Ethical Governance of Human Health Related Research / 中国医学伦理学

The frequent several ethical events in recent years suggested carry out the construction of ethical governance system involving human health-related research under the background of national governance. The subjects of ethical governance include the government, medical institutions, universities, scientific research institutes, enterprise, ethics committees, researchers, the public, etc., the multiple subjects are interrelated and interact with each other to restrict and standardize ethics through different governance tools. However, there are some problems in China’s ethical governance, such as the relative lag in the construction of ethical governance concept and system, insufficient multi-party participation, the difficulty in sole legislation to solve risk and ethical problems, the specification cannot be met, inadequate supervision, insufficient accountability for violations, researchers lack ethical awareness, ethical education lags behind and insufficient information disclosure to the public. It should be taken such as countermeasures as paying attention to the theoretical research of ethical governance system, strengthening the construction of ethical governance system, pluralistic co governance, agile governance, strengthening legislation, improving norms, implementing supervision, strengthening the construction of ethics committee, talent training, training researchers, ethical education, popular science public, academic self-discipline, information disclosure and public participation, so as to build a scientific and technological ethics governance system in line with China’s national conditions and in line with international standards, and contribute China’s wisdom for world ethical governance.

Reflection on Global Public Health Ethics from the Perspective of Community / 中国医学伦理学

The global spread of COVID -19 indicates that cultivating public health awareness and constructing the concept of human health community has become an urgent need and a long-term plan in the current social situation. In the post-epidemic period, only by adhering to the concept of human health community, strengthening the cooperation among individuals, families, communities, institutions, urban and rural areas, countries and so on, weaving closely and consolidating the "net bottom" of grass-roots prevention and control from point to area, and establishing the mechanism of group prevention, group control and joint prevention and control, can we thoroughly curb the spread of the epidemic in the world. Under the development concept and value orientation of human health community, the individual is not only a booster of public health, but also a component of public health, and also a beneficiary of public health. The realization of public health is inseparable from the practice of each individual. Under the guidance of the concept of human health community and the awareness of individual health first responsibility, all citizens need to shape health promotion behaviors that fit the individual’s own situation, promote the health maintenance atmosphere consciously followed by the whole society, create a healthy ecological environment accessible to everyone, and let all citizens share the good results of public health management, so as to achieve the good vision of human health community.

Alterações climáticas e sua repercussão sobre a saúde humana em países da América do Sul / Climate change and its impact on human health in South America

Nas últimas duas décadas as mudanças climáticas têm se intensificado, causado danos ao meio ambiente e aos indivíduos que nele habitam. Várias ações do ser humano têm contribuído para que cada vez mais essas mudanças climáticas sejam mais presentes e intensas. O aumento das desigualdades e vulnerabilidades sociais, o desmatamento, os incêndios florestais voluntários, a degradação do solo e a poluição ambiental aliados à variabilidade climática global da temperatura da água do mar podem potencialmente levar a eventos climáticos extremos, potencializando os efeitos negativos sobre a saúde. Neste trabalho é apresentado um resumo do relatório do Lancet Countdown South America, fruto da colaboração acadêmica multidisciplinar de instituições de ensino e agências sul-americanas de saúde de 12 países (Argentina, Bolívia, Brasil, Colômbia, Chile, Equador, Guiana, Paraguai, Peru, Uruguai, Venezuela e Suriname) publicado por Hartinger e cols. (2023). Este estudo é uma alerta, pois nele são publicados os resultados do levantamento sobre mudanças climáticas e seus efeitos sobre a saúde humana no continente sul-americano. Conhecê-las é o primeiro passo para que políticas de saúde pública sejam instituídas, e, preferencialmente, de modo preventivo.

Climate change has intensified in the last two decades, damaging the environment and those who inhabit it. Human activity has increased the prevalence and intensity of these changes. Increased social inequality and vulnerability, deforestation, intentional forest fires, soil degradation, and environmental pollution, when associated with sea temperature variability, can lead to extreme weather events, increasing negative health effects. This report summarizes Lancet Countdown South America (Hartinger et al. 2023), the result of multidisciplinary collaboration between education institutions and South American health agencies from 12 countries: Argentina, Bolivia, Brazil, Colombia, Chile, Ecuador, Guyana, Paraguay, Peru, Uruguay, Venezuela and Suriname. This should be considered a wake-up call because it contains the results of a climate change survey and its effects on human health in South America. Knowing these effects is the first step toward appropriate, preferably preventive, public health policies.

