Natureza e paisagem: a dupla face da montanha / Nature, and landscape: the dual face of the mountain

Por que admiramos e subimos montanhas? Para discutir essa questão, iniciamos esclarecendo as diferenças conceituais entre natureza e paisagem e como se dá a experiência estética paisagística, subjetiva e objetiva ao mesmo tempo, com o apoio da Filosofia da Paisagem. Na sequência, com base na historiografia da paisagem e na literatura da arte, narramos a invenção cultural da montanha no imaginário universal, no qual afirmou-se como uma realidade compósita, natureza e paisagem. Essa condição a faz admirada e visitada tanto pelos seus atributos naturais quanto pelos imateriais e afetivos. Dá-lhe também um valor estratégico: subir montanhas é uma experiência física e estética que nos incita a pensar, enriquece os nossos sentidos e imaginação, fundamentais para a nossa consciência de mundo. Do seu alto alcançamos tanto belezas quanto destruição e isso nos conduz a posicionamentos éticos. A decisão, em paisagem, é topológica.

Why do we admire and climb mountains? To discuss this topic, we begin by explaining the conceptual differences between nature and landscape and how the aesthetic experience of landscape occurs, with the support of the Philosophy of Landscape. Based on the historiography of the landscape and the literature of art, we continue to narrate the historical path of cultural invention of the mountain within the universal imaginary, in which it asserted itself as a double reality, nature and landscape. This condition made it admired and experienced by both their natural attributes and their immaterial and affective values. It also gives to it a strategic value: climbing mountains is both aesthetic and physical experience that incites us to think, enriches our senses and imagination, fundamental to our awareness of the world. Over the mountain, we can see beauty or destruction, and this leads us into ethical positions. The decision, in landscape, is topological.

Tongxie Yaofang Regulates Expression of NKG2DL to Enhance Anti-tumor Effect of NK Cells in Colon Cancer under Chronic Stress / 中国实验方剂学杂志

ObjectiveTo observe the effect of Tongxie Yaofang on the function of tumor-related natural killer （NK） cells under chronic stress and explore the possible molecular mechanism. MethodFifty SPF-grade BABL/C male mice were randomized into normal， model， and low-， medium-， and high-dose （6.825， 13.65， and 27.3 g·kg-1， respectively） Tongxie Yaofang groups， with 10 mice in each group. Other groups except the blank group were subjected to 7 days of chronic restraint stress， and then forced swimming and tail suspension tests were carried out to evaluate the modeling performance. After the successful modeling， rats in Tongxie Yaofang groups were administrated with low-， medium-， and high-doses of Tongxie Yaofang by gavage， while those in the other groups were administrated with normal saline by gavage. After 14 days， each group of mice was inoculated with subcutaneous colon cancer to establish the model of colon cancer under chronic stress. The pathological changes of the tumor tissue in each group of mice were observed using hematoxylin-eosin （HE） staining. The content of CD49b-positive cells in the peripheral blood and tumor tissue of mice was measured by flow cytometry. Enzyme-linked immunosorbent assay （ELISA） was employed to measure the content of molecules associated with NK cell activation in the peripheral blood. Western blot was employed to determine the protein levels of major histocompatibility complex class Ⅰ polypeptide-related sequences A and B （MICA+MICB） and UL-16-binding protein 1 （ULBP1） in the tumor tissue. ResultCompared with the normal group， the model group showed a decrease in 5-hydroxytryptamine （5-HT） content and an increase in corticosterone （CORT） content in the serum （P<0.05）. Compared with the model group， Tongxie Yaofang increased the 5-HT content and decreased the CORT content （P<0.05， P<0.01）. Compared with the normal group， the modeling increased the tumor volume and weight （P<0.05）， while Tongxie Yaofang inhibited such increases with no statistical significance. The tumor cells in the model group presented neat arrangement， irregular shape， uneven size， obvious atypia， common nuclear division， and small necrotic area， and blood vessels were abundant surrounding the tumor cells. Compared with the model group， Tongxie Yaofang groups showed sparse arrangement of tumor cells， different degrees of patchy necrosis areas in the tumor， and karyorrhexis， dissolution， and nuclear debris in the necrotic part. Compared with the normal group， the model group showed reduced CD49b-positive cells in the peripheral blood and tumor tissue （P<0.01）. Compared with the model group， Tongxie Yaofang increased CD49b-positive cells （medium dose P<0.01， high dose P<0.05， P<0.01）. Compared with the normal group， the modeling lowered the serum levels of granzymes-B （Gzms-B）， perforin （PF）， interferon （IFN）-γ， and tumor necrosis factor （TNF）-α （P<0.05， P<0.01）. Compared with the model group， low-dose Tongxie Yaofang elevated the serum levels of PF， Gzms-B， and TNF-α （P<0.05， P<0.01）， and medium-dose Tongxie Yaofang elevated the serum levels of Gzms-B， PF， IFN-γ， and TNF-α （P<0.05， P<0.01）. In addition， high-dose Tongxie Yaofang elevated the serum levels of PF， IFN-γ， and TNF-α （P<0.01）. Compared with the normal group， the model group presented down-regulated protein level of ULBP1 （P<0.05）. Compared with the model group， low-， medium-， and high-dose Tongxie Yaofang up-regulated the protein level of ULBP1 （P<0.05， P<0.01）， and medium- and high-dose Tongxie Yaofang up-regulated the protein level of MICA+MICB （P<0.05， P<0.01）. ConclusionTongxie Yaofang may promote NK cell activation by up-regulating the expression of MICA+MICB and ULBP1， thereby delaying the progression of colon cancer under chronic stress.

