Artritis séptica en el niño, resultados del tratamiento quirúrgico: revisión bibliográfica / Septic arthritis in children, results of surgical treatment: bibliographic review / Artrite séptica em crianças, resultados do tratamento cirúrgico: revisão bibliográfica

Introducción: A pesar de su baja incidencia, las infecciones osteoarticulares pueden generar complicaciones y secuelas devastadoras para el niño en desarrollo con su esqueleto en crecimiento. El manejo general de la patología debe ser multidisciplinario, asociando la terapia antibiótica y un tratamiento quirúrgico adecuado si se requiere. El objetivo de nuestro trabajo es analizar los resultados sobre las diferentes opciones terapéuticas quirúrgicas (punción-aspiración, lavado artroscópico o lavado abierto) en el tratamiento de la artritis séptica en la edad, mediante la realización de revisión sistematizada de la bibliografía. Metodología: Realizamos una búsqueda bibliográfica online en los buscador PubMed y en la Biblioteca Virtual en Salud (BVS) utilizando los siguientes términos MESH: ("Arthritis, Infectious/surgery"(Mesh) OR "Arthritis, Infectious/therapy"(Mesh)), utilizando filtros de búsqueda y aplicando criterios de inclusión y exclusión según nuestro objetivo. De los artículos incluidos se obtuvieron entre otros los siguiente datos: país, año, nivel de evidencia, número de pacientes con artritis séptica, articulación afectada, edad media, seguimiento promedio, tipo de tratamiento quirúrgico realizado de inicio y sus resultados según cada autor : complicaciones (de la enfermedad y del procedimiento ) y/o secuelas (en base a evolución clínica y radiológica), necesidad de un tratamiento quirúrgico adicional ante la falla del método terapéutico inicial y además de conclusiones relevantes de cada autor. Resultados: Se incluyeron un total de 22 artículos: 8 para el lavado por artroscopia, 6 para el lavado por artrocentesis, 4 para el lavado por artrotomía, ademas de otros 4 artículos que realizaba un análisis comparativo: dos de ellos entre lavado artroscópico y lavado por artrotomía y los otros dos entre lavado por artrocentesis y lavado abierto. El lavado artroscópico se encuentra en lo más alto de nuestra revisión ya que presenta los mejores resultados con solo un 6% complicaciones y/o secuelas (en solo 4 de los 8 artículos incluidos), con un total de 13 pacientes (8,7% ) que requirieron un tratamiento adicional (5 artrotomías y 8 un nueva lavado artroscópico ) y se destacan ademas 3 artículos con un 100% de buenos resultados, en los que no se presentaron complicaciones y/o secuelas, ni se requirió un segundo lavado, mientras que solo en 3 trabajos, de los 8, se necesitó de la artrotomía adicional para la resolución final. Para el lavado por artrocentesis se obtuvo el menor porcentaje de complicaciones y/o secuelas con un 2%, (reportado en tres de los 6 trabajos), y solo el 9,7% necesitaron de un segundo método terapéutico diferente a la aspiración articular (23 artrotomías y 2 artroscopias), destacando ademas la repetición de la punción (hasta 4 veces) como dentro de la directiva terapéutica del autor en dos artículos, y que para éste método se encontró el mayor número de pacientes. El lavado por artrotomía como método inicial obtuvo los peores resultados, con un 12% de complicaciones y/o secuelas y un 22,6% de lavados adicionales. Conclusiones: A pesar de que el lavado abierto por artrotomía se toma como el ¨ gold-standard ¨, teniendo indicaciones absolutas en el tratamiento quirúrgico de la artritis séptica en niños (especialmente en cadera), de nuestro análisis se desprende que ésta opción arroja los peores porcentajes de resultados, duplicando el porcentaje de necesidad de lavado adicional y el de complicaciones, en comparación con el lavado artroscópico. Existen otros métodos terapéuticos que se presentan como procedimientos menos invasivos, seguros y eficaces, respaldados por buenos resultados en la biografiaría, como son: el lavado por artroscopia (que presentó el porcentaje más bajo de pacientes con necesidad de lavado adicional, con el mayor número de artículos con buenos resultados en general, con un porcentaje de complicaciones por debajo del lavado por artrotomía) y el lavado por artrocentesis (que presentó el porcentaje de compilaciones más bajo de las 3 opciones analizadas.