The Construction of Human Health Community from the Perspective of Marx’s Space Theory: Challenges, Connotations, and Approaches / 中国医学伦理学

Capital’s penetration and mastery of global space shape a human health space that coexists with homogeneity and fragmentation, compressibility and expansion, digestion and remodeling. Capital exacerbates the deprivation of health resources in the global space through means such as controlling the power field, expanding the scope of flow, and monopolizing resource allocation, seriously constraining the overall improvement of human health. The human health community focuses on the healthy development of health in the global space, showing strong human sentiments and profound spatial implications. It aims to break the dominance of capital forces on human health in space, scientifically respond to the space crises caused by major public health events, and build a global space for the balanced and sustainable development of human health. It is Chinese concept, Chinese plan, and Chinese wisdom for reshaping the global justice space and safeguarding human health. To realize the value of health in the global space, it is necessary to take Marx’s space theory as the guide, continuously promote the construction of human health community from the three-dimensional space of individual micro, regional meso, and global macro, and create a space for health justice.

Climate change and communicable and non-communicable disease / Монголын Анагаах Ухаан

Introduction@#The rate of global warming has accelerated over the past 50 years, with 2014 and 2015 being the earth’s warmest years on record. The prevailing scientific view is that increased ambient temperatures are changing rainfall patterns and cause extreme weather conditions. Increasing surface temperature is melting glaciers and raising the sea level. More flooding, droughts, hurricanes, and heat waves are being reported. Accelerated changes in climate are already affecting human health, in part by altering the epidemiology of climate-sensitive pathogens.</br> Annually, one out of every four deaths worldwide is due to environmental pollution and climate change-related diseases. </br> Greenhouse gases from human activities are the most significant driver of observed climate change since the mid-20th century.</br> These warming trends may have profound effects not only on the environment but also on human health directly and indirectly. In fact, climate change has been considered the biggest threat to global health in the 21st century.

Research progress on sugar substitutes and human health / 环境与职业医学

Sugar reduction and restriction have become one of the most urgent health demands as the number of obese people increases globally. Sugar substitutes (mainly classified into sugar alcohols, natural sweeteners, and artificial sweeteners) have been widely used in food processing as alternatives to sugar for their low energy and high sweetness. Thus, the classification, metabolism pathways, advantages, applications, and human health effects of sugar substitutes, their effects on human health were introduced, and the relationships between sugar substitutes and obesity, diabetes, intestinal microbes, hypertension, and all-cause mortality were emphatically summarized in this paper. Generally, long-term high intake of sugar substitutes is associated with adverse health outcomes such as elevated blood pressure, higher risks of diabetes, cancer, and increased all-cause mortality. Meanwhile, sugar alcohols and natural sweeteners are more likely to associate with beneficial effects on human gut microbial diversity, while artificial sweeteners associate with imbalance of gut microbiota based on available evidence. Current published research focuses on single sugar substitute exposure with varied health effects, while nearly half of commercial sugar substitute products contain two or more sugar substitutes. The effects of exposure to multiple sugar substitutes on human health are not clear yet, so further strengthening the relevant epidemiological and molecular mechanism research is necessary.

