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1.
Laboratory Medicine Online ; : 60-63, 2016.
Article in Korean | WPRIM | ID: wpr-173767

ABSTRACT

The number of massive transfusions for pediatric patients has risen owing to the increasing number of complex surgeries and trauma centers. However, as there are only a few studies on pediatric massive transfusion, adult massive transfusion protocols are used for pediatric patients in many hospitals and institutions. Although massive transfusion protocols would improve the outcomes and reduce the received blood products during transfusion, pediatric patients differ from adults in the tolerability to transfusion, incidence of coagulopathy, and mechanisms of injuries. Therefore clinical physicians have requested for a pediatric massive transfusion protocol. Herein, we reviewed pediatric massive transfusion protocols that have been used in various clinical settings. To date, only a few single-center studies with a small number of pediatric patients have been performed. Even though these studies did not show improvement in outcomes such as mortality and side effects, they reported a short preparation time for fresh frozen plasma products and a low coagulopathy rate in pediatric massive transfusion groups. Therefore, large, prospective, multicenter studies are needed to identify the empiric ratio of blood products for improving outcomes of pediatric patients who need massive transfusion.


Subject(s)
Adult , Humans , Incidence , Mortality , Plasma , Prospective Studies , Trauma Centers
2.
Korean Journal of Hepato-Biliary-Pancreatic Surgery ; : 129-137, 2014.
Article in English | WPRIM | ID: wpr-46914

ABSTRACT

BACKGROUNDS/AIMS: Gallbladder carcinoma is usually associated with an unfavorable prognosis, and the clinical outcome has not improved much. This study was conducted to evaluate outcomes with gallbladder carcinoma according to the type of surgery performed, and the prognostic factors for survival. METHODS: One hundred and six patients with gallbladder carcinoma, who underwent surgery for the purpose of curative resection between January 1999 and June 2012 were reviewed retrospectively. RESULTS: Out of 106 patients, curative resection was achieved in 75 (70.8%). The cumulative 1-, 2- and 5-year survival rates of the gallbladder carcinoma patients were 93.4%, 80.9% and 63.0%, respectively. Radical resections, including extended cholecystectomy, were more beneficial for long term survival of patients. The 5-year survival rate in patients who underwent curative resection (56.9%) was significantly higher than in those who underwent palliative resection (0%, p=0.000). Multivariate analysis revealed that curative resection, preoperative CA19-9, T-stage, N-stage and differentiation of histology were independently significant prognostic factors. CONCLUSIONS: Curative resection and early detection of patients with gallbladder carcinoma were the most important factors for long term survival. Radical resection improves survival for patients with localized gallbladder carcinoma and can help to access exact prognosis and treatments.


Subject(s)
Humans , Cholecystectomy , Gallbladder , Multivariate Analysis , Prognosis , Retrospective Studies , Survival Rate
3.
The Journal of the Korean Society for Transplantation ; : 211-218, 2014.
Article in Korean | WPRIM | ID: wpr-60451

ABSTRACT

BACKGROUND: Liver transplantation is considered as the most powerful modality for patients with acute on chronic liver failure and fulminant hepatic failure. The aim of this study is to identify potential prognostic factors that may affect survival after emergent liver transplantation. METHODS: A total of 42 patients who underwent emergent liver transplantation at Gachon University Gil Medical Center from June 2005 to May 2013 were enrolled. The clinical scoring system analyzed for this study were as follows: Child-Turcotte-Pugh (CTP), model for end-stage liver disease (MELD), Model for end-stage liver disease with incorporation of serum sodium (MELD-Na), Acute physiology and chronic health evaluation II (APACHE II), and Sequential Organ Failure Assessment (SOFA). RESULTS: Preoperative SOFA and APACHE scores were closely related with patient's survival after the operation. Also, the changed value of SOFA while patients waited for their transplantation showed to be significant. In a univariate analysis, serum bilirubin and Glasgow Coma Scale (GCS) showed statistical significance for patient's prognosis. Several factors, such as the use of mechanical ventilator and inotropic agent for treating multiple organ failure were also important. The central nervous system and cardiovascular scores showed an intimate relation with the survival group by a more detailed analysis in SOFA. In a multivariate analysis, SOFA and bilirubin levels affected patient's survival. CONCLUSIONS: In emergent liver transplantation with acute on chronic liver failure and fulminant liver failure, recipient's hepatic function is an important factor along with the donated liver condition l eading to successful operation. Also, it is important to pay attention to the progression of organ failure in predicting the prognosis.


