ABSTRACT
As important regulators of apoptosis,bcl-2-family proteins regulate all major types of cell death,including apoptosis,necrosis,and autophagy.It's known that impaired apoptosis is a critical step in tumor development.Overexpression of antiapoptotic proteins of bcl-2 family is associated with the development and prognoses of malignant lymphoproliferative disorders.
ABSTRACT
Objective:To investigate the clinical features of the intracranial primary malignant lymphma(IPML).Methods:23 cases comfirmed by pathological examination in our department was reviewed.Results:The median survival time for the patients received complete surgical resection or partial resection combined with postoperative radiotherapy and chemotherapy was 10 months which was much longer than that in the patients who received operation only.Conclusion:The intracranial primary malignant lymphma is rare.There is no typical manifestation and image feature for the IPML and it is difficult to distinguish IPML from other central nervous system tumors before operation.The diagnosis relies on the pathological examinations.The combination of operation with radiotherpy and chemotherapy is the best therapeutic method.