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1.
China Pharmacy ; (12): 870-875, 2021.
Article in Chinese | WPRIM | ID: wpr-875822

ABSTRACT

OBJECTIVE:To systematically evaluate the efficacy and safety of Xianling gubao capsule combined with glucosamine in the treatment of knee osteoarthritis (KOA),and to provide evidence-based reference for clinical treatment of KOA. METHODS:Retrieved from Cochrane library ,PubMed,Embase,CNKI,Wanfang database ,CBM and VIP during the inception to Nov. 2020,randomized controlled trials (RCTs)about glucosamine (control group )combined with Xianling gubao capsule (trial group)in the treatment of KOA were collected. After data extraction ,Cochrane 5.1.0 system evaluator manual was used to evaluate the quality of the included clinical studies met inclusion criteria ,and Rev Man 5.4 software was used for Meta-analysis. RESULTS : A total of 11 RCTs with 970 patients were included in this study. Results of Meta-analysis showed that cure rate [OR =2.41,95%CI (1.48,3.93),P<0.001],marked effective rate [OR =1.95,95%CI(1.49,2.56),P<0.001],total effective rate [OR =4.00,95%CI (2.57,6.24),P<0.001],visual analogue scale (VAS)score [MD =-2.34,95%CI(-2.51,-2.17),P<0.001],knee function score [MD =31.32,95%CI(27.89,34.75),P<0.001],Japanese Orthopaedic Association (JOA)low back pain score [MD = 12.22,95%CI(9.68,14.76),P<0.001] and pain relief time [MD =-1.55,95%CI(-1.84,-1.25),P<0.001] of trial group were all significantly better than those of control group. The incidence of ADR in trial group was significantly lower than control group [OR =0.04,95%CI(0.02,0.12),P<0.001]. CONCLUSIONS :Xianing gubao capsule combined with glucosamine in the treatment of KOA is significantly better in cure rate ,marked effective rate ,total effective rate ,VAS,score,knee function score,JOA low back pain score and pain relief time ,and could significantly reduce the incidence of ADR.

2.
Asian Journal of Andrology ; (6): 103-108, 2021.
Article in English | WPRIM | ID: wpr-879715

ABSTRACT

We aimed to confirm the predictive ability of the presence of intraductal carcinoma of the prostate (IDC-P) for prognosis and the associations between IDC-P and clinicopathological parameters. Studies were identified in PubMed, Cochrane Library, EMBASE, Web of Science, and SCOPUS up to December 1, 2019. Hazard ratios (HRs) for survival data and odds ratios for clinicopathological data with 95% confidence intervals (CIs) were extracted. Heterogeneity was evaluated by the I

3.
Organ Transplantation ; (6): 215-2021.
Article in Chinese | WPRIM | ID: wpr-873733

ABSTRACT

Objective To evaluate the clinical efficacy of percutaneous transluminal angioplasty (PTA) combined with stent implantation in the treatment of transplant renal artery stenosis (TRAS) after renal transplantation. Methods Clinical data of 21 patients with TRAS after renal transplantation undergoing PTA combined with stent implantation were retrospectively analyzed. The incidence of TRAS in renal transplant recipients was summarized. The changes of relevant indexes in patients with TRAS were statistically compared before and after interventional treatment. Clinical prognosis of patients with TRAS was evaluated. Results The incidence of TRAS in renal transplant recipients was 4.1%(21/507). TRAS was diagnosed at postoperative 5 (4, 7) months, and 67% (14/21) of patients developed TRAS within postoperative 6 months. Compared with the values before interventional therapy, the serum creatinine level, systolic and diastolic blood pressure and peak flow velocity of transplant renal artery of patients with TRAS were significantly decreased, and the estimated glomerular filtration rate (eGFR) and interlobar arterial resistance index were significantly increased at 1 week and 1 month after interventional therapy (all P < 0.05). During postoperative follow-up after PTA combined with stent implantation, 1 patient suffered re-stenosis of the transplant renal artery, which was improved after simple balloon dilatation. One patient developed pseudoaneurysm formation at the puncture site of the right femoral artery. One patient presented with renal atrophy and loss of function due to atresia of the transplant renal artery. All the remaining 18 patients were well recovered after surgery. Conclusions PTA combined with stent implantation is the optimal treatment of TRAS after renal transplantation, which can significantly improve the function of transplant kidney and considerably prolong the survival time of transplant kidney.