Research progress on the role and changes of natural killer cells in sepsis / 中国小儿急救医学

Sepsis is the organ dysfunction caused by infection.It is one of the most common critical diseases in clinic.Its morbidity and mortality are increasing year by year，which has seriously threatened human health.Innate immunity is the first line of defense against pathogens.Nature killer（NK）cells are important cells involved in the regulation of innate immunity in sepsis，and can play an important role on the progression of sepsis by secreting cytokines，inducing apoptosis and mediating cytotoxic effects.It has been found that the changes of NK cells in the early stage of sepsis are related to the prognosis of the disease.Therefore，further study on the role of NK cells in sepsis can provide a new idea for the clinical diagnosis and treatment of sepsis，and contribute to the early identification of sepsis and the improvement of prognosis.This review summarized the role and changes of NK cell in sepsis.

Exploration on theoretical basis and approach of "Chinese materia medica transformation" of Indian natural medicine / 国际中医中药杂志

In history, there were frequent medical exchanges between China and foreign countries. After the introduction of foreign drugs, they are endowed with the properties of Chinese materia medica and undergo a process of utility evolution, which can be called "Chinese materia medica transformation". This article took natural drugs introduced from India as the research object and found that the common understanding between Ayurvedic medicine and TCM theory is the theoretical basis for the Chinese materia medica transformation" of natural drugs in India. Indian drugs need to complete the process of "Chinese materia medica transformation" through two approaches: the attribution of Chinese materia medica attributes based on the corresponding relationship between the two medical theories, and the supplementation of properties and effects beyond the common understanding. The case of "Chinese materia medica transformation" of natural drugs in India can provide a theoretical and practical basis for the research of "Chinese materia medica transformation" of more foreign new drugs.

Study on Ancient Documents of Vinegar into Prescriptions / 浙江中医药大学学报

[Objective]To explore the role of vinegar in ancient prescriptions,inherit and explore the unique value of vinegar in traditional Chinese medicine,and provide reference for modern clinic.[Methods]Based on the records of the efficacy of vinegar in traditional Chinese medicines and medical records from various dynasties,this paper classifies and sorts out the ancient literature on the vinegar in prescriptions.Combining the Qi and taste of vinegar,the theory of reinforcing and reducing about viscera,and the idea of visceral-Qi corresponding to nature rhythms,this paper explores the role of vinegar in prescriptions from five aspects:promoting Qi and blood circulation,promoting blood circulation and stopping bleeding,healing sores and relieving swelling,clearing heat and detoxicating,and calming endogenous wind and blooming the sprit.[Results]The sour taste of vinegar acting on the liver helps to regulate activities of Qi,tonifies the lungs to help regulate water passages,fragrance and warm of vinegar promote Qi,bitter and warm of vinegar eliminate dampness,thus eliminating the concretions and gatherings,and resolving phlegm-dampness.Vinegar fragrance acts on the spleen and sour acts on the liver,vinegar can achieve the effect of promoting blood circulation and stopping bleeding by regulating the liver and spleen.The main reason for its application in skin diseases is that vinegar tonifies the lungs with the sour taste,and lungs govern skin and hair,and vinegar has astringent properties.The sour taste of vinegar acting on the liver can help the liver detoxify,while the bitter taste can clear heat and detoxicate.Therefore,vinegar is often used in prescriptions such as detoxification of drugs,food and insects,etc.Sour acts on the liver to control conveyance and dispersion,while the fragrance of vinegar acts on the spleen to refresh the mind,so it is also used to treat symptoms such as stroke and fainting.[Conclusion]Vinegar tastes sour,bitter,fragrant and warm.It is the main reason why vinegar is used as a necessary medicine in promoting Qi and blood circulation,promoting blood circulation and stopping bleeding,healing sores and relieving swelling,clearing heat and detoxicating,and calming endogenous wind and blooming the spirit.According to the theory of reinforcing and discharging viscera,sour acts on the liver;According to the theory of visceral-Qi corresponding to nature rhythms,sour can regulate the heart,liver and lung.By combing the application of vinegar in ancient prescriptions systematically,it helps to provide literature support and theoretical reference for further improving the clinical application of vinegar in prescription.