Health Impact Assessment of the Mining Industry / Монголын Анагаах Ухаан

@#Health impact assessment is a means of evidence-based policy-making for improvement in health. It is a combination of methods whose aim is to assess the health consequences to a population of a policy, project, or program that does not necessarily have health as its primary objective. It is described as being “the leading global network on best practice in the use of impact assessment for informed decision-making regarding policies, programs, plans and projects”. In recent years, much evidence was revealed that the mining, metal mining, and processing industry has a greatly impact on humans. Residing population has affected directly and indirectly influenced to the health and wellbeing of human. </br>The mining, metal mining and processing industries play an important role in the economic and social development of Mongolia. With the rapid development of the mining industry in Mongolia, environmental protection and environmental rehabilitation have become a priority. Currently, there are 27 laws governing environmental legal acts in our country, and chapter 3 of the Hygiene Law covers environmental and health impact assessment. As stated the implementation of the law shall be financed from the state and local budgets, the central state administrative organization and the Governor at the appropriate level shall order the relevant professional organizations to carry out environmental research and analysis work and to develop projects, and in addition to financing with budget funds, as well as conducting research with their funds for interested citizens, enterprises, and organizations were are arrangements to support the implementation of the laws and its regulation. </br>However, Within the scope of the Law on Environmental Protection and Detailed Environmental Impact Assessment Procedures, the negative impact on the environment is identified but in the area of health impact, it is a lack of information on how the activities are conducted, and health impact assessments are not conducted according to procedures and methods. Thus, there are need to conduct health impact assessments of the mining area and its affected population.

Nutri-microbiome epidemiology, an emerging field to disentangle the interplay between nutrition and microbiome for human health

Diet and nutrition have a substantial impact on the human microbiome, and interact with the microbiome, especially gut microbiome, to modulate various diseases and health status. Microbiome research has also guided the nutrition field to a more integrative direction, becoming an essential component of the rising area of precision nutrition. In this review, we provide a broad insight into the interplay among diet, nutrition, microbiome, and microbial metabolites for their roles in the human health. Among the microbiome epidemiological studies regarding the associations of diet and nutrition with microbiome and its derived metabolites, we summarize those most reliable findings and highlight evidence for the relationships between diet and disease-associated microbiome and its functional readout. Then, the latest advances of the microbiome-based precision nutrition research and multidisciplinary integration are described. Finally, we discuss several outstanding challenges and opportunities in the field of nutri-microbiome epidemiology.

Avaliação dos repelentes: efeitos na saúde humana / Evaluation of repellents: effects on human health / Evaluación de repelentes: efectos sobre la salud humana

Este artigo teve como objetivo avaliar os efeitos do uso de repelentes na população brasileira. Para alcançar o objetivo proposto, foram utilizadas as metodologias da revisão de literatura e a pesquisa documental junto à ANVISA referentes aos repelentes registrados e comercializados no Brasil. De acordo com a RDC nº 7 de 2015 da ANVISA, os repelentes são classificados como produtos de Grau 2, compostos por Produtos de Higiene Pessoal, Cosméticos e Perfumes. Nessa categoria, constatou-se a existência de 113 produtos registrados para comercialização no Brasil. Verificou-se que, apesar do aumento do consumo devido às doenças causadas por picada dos mosquitos Aedes aegypti, a maioria dos repelentes comercializados possuem como princípio ativo as substâncias DEET, Icaridina ou IR3535, não resultando em reações tóxicas relevantes para a população, visto que, essas substâncias são de baixa toxicidade ou atóxicas, como é o caso do IR3535. Faz-se necessário considerar que o uso desses produtos deve seguir rigorosamente as orientações dos fabricantes disponíveis nos rótulos das embalagens no que tange à aplicação, reaplicação, frequência e uso específico para crianças, gestantes e lactantes. No que se refere à eficácia, a Icaridina apresenta-se como mais eficaz que o IR3535 quando considerados os fatores tempo de proteção versus concentração do princípio ativo. Entretanto, a Icaridina, em alguns casos, pode apresentar moderada toxicidade, enquanto que, o IR3535 é atóxico. Observa-se ainda, que mesmo diante desse cenário, o DEET é o mais comercializado e amplamente estudado no país.

This article aimed to evaluate the effects of the use of repellents in the Brazilian population. To achieve the proposed objective, the methodologies of literature review and documentary research with ANVISA regarding repellents registered and marketed in Brazil were used. According to ANVISA's RDC No. 7 of 2015, repellents are classified as Grade 2 products, composed of Personal Hygiene Products, Cosmetics and Perfumes. In this category, it was found the existence of 113 products registered for commercialization in Brazil. It was found that, despite the increased consumption due to diseases caused by bites from Aedes aegypti mosquitoes, most repellents marketed have as active ingredients the substances DEET, Icaridin or IR3535, not resulting in toxic reactions relevant to the population, since these substances are of low toxicity or non- toxic, as is the case of IR3535. It is necessary to consider that the use of these products should strictly follow the manufacturers' guidelines available on the packaging labels regarding application, reapplication, frequency and specific use for children, pregnant and lactating women. With regard to efficacy, Icaridin is more effective than IR3535 when considering the factors protection time versus concentration of the active ingredient. However, Icaridin, in some cases, may present moderate toxicity, while IR3535 is non- toxic. It is also observed that, even in this scenario, DEET is the most marketed and widely studied in the country.