4.
Acta Physiologica Sinica ; (6): 286-294, 2021.
Article in Chinese | WPRIM | ID: wpr-878257

ABSTRACT

Many studies have shown that high-altitude exposure could significantly influence human cognition, and the approaches which could enhance the human cognition in high-altitude hypoxia environment attract great attention. In the present study, we recruited a total of 60 subjects who had been migrated to Tibet University as adults for more than one year. These participants were randomly divided into the experimental group and the control group. The participants in the experimental group were instructed to complete a hyperbaric oxygen treatment, and those in the control group just completed a wait condition. By using the attention network test (ANT), the changes of the attention function before and after a single session of hyperbaric oxygen treatment were explored. The results showed that single hyperbaric oxygen treatment significantly improved the orienting function of attention, with an obvious post-intervention effect, but not the alerting and conflict function of attention. We also found a strong association between alerting function and conflict function after the end of intervention, suggesting the change of the overall performance of attention function. The present findings might suggest that the improvement of attention function by a single session of hyperbaric oxygen intervention is derived from the increase of general cognitive resources, rather than the transfer of cognitive resources within the attention system.


Subject(s)
Adult , Humans , Hyperbaric Oxygenation , Orientation , Oxygen , Reaction Time , Tibet , Transients and Migrants
5.
Chinese Journal of Dermatology ; (12): 397-401, 2021.
Article in Chinese | WPRIM | ID: wpr-885227

ABSTRACT

Objective:To analyze gene mutations in 3 families with self-improving collodion ichthyosis.Methods:Clinical data were collected from 3 patients with self-improving collodion ichthyosis. DNA was extracted from the peripheral blood of patients and their parents, and high-throughput sequencing was performed in the patients by using a multi-gene panel targeting congenital ichthyosis. After identification of causative gene loci, Sanger sequencing was performed to bidirectionally verify the mutations in the patients and their parents.Results:All the 3 patients presented with a collodion-like membrane at birth, which was shed within 2-4 weeks after birth, and then they gradually showed similar features of mild ichthyosis, including dry skin, tiny scales at local sites, flexural involvement, mild sweating, heat intolerance, cheek flushing, mild palmoplantar keratosis or palmar hyperlinearity. Compound heterozygous mutations were identified in the ALOX12B gene of the 3 patients, including a paternal mutation c.406_408delGAG and a maternal mutation c.77T>C in case 1, a paternal mutation c.1013C>T and a maternal mutation c.1286C>G in case 2, a paternal mutation c.1232T>C and a maternal mutation c.1440C>A in case 3. Function prediction analysis showed that 4 missense mutations c.77T>C, c.1286C>G, c.1013C>T, c.1232T>C and 1 deletion mutation c.406_408delGAG may exert pathogenic effect, and 1 nonsense mutation c.1440C>A led to the generation of a termination codon encoding a truncated protein p.Tyr480Ter, which may affect the protein function and cause disease. None of the 6 mutation sites had been reported in the past.Conclusion:Compound heterozygous pathogenic mutations were identified in the ALOX12B gene of the 3 patients with self-improving collodion ichthyosis, which were inherited from their parents.

6.
Chinese Journal of Geriatrics ; (12): 128-131, 2021.
Article in Chinese | WPRIM | ID: wpr-884855

ABSTRACT

Axial symptoms of Parkinson's disease, such as gait disturbance and postural instability, do not respond well to anti-Parkinson drugs or deep brain stimulation.It has been reported that spinal cord stimulation can improve these symptoms, but the effects are not consistent.This article reviews animal experiments and clinical trials on spinal cord stimulation in the treatment of Parkinson's disease, in order to explore the mechanisms of action of spinal cord stimulation and give some suggestions for future research and clinical application.