Subject(s)
Humans , APACHE , Bilirubin , Central Nervous System , End Stage Liver Disease , Glasgow Coma Scale , Liver , Liver Diseases , Liver Failure, Acute , Liver Transplantation , Multiple Organ Failure , Multivariate Analysis , Prognosis , Sodium , Ventilators, Mechanical
4.
Journal of Minimally Invasive Surgery ; : 9-14, 2014.
Article in English | WPRIM | ID: wpr-218970

ABSTRACT

PURPOSE: The conventional treatment for ingested foreign bodies (IFB) is removal, which is successful in most cases. However, it can be associated with severe complications, such as gastrointestinal tract perforation, and require emergency surgery. The aim of this study is to analyze clinical data relating to IFB and to develop a proper management plan to reduce the incidence of severe complications. METHODS: Between September 2001 and September 2009, 117 patients visited the emergency room complaining of IFB. Among these patients, 29 were diagnosed with bezoar and were excluded from the study. Medical data for the remaining 88 patients was reviewed retrospectively. For statistical analysis, the foreign bodies (FB) were classified into three subgroups according to their shape (round, sharp, and amorphous). RESULTS: The median age of patients with IFB was seven years, and the male-to-female ratio was 1.3:1. Many of these patients were preschool children under the age of seven who had accidentally sw allowed FB (56 cases, 63.6%). The most common symptom presented among the patients was FB sensation (18 cases, 21%). The results of subgroup analysis showed no significant relation between the shape of the FB and the treatm ent m odality. Spontaneous passage was observed in 21 cases (23.9%). Otherwise, endoscopic removal was performed successfully in 61.4% of cases, and 13 patients required emergency operations (14.8%). CONCLUSION: Early diagnosis and a prompt approach are significant in the successful treatment of IFB. Endoscopic or surgical procedures are sometimes required, particularly in cases where complications are suspected.


Subject(s)
Child, Preschool , Humans , Bezoars , Early Diagnosis , Emergencies , Emergency Service, Hospital , Endoscopy , Foreign Bodies , Gastrointestinal Tract , Incidence , Retrospective Studies , Sensation
5.
Korean Journal of Hepato-Biliary-Pancreatic Surgery ; : 118-125, 2013.
Article in English | WPRIM | ID: wpr-63498

ABSTRACT

BACKGROUNDS/AIMS: The diagnosis for cystic neoplasm of pancreas is based on the morphologic criteria through imaging studies, but the pre- and postoperative diagnoses are often inconsistent. This study aims at the analysis of clinical characteristics and the results of surgical treatments. METHODS: A retrospective review was performed on 93 patients who have undergone surgery for pancreatic cystic diseases in our hospital from January 2001 to February 2013. Among them, 69 patients were confirmed as cystic neoplasms based on pathologic findings. Their clinical manifestations, diagnostic accuracy, surgical method and complications, pathologic findings were analyzed. RESULTS: Serous cystic neoplasm was the most common (n=22), followed by mucinous cystic neoplasm (n=18), intraductal papillary mucinous tumor (n=11), solid pseudopapillary tumor (n=9), neuroendocrine tumor (n=7), and cystic lymphangioma (n=2). The most common clinical symptom is abdominal pains (49.3%). Preoperative imaging studies were consistent with pathological findings in 72% of patients. Cystic fluid CEA levels of 400 ng/ml or more were reliable to detect mucin secreting tumors. Pancreatoduodenectomy was performed for 13 cases and the remaining 54 patients were treated with left-side pancreatectomy. Malignancy was found in 9 cases (13%) of mucin secreting tumors; 5 cases (27.8%) in mucinous cystic neoplasm and 4 cases (36.4%) in intraductal papillary mucinous tumor. Two of these survived without recurrences during the follow-up periods. CONCLUSIONS: Exact treatment protocols for cystic neoplasm of pancreas are not decided because tumors are found with atypical forms. Surgical management is suggested for resectable tumors because a good prognosis can be expected with proper surgery if precancerous lesions are suspected at the time of discovery.