artículo tuvo como objetivo evaluar los efectos del uso de repelentes en la población brasileña. Para alcanzar el objetivo propuesto, se utilizaron las metodologías de revisión bibliográfica e investigación documental con ANVISA sobre repelentes registrados y comercializados en Brasil. De acuerdo con el CDR nº 7 de 2015 de ANVISA, los repelentes se clasifican como productos de Grado 2, compuesto por Productos de Higiene Personal, Cosméticos y Perfumes. En esta categoría, se constató la existencia de 113 productos registrados para comercialización en Brasil. Se constató que, a pesar del aumento del consumo debido a las enfermedades causadas por picaduras de mosquitos Aedes aegypti, la mayoría de los repelentes comercializados tienen como principios activos las sustancias DEET, Icaridina o IR3535, no resultando en reacciones tóxicas relevantes para la población, ya que estas sustancias son de baja toxicidad o no tóxicas, como es el caso del IR3535. Es necesario considerar que el uso de estos productos debe seguir estrictamente las directrices de los fabricantes disponibles en las etiquetas de los envases en cuanto a aplicación, reaplicación, frecuencia y uso específico para niños, mujeres embarazadas y lactantes. En cuanto a la eficacia, la Icaridina es más eficaz que el IR3535 si se consideran los factores tiempo de protección frente a concentración del principio activo. Sin embargo, la Icaridina, en algunos casos, puede presentar una toxicidad moderada, mientras que el IR3535 no es tóxico. También se observa que, incluso en este escenario, el DEET es el más comercializado y ampliamente estudiado en el país.

Genetically Modified Crop vs Hybrid Crops and their Impact on Health and Environment

Genetically modified crop (GMC) is a technology which includes transferring Deoxyribonucleic acid (DNA) in plant cells. On the other hand, Hybrid Crops are naturally occurring crops but it also involves manmade crosses to have at least 15-20% higher yield potential over high yielding inbred crop varieties using almost the same level of inputs and also can perform better even under unfavourable environments like drought and saline condition. These days, hybrid crops are one of the most commonly consumed foods for humans. In line with this GM crops have high yield potential and adaptive capability under wide range of environments even under fragile ecosystems. There are different aspects of both these types of crops. Human consumption of these crops has been a highly debatable topic in recent times. In this study, a brief discussion on GM crops and hybrid crops will be presented. Additionally, a comparison between them, in terms of health and productivity, will also be discussed.

Superalimentos: fundamentação científica / Superfoods: scientific basis / Superalimentos: base científica

Este trabalho tem por objetivo realizar uma pesquisa visando a fundamentação científica dos superalimentos. Embora não existam diretrizes oficiais para o que constitui um "superalimento", geralmente está denominação se aplica a produtos alimentícios que contêm grandes quantidades de nutrientes específicos (por exemplo, antioxidantes, vitaminas e minerais). Estes bioativos atuam como potenciais agentes de prevenção e complementam os tratamentos de doenças crônicas como síndrome metabólica, diabetes, hipertensão, inflamações, doenças autoimunes entre outras. Como exemplos de superalimentos, encontram-se os brotos, sementes, vegetais, frutas, cúrcuma, chá verde, algas como a espirulina, alho, gengibre, cacau, pólen, geleia real, mel de abelha, coco e açaí. Nesse sentido, outros estudos poderiam ser realizados para investigar como estão sendo compreendidos os superalimentos dentro do campo científico.