7.
Clinical Medicine of China ; (12): 26-30, 2021.
Article in Chinese | WPRIM | ID: wpr-884133

ABSTRACT

Objective:To investigate the correlation between serum high sensitivity C-reactive protein and carotid intima-media thickness.Methods:A total of 5 136 health examination subjects, aged ≥40 years old, who met the inclusion criteria and had complete data, were selected as the research objects.A unified questionnaire survey, blood biochemistry and carotid artery color doppler ultrasound examination were performed.According to the diagnostic criteria of hs-CRP published by American Heart Association (AHA), the subjects were divided into three groups: 0.05 mg/L<hs-CRP<1.00 mg/L, 1.00 mg/L≤ hs-CRP<3.00 mg/L, and hs-CRP≥ 3.00-10.00 mg/L.Stepwise linear regression, χ 2 trend test and stepwise regression analysis were used to explore the correlation between hs-CRP and CIMT. Results:(1)Five thousand one hundred and thirty-six patients were enrolled, including 3 048 males and 2 088 females, aged (54.87±11.65) years.(2) Taking CIMT as the dependent variable and hs-CRP (converted by Lg)as the independent variable, the stepwise linear regression analysis using the entry method showed that there was a linear correlation between hs-CRP and CIMT, and the standard regression coefficient was 1.107( P<0.01). (3) According to this study, CIMT was divided into two groups, CIMT≤ 0.84 mm group and CIMT>0.84 mm group.The results showed that when the concentration of hs-CRP was high, CIMT increased with the increase of hs-CRP( OR(95% CI) 1.24 (1.01~1.52), P<0.05). Conclusion:There was a positive correlation between hs-CRP and CIMT.Patients with higher levels of hs-CRP are more likely to develop CIMT thickening and increase the risk of arteriosclerotic disease.

8.
Article in Chinese | WPRIM | ID: wpr-876189

ABSTRACT

Objective To understand the epidemiological characteristics of syphilis in Songjiang District of Shanghai from 2007 to 2017, and provide evidence for further improvement in the prevention and control measures. Methods Descriptive analysis was performed on the syphilis case data in Songjiang District from 2007 to 2017. Results In 2007-2017, a total of 8 546 cases of syphilis were reported in Songjiang District, with an average annual incidence of 48.23/100 000.The overall incidence showed a U-shaped upward trend, with the highest incidence in 2016 (68.17/100 000);the average annual incidence decreased by 6.13/100 000 from 2007 to 2010, whereas increased by 5.64/100 000 from 2011 to 2017.Syphilis was characterized as follows:1) The epidemic was dominated by the cases with local household registration, latent syphilis (51.84%), reported in June-September, aged 20-59 years (81.24%).The cases in the age group over 60 years showed a significant upward trend.2) In the local syphilis cases, there were more men than women, and the sex ratio was 1.3 : 1 (especially the sex ratio in the stage 1 and stage 2 syphilis was 1.73 : 1).In the foreign cases from other provinces, there were less men than women, and the sex ratio was 0.6 : 1. 3) In the primary syphilis cases, there were more men (35.50%) than women (20.98%), while more female cases in the latent syphilis and secondary syphilis cases.Local primary and secondary cases were mainly in the age group of 30 to 59 years (59.06%).The cases from other provinces were mainly 20 to 49 years old (85.24%). Conclusion The incidence of syphilis in Songjiang District is increasing.As primary syphilis are more likely to be male and young adults, we should strength the surveillance, establish standardized diagnosis and treatment of syphilis, advocate sexually transmitted diseases prevention and treatment and safe sexual behavior, and also promote active screening in women and the elderly for further control of syphilis.