Establishment of TCM Syndrome Elements Knowledge Framework System for Intelligent Diagnosis / 中医杂志

Syndrome differentiation and treatment is a traditional Chinese medicine （TCM）-featured concept and method in diagnosis and treatment， which needs to be combined with the intelligent diagnosis of TCM in the future. At present， the intelligent diagnosis of TCM has gradually changed from the simple data-driven primary intelligence to the knowledge-driven advanced intelligence that integrates professional knowledge. Although syndrome element differentiation breaks down the elements of TCM diagnostic knowledge to form syndrome elements， which makes the original vague knowledge information more specific， the relationship between syndrome elements is not well classified and sorted out， resulting in the lack of hierarchical relationship and connection between syndrome elements， and thereby causing obstacles to the application of intelligent technology. Based on the understanding of etiology and pathogenesis from TCM， this paper concretized the syndrome element set of etiology， disease location and disease nature in TCM syndrome differentiation and treatment， and formed a knowledge framework system of syndrome elements with clear logical relationship， clear hierarchy and good explanation， thereby providing certain reference for realizing knowledge-driven advanced intelligence syndrome differentiation in the future.

Herbal Textual Research on Pyrrosiae Folium in Famous Classical Formulas / 中国实验方剂学杂志

This article systematically analyzes the historical evolution of the name， origin， producing area， quality evaluation， harvesting and processing， clinical efficacy of Pyrrosiae Folium by consulting the ancient materia medica， medical books and prescription books， combined with modern literature， in order to provide a reference for the development of famous classical formulas containing this herb. After herbal textual research， it was found that the names of Pyrrosiae Folium in the past dynasties were mostly derived from its color， shape and efficacy. And there were other nicknames such as Shizhe， Shipi and Shilan. Song， Yuan dynasties and before the period， the main origin of Pyrrosiae Folium was Pyrrosia petiolosa， in the Ming dynasty， the main origins were P. petiolosa and P. sheareri， during the Qing dynasty to the present， the main origins were P. sheareri， P. petiolosa and P. lingua. Anciently， the respected Dao-di production area of Pyrrosiae Folium was the area of Lianyungang city， Jiangsu province. In modern times， Anhui and Zhejiang provinces are the main producing areas of P. sheareri， Fujian and Taiwan provinces are the main producing areas of P. lingua， and Guizhou and Hubei provinces are the main producing areas of P. petiolosa. In ancient and modern times， Pyrrosiae Folium with large leaves and thick texture is considered to be the best， the medicinal part is the leaves， and the harvesting and processing methods recorded in the past dynasties were mainly shade-drying after harvesting in the February and July of the lunar calendar， while the modern ones are mostly harvested throughout the year. The processing methods of the past dynasties mainly included removing fuzz by scraping， lightly roasted， frying， fat-fried. However， in modern times， it is mostly used the raw products as a medicine after cleaning， cutting and drying. In ancient times， Pyrrosiae Folium was thought to have a neutral nature with slightly sweet and bitter taste， while in modern times， it is thought to have a slightly cold nature with slightly sweet and bitter taste， and the main effects in ancient and modern times are diuretic， clearing lung-heat， hemostasis and so on. Based on the research results， it is suggested that P. sheareri， P. petiolosa and P. lingua can be used as the medicinal base， processing method can be according to the requirements of formulas， and if the processing requirements are not indicated， the raw products can be selected as the medicine.

Scientific and Ethical Analysis of 840 Registered COVID-19 Clinical Studies / 中国医学伦理学

From January 23, 2020 to May 29, 2021, there were 17,550 clinical research registrations on the China Clinical Trial Registry Platform. The index of clinical research on COVID-19 showed 840 registrations, accounting for 4.79% (840/17 550) of the total registrations. According to the trend chart of epidemic development, 487 clinical research projects of COVID-19 registered from January 23, 2020 to March 18, 2020 were set as the early stage of epidemic discovery in the region, the following 15 months were divided into stable initial stage, stable later stage and the later stage of the first wave of domestic epidemic every five months. The proportion of COVID-19 research projects registered in each stage was 29.80%, 5.87%, 0.76% and 1.15% of all registered projects respectively. The registration ratios of COVID-19 in each clinical stage was 57.98%, 28.81%, 5.95% and 7.26% respectively. Intervention studies were 61.60% (300/487) in the early stage of the epidemic, and most of them were in biological agent and drug therapy, which were 40.49%, 50.00% and 73.77% respectively in the later stages. Stable initial stage biological agent projects decreased. Then the vaccine research program became a focused research program. Among the 58 registration projects involving vaccines, 25 were clinical trials of vaccines in different stages, with the major research units being biopharmaceutical companies. Of the 487 clinical studies registered in the early stage, 10.23%(50/487) were withdrawn, of which 38 were intervention treatment studies, most notably drug studies (17) and blood biological products (16), but they were still registered in the stable initial stage. It is necessary to reflect on the scientific and ethical nature of early COVID-19 clinical trials or research, including whether the three core values of equal respect, help to alleviate pain and fairness can be achieved. Whether the "ethics review meeting should pay special attention to the scientificity, safety, fairness, subject protection, informed consent documents and informed consent process, avoidance of conflicts of interest, etc. of clinical trials or research" has been implemented. Competent government departments at all levels and all clinical medical research institutions should organize evaluation, and then establish an effective evaluation mechanism when new clinical trials or research projects are registered in the future.