Introduction: Despite its low incidence, osteoarticular infections can generate devastating complications and sequelae for the developing child with his growing skeleton. The general management of the pathology must be multidisciplinary, associating antibiotic therapy and adequate surgical treatment if required. The objective of our work is to analyze the results on the different surgical therapeutic options (puncture-aspiration, arthroscopic lavage or open lavage) in the treatment of septic arthritis in the pediatric age, by carrying out a systematic review of the bibliography. Methodology: We conducted an online bibliographic search in the PubMed search engine and in the Virtual Health Library (VHL) using the following MESH terms: ("Arthritis, Infectious/surgery"(Mesh) OR "Arthritis, Infectious/therapy"(Mesh)), using search filters and applying inclusion and exclusion criteria according to our objective. The following data were obtained from the included articles, among others: country, year, level of evidence, number of patients with septic arthritis, affected joint, mean age, average follow-up, type of initial surgical treatment and its results according to each author: complications (of the disease and of the procedure) and/or sequelae (based on clinical and radiological evolution), the need for additional surgical treatment in the event of failure of the initial therapeutic method, and in addition to relevant conclusions of each author. Results: A total of 22 articles were included: 8 for arthroscopic lavage, 6 for arthrocentesis lavage, 4 for arthrotomy lavage, in addition to another 4 articles that performed a comparative analysis: two of them between arthroscopic lavage and lavage. by arthrotomy and the other two between lavage by arthrocentesis and open lavage. Arthroscopic lavage is at the top of our review as it presents the best results with only 6% complications and/or sequelae (in only 4 of the 8 articles included), with a total of 13 patients (8.7% ) that required additional treatment (5 arthrotomies and 8 a new arthroscopic lavage) and also highlight 3 articles with 100% good results, in which there were no complications and/or sequelae, nor did a second lavage be required, while that only 3 of the 8 studies required an additional arthrotomy for the final resolution. For lavage by arthrocentesis, the lowest percentage of complications and/or sequelae was obtained with 2% (reported in three of the 6 works), and only 9.7% required a second therapeutic method other than joint aspiration (23 arthrotomies and 2 arthroscopies), also highlighting the repetition of the puncture (up to 4 times) as within the author's therapeutic directive in two articles, and that the largest number of patients was found for this method. Arthrotomy lavage as the initial method obtained the worst results, with 12% complications and/or sequelae and 22.6% additional lavages. Conclusions: Even though open lavage by arthrotomy is taken as the ¨ gold-standard ¨, having absolute indications in the surgical treatment of septic arthritis in children (especially in the hip), from our analysis it can be deduced that this option yields the worse percentages of results, doubling the percentage of need for additional lavage and the percentage of complications, compared to arthroscopic lavage. There are other therapeutic methods that are presented as less invasive, safe and effective procedures, supported by good results in the biography, such as: arthroscopic lavage (which presented the lowest percentage of patients requiring additional lavage, with the highest number of articles with good results in general, with a percentage of complications below lavage by arthrotomy) and lavage by arthrocentesis (which presented the lowest percentage of compilations of the 3 options analyzed).