Subject(s)
Humans , Abdominal Pain , Clinical Protocols , Follow-Up Studies , Lymphangioma, Cystic , Mucins , Neoplasms, Cystic, Mucinous, and Serous , Neuroendocrine Tumors , Pancreas , Pancreatectomy , Pancreatic Cyst , Pancreaticoduodenectomy , Prognosis , Recurrence , Retrospective Studies
6.
The Korean Journal of Internal Medicine ; : 428-438, 2013.
Article in English | WPRIM | ID: wpr-212581

ABSTRACT

BACKGROUND/AIMS: Recurrence after hepatic resection is one of the most important factors impacting the prognosis and survival of patients with hepatocellular carcinoma (HCC). We identified prognostic factors affecting overall survival (OS) and disease-free survival (DFS) in patients with HCC after hepatic resection. METHODS: This study was of a retrospective cohort design, and 126 patients who underwent hepatic resection for HCC at Gachon University Gil Medical Center between January 2005 and December 2010 were enrolled. Various clinical, laboratory, and pathological data were evaluated to determine the prognostic factors affecting OS and DFS. RESULTS: Two- and 4-year OS and 2- and 4-year DFS were 78.1% and 65% and 51.1% and 26.6%, respectively. In a multivariate analysis, preoperative alpha-fetoprotein (> 400 ng/mL), tumor size (> or = 5 cm), multiple tumors (two or more nodules), presence of portal vein invasion, modified Union for International Cancer Control (UICC) stage III/IV, and Barcelona Clinic Liver Cancer (BCLC) stage B/C were independent prognostic factors affecting a shorter OS. In the multivariate analysis, presence of microvascular invasion, modified UICC stage III/IV, and BCLC stage B/C were independent prognostic factors for a shorter DFS. CONCLUSIONS: The presence of vascular invasion was an independent poor prognostic factor for OS and DFS in patients with HCC after hepatic resection. Thus, close postoperative surveillance for early detection of recurrence and additional treatments are urgently needed in patients with vascular invasion after hepatic resection.


Subject(s)
Female , Humans , Male , Middle Aged , Carcinoma, Hepatocellular/blood , Disease-Free Survival , Hepatectomy/adverse effects , Kaplan-Meier Estimate , Liver Neoplasms/blood , Multivariate Analysis , Neoplasm Invasiveness , Neoplasm Recurrence, Local , Neoplasm Staging , Proportional Hazards Models , Republic of Korea , Retrospective Studies , Risk Factors , Time Factors , Treatment Outcome , Tumor Burden , alpha-Fetoproteins/analysis
7.
The Korean Journal of Critical Care Medicine ; : 101-107, 2013.
Article in Korean | WPRIM | ID: wpr-643719

ABSTRACT

BACKGROUND: Patients with decompensated liver cirrhosis usually resulted in admission to the intensive care unit (ICU) during hospitalization. When admitted to the ICU, the mortality was high. The aim of this study is to identify multiple prognostic factors for mortality and to analyze the significance of prognostic survival model with each scoring system in patients with decompensated liver cirrhosis who was admitted to the ICU. METHODS: From January 2008 to December 2008, 60 consecutive patients with decompensated liver cirrhosis were admitted in the ICU and retrospectively reviewed. Prognostic models used were Child-Turcotte-Pugh (CTP), model for end-stage liver disease (MELD), model for end-stage liver disease with incorporation of serum sodium (MELD-Na), acute physiology and chronic health evaluation (APACHE) II, and sequential organ failure assessment (SOFA). The predictive prognosis was analyzed using the area under the receiver's operating characteristics curve (AUC). RESULTS: The median follow up period was 20 months, and ICU mortality was 17% (n = 10). A total of 24 patients (40%) died during the study period. The average survival of five prognostic models was related with the severity of the disease. All of the five systems showed significant differences in the cumulative survival rate, according to the scores on admission, and the MELD-Na had the highest AUC (0.924). Multivariate analysis showed that bilirubin and albumin were significantly related to mortality. CONCLUSIONS: The CPT, MELD, MELD-Na, APACHE II, and SOFA may predict the prognosis of patients with decompensated liver cirrhosis. The MELD-Na could be a better prognostic predictor than other scoring systems.