Mediating role of mental fatigue between nature exposure and mental health of prison police / 环境与职业医学

Background The mental health status of prison officers is crucial to the efficiency, security, and stability of a prison, and it is essential to pay attention to the factors that influence their mental health. Objective To understand the mental health status of prison officers, and analyze how nature exposure affects their mental health problems and a potential mediating role of mental fatigue. Methods A cross-sectional survey was carried out from May to June 2022 among 1392 prison officers from eight prisons in a province, and a total of 1284 valid questionnaires were recovered. The Nature Exposure Scale, Mental Fatigue Scale, and Depression-Anxiety-Stress Scale were used to assess nature exposure, mental fatigue, and mental health indicators among prison officers, and to explore the effect of nature exposure on mental health problems and a potential mediating role of mental fatigue. Results The recruited prison officers showed high levels of depression, anxiety, and stress. The prevalence rates of depression, anxiety, and stress were 59.11% (759/1284), 60.67% (779/1284),and 43.93% (564/1284), respectively. The results of correlation analysis revealed that nature exposure was negatively related with mental fatigue and mental health indicators (depression, anxiety, and stress) (rs=−0.242, −0.308, −0.235, −0.254, P<0.01), while mental fatigue was positively correlated with mental health indicators (depression, anxiety, and stress) (rs=0.546, 0.533, 0.536, P<0.01). The PROCESS macro results showed that the level of nature exposure among prison officers negatively associated with depression, anxiety, and stress (β=−0.180, −0.104, −0.123), and mental fatigue played a mediating role, with indirect effects of −0.200, −0.192, and −0.199, respectively. Conclusion The levels of depression, anxiety, and stress of prison officers are higher than those of other occupations. Nature exposure negatively associates with depression, anxiety, and stress, that is, it may directly alleviate the mental health problems of prison officers; and it may also alleviate mental health problems by relieving mental fatigue.

O estudo do comportamento, a dicotomia inato vs. aprendido e sua (possível) superação / Behavior studies, the nature vs. nurture dichotomy and its (possible) overcoming / El estudio del comportamiento, la dicotomía innato vs. aprendido y su (posible) superación / Les études du comportement, la dichotomie inné vs. appris et son (possible) dépassement

Resumo: O debate inato vs. aprendido continua presente na Academia, bem como na sociedade. Considerando tal cenário, este artigo apresenta o desdobrar das discussões que giram em torno das influências ambientais e genéticas, na gênese dos comportamentos. Para isso, primeiramente é apresentada uma reflexão acerca da definição de comportamento com a finalidade de apresentar o objeto da discussão, bem como a imprecisão em sua caracterização. Posteriormente, são destacadas as principais diferenças entre o pensamento behaviorista e o etológico, e em como essas diferenças impactaram a condução de pesquisas, além de sustentar discursos eugenistas e/ou discriminatórios. Por último, disserta-se sobre uma abordagem não-dicotômica ao tema, na forma dos Sistemas em Desenvolvimento, como uma proposta de superação do debate em questão.

Abstract: Given the remaining prominence of nature vs. nurture debate in academia and society, this article discusses environmental and genetic influences on the genesis of behavior. For this purpose, we first present the definition of behavior and discuss the imprecision in its characterization. Next, we examine the main differences between behaviorist and ethological thinking and their impact on research and on the support of eugenic discourses. To conclude, the article discusses a non-dichotomous approach to behavior based on the Developmental Systems Theory framework to overcome such dualism.

Resumen: El debate innato vs. aprendido permanece presente tanto en la academia como en la sociedad. Considerando este escenario, este artículo presenta el desarrollo de discusiones que giran en torno a las influencias ambientales y genéticas en la génesis del comportamiento. Para ello, en primer lugar, se presenta una reflexión sobre la definición de comportamiento con el fin de presentar el objeto de discusión, así como la imprecisión en su caracterización. Posteriormente, se destacan las principales diferencias entre el pensamiento behaviorista y el etológico, y su impacto en la realización de algunas investigaciones, además de fundamentarse en los discursos eugenésicos y/o discriminatorios. Para finalizar, este artículo discute un enfoque no dicotómico del tema, en la modalidad de Sistemas en Desarrollo, como propuesta para superar el debate en cuestión.