Introdução: Apesar de sua baixa incidência, as infecções osteoarticulares podem gerar complicações e sequelas devastadoras para a criança em desenvolvimento com seu esqueleto em crescimento. O manejo geral da patologia deve ser multidisciplinar, associando antibioticoterapia e tratamento cirúrgico adequado, se necessário. O objetivo do nosso trabalho é analisar os resultados das diferentes opções terapêuticas cirúrgicas (punção-aspiração, lavagem artroscópica ou lavagem aberta) no tratamento da artrite séptica em idade pediátrica, através da realização de uma revisão sistemática da bibliografia. Metodologia: Foi realizada uma busca bibliográfica online no buscador PubMed e na Biblioteca Virtual em Saúde (BVS) utilizando os seguintes termos MESH: ( "Arthritis, Infectious/surgery"(Mesh) OR "Arthritis, Infectious/therapy"(Mesh) ), utilizando filtros de busca e aplicando critérios de inclusão e exclusão de acordo com nosso objetivo. Os seguintes dados foram obtidos dos artigos incluídos, entre outros: país, ano, nível de evidência, número de pacientes com artrite séptica, articulação afetada, idade média, seguimento médio, tipo de tratamento cirúrgico inicial e seus resultados de acordo com cada autor: complicações (da doença e do procedimento) e/ou sequelas (com base na evolução clínica e radiológica), necessidade de tratamento cirúrgico adicional em caso de falha do método terapêutico inicial e, além das conclusões relevantes de cada autor. Resultados: Foram incluídos 22 artigos: 8 para lavagem artroscópica, 6 para lavagem artrocentese, 4 para lavagem artrotômica, além de outros 4 artigos que realizaram uma análise comparativa: dois deles entre lavagem artroscópica e lavagem por artrotomia e a outros dois entre lavagem por artrocentese e lavagem aberta. A lavagem artroscópica está no topo da nossa revisão por apresentar os melhores resultados com apenas 6% de complicações e/ou sequelas (em apenas 4 dos 8 artigos incluídos), com um total de 13 doentes (8,7%) que necessitaram de tratamento adicional (5 artrotomias e 8 uma nova lavagem artroscópica) e também destacam 3 artigos com 100% de bons resultados, nos quais não houve complicações e/ou sequelas, nem foi necessária uma segunda lavagem, enquanto que apenas 3 dos 8 estudos necessitaram de uma artrotomia para a resolução final. Para a lavagem por artrocentese, o menor percentual de complicações e/ou sequelas foi obtido com 2% (relatado em três dos 6 trabalhos), e apenas 9,7% necessitaram de um segundo método terapêutico diferente da aspiração articular (23 artrotomias e 2 artroscopias), destacando também a repetição da punção (até 4 vezes) conforme diretriz terapêutica do autor em dois artigos, e que o maior número de pacientes foi encontrado para este método. A lavagem por artrotomia como método inicial obteve os piores resultados, com 12% de complicações e/ou sequelas e 22,6% de lavagens adicionais. Conclusões: Apesar de a lavagem aberta por artrotomia ser tida como ¨padrão-ouro¨, tendo indicações absolutas no tratamento cirúrgico da artrite séptica em crianças (especialmente no quadril), da nossa análise pode-se deduzir que esta opção rende os piores percentuais de resultados, dobrando o percentual de necessidade de lavagem adicional e o percentual de complicações, em comparação com a lavagem artroscópica. Existem outros métodos terapêuticos que se apresentam como procedimentos menos invasivos, seguros e eficazes, corroborados por bons resultados na biografia, tais como: a lavagem artroscópica (que apresentou a menor percentagem de doentes que necessitaram de lavagem adicional, com o maior número de artigos com boa resultados em geral, com percentual de complicações abaixo da lavagem por artrotomia) e lavagem por artrocentese (que apresentou o menor percentual de compilações das 3 opções analisadas).

Native 1st Metatarso-Phalangeal Joint Infection: A Rare Case Report / 대한족부족관절학회지

Septic arthritis is a serious medical condition that can lead to significant complications if misdiagnosed or mismanaged. A rare case of a 1st metatarso-phalangeal joint septic arthritis in a native joint is presented in a patient with no significant risk factors. A 41-year-old patient was referred by his general practitioner owing to ongoing pain and swelling over his native 1st metatarso-phalangeal joint with difficulty on weightbearing for three months. After a series of investigations, including blood tests and a foot magnetic resonance imaging, which were inconclusive, the patient was led to the operating theatre for sampling and washout of his joint. The samples taken in the theatres revealed septic arthritis with Streptococcus mitis as the causative microorganism. The patient was treated with six weeks of oral antibiotics with a good functional outcome. This case report illuminates this rare condition and makes foot and ankle surgeons aware of its existence. A high suspicion for this condition can prevent misdiagnosis and mismanagement.

Treatment of Pyogenic Arthritis of the Knee Using Drainage Tube Insertion in the Posterior Compartment through the Posterior Transeptal Portal after an Arthroscopic Synovectomy / 대한정형외과학회잡지

PURPOSE: This study analyzed the treatment effects of drain insertion in the posteromedial portal after an arthroscopic synovectomy and posterior septum resection for pyogenic arthritis. MATERIALS AND METHODS: From June 2005 to December 2016, 56 cases (55 patients, 1 case of bilateral knee) were diagnosed with pyogenic arthritis and arthroscopic treatment was performed. Fourteen patients (25.0%) were identified with causative organisms. The average follow-up period was 12.3 months, and the mean age was 67.8 years old. Twenty-four cases were males and 31 cases were females. Kellgrene–Lawrence grade (K–L grade) I was 6 patients, II was 20 patients, III was 11 patients, and IV was 18 patients. Surgery was performed through six portal. The posterior septum was removed and a drainage tube was inserted from the posterior medial side to the posterior side of the joint. The Lysholm score was used after surgery for a functional evaluation. The K–L grade at the time of admission and at the last follow-up were compared for a radiological evaluation. RESULTS: The mean normalization period of the C-reactive protein was 59.8 days (6–164 days). Intravenous antibiotics were used for an average of 37.1 days. The results of the functional evaluation revealed a mean Lysholm score of 64.5 (30–98) in a total of 56 cases. Two reoperations was performed, but the treatment was completed with same method in all patients. The K–L grade was similar at the time of surgery and at the last follow-up (p>0.05). CONCLUSION: The method of drain insertion in the posteromedial portal after arthroscopic synovectomy and posterior septum resection for pyogenic arthritis is an effective technique that can obtain satisfactory results by inducing proper exudate discharge.

