ABSTRACT
Previous studies have demonstrated that Java ginger ( Zingiber purpureum) that is called ‘Bangle’ in Indonesia have some kinds of cognitive effects. In order to evaluate the safety of Java ginger bangle, we studied the genotoxicity by micronucleus test. The result shows that Java ginger bangle have no effect inducing appearance of micronucleus.
ABSTRACT
The review reveals latest studies of Bangle that has unique ingredients, safety, healthy effect and especially neurotrophin activity. Banglenes have some neurotrophin activity such as neuritogenesis without NGF in vitro, property that enhances hippocampal neurogenesis and crosses the blood-brain barrier (BBB) in vivo. On the other hand, Java ginger bangle (Extract) improves spatial learning in Senescence-Accelerated Mouse. Moreover the human clinical trial for MCI (Mild Cognitive Impairment) have been just started.