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Asian Journal of Andrology ; (6): 651-658, 2008.
Article in English | WPRIM | ID: wpr-359988


<p><b>AIM</b>To conduct a double-blind, placebo-controlled randomized and dose-ranging study to evaluate the safety and efficacy of the extract of Ganoderma lucidum (G. lucidum) in men with lower urinary tract symptoms (LUTS).</p><p><b>METHODS</b>We enrolled male volunteers (> or = 50 years) with an International Prostate Symptom Score (IPSS; questions 1-7) > or = 5 and a prostate-specific antigen (PSA) value < 4 ng/mL. Volunteers were randomized into groups of placebo (n = 12), G. lucidum of 0.6 mg (n = 12), 6 mg (n = 12) or 60 mg (n = 14), administered once daily. Efficacy was measured as a change from baseline in IPSS and the peak urine flow rate (Q(max)). Prostate volume and residual urine were estimated by ultrasonography, and blood tests, including PSA levels, were measured at baseline and at the end of the treatment.</p><p><b>RESULTS</b>The overall administration was well tolerated, with no major adverse effects. Statistical significances in the magnitude of changes between the experimental groups were observed at weeks 4 and 8. No changes were observed with respect to Q(max), residual urine, prostate volume or PSA levels.</p><p><b>CONCLUSION</b>The extract of G. lucidum was well tolerated and an improvement in IPSS was observed. The recommended dose of the extract of G. lucidum is 6 mg in men with LUTS.</p>

Aged , Humans , Male , Middle Aged , Dose-Response Relationship, Drug , Double-Blind Method , Drugs, Chinese Herbal , Therapeutic Uses , Phytotherapy , Methods , Pilot Projects , Prostate , Pathology , Prostate-Specific Antigen , Blood , Prostatic Hyperplasia , Drug Therapy , Reishi , Treatment Outcome , Urinary Bladder, Overactive , Drug Therapy , Urinary Incontinence , Drug Therapy
Asian Journal of Andrology ; (6): 777-785, 2008.
Article in English | WPRIM | ID: wpr-359986


<p><b>AIM</b>To evaluate the safety and efficacy of an extract of Ganoderma lucidum that shows the strongest 5alpha-reductase inhibitory activity among the extracts of 19 edible and medicinal mushrooms by a double-blind, placebo-controlled, randomized and dose-ranging study in men with lower urinary tract symptoms (LUTS).</p><p><b>METHODS</b>In this trial, we randomly assigned 88 men over the age of 49 years who had slight-to-moderate LUTS to 12 weeks of treatment with G. lucidum extract (6 mg once a day) or placebo. The primary outcome measures were changes in the International Prostate Symptom Score (IPSS) and variables of uroflowmetry. Secondary outcome measures included changes in prostate size, residual urinary volume after voiding, laboratory values and the reported adverse effects.</p><p><b>RESULTS</b>G. lucidum was effective and significantly superior to placebo for improving total IPSS with 2.1 points decreasing at the end of treatment (mean difference, -1.18 points; 95% confidence interval, -1.74 to -0.62; P < 0.0001). No changes were observed with respect to quality of life scores, peak urinary flow, mean urinary flow, residual urine, prostate volume, serum prostate-specific antigen or testosterone levels. Overall treatment was well tolerated with no severe adverse effects.</p><p><b>CONCLUSION</b>The extract of G. lucidum was well tolerated and improved IPSS scores. These results encouraged a further, large-scale evaluation of phytotherapy for a long duration using the extract of G. lucidum on men with LUTS.</p>

Aged , Humans , Male , Middle Aged , Drugs, Chinese Herbal , Ethanol , Phytotherapy , Placebos , Reishi , Solvents , Treatment Outcome , Urination Disorders , Drug Therapy , Urodynamics
Japanese Journal of Physical Fitness and Sports Medicine ; : 163-171, 1982.
Article in Japanese | WPRIM | ID: wpr-376761


The following two aspects will be considered in this paper. First, in order to elucidate the effects of experimental increase of heat production on the cold-induced vasodilation (CIVD), we examined 20 males in CIVD before and after each exercise. Second, in terms of the difference in CIVD between trained and untrained individuals, 160 trained and 34 untrained males were examined. The results obtained from both of the experiments may be summarized as follows.<BR>1. The CIVD after one hour's outdoor exercise was enhanced in comparison with that before exercise. After exercise, the temperature before water immersion (TBI), mean skin temperature (MST) and temperature at first rise (TFR) during immersion were significantly higher, and the time to temperature rise (TTR) during immersion was significantly shorter.<BR>The amplitude of temperature (AT) was likewise significantly higher. These scores were calculated into resistance indices (RI) by Yoshimura's method and Nakamura's method (3 point method and 5 point method) . As a result, the RI by Yoshimura's method was significantly higher after exercise while that by Nakamura's method showed no difference. This suggests that a transient increase of heat content by physical exercise is ignored in the latter method.<BR>2. In regard to the features of CIVD in the trained as compared with the untrained, TBI, MST, TFR and AT were higher, and TTR was shorter and RI was significantly higher. There was a significant positive correlation between the years of experience of sports and RI.<BR>3. The CIVD was higher in those trained in outdoor sports than in indoor sports. The RI, classified by sport events was the highest in swimming followed in decreasing order by rowing, karate, baseball, track and field, judo, tennis, rugby, basketball, soccer, kendo, badminton, volleyball and table-tennis.<BR>This order was almost the same even after eliminating the effects of the years of experience of sports. Thus, it follows from this observation that the RI was higher in the trained in outdoor sports than in the trained in indoor sports. This result may be atrributed to the fact that outdoor sportsmen have more opportunities to be exposed to outdoor cold as compared with indoor sportsmen.