Subject(s)
Humans , APACHE , Area Under Curve , Bilirubin , Follow-Up Studies , Hospitalization , Critical Care , Intensive Care Units , Liver , Liver Cirrhosis , Liver Diseases , Multivariate Analysis , Prognosis , Retrospective Studies , Sodium , Survival Rate
8.
The Journal of the Korean Society for Transplantation ; : 176-183, 2011.
Article in English | WPRIM | ID: wpr-45595

ABSTRACT

BACKGROUND: We wanted to explore performing hepatic arterial reconstruction in living donor liver transplantation (LDLT) using right lobe liver grafts and cadaveric liver transplantation (CLT) in a single center. METHODS: Thirty five LDLTs were performed from April 2005 to August 2009. The back wall support suture without twisting was used in most cases. A single RHA was anastomosed to the RHA in 24 patients, to the proper HA in 2 patients, to the RAHA in 4 patients, to the LHA in 2 patients and to an aberrant RHA arising from the SMA in 3 patients. The diameter of the donor RHA was between 1.5 mm and 3.0 mm (mean: 2.5 mm). In the 34 patients who underwent CLT, most of the arterial anastomoses were usually performed using two cuffs at the recipient HA and the GDA bifurcation and a branching point on the donor CHA with running and intermittent stay suture. RESULTS: The total incidence of HA complication was 4.34% (3/69): 1 HAT (2.85%) occurred in a case of LDLT and 2 HAS (5.88%) occurred in a case of CLT. HAT occurred in 1 recipient on the 1st day following LDLT and 2 HAS occurred in CLT recipients at one and two months, respectively, following LDLT. CONCLUSIONS: HA complications occurred as a mild type of late complication and these complications might not be fatal in CLT. A low incidence of HAT can be achieved with using non-twisting method-guided microsurgical techniques for creating hepatic arterial anastomosis in LDLT. When early HAT occurs, early surgical reconstruction is mandatory for preventing the loss of the graft. Back wall sutures with only single needle suture might be a feasible method for HA microsurgical reconstruction.


Subject(s)
Humans , Arterial Occlusive Diseases , Cadaver , Hepatic Artery , Incidence , Liver , Liver Transplantation , Living Donors , Needles , Running , Sutures , Thrombosis , Tissue Donors , Transplants
9.
Korean Journal of Hepato-Biliary-Pancreatic Surgery ; : 157-163, 2011.
Article in English | WPRIM | ID: wpr-38994

ABSTRACT

BACKGROUNDS/AIMS: Choledochal cyst of the bile duct is characterized by cystic dilatation of the intra- or extrahepatic bile ducts. It is a relatively uncommon disease and there is still much controversy regarding its etiology as being congenital or acquired. METHODS: The medical records of 60 patients who underwent surgical treatments for choledochal cyst between April 1995 and April 2009 at the Gachon University Gil Hospital were reviewed retrospectively. To compare the clinical characteristics, patients under 19 years of age were grouped into children and the others were grouped into adults. RESULTS: Of the overall 60 patients, 24 were grouped into children and 36 were grouped into adults. Female predominance was common in both groups (M : F=1 : 6.5). The most common clinical symptom was abdominal pain (73.3%) in both groups. Children had remarkable jaundice (33.3% vs. 0%) and gastrointestinal symptoms including nausea and vomiting. Fever and chills were more common in children because of the associated complications of cholangitis. According to the Todani classification, type I was the most common form of choledochal cyst in both groups, and type IVa was significantly more common in children than adults (45.3% vs. 16.7%). Thirty patients (50%) had anomalous pancreaticobiliary ductal union which was confirmed by preoperative imaging studies or intraoperative cholangiography. All patients except for one child underwent cyst excision with hepaticojejunostomy. CONCLUSIONS: There was no significant difference in the clinical characteristics of choledochal cysts between children and adults. However, combined diseases especially bile duct malignancy were common in aged patients, early detection and more aggressive surgery is necessary for patients with choledochal cysts.


