms can meet the design requirements for clinical use. Methods Mechanism 1 used the method of electromagnetic drive to pull in and Mechanism 2 used the magnetization method of permanent magnet to pull in. The finite element model of static electromagnetic field was established. The force of the two mechanisms under different currents was compared, and the distribution of magnetic field lines and magnetic induction intensity was analyzed. Simulation experiments were designed for preliminary experimental research. Results Under the pull-in state, the maximum magnetic induction of Mechanism 1 and Mechanism 2 at the closed end surface was found in contact area of the two iron cores. The suction force of Mechanism 1 could be adjusted by the current. When the current was 1 A, the maximum magnetic induction intensity at the closed end was 0.76 T, the electromagnetic force measured by the experiment was 6.08 N, the magnetic force of Mechanism 2 was 6.68 N, which was smaller than the 8 N suture tension. Mechanism 2 was separated by supplying the driving coil with a reverse magnetic field. Conclusions When the current was 1 A, Mechanism 1 could meet the magnetic attraction requirements, and Mechanism 2 could be separated when the current reached 1.8 A. Both mechanisms met the requirements of clinical design, but Mechanism 2 was more secure in the process of application. The feasibility of the mechanism structure was verified by finite element analysis and experimental test.

15.
Article in Chinese | WPRIM | ID: wpr-862584

ABSTRACT

Abstract@#The visual health of children and adolescents in China has become a major issue that is relevant to the nation s present and its future. This article analyzed the value of map reading and searching for specific features during orienteering projects for myopia prevention and control. The findings suggest that orienteering exercises show good regulatory effects on eye muscles, effectively improve concentration, and help to stimulate mental activity and visual system. Targeted exercises, including scanning maps for specific features, is beneficial for myopia prevention and control. It is proposed that, by changing the teaching style of cross-country orienteering, teaching space, and teaching scene, exercises can be tailored to treat and relieve eye strain, as well as to prevent and control myopia, which is essential to promote the visual health of children and adolescents.

16.
Article in Chinese | WPRIM | ID: wpr-887963

ABSTRACT

In this study, patients with prehypertensive liver-fire hyperactivity syndrome(LFHS) were selected as the research objects. The plasma samples of healthy volunteers and patients with prehypertensive LFHS were analyzed by non-targeted metabolomics based on UPLC-Q-Exactive MS. The differential biomarkers and metabolic pathways were screened out by multivariate statistics and metabolic pathway analysis, which revealed the characteristics of metabolic patterns of the syndrome. Thirty-three potential biomarkers such as androsterone and lysophosphatidylcholine and 16 related metabolic pathways such as steroid hormone metabolism and lipid metabolism were identified, and a partial least squares-discriminant analysis(PLS-DA) model of traditional Chinese medicine(TCM) syndromes was preliminarily constructed: Y =-0.070X_(13)-0.006X_8+ 0.040X_5-0.152X_1+0.131X_(10)+0.036X_(11)+0.043X_(23)+0.076X_(16)+0.132X_(20)+0.081X_(19)-0.101X_(31)+0.082X_(15)-0.038X_9+0.079X_(24). The predictive value of the model was 88.1%, and the explanatory power was 88.4%. In this study, the characteristic metabolic pattern of the prehypertensive LFHS was distinguished and revealed by metabolomics. The constructed PLS-DA model is expected to provide an objective basis for the identification of TCM syndromes in prehypertension, and inspiration for exploring the biological basis of TCM syndromes at small-molecular and overall levels.


Subject(s)
Biomarkers , Chromatography, High Pressure Liquid , Humans , Liver , Metabolomics , Syndrome , Technology
17.
Article in Chinese | WPRIM | ID: wpr-887877

ABSTRACT

Circular RNA(circRNA)is a novel type of endogenous non-coding RNA.Most circRNAs act as microRNA(miRNA)sponges to regulate the expression of functional genes.In addition,some circRNAs can be translated and interact with RNA-binding proteins to perform biological functions.The expression of circRNAs is prevalent in tissues and body fluids,and their abnormal expression is related to tumor progression.circRNAs are stable even under the treatment of RNase R because of their circular conformation.As circRNAs have construct stability,wide variety,specific regulation of tumor progression and high expression in body fluids,it is potential for circRNAs to serve as candidate diagnostic,prognostic and therapeutic targets.However,the knowledge about circRNAs remains poor.In addition to the not completely resolved functions and generation mechanisms of circRNAs,the annotations of circRNAs are also waiting for expanding.Here,we review the generation mechanisms,biological functions,and application of circRNAs in tumor research,aiming to provide integrated information for the future research.