Résumé : Le débat inné vs. savant reste toujours présent dans l'Académie ainsi que dans la société. Au vu ce scénario, cet article discute des influences environnementales et génétiques sur la genèse du comportement. Pour ce faire, on reflète sur la définition du comportement et les imprécisions dans sa caractérisation pour ensuite explorer les principales différences entre la pensée béhavioriste et éthologique et leur impact sur certaines recherches et sur le soutien des discours eugéniques. L'article conclu par présentant une approche non dichotomique fondée sur la Developmental Systems Theory pour surmonter le débat en question.

A criação da Fundação Brasileira para a Conservação da Natureza / The creation of the Fundação Brasileira para a Conservação da Natureza

Abstract This study within the field of environmental history explores the scenario amid which the Fundação Brasileira para a Conservação da Natureza (Brazilian Foundation for Nature Conservation) was founded between 1958 and 1966; this important Brazilian non-governmental organization headquartered in Rio de Janeiro worked at the local, national, and international levels. Primary documentary sources were utilized, along with research of the related literature. The conclusions demonstrate the importance of non-governmental organizations predating this foundation, and the influence of conservationists on its establishment and current work.

Resumo Este estudo se insere no campo da história ambiental e tem o objetivo de compreender o cenário de criação, entre 1958 e 1966, da Fundação Brasileira para a Conservação da Natureza, importante organização não governamental ambientalista brasileira, com sede no Rio de Janeiro e atuação local, nacional e internacional. Para isso, utiliza fontes documentais primárias e pesquisa bibliográfica relacionada. As conclusões demonstraram a importância da existência de organizações não governamentais mais antigas que a fundação e a influência de conservacionistas sobre sua criação e sua atuação inicial.

The characteristics of stingless bee nests (Apidae: Meliponini) in the Cycloop Mountain Nature Reserve, Indonesia

Introduction: Stingless bees are widespread in tropical and subtropical regions. In Indonesia, the distribution of stingless bees are grouped in three regions, namely Indo-Malayan, Wallacea, and Indo-Australian. Ten species of stingless bees have been recorded in Papua, seven of which are endemic. The Cycloop Mountains Nature Reserve (CMNR) is one of the conservation area in Papua, Indonesia, for flora and fauna. Unfortunately, the study of the diversity of stingless bees in Papua has been limited. Objective: To measure the diversity, nesting sites, nest entrance characteristics and nest architecture of stingless bees. Methods: Observation of the stingless bee nests in the nature reserves and in the residential areas used a road sampling method and information from local people, respectively. A total of 22 colonies were studied. Results: Two species of stingless bee were found, namely Tetragonula sapiens (Cockerell, 1911) and Heterotrigona (Platytrigona) planifrons (Smith, 1865). The current study showed new distribution records for T. sapiens and H. planifrons in the CMNR. The nesting site of T. sapiens was commonly found in house foundation, while that of H. planifrons was in coconut palm cavities. The nest entrance of T. sapiens varied, i.e., elliptical, oval, rounded, irregular, horizontally or vertically elongated. Meanwhile, the nest entrance of H. planifrons was vertically elongated. The brood cells of T. sapiens varied, i.e., vertical, horizontal, or semi-clusters, while in H. planifrons was layered vertically. Conclusions: Two species of stingless bees found, T. sapiens and H. planifrons, showed a new distribution records and T. sapiens was a dominant species in Papua. The nest entrance of the species varied in shape, color, and texture.

Introducción: Las abejas sin aguijón están muy extendidas en las regiones tropicales y subtropicales. En Indonesia, la distribución de las abejas sin aguijón se agrupa en tres regiones: Indo-Malayan, Wallacea e Indo-Australian. Se han registrado diez especies de abejas sin aguijón en Papua, siete de las cuales son endémicas. La Reserva Natural de las Montañas Cycloop (CMNR) es una de las áreas para la conservación de flora y la fauna en Papua, Indonesia. Desafortunadamente, el estudio de la diversidad de abejas sin aguijón en Papua ha sido limitado. Objetivo: Medir la diversidad, los sitios de anidación y describir la arquitectura y características de entrada al nido de las abejas sin aguijón. Métodos: Se observaron los nidos de abejas sin aguijón en reservas naturales y áreas residenciales, mediante el método de muestreo de caminos e información de la población local, respectivamente. Se estudiaron 22 colonias. Resultados: Se encontraron dos especies de abejas sin aguijón, Tetragonula sapiens (Cockerell, 1911) y Heterotrigona (Platytrigona) planifrons (Smith, 1865). Este estudio mostró nuevos registros de distribución de T. sapiens y H. planifrons en el CMNR. El sitio de anidación de T. sapiens se encontró comúnmente en los cimientos de las casas, mientras que el de H. planifrons estaba en las cavidades de las palmas de coco. La forma de la entrada al nido de T. sapiens varió: elíptica, ovalada, redondeada, irregular, alargada horizontal o verticalmente. Mientras tanto, la entrada al de H. planifrons se alarga verticalmente. Las celdas de cría de T. sapiens variaron, entre verticales, horizontales o semi-racimos, mientras que en H. planifrons eran verticales. Conclusiones: Se encontraron dos especies de abejas sin aguijón, T. sapiens y H. planifrons, que mostraron nuevos registros de distribución y T. sapiens fue una especie dominante en Papúa. La entrada al nido de las especies varió en forma, color y textura.

