Contrasting effects of DOM and lisuride on impul-sive decision-making in delay discounting task / 中国药理学与毒理学杂志

OBJECTIVE The 5-HT2A receptor is the major target of classic hallucinogens.Both DOM(2,5-dimethoxy-4-methylamphetamine)and lisuride act at 5-HT2A receptors,and lisuride shares comparable affinity with DOM and acts as a partial agonist at 5-HT2A recep-tors.However,not like DOM,lisuride lacks hallucinogenic properties.Impulsive decision-making refers to the prefer-ence for an immediate small reinforcer(SR)over a delayed large reinforcer(LR).The current study aims to compare the effects of DOM and lisuride on impulsive decision-making and further to investigate the possible receptor mechanisms responsible for the actions of the two drugs.METHODS Impulsive decision-making was evaluated in male Sprague-Dawley rats by the percent-age of choice for the LR in delay discounting task(DDT).Delay to the LR changed in an ascending order(0,4,8,16,and 32 s)across one session.RESULTS DOM(0.3 and 0.5 mg·kg-1)increased impulsive decision-making,and the effects of DOM(0.5 mg·kg-1)was blocked by the 5-HT2A receptor antagonist ketanserin(1.0 mg·kg-1)rather than the 5-HT2C receptor antagonist SB-242084(1.0 mg·kg-1).Contrarily,lisuride(0.1,0.3 and 0.5 mg·kg-1)decreased impulsive decision-making.The effects of lisu-ride(0.3 mg·kg-1)were not antagonized by ketanserin(1.0 mg·kg-1),selective 5-HT1A antagonist WAY-100635(1.0 mg·kg-1)or selective dopamine D4 receptor antagonist L-745870(1.0 mg·kg-1),but were attenuated by the selec-tive dopamine D2/D3 receptor antagonist tiapride(40 mg·kg-1).CONCLUSION DOM and lisuride have contrasting effects on impulsive decision-making via distinct recep-tors.DOM-induced increase of impulsivity is mediated by the 5-HT2A receptor,while lisuride-induced inhibition of impulsivity is regulated by the dopamine D2/D3 receptor.

Inventário de Adiamento de Gratificação (DGI-35): propriedades psicométricas da versão brasileira / The 35-Item Delaying Gratification Inventory (DGI-35): psychometric properties of the Brazilian version / Inventario de Aplazamiento de Bonificación (DGI-35): propiedades psicométricas de la versión brasileña

O Inventário de Adiamento de Gratificação (DGI-35) foi desenvolvido para avaliar os diferentes níveis de adiamento de gratificação presentes na população geral. O objetivo deste estudo foi apresentar as propriedades psicométricas do DGI-35 para a população brasileira e evidências de validade convergente com a Escala de Impulsividade de Barratt (BIS-11). Participaram 405 brasileiros (61,2% mulheres), com idades entre 18 e 46 anos (M = 22,32, DP = 4,78). Foram conduzidas análises fatoriais exploratórias e confirmatórias com vistas a avaliar a estrutura interna do instrumento. Dos cinco fatores originais, quatro tiveram estrutura interna semelhante à versão original, exceto o fator "Físico" que não se ajustou ao modelo, levando a criação de uma alternativa de 28 itens à escala original (DGI-28), que apresentou adequados índices de ajuste. Conforme esperado, o escore global da DGI-28, bem como os seus fatores estiveram negativamente relacionados ao escore global da BIS-11. (AU)

The Delaying Gratification Inventory (DGI-35) was developed to evaluate different levels of gratification delaying in the general population. The purpose of this study was to present the psychometrics properties of the DGI-35 in the Brazilian population and evidence of convergent validity with the Barrat Impulsivity Scale (BIS-11). A total of 405 participants were selected (61.2% women) aged between 18 and 46 years (M = 22.32, SD = 4.78). Exploratory and confirmatory factor analyses were conducted to evaluate the internal structure of the instrument. Four out of five original factors showed identical consistency, except for the "Physical" factor that did not fit the model, leading to the creation of an alternative of 28 items to the original scale (DGI-28), which presented good fit indices. As expected, the global score of the DGI-28, as well as its factors were negatively correlated to the global score of the BIS-11. (AU)