Subject(s)
Adult , Aged , Child , Female , Humans , Abdominal Pain , Bile Ducts , Bile Ducts, Extrahepatic , Chills , Cholangiography , Cholangitis , Choledochal Cyst , Dilatation , Fever , Jaundice , Medical Records , Nausea , Retrospective Studies , Vomiting
10.
The Korean Journal of Gastroenterology ; : 103-108, 2010.
Article in Korean | WPRIM | ID: wpr-110440

ABSTRACT

Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is the most common form of primary extranodal lymphomas. In most cases, it is developed as multifocal and mucosal lesions, and its initial diagnosis is made by biopsy of suspicious lesions on endoscopy. However, when gastric MALT lymphoma afflict submucosal site without typical mucosal lesion, further procedures are necessary for diagnosis, such as endoscopic mucosal resection and endoscopic ultrasonography. We recently experienced two cases of submucosal tumor-like gastric MALT lymphoma. Both cases were without any mucosal lesion. One case was confirmed by endoscopic mucosal resection, and the latter was by wedge resection. Treatment modalities included endoscopic mucosal resection, surgery, H. pylori eradication, and/or chemotherapy. Both cases achieved complete remission until our 18 months' and 16 months' follow up.


Subject(s)
Female , Humans , Male , Middle Aged , Anti-Bacterial Agents/therapeutic use , Endosonography , Gastric Mucosa/pathology , Gastroscopy , Helicobacter Infections/drug therapy , Helicobacter pylori , Lymphoma, B-Cell, Marginal Zone/diagnosis , Stomach Neoplasms/diagnosis
11.
Journal of the Korean Society for Vascular Surgery ; : 43-47, 2010.
Article in Korean | WPRIM | ID: wpr-63934

ABSTRACT

Abdominal vascular injury after blunt trauma does not occur very frequently. Penetrating trauma is the most common cause (90%) of abdominal vascular injury. A 57-year-old male presented with abdominal pain and color change of the right lower leg after blunt trauma. The physical examination showed rigid tenderness in the entire abdomen and no pulse in the right femoral artery. Computed Tomography (CT) demonstrated the acute aortic dissection, which extended from the infrarenal aorta to the iliac artery and there was embolic occlusion below the right common iliac artery. He underwent endarterectomy after thrombectomy, fasciotomy and small bowel segmental resection. A 65-year-old male presented with abdominal pain after an auto-bicycle crash. On the physical examination, there was tenderness and rebound tenderness noted on the entire abdomen. The CT done outside our hospital demonstrated an intramural hematoma around the descending aorta. He underwent small bowel and sigmoid segmental resection and S-colostomy. On day 1 after operation, he complained of sudden abdominal pain. He then developed the signs of acute liver and renal failure. His condition deteriorated rapidly with conservative management, and he died on day 2.


Subject(s)
Aged , Humans , Male , Middle Aged , Abdomen , Abdominal Pain , Aorta , Aorta, Thoracic , Colon, Sigmoid , Endarterectomy , Femoral Artery , Hematoma , Iliac Artery , Leg , Liver , Physical Examination , Renal Insufficiency , Thrombectomy , Vascular System Injuries
12.
Journal of the Korean Society for Vascular Surgery ; : 61-63, 2010.
Article in Korean | WPRIM | ID: wpr-63930

ABSTRACT

Saphena varix is very rare disease that characterized by isolated distention of the saphenous vein below the sapheno-femoral junction. Saphena varix must be differentiated from other medical problems that can cause a groin mass. A 49-year-old man presented with a palpable mass on the right upper thigh and he'd had the mass for 6 months. There was no history of trauma, and the mass was especially noticeable when he was standing. On the physical examination, a 5 cm-sized soft, nontender, compressible mass was detected at the right upper medial thigh near the femoral foramen. Doppler sonography showed a saccular venous dilatation of the great saphenous vein just below the saphenofemoral junction. On computed tomography, there were superficially dilated veins in the right thigh and calf, a focal saccular aneurysm at the proximal segment of the right greater saphenous vein and no evidence of deep vein thrombosis. Aneurymal excision and stripping of the greater saphenous vein were performed. No complication was observed at the 2 week follow-up.


Subject(s)
Humans , Middle Aged , Aneurysm , Dilatation , Follow-Up Studies , Groin , Hernia, Femoral , Physical Examination , Rare Diseases , Saphenous Vein , Thigh , Varicose Veins , Veins , Venous Thrombosis
13.
Journal of the Korean Surgical Society ; : 51-54, 2010.
Article in Korean | WPRIM | ID: wpr-19170