Leukocyte Adhesion Deficiency Associated with Neonatal Septic Hip in a Late Preterm Infant

Leukocyte adhesion deficiency is a rare primary immunodeficiency and autosomal recessive disorder caused by a mutation in the gene encoding CD18, which is a constituent of leukocyte integrins. Clinical features usually begin with a delay in the separation of the umbilical cord in the neonatal period, and are characterized by marked leukocytosis with infection, delayed wound healing, and repeated bacterial and fungal infections. We experienced a case of leukocyte adhesion deficiency diagnosed in the neonatal period, in which a late preterm infant admitted to neonatal intensive care unit presented with a septic hip. Flow cytometry analysis of whole blood showed a decrease in the expression of CD11b/CD18. This is the first case of leukocyte adhesion deficiency with neonatal septic hip diagnosed in Korea.

Outcomes of Shoulder Arthroplasty Performed for Postinfectious Arthritis

BACKGROUND: The purpose of this study was to evaluate the functional outcomes, infection rate, and complications associated with shoulder arthroplasty for sequelae of prior septic arthritis. METHODS: This is a retrospective cohort study of 17 patients who underwent shoulder arthroplasty for sequelae of septic arthritis. Patients were analyzed for patient-reported outcomes, complications, and reoperations. RESULTS: The 17 patients in this cohort were an average age of 65.4 ± 12.2 years old, were 58.8% male, and had an average body mass index of 27.9 ± 4.1 kg/m2. These patients underwent 14 reverse shoulder arthroplasties (RSAs; 11 after antibiotic spacer placement), one anatomic total shoulder arthroplasty after antibiotic spacer placement, and two hemiarthroplasties (both after antibiotic spacer placement). Two patients underwent reoperation (dislocated RSAs). There were four complications (23.5%): two RSA dislocations, one acromial stress fracture, and one atraumatic rotator cuff tear after hemiarthroplasty. There were no cases of postoperative wound complications or infection. At an average of 4.1 ± 1.8 years of follow-up for all 17 of 17 cases, the average visual analogue scale pain score was 4.6 ± 2.3, average Single Assessment Numeric Evaluation Score was 59.3 ± 23.7, average American Shoulder and Elbow Surgeons Score was 57.6 ± 15.5, and average Simple Shoulder Test was 6.9 ± 2.6 based on “yes” responses. CONCLUSIONS: Shoulder arthroplasty after septic arthritis had inconsistent functional outcomes and high complication rates but no reinfection.

To strengthen the recognition to children arthritis related infection / 中华实用儿科临床杂志

Children arthritis associated infection can be divided into children infectious (invasive) arthritis and post infectious arthritis.Infectious arthritis onset with direct effects on the joints by pathogens,such as bacteria,fungi,viruses,tuberculosis infection.Post infectious arthritis onset often secondary to infection after infection factors of arthritis due to autoimmune reaction,such as reactive arthritis,arthritis after streptococcus infection,and so on.There are their clinical characteristics respectively in infectious arthritis and post infection arthritis in children,and it is important for the diagnosis,treatment and prognosis of children with arthritis to be familiarity with their characteristics.In addition,the factor of infection is closely related to juvenile idiopathic arthritis.It should be pay attention to the role of infectious factors in triggering and aggravating the disease.

