Computational investigation of Artemisia pollen deposition in realistic nasal cavities of residents in northwest China / 中华耳鼻咽喉头颈外科杂志

Objective@#To investigate the deposition rate of Artemisia pollen in different nasal cavity regions and its influence factors in residents of northwest China.@*Methods@#Thirty healthy adults from northwest China were enrolled. The computational fluid dynamics (CFD) and discrete phase model (DPM) were used for numerical simulation of nasal structures. The pollen deposition fraction in each anatomical part was counted and the effects of pollen density and breathing rate on deposition were analyzed. SPSS 19.0 software was used for statistical analysis.@*Results@#The hottest deposition parts of Artemisia pollen were nasal septum (30.70%±12.27%), vestibule (27.45%±8.21%), middle turbinate area (13.59%±8.98%) and nasopharynx (7.14%±5.90%). When the inspiratory flow rate increased to 30 L/min, the deposition rates of pollen in nasal vestibule and nasal septum were significantly higher than that at the rate of 15 L/min (43.20%±11.14% vs 27.45%±8.21%, 51.48%±9.77% vs 30.70%±12.27%, t value was -8.126,-5.264, respectively, all P<0.05), which indicated that with the increase of the inspiratory flow rate, the deposition hotspot moved forward. Compared with the wet Artemisia pollen, the deposition rate of the dry pollen in nasal vestibule and nasal septum decreased significantly (16.55%±4.33% vs 27.45%±8.21%, 7.09%±3.69% vs 30.70%±12.27%, t value was 8.669, 9.173, respectively, all P<0.05). The escape rate at outlet increased from 17.00%±9.57% to 43.48%±13.43% (t=-9.282, P<0.05).@*Conclusions@#The deposition of Artemisia pollen in nasal cavity is highly concentrated. The inhalation velocity and the dry-wet degree of pollen are the main determinants of the deposition site.

The role of emotional states in fruit and vegetable consumption in Brazilian adults / O papel dos estados emocionais no consumo de frutas e vegetais em adultos brasileiros

Abstract The objective was to investigate the association between emotional states with adequate fruit and vegetable consumption (FVC). This is a population-based cross-sectional study with 1,100 adults from a medium-sized city in Southern Brazil. Adequate FVC was defined as concomitant intake ≥ 3 fruits and ≥ 5 tablespoons of vegetables per day. Exposures were self-perception of nervousness/stress and minor psychiatric disorders (MPD). Data analysis used logistic regression. After controlling for demographic, socioeconomic and behavioral variables, adults reporting lack of nervousness/stress were twice more likely to report adequate FVC than those who reported it. Similarly, those reporting not having MPD symptoms were 52% more likely to have adequate FVC than those who did not. These effects increased and remained significant among women.

Resumo O objetivo foi verificar a associação entre a autopercepção do estado emocional com o consumo adequado de frutas, verduras e legumes (FVL). Este é um estudo transversal de base populacional com uma amostra probabilística de 1100 adultos residentes na zona urbana de um município de médio porte do Brasil. Considerou-se como consumo adequado uma ingestão ≥ 3 frutas concomitante com ≥ 5 colheres de verduras/legumes ao dia. O estado emocional foi avaliado através da autopercepção do nervosismo/stress e distúrbios psiquiátricos menores (DPM). Potenciais fatores de confundimento incluíam variáveis demográficas, socioeconômicas e comportamentais. Foram observadas associações significativas entre a autopercepção de nervosismo/stress e DPM com o consumo adequado de FVL. Após o controle de fatores de confusão, adultos relatando ausência de nervosismo/stress possuíam uma chance de apresentar um consumo adequado duas vezes maior do que aqueles relatando nervosismo/stress. Similarmente, participantes com ausência de distúrbios psiquiátricos possuíam uma chance de consumo adequado FVL 52% mais elevada quando comparados àqueles que relataram presença desses sintomas. Quando estratificada por gênero, esse efeito aumentou e manteve-se com significância estatística apenas entre as mulheres.

The effect of A_(1015) on DNA synthesis of D-galactosamine damaged mice hepatotoxicity / 中国药理学通报

AIM To study the effect of A 1015 on D galactosamine induced mice hepatotoxicity. METHODS The effect of three doses of A 1015 on DNA biosynthesis of D galactosamine induced mice hepatotoxicity were tested. The time curve of A 1015 on DNA synthesis of D GL induced mice hepatotoxicity was also observed. RESULTS The experiments demonstrated that 2 5 mg?kg -1 is the optimum dose for A 1015 to show liver protective activity. The results suggested that HGF can not only offset the hepatotoxicity induced by D GL, but also promote the DNA synthesis of mice liver cells. And the highest DPM value for HGF group is higher than that of A 1015 group. Thus both HGF and A 1015 showed anti hepatotoxic activity and promoting activity on mice liver cell DNA synthesis. CONCLUSION A 1015 may reduce liver necrosis induced by D galactosamine and promote the DNA synthesis of mice liver cells.