ABSTRACT

PURPOSE: Failure of hemodialysis access is the main medical problem in chronic renal failure patients. This resulted from complications such as thrombosis, infection, pseudoaneurysm, steal syndrome and so on. This study was undertaken in an attempt to describe the clinical characteristics and significances of dialysis failure due to iatrogenic fistula between prosthetic graft and native vein at puncture site. METHODS: During 5 years between Feb. 2005 and Feb. 2009, five Iatrogenic fistulas were identified in a retrospective review of 133 patients performed 220 times fistulography due to dialysis failure in PTFE (polytetrafluoroethylene) graft. RESULTS: Overall incidence is 3.8 % in PTFE graft cases. Mean age is 50 (28~75) years, male to female ratio 2:3. Median 1st patency period is 20 months (6~36). All iatrogenic fistula is usually located in not venous but arterial limb of forearm loop, combined with the stenosis in venous limb and anastomosis site. More than 70% venous anastmotic stenosis in 4 cases (80%) and diffuse stenosis of venous limb in 3 cases (60%), revised concomitantly either by patch angioplasty or ballooning. Medial follow-up period is 8 months (5~12), graft occlusion occurred in one case. CONCLUSION: All iatrogenic fistula usually occurs in not venous but arterial limb of forearm loop graft. Most iatrogenic fistula is combined with the stenosis in venous limb and anastomosis sites, must be revised concomitantly either by patch angioplasty or ballooning. Close assessment to superficial vein and graft is needed for early detection. Fistulography is the most useful diagnostic tool. Careful cannulation method is required to prevent the occurrence of iatrogenic fistula in chronic renal failure patients.


Subject(s)
Female , Humans , Male , Aneurysm, False , Angioplasty , Catheterization , Constriction, Pathologic , Dialysis , Extremities , Fistula , Follow-Up Studies , Forearm , Incidence , Kidney Failure, Chronic , Polytetrafluoroethylene , Punctures , Renal Dialysis , Retrospective Studies , Thrombosis , Transplants , Veins
14.
The Korean Journal of Gastroenterology ; : 376-383, 2010.
Article in Korean | WPRIM | ID: wpr-12844

ABSTRACT

BACKGROUND/AIMS: It is difficult to clinically and endoscopically differentiate intestinal tuberculosis (ITB) and Crohn's disease (CD). The aim of this study was to evaluate the usefulness of in vitro interferon-gamma (INF-gamma) assay for differential diagnosis between ITB and CD. METHODS: Sixty patients for whom differential diagnosis between ITB and CD was difficult were enrolled between January 2007 and January 2009. The INF-gamma-producing T-cell response to early secreted antigenic target 6 and culture filtrate protein 10 were measured by T-SPOT.TB blood test in vitro. We evaluated the usefulness of T-SPOT.TB blood test by comparing its results with the final diagnosis. RESULTS: Twenty and forty patients were revealed to be positive and negative in T-SPOT.TB blood test, respectively. Of the 20 patients found to be positive, 12 patients (60%) were finally diagnosed as ITB, 6 patients as CD, and 2 patients as Behcet's enterocolitis. Of the 40 patients with negative results, 38 patients (95%) were diagnosed as CD; one as Behcet's enterocolitis; one as nonspecific colitis; none as ITB. The sensitivity and specificity of T-SPOT.TB blood test for ITB were 100% and 83.3%, respectively. Positive and negative predictive values of T-SPOT.TB blood test for ITB were 60.0% and 100%, respectively. CONCLUSIONS: When differential diagnosis between ITB and CD is difficult, T-SPOT.TB blood test may be a helpful and rapid diagnostic tool to exclude ITB. Prospective large-scaled studies are required for further evaluation of the usefulness of T-SPOT.TB blood test for differential diagnosis between ITB and CD.


Subject(s)
Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Crohn Disease/diagnosis , Diagnosis, Differential , Interferon-gamma/blood , Polymerase Chain Reaction , Reagent Kits, Diagnostic , Retrospective Studies , Tuberculosis, Gastrointestinal/diagnosis
15.
Journal of the Korean Surgical Society ; : 360-363, 2009.
Article in Korean | WPRIM | ID: wpr-35513