El Inventario de Aplazamiento de Bonificación (DGI-35) fue desarrollado para evaluar los diferentes niveles de prórrogas de bonificación presentes en la población general. El objetivo de este estudio fue presentar las propiedades psicométricas del DGI-35 para la población brasileña y evidencias de validez convergentes con la Escala de Impulsividad de Barratt (BIS-11). Participaron 405 brasileños (61,2% mujeres) con edades entre 18 y 46 años (M = 22,32, DE = 4,78). Fueron realizados análisis factorial confirmatoria y exploratorio que evaluaron la estructura interna del instrumento. De los cinco factores originales, cuatro tuvieron estructura interna semejante a la versión original, excepto el factor "Físico" que no se ajustó al modelo, creándose una alternativa de 28 ítems (DGI-28) a la escala original, la cual presentó índices de ajuste adecuados. Como se esperaba, la puntuación global de la DGI-28, así como sus factores estuvieron negativamente relacionados con la puntuación global de la BIS-11. (AU)

Ivestigation of intertemporal decision-making function and its correlation with impulsive personality characteristics of geriatric depressive patients / 中华行为医学与脑科学杂志

Objective To explore the intertemporal decision-making function in geriatric depressive patients and it's correlation with impulsive personality traits.Methods Forty patients with geriatric depression(GD group) and Forty demographic characteristic matched health controls (HC group) were recruited.The delay discounting task was used to measure the decision-making function,and the barratt impulsiveness scale was used to measure the impulsive traits.The delay discounting rate (k) transformed to common logarithm lgk.Results Lgk and the scores of barratt impulsiveness scale,attention impulsiveness subscale,motor impulsiveness subscale in GD group((-2.00±0.81),(42.67±8.51),(46.50± 16.84),(43.50± 10.45)) were more larger than those in HC group ((-2.31±0.51),(32.27±6.18),(34.81±8.15),(26.88±7.65),and the differences were statistically significant (t=2.060,P=0.043;t=6.252,P＜0.01;t=3.951,P＜0.01;t =8.117,P＜0.01).In addition,lgk had positive correlation with the scores of motor impulsiveness factor in GD group(r=0.408,P=0.009).Conclusion The delayed discounting ability is impaired and correlated with the motor impulsiveness in GD patients.

A comparison of delayed discount and personality characteristics between male impulsive and premeditated prisoners / 中华行为医学与脑科学杂志

Objective To explore the delayed discount and personality characteristics of impulsive and premeditated male prisoners and their correlation.Methods A total of 120 male prisoners with aggressive behaviors were tested by Self-made General Situation Questionnaire,Impulsive / Premeditated Aggression Scale (IPAS),NEO Five-Factor Inventory (NEO-FFI),Delay Discount Task (DDT).The effective participants were ninety,including 51 in impulsive group and 39 in premeditated group.Analyzed the difference of delayed discount and personality characteristics between the two group.Results (1) In the delayed discount task,the delay discount rat (K) of the impulsive violence group (0.0278 ± 0.0555) was significantly higher than that of the premeditated violence group (0.0042±0.0078).The difference was statistically significant (t=3.004,P =0.004).(2) The scores of agreeableness (35.84 ± 4.08) and conscientiousness (37.04±4.83) in impulsive violence group were lower than that in premeditated violence group(38.46±5.53,42.31±5.96),and the difference was statistically significant (t=-2.587,P=0.011;t =-4.634,P＜0.01).(3) Correlation analysis showed that K value was not significantly correlated with all dimensions of the big five personality(P＞0.05).Conclusion Male impulsive prisoners have faster tendency to delay discounting compared with male premeditated prisoners.Lower agreeableness and conscientiousness are the personality characteristics of male impulsive prisoners.

Relación de las creencias mágicas con el descuento de recompensas monetarias / Relation of magical beliefs with discounting of monetary rewards

Resumen Se ha sugerido que las creencias mágicas, religiosas y supersticiosas, están relacionadas con las conductas de autocontrol/ impulsividad y de aversión/propensión al riesgo. Estas conductas pueden cuantificarse con la métrica del descuento del valor de una recompensa en función de su demora de entrega o probabilidad de ocurrencia. Así, el propósito del presente trabajo fue averiguar la relación entre las creencias mágicas y el autocontrol/impulsividad y la aversión/propensión al riesgo, utilizando el método del descuento del valor relativo de las recompensas. Ochenta participantes respondieron tres tareas; una de creencias mágicas, otra de descuento temporal y una de descuento probabilístico. El resultado principal del estudio fue que los participantes que mostraron un mayor índice de credulidad en creencias religiosas y supersticiosas mostraron una mayor tasa de descuento temporal y probabilístico que los participantes que tuvieron índices más bajos de credulidad en las mismas creencias. Estos resultados sugieren una relación entre las creencias mágicas y los fenómenos estudiados con la métrica del descuento del valor relativo de recompensas demoradas o probables. Esto es, los datos sugieren que los participantes con un nivel más alto de creencias mágicas también mostraron más conductas impulsivas y de aversión al riesgo que los participantes con niveles más bajos de creencias.