Study of Deliberate Self-Poisoning Among Adult Females in A Tertiary Care Hospital

Background: Poisoning is a common medico-social problem in our country causing around 300,000 episodes and around 2000 deaths per year. Attempted suicide among adult females are a major public health problem. The number of self-poisoning in females are increasing in our country day by day. The incidence, nature, etiology, age group affected and the outcome of self-poisoning in females of our country is different from that of the western world. Objective: The objective of the study was to analysis the socio-demographic profile & pattern of deliberate self-poisoning among adult females admitted in the Medicine Department, Dhaka Medical College Hospital. Material and Methods: This was a descriptive cross sectional study conducted in the Department of Medicine, Dhaka Medical College Hospital from January 2016 to June 2016. 100 admitted female participants were enrolled in this study as study population. A purposive sampling method was applied for sampling from study population. Results: The age of the participants were from 18 to 55 years with the mean age of 28.19 (± 9.84) years. Most number of the participants were in 21-29 year’s age group (42%) followed by ?20 year’s (29%). House wife (30%) was the most common occupation followed by student (25%). Most of the participants were from lower economic class (51%), followed by middle class (41%). 48% participants were in primary level, 24% in secondary level and 22% were illiterate. Most of the participants were married (51%), followed by unmarried (35%), divorced (9%) and widow (5%). 62% participants from rural and 38% from urban area. 75% were Muslim and 25% were Hindu. 55% were from the joint family and 45% were from the nuclear family. Most of the self-poisoning occurred between 6 am to 12 pm (42%), followed by 6 pm to 12 am (30%), 12 pm to 6 pm (20%) and 12 am to 6 am (8%). Insecticide was the most common poison materials (43%), followed by drug ingestion (30%), household detergent (13%), rodenticide (6%) and others (8%). Maximum participants reported the reason for self-poisoning was family disharmony (35%) followed by romantic disappointment (27%). 17% participants reported previous suicidal attempt and 11% had previous psychiatric disorder. Nearly half of the participants (43%) sought medical care within 2 hours and one fourth participants (31%) within 4 hours. About two-thirds of the participants (66%) received primary medical care from different govt. hospitals. Most of the female participants with self-poisoning were recovered completely (71%), while 20% participants recovered with complications and 9% participants died. In the study, fatality rate was found 33.3% in rodenticide and 16.3% in insecticide poisoning. Conclusions: As evident from the study, by intervene these problems by various measures might be helpful to prevent many of deliberate self-harm. Early diagnosis and prompt institution of appropriate treatment can make a favorable outcome in deliberate self-poisoning of female participants.

Effect of spirituality, exercise, music, and engagement with nature on intelligence, stress, and cognition

Background: Spirituality is recognition of a sense that there is something greater than myself. Physical exercise is any bodily activity that enhances physical fitness and overall health. Music is a universal language to express mind through tone and emotions. Nature is the physical world or the universe. Intelligence is the global capacity of the individual to act purposefully, to think rationally. Emotional intelligence is the ability to understand one’s own emotions and emotions of others. Adversity quotient deals with ability of a person to deal with adversities in life. Aims and Objectives: The present study was designed to study the effect of different interventions on intelligence, stress and cognitive functions. Materials and Methods: The present study was performed on 144 subjects in age group of 30–39 years. Their basal level of intelligence quotient (IQ), emotional quotient (EQ), resilience score (RS), acute stress score (ASS), perceived stress score (PSS), isometric handgrip (IHG), and stroop tests was recorded. The subjects were divided into four groups of 36 each. Four groups were allotted different interventions of spirituality practices, moderate intensity physical exercise, receptive music, and engagement with nature respectively for 1 month duration. Statistical analysis: ANOVA and post hoc tests along with student t-test were used for computing the results. Results: IQ, EQ, RS, ASS, IHG, PSS, and stroop subtests yielded mixed results with four interventions at different levels of significance. Conclusion: Although every intervention had different and positive impact on parameters, overall spiritual practices exhibited better response on parameters.