ABSTRACT

PURPOSE: There are many reports that delayed operation of appendicitis in children is safe, but it is controversial whether the same principle can be applicable in adult patients. The aim of this study was to evaluate the relationship between the interval from onset of symptoms to operation and the pathologic degree of appendicitis. METHODS: In this retrospective study, 783 adult patients (16 years old or more) diagnosed with appendicitis pathologically between 2004 and 2007 were included. The time from onset of symptoms to hospital arrival (patient interval) and time from hospital arrival to operation (hospital interval) were investigated. Pathologic and gross state of the appendicitis was graded as G1 (suppurative), G2 (gangrenous), G3 (ruptured), G4 (periappendiceal abscess). RESULTS: The median time from symptom onset to operation (total interval) was 35 hours. The percentage of G1, G2, G3, and G4 was 86.3%, 11.4%, 2.4%, and 0% when total interval was <24 hours, 61.3%, 21.3%, 15.8%, and 1.6% when between 24 and 72 hours, and 23.8%, 13.9%, 36.9%, and 25.4% when the interval was over 72 hours. The advanced grade of appendicitis correlated with increased hospital stay (P<0.0001). CONCLUSION: This study suggests that delayed appendectomy in acute appendicitis in adults is a risk factor for advanced grades, and that the sooner the operation is undertaken, the better the outcome is.


Subject(s)
Adult , Child , Humans , Appendectomy , Appendicitis , Length of Stay , Retrospective Studies , Risk Factors
16.
The Journal of the Korean Society for Transplantation ; : 43-51, 2009.
Article in Korean | WPRIM | ID: wpr-101821

ABSTRACT

BACKGROUND: The purpose of this study was to promote organ donation by active identification and proper management of brain-dead donor with collaborating network system and to assume operating expenses in the setting of independent organ procurement organization (IOPO) in Korea. METHODS: Seoul National University Hospital and Gachon University Gill Hospital worked together as regional OPO during 8 months from April to December 2008. RESULTS: We constructed cooperative network system with five base-hospitals by MOU (memorandum of understanding). We visited 138 hospitals 223 times and built up brain-dead organ donation. Among total 265 dead patients in intensive care unit (ICU), 95 (36%) patients were considered as potential organ donors, but only 14 (14.7%) donated their organs actually. During the previous 8 months, there were 67 contacts for potential donor evaluation and total 100 solid organs were actually procured from 31 brain-dead donors except 4 cases. We also established and applied a flow chart and critical pathway of potential brain-dead donor. It was worthy of notice to manage 3 brain-dead donors and successfully procured their organs without donor transportation to HOPO. Apart from operating and depreciation expenses, we could estimate the expenses loss of mean 850,000 won per organ in the current system. CONCLUSIONS: Our results showed hope for success of IOPO in Korea which would be founded in the near future. Besides persistent active relationship with regional hospitals, a certain degree of financial support or other means such as increase of organ fee and medical insurance coverage should be considered.


Subject(s)
Animals , Humans , Brain , Brain Death , Critical Pathways , Depreciation , Fees and Charges , Financial Support , Gills , Insurance Coverage , Intensive Care Units , Korea , Tissue and Organ Procurement , Tissue Donors , Transportation
17.
Yonsei Medical Journal ; : 555-559, 2009.
Article in English | WPRIM | ID: wpr-178606

ABSTRACT

PURPOSE: Intrabdominal actinomycosis is difficult to diagnose preoperatively. This chronic infection has a propensity to mimic many other diseases and may present with a wide variety of symptoms. The aim of this study was to evaluate the characteristic clinical features with review of the literature. MATERIALS AND METHODS: We retrospectively analyzed 22 patients with intrabdominal actinomycosis between January 2000 and January 2006. RESULTS: There were two men and 20 women with a mean age of 42.8 years (range, 24 - 69). Twelve patients presented with masses or abdominal pain, whereas 3 patients presented with acute appendicitis. The rate of performing an emergency surgery was 50% due to symptoms of peritonitis. The mean size of tumor was 5.5 cm (range, 2.5 - 11.0). Sixty percent (n = 12) of female patients had intrauterine device (IUD). The average time to definite diagnosis was 10.6 days. CONCLUSION: Intrabdominal abdominal actinomycosis must first be suspected in any women with a history of current or recent IUD use who presents abdominal pain. If recognized preoperatively, a limited surgical procedure, may spare the patient from an extensive operation.


Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Abdominal Pain/etiology , Actinomycosis/diagnosis , Intrauterine Devices , Peritonitis/pathology
18.
Journal of the Korean Society for Vascular Surgery ; : 160-162, 2009.
Article in Korean | WPRIM | ID: wpr-209633

ABSTRACT

True aneurysm of the radial artery is very rare, and the false aneurysms are more common. True aneurysms of the radial artery are usually secondary to trauma or iatrogenic injury. A 71-year-old male presented with a several year history of a left forearm-pulsating mass. He suffered from a brain infarct and had received acupuncture for his hemiplegia for the previous year. The physical examination revealed two pulsating masses on the left forearm. The left ulnar and radial arteries were palpable. The laboratory values were normal. Computerized tomography showed two 40x25 and 37x20 mm-sized saccular true aneuryms containing mural thrombosis in the left proximal radial artery with atherosclerotic change. The aneurysms were resected with reconstruction by using the cephalic vein. Distal flow was reestablished by using end-to-end anastomosis. No complications have been observed during the 4 weeks of follow-up.


Subject(s)
Aged , Humans , Male , Acupuncture , Aneurysm , Aneurysm, False , Brain , Follow-Up Studies , Forearm , Hemiplegia , Physical Examination , Radial Artery , Thrombosis , Veins
19.
Intestinal Research ; : 8-13, 2009.
Article in English | WPRIM | ID: wpr-36316

ABSTRACT

BACKGROUND/AIMS: Acute hemorrhagic rectal ulcers (AHRUs) are rare and have not been thoroughly studied. This study aimed to assess the clinical and endoscopic characteristics of AHRUs and to determine the risk factors for rebleeding after the initial management. METHODS: Thirty patients who underwent colonoscopy within 48 hours of the onset of hematochezia were consecutively enrolled between January 2004 and December 2007. The patients were divided into a rebleeding group and a non-rebleeding group according to presence of recurrent bleeding after initial management. We analyzed the clinical features, including the underlying disorder, the Karnofsky performance status (PS), the use of anticoagulant or antiplatelet agents, the endoscopic findings, and the methods used for hemostasis. RESULTS: All of the patients were elderly, in a bedridden status, and all had experienced the sudden onset of massive, fresh rectal bleeding without pain. The characteristics of the lesions on colonoscopy included solitary or multiple rectal ulcers, or Dieulafoy lesions located in the distal rectum. There were no differences between the two groups based on mean age, gender, use of anticoagulant or antiplatelet agents, PS, methods of hemostasis, and clinical outcomes. The PT (INR) and endoscopic findings (Dieulafoy types), however, differed significantly between the two groups (p=0.024 and p=0.013, respectively). CONCLUSIONS: When massive hematochezia occurs in bedridden patients with severe comorbid illnesses, AHRUs should be considered in the differential diagnosis. It is advisable to be vigilant for rebleeding in patients with prolongation of the PT (INR) and Dieulafoy-type ulcers on colonoscopy.


Subject(s)
Aged , Humans , Colonoscopy , Diagnosis, Differential , Gastrointestinal Hemorrhage , Hemorrhage , Hemostasis , Karnofsky Performance Status , Platelet Aggregation Inhibitors , Rectum , Risk Factors , Ulcer
20.
Journal of the Korean Society of Coloproctology ; : 373-379, 2008.
Article in Korean | WPRIM | ID: wpr-31926

ABSTRACT

PURPOSE: The aims of this study were to assess the oncologic safety of laparoscopic colorectal surgery compared to that of conventional open surgery and to compare the disease-free survival (DFS) rates between laparoscopic and open colorectal surgery for radical treatment of colorectal cancer. METHODS: From January 2001 to December 2005, 583 patients underwent laparoscopic or conventional open surgery. To address only radical treatment of colorectal cancer, we excluded subjects who had undergone emergency or palliative operation. Four hundred ninety patients were identified for this study. The laparoscopic (LG) and open group (OG) had 74 and 166 patients, respectively, for colon cancer, and 92 and 158 patients, respectively, for the rectal cancer. RESULTS: No difference was noted in the lengths of the distal margins of the resected bowels between the LG and the OG for rectal cancer (P>0.05). In addition, no significant difference was found in DFS rates between the LG and the OG for both colon and rectal cancer (P>0.05). CONCLUSIONS: The laparoscopic technique does not seem to present any disadvantages and is safe and feasible for the treatment of colorectal cancer. No difference was found between laparoscopic and open surgery in terms of DFS for colorectal cancer.


Subject(s)
Humans , Colon , Colonic Neoplasms , Colorectal Neoplasms , Colorectal Surgery , Disease-Free Survival , Emergencies , Laparoscopy , Rectal Neoplasms
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