Abstract It has been suggested that magical beliefs like religious and superstitious ones are related with self-controlled/impulsive and risk aversion/proneness behaviors that people show. These behaviors could be quantified with discounting of the value of a reward as a function of its delay of delivery or probability of occurrence, respectively. Therefore, the purpose of this work was to investigate the relationship between magical beliefs and self-controlled/impulsive and risk-aversion/proneness behaviors using the method of discounting the relative value of the rewards. Eighty participants answered three tasks that were a magical beliefs one, a delay discounting one and a probability discounting one. The main finding of the study was that participants who had a higher score in the religious and the superstitious beliefs also had higher discount rates on temporal and probability discounting tasks than the ones who had a lower score in the magical beliefs. These results suggest a relation between magical beliefs and the phenomena studied with the discounting of the subjective value of delayed or probabilistic rewards. That is, these data suggest that the participants who showed a higher level of magical beliefs also showed more impulsive and risk-averse behaviors than the participants who showed lower level of beliefs.

Decision-making impulsivity in patients with idiopathic generalized epilepsy / 中华行为医学与脑科学杂志

Objective To explore the decision-making impulsivity in patients with idiopathic generalized epilepsy.Methods 39 patients with idiopathic generalized epilepsy and 40 healthy controls completed delay discounting task.The participants were demanded to make a series of choices between two different rewards after a delayed period (a smaller sooner reward or a larger longer reward).Results The delay discount rate k was transformed to common logarithm lg (k),and lg (k)=-1.75±0.86 in IGE group was more larger than that in HC group lg (k)=-2.21±0.72(t=2.58,P=0.01).IGE group performed worse than HC group in verbal fluency test-semantic (M (P25,P75):16.00 (14.00,19.00) vs 18.00 (16.00,22.75),Z =-2.86,P＜0.01),verbal fluency test-voice (M (P25,P75):4.00 (3.00,6.00) vs 7.00 (6.00,10.00),Z =-4.26,P＜0.01) and digital span backward test (M(P25,P75):5.00(5.00,7.00) vs 6.00 (5.00,8.00),Z=-2.48,P=0.01).In addition,lg (k) had significant correlation with verbal fluency test-semantic (r=0.32,P=0.048).Conclusion IGE group prefer immediate rewards and show more impulsive than HC group in delay discounting task.IGE group has cognitive deficit in frontal lobe language function and attention function.In addition,impulsivity is correlated with frontal lobe function.

Delay discounting: concepts and measures

Delay discounting, one element which underlies decision-making, can be defined as the depreciation of the value of a reward related to the time that it takes to be released. High rates of delay discounting are found in subjects who are willing to forgo greater rewards available only after some length of time and who show a preference for smaller rewards that are available immediately. Widely used as a measure of impulsiveness, delay discounting can be evaluated using experimental tasks. The present review evaluated tasks of delay discounting, their features, measures of evaluation and anomalies, and some variables that can affect delay discounting results and applications in the study of individual and intra-individual differences.

Prenatal alcohol exposure did not affect impulsivity in rats that performed delay or probability discounting tasks

Individuals who fall under the spectrum of the Fetal Alcohol Syndrome have a higher prevalence of several cognitive disturbances, including a greater probability of being diagnosed with attention-deficit hyperactivity disorder (ADHD). Some of these effects, such as hyperactivity and attentional impairments, are already well established in the literature. The assessment of impulsive choice, however, has received little attention in human and animal studies. In the present study, we attempted to investigate the effects of prenatal ethanol exposure on two tasks related to impulsive choice that have never been studied in this condition: delay and probability discounting. METHOD: Rats prenatally exposed to ethanol (liquid diets with 0 percent, 10 percent, or 35 percent ethanol-derived calories [EDC] or laboratory chow) were trained to respond for food in either delay (n = 21) or probability (n = 48) discounting tasks performed in computer-controlled operant conditioning chambers. RESULTS: Prenatal treatment failed to differentiate the rates at which the rats chose the larger reinforcer associated with delay - in a task in which 35 percent EDC was not tested - or risk, although the results suggest that further tests are warranted.