9.
Acta Physiologica Sinica ; (6): 181-189, 2020.
Article in Chinese | WPRIM | ID: wpr-827069

ABSTRACT

Long-term exposure to high altitude affects spatial working memory. Previous studies have focused on the analysis of electroencephalogram (EEG) components in time domain rather than in frequency domain. To explore the influence of long-term high altitude exposure on time dynamic characteristics and neural oscillation process of the spatial working memory, n-back task combined with the technology of event related potential recording was performed on 20 young migrants who grew at low altitude before the age of 18 and moved to high altitude more than three years ago, and 21 young people who had never been to the high altitude. EEG data were recorded, and the time domain and frequency domain analyses were performed. The results showed that the response time was longer and the accuracy rate was lower under the 2-back condition in the high altitude group compared with those in low altitude group. The late positive potential (LPP) amplitude was more negative, P2 amplitude was more positive in the 2-back condition, and the power value of early delta frequency band (1-4 Hz, 160-300 ms) was larger, while the power values of late delta frequency band (1-4 Hz, 450-650 ms) and theta frequency band (4-8 Hz, 450-650 ms) were smaller in the high altitude group compared with those in low altitude group. The results suggested that long-term exposure to high altitude affected the spatial working memory ability of the migrants, which was reflected in the lack of attention resources in the later matching stage, decreased response inhibition ability and information maintenance ability, and thus resulted in impaired spatial working memory.


Subject(s)
Altitude , Brain , Electroencephalography , Humans , Memory, Short-Term , Reaction Time , Spatial Memory , Transients and Migrants
10.
Acta Pharmaceutica Sinica ; (12): 2942-2950, 2020.
Article in Chinese | WPRIM | ID: wpr-862291

ABSTRACT

We used the network pharmacology to explore the active ingredients and mechanism of action of Danqi tablets in the treatment of coronary heart disease, providing a theoretical basis for the treatment of clinical coronary heart disease. The TCMSP database was used to screen for active ingredients and targets in Danqi tablets; the predicted targets of coronary heart disease were screened through the GeneCards database; then, the intersection of the two targets was mapped; we used STRING database to construct a protein interaction network map and identified 65 cores targets; then, the DAVID database was used for enrichment analysis of gene ontology (GO) biological processes and KEGG signaling pathways, and finally the Cytoscape-3.6.2 software was used to construct a network diagram of traditional Chinese medicine-active ingredient-key targets-pathway. The H2O2-induced H9C2 cells injury model was used for experimental verification. The results suggest that Danqi tablets act on inflammatory factors and apoptosis-related pathways through quercetin, luteolin, tanshinone IIA, and other active ingredients, and improve proinflammatory or anti-inflammatory imbalances in the body and protect cardiomyocytes. This study confirms the multi-component and multi-target effects of Danqi tablets in the treatment of coronary heart disease, and provides an objective basis for their use in further experimental research and the clinical diagnosis and treatment of coronary heart disease.

11.
Article in Chinese | WPRIM | ID: wpr-873073

ABSTRACT

The necessity of establishing the review system in the administration of national drug standards was analyzed, in order to provide suggestions for improving the national drug standard work. The problems existed in national drug standard administration were analyzed and summarized, the purpose and significance of standard review system was analyzed, and the implementation of standard review system in other industries was reviewed. At present, there are some problems in the administration of national drug standards, such as imperfect working mechanism, unsatisfactory progress in the improvement of standards, low participation of manufacturers in the work of national standards, and unsmooth elimination mechanism of standards. The establishment of standard review system in national drug standard administration conforms to the objective law of standard management, which is helpful to improve the top-level design of national drug standard activities, solve the bottleneck problems in the durg standard work, realize the dynamic management of national drug standard, and promote the re-evaluation work of drugs after being put on the market. In a word, the establishment and implementation of the standard review system is conducive to the development of national drug standards.