Reporte de caso de tuberculosis osteoarticular: dificultad diagnóstica y probable infección primaria / Case report of osteoarticular tuberculosis: diagnostic difficulty and probable primary infection

Se presenta el caso de un varón de 36 años, procedente de Ancash, Perú, quien acude a un hospital de su localidad por dolor articular en rodilla derecha de tres años de evolución. No se consigue diagnosticar al paciente en dicho hospital y meses después acude al Hospital Nacional Dos de Mayo en la capital, donde posterior al hallazgo de un proceso inflamatorio granulomatoso en una biopsia ósea se inicia una evaluación y tratamiento para tuberculosis osteoarticular, diagnóstico que será posteriormente confirmado por cultivo positivo de líquido sinovial tras un tiempo de enfermedad de más de 45 meses. La presentación atípica, la ausencia de un foco primario y dificultad diagnóstica, en un país donde la tuberculosis es aún endémica, motivaron su descripción para su publicación

We report the case of a 36-year-old male from Ancash, Peru, who attended to a local hospital due to articular pain in the right knee for three years. Diagnosis was not reached in that hospital and months later he visited Hospital Nacional Dos de Mayo in the capital city, where evaluation and treatment for osteoarticular tuberculosis was started after finding a granulomatous inflammatory process in a bone biopsy. Such diagnosis was confirmed later by a positive culture of synovial fluid after a more than 45-month disease period. The atypical presentation, absence of a primary site and diagnostic difficulty of the disease in a country where tuberculosis is still endemic encouraged the publication of this case report

Septic Arthritis after Arthroscopic Meniscal Repair / 대한정형외과학회잡지

The incidence of septic arthritis after knee arthroscopy surgery has rarely been reported in approximately 0.04% to 3.4%. Moreover, septic arthritis after arthroscopic meniscal repair is more rare. There have been some reported cases, but in Korea, it has not been reported thus far. Herein, we report two cases of septic arthritis after arthroscopic meniscal repair with review of literature.

Causative Factors Regarding the Clinical Outcomes after Arthroscopic Treatment for Pyogenic Knee Arthritis / 대한정형외과학회잡지

PURPOSE: The purpose of this study is to analyze the causative factors that affect the recurrence and positive culture results of pyogenic knee arthritis after arthroscopic treatment. MATERIALS AND METHODS: A total of 69 patients, who were followed-up for more than one year after arthroscopid lavage and debridement for pyogenic knee arthritis, between February 2011 and February 2015, were retrospectively reviewed for analysis. We analyzed the factors affecting the recurrence rate, preoperative C-reactive protein (CRP) level, neutrophil count in synovial fluid, growth of bacteria in culture, and normalization of CRP level, and also analyzed potential factors that may influence the treatment results and recurrence. RESULTS: The recurrence rate was significantly higher in the culture-positive group (p=0.014). Culture-positive patients had low preoperative CRP (p=0.004), shorter duration for normalization of CRP (p=0.037), shorter duration of hospital stay (p=0.001) and intravenous antibiotics use (p=0.021). The duration for normalization of the CRP level had was associated with symptom-to-treatment interval (p=0.005), neutrophil count in synovial fluid (p=0.007), and growth of bacteria in the culture (p=0.001). There were 16 cases (23.2%) culture-positive cases and 15 cases (21.7%) recurrent cases. CONCLUSION: According to our study, early diagnosis and management affect rapid recovery of the CRP level in pyogenic arthritis of the knee. Preoperative CRP and leukocyte counts in the joint fluid are of diagnostic value in acute infection. However, it should not be overlooked that their diagnostic value is limited as a single factor as they may have low preoperative values. Therefore preoperative CRP and leukocyte counts in the joint fluid should be considered in conjunction with symptoms and intra-articular fluid manifestations. Bacteria growth in the culture are meaningful factors in an evaluation for postoperative recovery and recurrence.

Identification of streptococcus dysgalactiae subsp. equisimilis from septic knee by 16S rRNA gene sequencing / 고신대학교의과대학학술지

Septic arthritis is the infection of a joint by an infectious agent, leading to arthritis. It is therefore important to identify and treat the correct bacteria in septic arthritis. However, accurate identification of bacteria by conventional methods is difficult because of the distinct biochemical characteristics of individual bacteria. This case report aims at assessing septic arthritis caused by Streptococcus dysgalactiae subsp. equisimilis(SDSE) using nucleotide sequences and discusses the associated treatment. Here, Streptococcus agalactiae was determined to be the causative bacteria for septic arthritis in a 77 year-old woman using the conventional method of hemolysis pattern interpretation and morphology. However, nucleotide sequence analysis of 16S ribosomal RNA revealed that SDSE was the causative strain. 16S rRNA gene sequencing can correctly identify bacteria strains that are difficult to be identified by traditional method, and this correct identification can provide patients with the opportunity for adequate treatment using the proper antibiotics.