This work aims to carry out research aiming at the scientific foundation of superfoods. While there are no official guidelines for what constitutes a "superfood", this designation generally applies to food products that contain large amounts of specific nutrients (eg, antioxidants, vitamins and minerals). These bioactives act as potential preventive agents and complement treatments for chronic diseases such as metabolic syndrome, diabetes, hypertension, inflammation, autoimmune diseases, among others. As examples of superfoods, there are sprouts, seeds, vegetables, fruits, turmeric, green tea, algae such as spirulina, garlic, ginger, cocoa, pollen, royal jelly, bee honey, coconut and açaí. In this sense, other studies could be carried out to investigate how superfoods are being understood within the scientific field.

El objetivo de este trabajo es realizar una investigación sobre la base científica de los superalimentos. Aunque no existen directrices oficiales sobre lo que constituye un "superalimento", esta denominación se aplica generalmente a los productos alimenticios que contienen grandes cantidades de nutrientes específicos (por ejemplo, antioxidantes, vitaminas y minerales). Estos bioactivos actúan como agentes potenciales para prevenir y complementar los tratamientos de enfermedades crónicas como el síndrome metabólico, la diabetes, la hipertensión, la inflamación, las enfermedades autoinmunes y otras. Como ejemplos de superalimentos, están los germinados, las semillas, las verduras, las frutas, la cúrcuma, el té verde, las algas como la espirulina, el ajo, el jengibre, el cacao, el polen, la jalea real, la miel de abeja, el coco y el acai. En este sentido, se podrían realizar otros estudios para investigar cómo se entienden los superalimentos dentro del ámbito científico.

Salud y medio ambiente / Health and Environment

Resumen A partir de la Revolución Industrial, las actividades humanas han causado diversas y significativas afectaciones al planeta, ampliamente investigadas e informadas. Los seres humanos y el resto de los seres vivos tienen una interdependencia permanente con el medio ambiente, lo cual se ha hecho más evidente en la actualidad. Los daños en la calidad del agua, aire y suelo, aunados al progresivo deterioro y pérdida de los ecosistemas y las afectaciones a la flora y a la fauna, han propiciado cambios que se traducen en peligros y riesgos de diversa índole e importancia para la salud humana, ya sea a corto o a largo plazo. Estas alteraciones ambientales se acompañan y se potencian con factores sociales, económicos, culturales y políticos, cuyos impactos en la salud se manifiestan a nivel local, regional, e incluso planetario. En este artículo se describen los principales cambios ambientales y sus efectos adversos en la salud, se destaca la importancia de que los médicos los consideren en el trato cotidiano con los pacientes y su entorno familiar, en particular cuando se tienen identificadas poblaciones vulnerables. Se concluye con la recomendación de que el sector salud muestre un mayor interés en el tema de medio ambiente y salud, adoptando un liderazgo para fortalecer los programas de salud pública ambiental con abordajes intersectoriales e interdisciplinarios. Cabe esperar que el campo de la salud y su base ambiental se constituyan en la formación integral de recursos humanos y en promover la investigación que proporcione elementos para definir e instrumentar políticas públicas exitosas.

Abstract Since the Industrial Revolution, human activities have caused various and significant effects on the planet widely investigated and reported. Human beings and the rest of living beings have a permanent interdependence with the environment, which has become more evident today. Damage to the quality of water, air and soil, coupled with the progressive deterioration and loss of ecosystems and the effects on flora and fauna, have led to changes that translate into dangers and risks of various kinds and importance for human health, either short term or long term. These environmental changes are accompanied and enhanced by social, economic, cultural and political factors, whose impacts on health are manifested at the local, regional and even global levels. This article describes the main environmental changes and their adverse effects on health, highlighting the importance of physicians considering them in their daily dealings with patients and their families, particularly when vulnerable populations have been identified. It concludes with the recommendation that the health sector show greater interest in the environment and health issue, adopting leadership to strengthen environmental public health programs with intersectoral and interdisciplinary approaches. Let's hope that the health field and its environmental base constitute the comprehensive training of human resources and promote research that provides elements to define and implement successful public policies.

