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Chinese Journal of Pharmacology and Toxicology ; (6): 540-540, 2023.
Article in Chinese | WPRIM | ID: wpr-992215


OBJECTIVE The N-methyl-D-aspartate(NMDA)receptor has been shown to be strongly associ-ated with rapid antidepressant effects.GW043 is a com-pound with a novel structure that we designed and syn-thesized to act on the NMDA receptor(NMDAR).METH-ODS In this study,we first confirmed the target of GW043 using a receptor binding assay.We observed the effect of GW043 on NMDAR currents in vivo and in vitro assays using a membrane clamp technique with a view to characterizing the function of GW043.We investi-gated the antidepressant effect of GW043 in rodent behavioral models such as FST,TST and CUMS.Fur-thermore,we explored the mechanism of GW043 onset using Western blotting,BrdU staining,Golgi staining and electrophysiological techniques.RESULTS GW043 interacts with high affinity only at the NMDAR.Electro-physiological studies have indicated that GW043 is a par-tial agonist of NMDAR.Meanwhile,behavioral experi-ments were conducted to confirm the antidepressant effect of GW043 in rodents.The mechanism study found that GW043 regulate synaptic plasticity through LTP and BDNF/mTOR pathways and increase the number of new-born neurons to cause antidepressant effects.GW043,a partial agonist of NMDAR,reversed depression-like behav-ior in rats by modulating synaptic plasticity,suggesting an antidepressant effect.CONCLUSION The results suggest that GW043 is a partial agonist of NMDA recep-tors and has significant antidepressant effects.

Journal of Clinical Hepatology ; (12): 1763-1765, 2016.
Article in Chinese | WPRIM | ID: wpr-778405


ObjectiveTo investigate the clinical diagnosis and treatment of hypertriglyceridemic pancreatitis in pregnancy (HPP). MethodsThe clinical data of 29 patients with HPP who were admitted to Yulin Hospital of Traditional Chinese Medicine from June 2005 to June 2015 were retrospectively analyzed. ResultsOf all the 29 patients, 5 (17.2%) were in the first trimester and 24 (82.8%) were in the third trimester; among them, 8 (27.6%) had mild pancreatitis, 14 (48.3%) had moderate pancreatitis, and 7 (24.1%) had severe pancreatitis. The patients had a mean serum triglyceride level of 15.5 mmol/L. No pregnant women died; the mortality rate of the fetuses reached 17.2% (5/29), and all of the five cases were intrauterine fetal death. ConclusionAlthough the prevalence of HPP is low, its incidence rate is increasing gradually, and HPP is commonly seen in the third trimester. HPP is always associated with a high fetal mortality rate, and therefore, timely diagnosis and treatment should be provided to improve the prognosis of mother and fetus.

Journal of Biomedical Engineering ; (6): 575-580, 2015.
Article in Chinese | WPRIM | ID: wpr-359604


A digital system for bioimpedance and electrical impedance tomography (EIT) measurement controlled by an ATmega16 microcontroller was constructed in our laboratory. There are eight digital electrodes using AD5933 to measure the impedance of the targets, and the data is transmitted to the computer wirelessly through nRF24L01. The structure of the system, circuit design, system testing, vitro measurements of animals' tissues and electrical impedance tomography are introduced specifically in this paper. The experimental results showed that the system relative error was 0.42%, and the signal noise ratio was 76.3 dB. The system not only can be used to measure the impedance by any two electrodes within the frequency of 1-100 kHz in a sweep scanning, but also can reconstruct the images of EIT. The animal experiments showed that the data was valid and plots were fitting with Cole-Cole theory. The testing verified the feasibility and effectiveness of the system. The images reconstructed of a salt-water tank are satisfactory and match with the actual distribution of the tank. The system improves the effectiveness of the front-end measuring signal and the stability of the system greatly.

Animals , Electric Impedance , Electrodes , Tomography , Methods