Septic arthritis of the temporomandibular joint: a case report

Septic arthritis of the temporomandibular joint (TMJ) is a rare disease. The most common symptoms of this disease are acute malocclusion, limited mouth opening, swelling, and tenderness of affected TMJ. These symptoms are often confused with internal derangement of the articular disc, rheumatoid arthritis, retrodiscitis, or osteoarthritis. Therefore, differential diagnosis by image examination is required. Usually, antimicrobial treatment and surgical drainage by needle aspiration, arthroscopy, or arthrotomy are effective treatment approaches. In this study, a patient who was diagnosed with septic arthritis was treated with arthrocentesis and antibiotics without significant complications. We present a case report with a review of the literature.

A Case of Infectious Arthritis due to Staphylococcus lugdunensis in Seronegative Rheumatoid Arthritis, Diabetes Mellitus Patient, after Intraarticular Hyaluronic Acid Injection

Intra-articular hyaluronic acid injections for symptomatic treatment of osteoarthritis are widely used but can result in complications, such as infectious arthritis. Staphylococcus lugdunensis is a common normal skin flora but can cause severe infectious disease, such as infective endocarditis. We present the first report of infectious arthritis caused by methicillin-sensitive S. lugdunensis after intra-articular hyaluronic acid injection in an immunocompromised patient in Korea.

Acromioclavicular Septic Arthritis and Sternoclavicular Septic Arthritis with Contiguous Pyomyositis

Acromioclavicular (AC) and sternoclavicular (SC) septic arthritis with contiguous pyomyositis are rare, especially in immunocompetent individuals. We report a case of septic AC joint with pyomyositis of the deltoid and supraspinatus muscles and a separate case with septic SC joint with pyomysitis of the sternocleidomastoid muscle. Both patients had similar presentations of infections with Staphylococcus aureus and were successfully treated with surgical incision and drainage followed by prolonged antibiotic therapy.

Septic Knee Arthritis Caused by Staphylococcus lugdunensis After Intraarticular Injection Therapy

Staphylococcus lugdunensis is a coagulase-negative staphylococcus. However, it causes various clinically important human infections and behaves similar to Staphylococcus aureus. S. lugdunensis reportedly causes infective endocarditis, skin and soft tissue infection, bone and joint infection, septicemia, endarteritis, urinary tract infection, ocular infection, and peritonitis. There are no reports of septic arthritis by this organism in Korea. We presented a case of septic arthritis due to S. lugdunensis in an elderly patient with diabetes mellitus after an intra-articular injection.

Surgery for Synovial Fistula after Excision of the Lateral Malleolar Bursitis of the Ankle: A Case Report / 대한족부족관절학회지

Lateral malleolar bursitis of the ankle is a commonly encountered disease in the department of orthopedic surgery. Although most cases of lateral malleolar bursitis are managed by conservative treatments, operative treatment is considered in cases of infected bursitis or complication after surgery. There are several potential complications associated with operative treatment, including wound healing problem, skin necrosis, nerve injury, or recurrence. However, synovial fistula of the ankle as a complication after surgery for lateral malleolar bursitis has not been previously reported. The author experienced the complication of synovial fistula after surgery for lateral malleolar bursitis and obtained a satisfactory result in revision surgery for the complication, which was coverage of the fistular formation with a periosteal flap from the distal fibula.

Artritis séptica en pacientes adultos en un hospital general de Chile / Septic arthritis in adult patients in a general hospital in Chile

Background: Septic arthritis is an infrequent condition of prolonged morbidity and there is no previous publications in Chile that allow orientate therapy. Aim: To characterize a group of adult patients with septic arthritis confirmed by culture. Material and Methods: Descriptive study of a case series. Results: From 2003 to august 2013, 24 patients with 25 events of septic arthritis were identified in a general hospital. Mean age was 68.3 years old (range 24-94). Predisposing conditions were harbored by 91.7%. Predominant clinical manifestations were pain (92%) and impaired joint movement (95.7%). Fever was present in 64%, hypotension in 28% of events, and C-reactive protein > 100 mg/L in 90.6%. Gram positive cocci were the most frequently isolated microorganisms (81.5%), predominating S. aureus (48.1%), and with 4 isolates methicillin resistant isolates (26.7%). Resistant isolates trend to be associated with previous surgery (p = 0.055) and all cases caused by non-fermentative Gram negative bacilli had recent hospitalization or surgery, a feature that did not reach a significant difference. Nine events were associated to bacteremia (36%). Outcome analysis indicated 32% of events with full recovery, 28% with a favorable evolution, 20% with therapy failure and 16.7% patients that died. A total of 24% of the series remained with significant sequels. Conclusions: Septic arthritis is an infrequent disease that affects in most cases patients with predisposing conditions. Associated symptoms include pain and impaired joint movement, sometimes fever, hypotension, positive blood cultures and frequently a C-reactive protein > 100 mg/L. Predominant agents are Gram positive cocci, specially S. aureus, including methicillin resistant isolates. Case-fatality ratio, treatment failure and sequels are important.