Three years of COVID-19 pandemic: comparative analysis of incidence, lethality and mortality among the States of the south region of Brazil / Três anos de pandemia da COVID-19: análise comparativa da incidência, letalidade e mortalidade entre os Estados da região sul do Brasi

Introduction: the first COVID-19 case in Brazil was confirmed on February 26, 2020. As of March 17, 2023, the Ministry of Health reported 699,634 deaths from COVID-19, with a case fatality rate of 1.9%. The impact of the COVID-19 pandemic in Brazil extends to socioeconomic and healthcare systems, reflecting significant regional disparities. Objective: To analyze mortality, incidence, and case fatality rates for COVID-19 in the states of Paraná and Santa Catarina, in the southern region of Brazil. Methods: This is an ecological time-series study using official Brazilian secondary data for COVID-19 cases and deaths. Data were extracted from the dashboard of the State Health Department of Santa Catarina and Paraná. Temporal series were developed for trend analysis using the Prais-Winsten regression model. Statistical analyses were performed using STATA 14.0 software (College Station, TX, USA, 2013). Results: In the analysis of rates over the entire period, trends for mortality, case fatality, and incidence in the state of Santa Catarina are decreasing, decreasing, and stationary, respectively. In Paraná, rates over the entire period showed a stationary trend for mortality, decreasing for case fatality, and increasing for incidence. Conclusion: COVID-19 had a devastating effect on the states of Santa Catarina and Paraná. Both states experienced the progression of the COVID-19 pandemic, with higher case fatality and mortality rates observed in Paraná, while Santa Catarina had a higher incidence rate over the three years of the COVID-19 pandemic.

O percurso categorial da natureza e da história: pertinência para os estudos sobre o ser social e sua corporeidade no âmbito da Educação Física / The categorical path of nature and history: relevance for studies on the social being and its corporeality in the scope of Physical Education / El camino categórico de la naturaleza y la historia: relevancia para los estudios sobre el ser social y su corporeidad en el ámbito de la Educación Física

O presente trabalho acompanha o desenvolvimento das categorias natureza e história no pensamento filosófico-social ocidental até o século XVIII. O estudo centrado nestas categorias as entendem como importantes pressupostos para uma ontologia do ser social marxiana-lukasciana. Também entende como necessária a revisão da elaboração destes fundamentos para se compreender o corpo e a corporeidade humana constituídos no complexo relacional destas categorias. Conclui-se que a antinomia entre o natural e histórico-social neste período não possui resoluções concretas e satisfatórias para o entendimento do complexo, mas é possível observar a tentativa de cisão e superação da natureza pelo espírito racional.

This present paper follows the development of the nature and history categories in Western social-philosophical thought until the 18th century. The study focused on these categories, understanding them as important assumptions for a Marxian-Lukascian ontology of social being. It is also understood as necessary to review the elaboration of these foundations in order to understand the human body and corporeality constituted in the relational complex of these categories. It is concluded that the antinomy between the natural and the historical-social in this period does not have concrete and satisfactory resolutions for the understanding of the complex, but it is possible to observe the attempt to split and overcome nature by the rational spirit.

Este ensayo sigue el desarrollo de las categorías naturaleza e historia en el pensamiento socio-filosófico occidental hasta el siglo XVIII. El estudio centrado en estas categorías, las entiende como presupuestos importantes para una ontología del ser social presente en la obra de Marx, Engels y Lukács. Entiende también como necesaria, la revisión de la elaboración de estos fundamentos para comprender el cuerpo y la corporeidad humana constituida en el complejo relacional de estas categorías. Se concluye que la antinomia entre lo natural y lo histórico-social en este período no tiene resoluciones concretas y satisfactorias para la comprensión del complejo, pero es posible observar el intento de escisión y superación de la naturaleza por parte del espíritu racional.

Analysis of current status and risk of development in occupational medical examination institutions in Guangdong Province / 中国职业医学

Objective: To analyze the status of occupational medical examination (OME) institutions in Guangdong Province and the critical control points affecting their future development. Methods: A total of 211 OME institutions registered in Guangdong Province were selected as the research subjects. Their current statue was investigated, and the risk assessment of their future development was carried out based on hazard analysis and critical control point theory. Results: The OME institutions were mainly concentrated in the Pearl River Delta, accounting for 72.0%. The public and private medical and health institutions accounted for 70.6% and 29.4% respectively. The filing rates of different OME categories from high to low in the order were physical factors, chemical factors, dust, other, radiation factors, biological factors (P<0.01), and the filing rates were 89.6%, 88.6%, 84.8%, 63.0%, 7.1% and 1.0%, respectively. The rates of excellence in the field assessment from high to low in the order were hearing atlas analysis personnel, lung function examination operators, chest film reading personnel, chief examination physician, technical director, quality director (P<0.01), and the rates of excellence were 49.4%, 26.2%, 20.6%, 10.8%, 8.2% and 4.6%, respectively. A total of 37 institutions did not submit OME information, of which 23 institutions did not carry out OME work after filing. The required diagnosis rate and confirmed diagnosis rate of suspected occupational diseases in 2020 were 34.3% and 55.3%, respectively. In 2021, the detection rate of suspected occupational diseases was only 1.1‰. Among the institutions with biological monitoring records, 64.1% did not participate in external quality assessment program in laboratory, and the unqualified rate of 38 participating institutions was 55.3%. The risk assessment results show that the future development of OME institutions needs to focus on private institutions, institutions that have not reported OME information, institutions that have missed diagnosis and missed reporting of suspected occupational diseases, institutions that have not participated in external quality assessment program in laboratory and core personnel such as quality managers, technical leaders, and main inspection physicians. Conclusion: OME institutions in Guangdong Province show the characteristics of centralized filing category, centralized filing region and centralized filing institution nature. Combined with the potential risks of OME institutional capacity building, it is necessary to implement classified management, strengthen information construction, supervision and management, implement post responsibilities, and promote the high-quality development of OME institutions.