12.
Article in Chinese | WPRIM | ID: wpr-872980

ABSTRACT

Objective::To study the effect of Hei Xiaoyaosan on the expression of calcium calmodulin-dependent protein kinase Ⅱ alpha(CaMKⅡα) and its phosphorylation in hippocampus and cortex of mice with Alzheimer's disease. Method::After weighing, 30 APP/PSI transgenic male mice were divided into model group, donepezil hydrochloride group and Hei Xiaoyaosan group according to random principle and 10 in each group.At the same age, wild-type C57BL/6 10 mice of the same species were treated as blank group. Donepezil hydrochloride group (6 g·kg-1) and Hei Xiaoyaosan group (3.25 mg·kg-1) were administered for 90 days, then the behavior of all the mice were detected by Morris water maze, the expression of CaMKⅡα, p-CaMKⅡα proteins in hippocampus and cortex by immunohistochemical technique and Western blot. Result::After intervention 3 months, compared with blank group, the average escaping latency periods prolonged significantly and the number of cross-platform and effective areas were decreased distinctly in model group mice(P<0.01), CaMKⅡα protein relative expression decreased significantly(P<0.01), p-CaMKⅡα protein relative expression increased significantly(P<0.01). Compared with the model group, the escape latency of donepezil hydrochloride and Hei Xiaoyaosan group were significantly shortened, and the number of crossing platforms and effective areas was significantly increased (P<0.05, P<0.01), the expression of CaMKⅡα protein in the hippocampus and cortex of drug groups was significantly increased (P<0.01), p-CaMKⅡα protein in the hippocampus and cortex of drug groups was significantly decreased (P<0.05, P<0.01). Conclusion::Hei Xiaoyaosan can improve the learning and memory ability of AD mice by regulating the expression of CaMKⅡα and its phosphorylation, which are key proteins involved in the mechanism of cell memory formation in different brain regions of AD mice.

13.
Article in Chinese | WPRIM | ID: wpr-872717

ABSTRACT

Alzheimer's disease(AD) is an incipient aging neurodegenerative disease, which increases rapidly along with the development trend of social aging and seriously threatens the health of the people. In the absence of effective preventive measures, it will have an enormous impact on the socio-economic and healthcare system. The study found that abnormal cell signal transduction is a key link in many diseases. Cell signal transduction theory has been widely used to clarify the essence of traditional Chinese medicine visceral image and the mechanism of traditional Chinese medicine. 'Correlation of Liver and Kidney' is one of the core plates of the theory of 'Correlation of Five Organs', which is suitable for explaining the pathogenesis of complex diseases and the correlation of multiple syndromes, and guiding the prescription of clinical syndrome. Hei Xiaoyaosan, as the first choice compound for the prevention and treatment of AD based on the theory of "Correlation of Liver and Kidney' in our team, can play the effects of prevention and treatment by soothing liver and nourishing blood, strengthening spleen and tonifying kidney, and promoting brain collaterals and dredging viscerab spirit. Based on the theory of 'Correlation of Liver and Kidney', this paper expounds the pathogenesis of AD from the perspective of traditional Chinese medicine, and puts forward the methods and ideas of the preventing and treating of AD from Ca2+-calcium/calmodulin dependent protein (CaM)/calcium/calmodulin dependent protein kinaseⅡ(CaMKⅡ)-cyclic adenosine phosphate reactive element binding protein (CREB) cell signal transduction pathway by consulting literatures and previous studies.

14.
Chinese Journal of Dermatology ; (12): 551-553, 2020.
Article in Chinese | WPRIM | ID: wpr-870322

ABSTRACT

A 26-month-old male child was admitted for hair abnormality after birth. There was no hair growth on the scalp of the child after birth, rough skin and scattered rice-grain-sized follicular papules were observed all over the body, and erythema was seen in the perianal region. Fifteen days after birth, the patient was found to be photophobic. Skin examination showed diffusely distributed rice-grain-sized follicular papules all over the body, no growth of hair, eyelashes or eyebrows, and well-circumscribed perianal erythema with scaling at the edges. Genetic testing revealed a c.661T>A mutation in the MBTPS2 gene on the X chromosome of the child, which caused a substitution of phenylalanine by isoleucine at amino acid position 221 (p. Phe221Ile) . A heterozygous mutation at the same locus was identified in the patient′s mother. The patient was diagnosed with ichthyosis follicularis, alopecia, and photophobia syndrome.