Antecedentes: Los cuadros de artritis séptica son esporádicos pero de elevada morbilidad y no hay publicaciones en Chile que permitan orientar el tratamiento de ellos. Objetivos: Caracterizar un grupo de pacientes con cuadros de artritis séptica confirmados microbiológicamente. Pacientes y Métodos: Serie de casos. Resultados: Un total de 24 pacientes con 25 eventos de artritis séptica fue identificado entre el 2003 y agosto de 2013. La edad promedio fue de 68,3 años (24-94) y 91,7% tuvo condiciones que predisponen. Las manifestaciones clínicas dominantes fueron dolor (92%) e impotencia funcional (95,7%), 64% presentó fiebre y 28% tuvo hipotensión arterial. Un 90,6% tuvo PCR > 100 mg/L. Las cocáceas grampositivas fueron los microorganismos más frecuentes (81,5%), predominando Staphylococcus aureus (48,1%) y cuatro cepas estafilocóccicas presentaron resistencia a cloxacilina (26,7%). Las cepas resistentes tendieron a estar asociadas a pacientes con cirugía articular previa (p: 0,055) y todos los casos asociados a bacilos gramnegativos no fermentadores tenían antecedentes de hospitalización reciente o cirugía articular previa. Nueve eventos (36%) se asociaron a bacteriemia. Un 32% de los pacientes tuvo curación, 28% un curso favorable, 20% fracaso y 16,7% falleció. Un 24% quedó con secuelas. Conclusiones: Los cuadros de artritis séptica son infrecuentes, afectan en su mayor parte a pacientes con factores que predisponen, se presentan con dolor e impotencia funcional, a veces fiebre, hipotensión arterial o bacteriemia y generalmente con PCR > 100 mg/L. Se asocian a cocáceas grampositivas, especialmente S. aureus, incluyendo aislados resistentes a cloxacilina. La letalidad, fracaso del tratamiento y secuelas no son despreciables.

Primeiro caso de febre maculosa brasileira branda associada à artrite / First report of mild Brazilian spotted fever associated to arthritis

Descrevemos o primeiro caso brasileiro de Riquetsiose branda, agravada por monoartrite em joelho, em adulto jovem picado por carrapato na perna esquerda na região de Camburi, localizada no município de São Sebastião, sul da região costeira do estado de São Paulo, Mata Atlântica, Brasil. O paciente apresentou uma escara de inoculação no local da picada do carrapato, associada ao aumento ganglionar em virilha esquerda, febre, poliartralgia, cefaleia e erupção macular. Vinte dias após o episódio da picada de carrapato, o paciente apresentou monoartrite em joelho direito. O diagnóstico de Riquetsiose branda foi estabelecido pela análise imunológica sequencial em amostras de soro e líquido sinovial, tendo sido empregada a técnica de imunofluorescência (IF) indireta para anticorpos reativos contra Rickettsia parkeri e Rickettsia rickettsii. A Riquetsiose branda é uma zoonose emergente, que deve ser investigada pelos médicos, incluindo reumatologistas, em pacientes que apresentem erupção macular, febre e, eventualmente, artrite, após visita ao sul da região costeira da Mata Atlântica no Brasil.

We describe the first Brazilian case of mild Rickettsiosis, complicated by knee monoarthritis, in young adult bitten by a tick on his left leg in Camburi zone, located in São Sebastião municipality, southern coastal region of the State of São Paulo, in the Atlantic rainforest region, Brazil. The patient developed inoculation eschar at the tick bite site associated with enlarged lymph nodes in the left groin, fever, polyarthralgia, headache and macular rash. Twenty days after tick bite episode, he displayed monoarthritis in his right knee. The diagnosis of mild Rickettsiosis was established by sequential immunological analysis in serum and synovial fluid, using the indirect immunofluorescence (IF) assay for antibodies reactive with Rickettsia parkeri and Rickettsia rickettsii. The mild Rickettsiosis is an emerging zoonosis, that must be investigated by physicians, including rheumatologists, in patients that present macular rash, fever and eventually arthritis, after visiting the southern coastal Atlantic rainforest region in Brazil.