Comparison of Knee Kinematics during Single Leg Squat across Physically Active Females with and without Dynamic Knee Valgus

@#Introduction: Introduction: Knee valgus which also known as dynamic knee valgus (DKV), is frequently linked to non-contact lower-limb injuries, especially in females. This retrospective study aims to compare the kinematic variables of lower limb joints in physically active females with normal versus excessive DKV during single leg squat (SLS) at 45° and 60° knee flexion. Methods: Based on the outcomes of drop vertical jump screening test, 34 females were recruited and divided into two groups (i.e., normal and excessive DKV). Participants performed SLS at 45° and 60° knee flexion with three-dimensional motion capture and analysis. The kinematic variables of lower limb joints at both knee flexion of SLS were compared across groups using independent T-test. Results: During 45° SLS with the dominant limb, the normal DKV group performed significantly greater hip adduction angle (4.49±3.25°, t(32) = 2.371, p= 0.024) than the excessive DKV group (1.426±4.23°). During 60° SLS with the dominant limb, the normal DKV group showed knee adduction (0.223±0.07°, t(16.048) = 10.707, p=0.001) while the excessive DKV group showed knee abduction (-4.478±1.81°). Conclusion: Females with excessive DKV showed significantly different lower limb kinematics and motion control strategy compared to females with normal range of DKV. The findings highlighted the importance of DKV screening among physically active females, and the rationale for prescribing individualized exercise intervention to prevent lower limb non-contact injuries.

Emerging and re-emerging zoonoses is a persistent challenges for human health / 中国热带医学

@#Zoonoses are a class of infectious diseases that are transmitted from animals to humans. More than 200 known types of zoonoses have been reported across the world until now. Among 1 400 pathogens of human infectious diseases, approximately 61% are zoonotic origin, and 75% human emerging infectious diseases are zoonoses. These zoonoses pose a great threat to human and animal health and decrease livestock production. To effectively tackle the persistent challenges resulting from zoonoses, WHO collaborates with member governments, academia, non-governmental and charitable organizations, and regional and international partners to prevent and manage zoonotic threats and their public health, social and economic impacts. Although great success has been achieved in the management of zoonoses, there are still multiple challenges for zoonoses control in China due to environmental, climate, socioeconomic factors and antimicrobial resistance. Based on the One Health concept, the integration of modern biological, information, artificial intelligent and big data tools through multidisciplinary and multi-sectorial collaborations may facilitate the containment and elimination of zoonoses.

Reconsideration on "Mutual Assistance" under the Public Health Emergencies / 中国医学伦理学

With increasingly being used in the field of public health, "mutual assistance" is in line with the realistic ethical demands of public health, and has become a new safety product provided by China for global public health security governance. To ensure "mutual assistance" under public health emergencies, it is crucial to fundamentally follow "protecting the lives and health of the people", take "building a community of health for mankind" as a long-term version, and take "solidarity and mutual assistance" as the action direction. "Mutual assistance" is of great practical value, and it is important to seek common ground while reserving differences in resolving the practical dilemma of public health emergencies.

Agrotóxicos, desfechos em saúde e agroecologia no Brasil: uma revisão de escopo / Pesticides, health outcomes and agroecology in Brazil: a scope review

RESUMO A presente revisão de escopo objetivou evidenciar o perfil das pesquisas brasileiras que investigam os desfechos em saúde ocasionados pela exposição a agrotóxicos, procurando entender os principais achados, tais como metodologia empregada, tipo de substância, desfechos em saúde, locais investigados, sugestões de ações e diálogo com a agroecologia. Foi utilizada a metodologia 'scoping review', seguindo o modelo Prisma-ScR. Entre os 83 artigos encontrados, 61 estudaram os/as agricultores/as e 22 estudaram outros grupos populacionais. Houve predomínio de estudos primários e quantitativos, seguidos por revisões sistemáticas. Do total, 79 encontraram desfechos, com destaque aos danos hematológicos e genéticos, em sua maior parte causados pela intoxicação por mais de 1 agrotóxico. O maior número de estudos foi realizado na região Sul, seguida das regiões Sudeste, Nordeste, Centro-Oeste e Norte. Apenas uma pesquisa sugeriu a transição agroecológica enquanto solução para a problemática. Conclui-se que, perante um cenário de crescimento do uso de agrotóxicos, fazem-se urgentes proposições de ações intersetoriais e que não envolvam somente educação em saúde ou o setor saúde de forma isolada, como sugere a maioria dos artigos, sendo necessária a articulação entre setores ligados à agricultura, abastecimento, educação, saúde e meio-ambiente.