15.
Chinese Journal of Dermatology ; (12): 501-507, 2020.
Article in Chinese | WPRIM | ID: wpr-870318

ABSTRACT

Hemangiomas and vascular malformations are common diseases in children. With the continuous update of disease classification criteria, their diagnosis and treatment have also gradually developed. Infantile hemangioma has a good prognosis, but the timing and method of treatment are crucial to the prognosis. Beta-blockers are the first-line drugs for the treatment of infantile hemangioma. The correct diagnosis and differential diagnosis of vascular malformations, especially some vascular malformation-related syndromes with low incidence, are still challenges in the field of modern medicine. Recent studies have shown that the pathogenesis of vascular malformations is associated with mutations in related genes, which provides a theoretical basis for targeted drug therapy. Multidisciplinary integration is the future trend in the diagnosis and treatment of vascular malformations. This review describes the current status of, as well as problems and future research directions in the diagnosis and treatment of common hemangiomas and vascular malformations.

16.
Chinese Journal of Dermatology ; (12): 569-572, 2020.
Article in Chinese | WPRIM | ID: wpr-870313

ABSTRACT

Classification of hemangiomas and vascular malformations has gone through centuries of history from the most primitive morphological classification to the current biological classification. In 2018, the International Society for the Study of Vascular Abnormalities (ISSVA) refined and supplemented the classification of vascular tumors based on the 1996 and 2014 editions, and added 15 rare vascular tumors; for vascular malformations, the 2018 ISSVA classification reclassified the subtypes of capillary malformations, renamed "verrucous hemangioma" as "verrucous vascular malformation", added "limb capillary malformation with congenital non-progressive limb overgrowth", "CLAPO syndrome", PIK3CA-related hyperproliferative diseases, and so on. This review elaborates the primitive classification, traditional classification and modern classification of hemangiomas and vascular malformations, compares the similarities and differences among the 1996, 2014 and 2018 ISSVA classifications, and discusses the significance of the modern classification of hemangioma and vascular malformations for diagnosis and treatment.

17.
Chinese Journal of Dermatology ; (12): 266-270, 2020.
Article in Chinese | WPRIM | ID: wpr-870262

ABSTRACT

Objective:To detect gene mutations in two patients with xeroderma pigmentosum (XP) .Methods:Clinical data were collected from two patients with XP. DNA was extracted from peripheral blood of the patients and their parents, and high-throughput whole-exome sequencing was performed in the patient to identify pathogenic gene mutations. Then, Sanger sequencing was performed to bidirectionally verify the mutations in the patients and their parents, with a focus on mutations in the candidate genes XPA, ERCC3, XPC, ERCC2, DDB2, ERCC4, ERCC5 and POLH.Results:Case 1, a 3-year-old male patient, presented with brown spots and hypopigmented macules on the face, ears, neck and back of both hands for 2 years, as well as gait instability for 1 year. The skin lesions were mainly distributed in sun-exposed areas and worsened in summer. Case 2, a male patient aged 1 year and 5 months, presented with scattered brown spots and a few hypopigmented macules on the face for 1 year. Genetic testing showed compound heterozygous mutations in the ERCC2 gene of case 1, including c.1805G>A (p.Gly602Asp) mutation inherited from his father and c.586C>T (p.Arg196Ter) mutation inherited from the his mother, so case 1 was diagnosed with XP group D (XPD) . Compound heterozygous mutations were identified in the ERCC5 gene of case 2, including c.2533+2T>C mutation inherited from his father and c.2453C>T (p.Ala818Val) mutation inherited from his mother, so case 2 was diagnosed with XP group G (XPG) . The c.586C>T (p.Arg196Ter) and c.2533+2T>C mutations had not been reported before. Sun protection was suggested. After a follow-up of 2 years, skin lesions increased in the 2 patients, but no malignant tumors occurred.Conclusions:The compound heterozygous mutations in the ERCC2 gene can lead to XPD, mainly manifesting as cutaneous and neurological symptoms, while the compound heterozygous mutations in the ERCC5 gene can lead to XPG, manifesting as a mild phenotype. Early clinical features combined with genetic testing are helpful for accurate diagnosis and classification of XP.