Elongación de tibia hasta 14 cms en niña caboverdiana / Tibia elongation up to fourteen centimeters in cape verdean girl

Introducción: la discrepancia de los miembros inferiores obedecen a numerosas causas, ya sean congénitas o secuela de múltiples enfermedades. Los fijadores externos, en sus más disímiles presentaciones se diseñan para resolver este problema, sobre todo cuando el alargamiento será mayor a diez cm. Presentación de caso: paciente femenino, raza negra, 14 años de edad, con antecedentes de haber padecido una artritis séptica en cadera izquierda, quedando como secuela un acortamiento del miembro inferior izquierdo de 18 cm. Además de presentar un equino del pie izquierdo compensatorio para la deambulación, el resto del examen físico no se recogieron datos de interés que indicaran afectación de la circulación, conducción nerviosa, o fuerza muscular de dicha extremidad, por lo que se decide comenzar a realizar el alargamiento de 14 cms partiendo de una corticotomía proximal de tibia y peroné a diferente nivel y la colocación de un fijador distractor metafisario RALCA para elongar a razón de un milímetro por día hasta llegar a la longitud deseada y así preparar al paciente para la futura colocación de una prótesis total de cadera. Conclusiones: el fijador externo RALCA, distractor metafisario es una buena elección para lograr un alargamiento que supere los 10 cm en la tibia de un niño con el mínimo de complicaciones, ofreciendo seguridad en la osificación del hueso formado.

Introduction: lower limbs discrepancy is due to numerous causes, either congenital or sequels of several diseases. External fixators, in their various presentations, are designed to solve this problem, above all when the elongation is larger than ten centimeters. Case presentation: female patient, black race, 14 years old, with antecedents of septic arthritis in left hip, being a sequel a 18-cm elongation of the left lower limb. Besides presenting a left equinovarus foot countervailing for strolling, in the rest of the physical examination no data of interest was collected that indicate any circulatory affection, nervous conduction, or muscular force of that limb, reason why it is concluded to start the 14-cm elongation from a tibia and fibula proximal corticotomy at different level and the placement of a metaphysiary distracting fixator RALCA to elongation at 1 mm per day up to the wanted length, and thus to prepare the patient for the future placement of a total hip prosthesis. Conclusions: the external fixator RALCA metaphysiary distracting device is a good choice for elongations over 10cm in children tibia with the minimum of complications, providing safeness in the ossification of the new bone.

Artrite séptica pelo Haemophilus influenzae subtipo não b: relato de caso / Septic arthritis by Haemophilus influenzae not subtype b: case report

Haemophilus influenzae é um microorganismo responsávelpor uma variedade de infecções, sendo que namaioria das vezes são causadas pelo subtipo b. Relatamosum caso de artrite séptica pelo subtipo não b, associadoà meningite e piomiosite e sem evidência de fatorese condições predisponentes a infecção por esse agente.O paciente apresentou uma boa evolução clínica que foiatribuída a antibioticoterapia precoce e adequada.

Haemophilus influenzae is a microorganism responsiblefor a variety of infections, and most often are caused by subtypeb. We report a case of septic arthritis by subtype not b,associated with meningitis and pyomyositis and no evidenceof factors and conditions predisposing to infection by thispathogen. The patient had a clinical improvement was attributedto early and appropriate antibiotic therapy.

Open Synovectomy for Chronic Infectious Arthritis of the Wrist

PURPOSE: We reported the results of open synovectomy for chronic infectious arthritis of the wrist. METHODS: Fifteen patients who had chronic infectious arthritis of the wrist and underwent open synovectomy were reviewed retrospectively baesd on preoperative periods, symptoms, results of laboratory tests, radiological findings including magnetic resonance imaging (MRI), hospitalization period, and others. Pain scale and subjective satisfaction were checked by phone interview. RESULTS: Average preoperative period was 96.1 days. Pain on motion and edema were observed in all cases. Four patients had positive bacterial cultures and three were identified as tuberculous infection. Signal changes of bones were observed in MRI of 10 patients. Osteomyelitis was found in 8 patients during the operation and bone resection or fusion should be performed in three. Average number of operation times was 1.53. CONCLUSION: When the patients show chronic swelling and pain on motion of the wrist, diagnostic work-ups for chronic infectious arthritis should be performed including arthrocentesis and MRI. Treatment including open synovectomy should be done immediately.