ABSTRACT The present scope review aimed to highlight the profile of Brazilian research that investigates health outcomes caused by exposure to pesticides, seeking to understand the main findings, such as methodology used, type of substance, health outcomes, investigated locations, suggested actions, and dialogue with agroecology. The scoping review methodology was used, following the Prisma-ScR model. Among the 83 articles found in the review, 61 studied farmers and 22 studied other population groups. There was a predominance of primary and quantitative studies, followed by systematic reviews. Of the total, 79 articles found outcomes, with emphasis on hematological and genetic damage, mostly caused by poisoning by more than 1 pesticide. The largest number of studies were carried out in the South, followed by the Southeast, Northeast, Midwest, and North. Only 1 survey suggested the agroecological transition as a solution to the problem. It is concluded that, faced with a scenario of growth in the use of pesticides, it is urgent to have proposals for intersectoral actions and that do not involve only health education or the health sector in isolation, as most articles suggest, requiring articulation between sectors related to agriculture, supply, education, health, and the environment.

Polyphenols for improvement of inflammation and symptoms in rheumatic diseases: systematic review

ABSTRACT BACKGROUND: Rheumatic diseases (RDs) are a group of pathological conditions characterized by inflammation and functional disability. There is evidence suggesting that regular consumption of polyphenols has therapeutic effects capable of relieving RD symptoms. OBJECTIVE: To synthesize data from randomized controlled trials on administration of polyphenols and their effects on RD activity. DESIGN AND SETTING: Systematic review conducted at Universidade Federal de Ouro Preto, Minas Gerais, Brazil. METHODS: A systematic search was conducted in the databases PubMed (Medline), LILACS (BVS), IBECS (BVS), CUMED (BVS), BINACIS (BVS), EMBASE, Web of Science and Cochrane Library and in the grey literature. The present study followed a PRISMA-P checklist. RESULTS: In total, 646 articles were considered potentially eligible, of which 33 were then subjected to complete reading. Out of these, 17 randomized controlled trials articles were selected to form the final sample. Among these 17 articles, 64.71% assessed osteoarthritis (n = 11), 23.53% rheumatoid arthritis (n = 4), 5.88% rheumatoid arthritis and fibromyalgia (n = 1) and 5.88% osteoarthritis and rheumatoid (n = 1). Intake of polyphenol showed positive effects in most of the studies assessed (94.12%): it improved pain (64.70%) and inflammation (58.82%). CONCLUSION: Polyphenols are potential allies for treating RD activity. However, the range of polyphenol sources administered was a limitation of this review, as also was the lack of information about the methodological characteristics of the studies evaluated. Thus, further primary studies are needed in order to evaluate the effects of polyphenol consumption for reducing RD activity. SYSTEMATIC REVIEW REGISTER: PROSPERO - CRD42020145349.

Mudanças climáticas, mudanças produtivas e saúde: complexas interações na literatura nacional / Climate change, changes in productivity and health: complex interactions in the national literature

Resumo Este artigo caracteriza a produção científica divulgada em periódicos nacionais sobre as interações que se estabelecem entre os conceitos de mudanças climáticas, mudanças produtivas (incluídas as mudanças no uso do solo) e saúde humana, nos últimos dez anos (de 2008 a 2017), com destaque para as tendências teórico-metodológicas dessa produção. Para tanto, realizou-se uma revisão da literatura a partir de publicações disponibilizadas nas bases Scientific Electronic Library Online (SciELO) e Portal de Periódicos CAPES. Os resultados obtidos demonstraram os avanços experimentados nos últimos dez anos pelas equipes interdisciplinares que se debruçaram sobre o tema ao longo do período analisado, bem como permitem identificar lacunas de pesquisa que podem ser exploradas em investigações futuras. Adicionalmente, foi identificada uma positiva sofisticação e refinamento das ferramentas e instrumentos analíticos que se mostram capazes de reunir informações consistentes sobre uma realidade ampla e complexa, caracterizada pela diversidade dos biomas, cenários climáticos e sistemas produtivos.