The application law of Moutan Cortex in Synopsis of the Golden Chamber / 国际中医中药杂志

We aimed to study the articles and applied prescriptions of Moutan Cortex in Synopsis of theGolden Chamber, summarize and analyze its laws on the disease location and disease nature, and analyze its compatibility, dosage and processing laws. Based on the knowledge of Moutan Cortex by Zhongjing, we found that the kidney, bladder, uterus and intestine involved in Zhongjing's application of peony bark prescription, which belongs to the disease of "lower abdomen" in Huangdi Nei Jing. And the prescription of Moutan Cortex mainly focused on the syndromes of "depression" and "blood stasis", which are characterised by five kinds: water depression, dampness depression, stasis-heat, blood stasis and ecchymosis. and the compatibility rule of Zhongjing application of Moutan Cortex is analyzed accordingly. In addition, the study found that as the downward movement of the disease position, the amount of Moutan Cortex increased, and the processing of the problem followed the principle of "if disease is slow onset, the Moutan Cortex heart should be removed, but if disease is acute, Moutan Cortex heart should be kept". Finally, we combined modern clinical application of Moutan Cortex with modern pharmacological research, in order to expand the scope of clinical application of Moutan Cortex and "the same treatment of different diseases" to provide theoretical guidance.

Relationship between intestinal flora and location and nature of diarrheal irritable bowel syndrome in Traditional Chinese Medicine / 国际中医中药杂志

Irritable bowel syndrome is a common functional gastrointestinal disorder, among which diarrhea-type irritable bowel syndrome (IBS-D) is the main type in China, which is seriously affecting the quality of life for patients. The pathogenesis of IBS-D is still unclear. It has been found that Intestinal flora disorder is an important pathogenesis of IBS-D. There is a close relationship between intestinal flora and IBS-D TCM syndrome types, and there are differences in intestinal flora of different TCM syndrome types of IBS-D. However, TCM syndrome types are a complex and multi-factor combination. Therefore, based on the TCM theory of nature and location of disease, this article proposed the following conclusions through analyzing previous studies on intestinal flora of different TCM syndromes of IBS-D, including that the intestinal flora of different TCM syndromes have different characteristics and there are differences in the functions of flora, deficiency and excess of disease are associated with the diversity and abundance of intestinal flora, cold and heat of disease are related to the proportion of beneficial bacteria and opportunistic pathogens, and the characteristics of intestinal flora are the microcosmic manifestation of the disease position of TCM. In addition, this article also proposed the application of fecal bacteria transplantation based on the theory of nature and location of disease. Based on this theory, the study on intestinal flora of IBS-D can provide help for objectification of TCM syndrome types, and also provide TCM research ideas for revealing the pathogenesis of IBS-D.

Development of a nature posture treatment suspension therapy based on ICF-CY / 中国康复理论与实践

ObjectiveTo develop a rehabilitation program of nature posture treatment (NPT) suspension therapy based on the International Classification of Functioning, Disability and Health-Children and Youth version (ICF-CY) framework, and apply it to neurodevelopmental disorders. MethodsThe ICF-CY theoretical group (group A) and NPT suspension therapy group (group B) were established. Group A searched literature from common databases, to extract high-frequency words related to suspension therapy and match with categories of ICF-CY, to develop ICF-CY theoretical framework of the NPT suspension therapy. Group B developed specific rehabilitation procedures and training items based on the framework to compose the training pool. A total of 110 children aged less than six years with neurodevelopmental disorders and associated motor impairments were selected from outpatient or inpatient of the First Affiliated Hospital of Xinxiang Medical University, between October, 2019 and October, 2022. They were randomly divided into control group (n = 55) and clinical group (n = 55), who received routine neurodevelopmental therapy and NPT suspension therapy program based on ICF-CY, respectively, for a week. The incidence of satisfaction, acceptance and adverse events were observed. ResultsTwo cases in the control group and four cases in the clinical group dropped down. For the clinical group, the incidence of satisfaction was 98% (50/51), with acceptance of 96% (49/51), and one adverse event occurred. For the control group, the incidence of both the satisfaction and acceptance was 100%, and no adverse event occurred. There was no significant difference in the incidence of satisfaction, acceptance and the adverse event (P > 0.05). ConclusionThe NPT suspension therapy program based on the ICF-CY framework is safe and acceptable for children with neurodevelopmental disorders.