ABSTRACT
The high incidence and mortality of heart disease seriously affect human health. Among them, ischemic heart disease and myocardial hypertrophy are the most common. The transcription factor FOXOs can protect heart tissue by fighting oxidative stress and promoting apoptosis and autophagy, playing an important role in the treatment of heart disease. This article reviews the role of FOXOs in heart disease and signaling pathways. for the treatment of heart disease, FOXOs, as a potential target, provide new ideas for the treatment of heart disease.
ABSTRACT
As one subclass of forkhead proteins, the forkhead box O ( FoxO) transcription factors take part in a series of bio-logical processes including cellular apoptosis, damaged DNA re-pair and cleavage of reactive oxygen species(ROS). Increasing evidence highlights that oxidative stress elicited by FoxOs con-tributes to imbalance of redox status in cells related to bone me-tabolism, resulting in development of the pathogenesis of osteo-porosis. This article reviews the relationship of FoxOs and osteo-porosis, which may be beneficial for the research of pathological mechanism and therapeutic strategy of osteoporosis.