Abstract This article reviews the scientific output published in national journals on the interactions that are established between the concepts of climate change, productive changes (including changes in land use) and human health in the last ten years (from 2008 to 2017), highlighting the theoretical-methodological trends of this output. To achieve this, a review of the literature was made from publications made available in the Scientific Electronic Library Online (SciELO) and the CAPES Journals Portal. The results obtained demonstrate the advances made in the last ten years by the interdisciplinary teams that dealt with the subject over the period analyzed. At the same time, this article identifies the research gaps that can be exploited in future research. In addition, a positive sophistication and refinement of analytical tools and instruments have been identified that are able to gather consistent information about a broad and complex reality characterized by the diversity of biomes, climatic scenarios and productive systems.

Compostos voláteis associados ao risco carcinogênico e não carcinogênico / Volatile compounds associated with carcinogenic and non-carcinogenic risk

RESUMO O presente trabalho consiste na avaliação da existência de risco e sua quantificação em casos de vazamentos de derivados do petróleo em uma refinaria localizada na Região Sudeste do Brasil. A área apresenta solo subsuperficial e água subterrânea contaminados por hidrocarbonetos de petróleo e outras substâncias em consequência do funcionamento de uma refinaria. Foram consideradas as vias de exposição por inalação aos contaminantes presentes nesses dois meios. A quantificação do risco de câncer e do quociente de perigo foi realizada para cada substância química, permitindo verificar que, para a exposição a água subterrânea contaminada, não houve efeito carcinogênico e não carcinogênico para os compostos analisados por meio da via de inalação. Já para a exposição a solo subsuperficial contaminado, verificou-se que todos os elementos detectados apresentaram riscos carcinogênicos para ambas as condições analisadas (ambiente aberto e fechado) e ambos os receptores (trabalhadores e comercial). Os elementos benzeno, tolueno, etilbenzeno, o-xileno e m-xileno apresentaram risco não carcinogênico para ambientes fechados em solo subsuperficial contaminado. Em ambientes abertos, somente o xileno,m- não apresentou risco não carcinogênico. Para receptores trabalhadores, somente o benzeno apresentou risco não carcinogênico. Destaca-se a grande importância do gerenciamento de risco para posterior recuperação dessa área afetada.

Abstract The present study was an assessment and risk quantification of derivatives from oil spill at a refinery located in the Southeast of Brazil. The area presents subsurface soil and groundwater contaminated by petroleum hydrocarbons and other substances from the refinery. Inhalation exposure routes have been evaluated due to the presence of contaminants in the affected area. Risk quantification and hazard ratio were performed for each chemical substance, allowing to verify that, for exposure from contaminated groundwater, there was no carcinogenic and non-carcinogenic effect considering the inhalation route. As for exposure to contaminated subsurface soil, all the elements were detected as having the carcinogenic risk for both analyzed conditions (open and closed environments), and both receptors (worker and commercial). The elements Benzene, Toluene, Ethylbenzene, o-Xylene, and m-Xylene, have presented a non-carcinogenic risk for closed environments from contaminated subsurface soil. In open environments, only m-Xylene did not present non-carcinogenic risk. For the workers receptors, only Benzene has presented a non-carcinogenic risk. It might be highlighted the importance of risk management for the subsequent recovery of this affected area.

Biopeptides of Pyropia yezoensis and their potential health benefits: A review

Pyropia yezoensis (P. yezoensis) is a popular species of red algae that are commercially cultivated and consumed in East Asia, China, Japan, and Korea. The high protein content of P. yezoensis provides a source of multiple bioactive peptides exhibiting antioxidant, anti-inflammatory, antihypertensive, anticancer, tissue healing, immunomodulatory, and anticoagulant properties. Furthermore, many other biologically active substances in P. yezoensis, including carbohydrates, lipids, dietary fibers, and polyphenols, have shown potential health benefits and are important in both the food and agriculture industries. This review provides a detailed summary of researches over the last decade on the biological and medicinal properties of bioactive peptides. The information was extracted from various electronic resources, including Google Scholar, PubMed, MEDLINE, and Google Patents.