Subject(s)
Biomarkers, Tumor/genetics , MicroRNAs , Prognosis , RNA, Circular
19.
Chinese Journal of Urology ; (12): 1-5, 2021.
Article in Chinese | WPRIM | ID: wpr-884948

ABSTRACT

Objective:To investigate the effect of modified transanal approach in the repair of vesicorectal fistula after radical prostatectomy.Methods:From September 2011 to December 2019, 32 cases of vesicorectal fistula after radical prostatectomy were retrospectively analyzed. All patients underwent cystostomy before repair operation. The average diameter of the fistulas was 19 (3-40) mm. There was only one fistula in 24 cases and 8 cases with more than 2 fistulas. The operation was performed in the jack knife position, and the fistula was prepared by resection of the fistula through the anus with bipolar resectoscope. Then bladder wall and rectum wall were separated by the loop and sutured respectively. After operation, the patients were treated with antispasmodic and anti-infective treatment, and the catheter was retained. Cystography and cystoscopy were reexamined 3 months after operation. Catheter was removed in the successful cases, and the failure was repaired again.Results:All operations were completed successfully. The mean operation time was 67(55-125) min, and the median follow-up was 22 (6-30) months. Thirty-one cases (96.8%) were successfully repaired, of which 25 cases were successfully repaired at the first operation, and 6 cases were successfully repaired again (all by transanal route). One case failed to be repaired. He had received external pelvic radiotherapy before operation. After the failure of repair, cystoscopy showed large fistula and stiff surrounding tissue. Then bilateral ureteral skin stoma and cystectomy were performed.Conclusions:Modified transanal approach in the repair of vesicorectal fistula after radical prostatectomy is an effective method. This kind of operation has less trauma, fewer complications and can be operated repeatedly. It is suitable for patients with low position, small fistula and without radiotherapy.

20.
Article in Chinese | WPRIM | ID: wpr-884826

ABSTRACT

Objective:To investigate the joint associations of smoking and insufficient physical activity with hypertension, diabetes and dyslipidemia in male adults.Methods:Based on the data from the 2017 Nanjing Chronic Diseases Risk Factors Surveillance Program, 61 098 Nanjing residents aged 18 and older was randomly recruited from 12 districts, using the multi-stage stratified cluster sampling method. Information about smoking behaviors, physical activity and chronic disease-related indicators within the first 12 months before the survey was obtained through questionnaires.Results:Among the 29 848 valid male samples, the proportions of non-smokers, current smokers and ex-smokers were 59.6%, 37.2% and 3.2%, and the proportions of those who had physically active<600 MET-min/w (insufficient physically active) and ≥600 MET-min/w (adequate physically active) were 18.8% and 82.2%, respectively. In non-smokers, current smokers and ex-smokers, the prevalence of hypertension was 24.7%, 34.0% and 43.8%, and the prevalence of diabetes was 8.8%, 12.3% and 16.5%, and the prevalence of dyslipidemia was 26.8%, 36.1% and 41.9%, respectively. Multivariate logistic regression analysis showed that current smokers had a higher risk of hypertension ( OR=1.164, 95% CI: 1.086-1.248), diabetes ( OR=1.324, 95% CI: 1.207-1.452), and dyslipidemia ( OR=1.291, 95% CI: 1.216-1.371) than non-smokers in male adults. Compared with people who had adequate physical activity, someone with insufficient physical activity had higher hypertension ( OR=1.452, 95% CI: 1.331-1.583), diabetes ( OR=1.170, 95% CI: 1.041-1.315) and dyslipidemia ( OR=1.245, 95% CI: 1.158-1.338). And current smokers with insufficient physical activity had the highest risk of hypertension ( OR=1.749, 95% CI: 1.550-1.974), diabetes ( OR=1.363, 95% CI: 1.165-1.595), and dyslipidemia ( OR=1.614, 95% CI: 1.461-1.782) in male adults. Conclusions:Smoking and insufficient physical activity are risk factors for hypertension, diabetes, and dyslipidemia. People who is characterized by smoking together with insufficient physical activity presents with increased risk on developing hypertension, diabetes, and dyslipidemia.

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