18.
Chinese Journal of Geriatrics ; (12): 896-900, 2020.
Article in Chinese | WPRIM | ID: wpr-869489

ABSTRACT

Objective:To investigate the correlation between mild cognitive impairment(MCI)and sleep disorder in the elderly.Methods:A total of 220 elderly patients in our hospital from March 2018 to April 2020 were enrolled in this study, including 65 single amnestic patients, 97 multiple amnestic patients and 58 non-amnestic patients.The Pittsburgh Sleep Quality Index (PSQI)and Epworth sleepiness scale(ESS)were used to evaluate subjective sleep patterns.The quality of sleep were monitored and analyzed through polysomnography.The Spearman univariate correlation between MCI and sleep disorder was analyzed.Results:The average PSQI score of 220 patients was(17.1±3.9)points.The Spearman univariate correlation analysis showed the following results.(1)In the single amnestic group, MCI was positively correlated with the sleep quality, sleep time, daytime dysfunction, total PSQI score, arousal index and ESS score( rs=0.356, 0.324, 0.351, 0.412, 0.361 and 0.327, respectively, all P<0.05). (2)In the multiple amnestic group, MCI was positively correlated with the sleep quality, sleep time, sleep disorder score, hypnotic drug score, total PSQI score, arousal index, light sleep period and ESS score( rs=0.283, 0.323, 0.346, 0.401, 0.379, 0.412, 0.228, 0.251, all P<0.05). (3)In the non-amnestic group, MCI was positively correlated with the sleep time, hypnotic drug score, total score of PSQI, REM sleep disorder and light sleep period( rs=0.348, 0.307, 0.391, 0.355 and 0.228, all P<0.05). Conclusions:There are correlations between the MCI types and sleep disorders in the elderly, and different MCI types are associated with different factors on sleep disorder.

19.
Chinese Journal of Geriatrics ; (12): 722-727, 2020.
Article in Chinese | WPRIM | ID: wpr-869459

ABSTRACT

Parkinson's disease(PD)can lead to falls as the disease progresses, and falls increase the mortality of PD patients.Therefore, it is important to understand the risk factors for falls in PD and use prediction tools with high accuracy in order to predict falls and propose prevention strategies.This paper summarizes the risk factors for falls in Parkinson's disease and reviews studies evaluating the accuracy of prediction tools for falls, with the aim of providing help in clinical practice.

20.
Chinese Journal of Endemiology ; (12): 551-556, 2020.
Article in Chinese | WPRIM | ID: wpr-866160

ABSTRACT

Objective:To expound the pathogenesis relationship between Yunnan unexplained sudden death (YUSD) and desmosomal protein gene mutations of arrhythmogenic right ventricular cardiomyopathy (ARVC).Methods:Four YUSD cases families by ARVC pathological diagnosis were selected, to collect heart blood samples of YUSD cases by ARVC pathological diagnosis( n=3), venous blood samples of immediate relatives with genetic relationship (case relatives, n=4) and control population without genetic relationship ( n=7). DNA was extracted for PCR amplification and sequencing of a total of 97 exons of the ARVC desmosomal protein genes plakophilin 2 (PKP2), desmoplakin (DSP), desmoglein 2 (DSG2), desmocollin 2 (DSC2), and junction plakoglobin (JUP), and the mutations of the 5 genes were analyzed in combination with the genetic family. Results:DSP gene mutations were found in all YUSD cases by ARVC pathological diagnosis and case relatives, and PKP2, DSG2, DSC2 and JUP genes mutations were found in 1 person each. The same person carried 1-3 genes mutations. DSP gene existed 4 exon mutation sites, and 1 of which was a newly discovered heterozygous synonymous mutation c.4014 C>A (p.A1338A). PKP2 gene existed 2 exon missense mutation sites in 1 YUSD case by ARVC pathological diagnosis, and 1 of which was a newly discovered heterozygous mutation c.739 G>C (p.G247R). One heterozygous missense mutation site c.799 G>A (p.A267T) of JUP gene was newly discovered, and the predictive value of protein function was 0.963, the possibility of abnormal changes in protein function was high. DSG2 and DSC2 genes each had one mutation site. However, no mutation was found in control population.Conclusions:Both YUSD cases by ARVC pathological diagnosis and case relatives carry ARVC desmosomal protein genes DSP, PKP2, DSG2, DSC2 and JUP mutations. There may be a certain pathogenesis relationship between YUSD and ARVC desmosomal protein gene mutations.

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