ABSTRACT
Resumen: El panel intergubernamental sobre cambio climático estima que para el año 2100 74% de la población estará expuesta a olas de calor en el peor escenario (definido como 3 días consecutivos con temperaturas igual o sobre el percentil 95 de un periodo de tiempo), abarcando en Santiago hasta 40% de los días de verano con temperaturas extremas. Producto de la crisis climática también pueden ocurrir eventos de frío extremo. Ambos fenómenos constituyen un riesgo para la salud, particularmente para las enfermedades cardiovasculares. Objetivo: Estudiar la asociación entre temperaturas extremas y enfermedades cardiovasculares (mortalidad por enfermedades cardiovasculares, infarto agudo al miocardio, accidente cerebrovascular, hipertensión y paro cardíaco extra hospitalario). Métodos: Se realizó una revisión bibliográfica en los buscadores ISI-Web of Science, Scopus y Nature utilizando los términos de búsqueda heatwave, cardiovascular disease y extreme heat entre los años 2016-2021 incluyendo trabajos que presenten medidas de asociación entre temperaturas extremas (percentil 5 para temperaturas bajas y percentil 90 para temperaturas altas) y enfermedades cardiovasculares, arrojando 130 resultados de los cuales se seleccionaron 19. Resultados: Tanto las temperaturas altas como bajas aumentaron el riesgo de muerte por infarto agudo al miocardio (IAM) (RR: 2,29 [2,18-2,40] y RR: 2,3 [1,2-4,6], respectivamente) y paro cardíaco (OR 3,34 [1,90-3,58] y OR: 1,75 [1,23-2,49], respectivamente). La mortalidad por hipertensión arterial se asoció a temperaturas altas (OR 1,91 [1,2-3,1]), mientras que la mortalidad por enfermedades cardiovasculares (ECV) en general a bajas (RR: 1,79 [1,64 - 1,95]). En hospitalizaciones por ECV el riesgo por temperaturas altas (P99) fue RR: 1,74 [IC95%: 1,30-2,32]. Se identificaron diferencias por sexo y mayor riesgo en los mayores de 75 años y quienes presentaron exposiciones prolongadas. Conclusión: Hay una fuerte asociación entre hospitalizaciones y muerte por ECV y temperaturas extremas. Las mujeres y los adultos mayores son los más afectados.
Abstract: The Inter governmental panel estimates that in a worst case scenario, by 2100 74% of people will be exposed to heat waves (3 consecutive days with temperatures at or above the 95% percentile). This might be the case in up to 40% of days in Santiago. As a consequence of climate change there will also be periods with extremely low temperatures. Both conditions increase the risk of cardiovascular disease. Aim: to study the association of extreme temperatures with the incidence of cardiovascular disease (death, myocardial infarction, stroke and out of hospital sudden death). Method: The ISI-Web of Science, Scopus and Nature databases were searched using the terms "heat wave", "cardiovascular disease" and "extreme heat" for articles published between 2016 and 2021.
Subject(s)
Humans , Cardiovascular Diseases/etiology , Cardiovascular Diseases/epidemiology , Hot Temperature , Climate Change , Public Health , Global HealthABSTRACT
Objective To investigate the effect of different freezing thawing conditions on the stability of metronidazole sodium chloride injection in extreme cold environment. Methods The freezing process of metronidazole sodium chloride injection in extremely cold environment was simulated and appropriate conditions were given to melt. The effects of room temperature, 60 ℃ water bath thawing and freeze-thaw times on the content of metronidazole were investigated by HPLC, and the changes were analyzed by quality control chart. Results The linear range of metronidazole was 0.01~1.00 mg/ml and the relationship was acceptable, r=1.000, the average recovery was 101.03% (RSD=1.17%), which met the requirements of methodology. The samples were frozen at −20 ℃ and thawed in 60 ℃ water bath for 18 times with good stability. However, when thawed at room temperature, acicular crystals formed and the content decreased. Conclusion In extreme cold environment, the stability of metronidazole sodium chloride injection could be affected by freezing and thawing conditions. Therefore, in the use of Metronidazole and Sodium Chloride Injection, the number of freeze-thaw cycles should be minimized, and try to avoid thaw at room temperature.
ABSTRACT
Objective@#To investigate the effects of extreme high and low temperatures on admission risk of acute ischemic stroke (AIS) and its etiology subtypes.@*Methods@#From January 1, 2016 to December 31, 2017, the data of inpatients with AIS from Zhongnan Hospital of Wuhan University and the meteorological data and air pollution data from China Meteorological Data Network in the same period were collected continuously. According to TOAST etiology criteria, the patients were divided into large artery atherosclerosis (LAA), small vessel occlusion (SVO), cardioembolism (CE), and stroke of other etiology (SOE). A time series analysis of the distributed lag model was used to investigate the effects of extreme high and low temperatures on the admission of patients with AIS and its etiology subtype, and air pollution, air pressure, humidity, and wind speed were used as confounding factors to exclude interference.@*Results@#A total of 1 413 patients with AIS were enrolled, including 906 men (64.4%), age 67.7±12.8 years. The thresholds of extreme low temperature (1%, 5% and 10% of the average temperature) were 0.7 ℃, 3.3 ℃, and 4.9 ℃. The thresholds of extreme high temperature (90%, 95% and 99% of the average temperature) were 29.2 ℃, 31.6 ℃, and 32.9 ℃. Extreme high temperature increased the risk of hospitalization in patients with AIS (lag 0 day; relative risk [RR] 1.54, 95% confidence interval [CI] 1.01-2.34). It was mainly related to the increased risk of hospitalization in patients with CE subtype (lag 0 day; RR 7.64, 95% CI 1.19-49.09). There was no significant correlation between the extreme low temperature and the risk of hospitalization of AIS (lag 2 days; RR 0.99, 95% CI 0.71-1.37), but it significantly increased the risk of hospitalization in patients with LAA subtypes (lag 2 days; RR 3.04, 95% CI 1.33-6.95), and it was still statistically significant at lag 3 days (RR 2.87, 95% CI 1.57-5.25) and lag 4 days (RR 2.19, 95% CI 1.15-4.15).@*Conclusion@#Extreme high temperature may increase the risk of hospitalization in patients with AIS and CE subtypes, while extreme low temperature may increase the risk of hospitalization in patients with LAA subtypes.
ABSTRACT
Chilblains are an inflammatory skin condition that develops following exposure to the cold. They consist of pruritic and/or painful erythematous-to-violaceous acral lesions and are the result of an abnormal vascular response to exposure to the cold. This benign condition is common in southern Brazil, particularly in Rio Grande do Sul where climatic conditions, together with cultural and economic aspects, facilitate the development of these sores.
Eritema pérnio é uma condição inflamatória da pele que ocorre após exposição ao frio e se manifesta com lesões eritêmato-violáceas, pruriginosas e dolorosas nas extremidades. Ocorre devido a uma resposta vascular alterada à exposição ao frio. Esta condição benigna é frequente na região sul do Brasil, especialmente no Rio Grande do Sul, onde as características clínicas, associadas a aspectos culturais e econômicos, promovem o desenvolvimento do eritema pérnio.