ABSTRACT
OBJECTIVE: To pave the way for clinical therapy and reasonable use of antibiotics through investigation on the current status of nosocomial infections and antibiotics resistance in paralytic patients. METHODS: Comprehensive analyses on the bacteriology of infection sites and drug resistance were performed in the hospitalized paralytic patients of our hospital from Jan., 2010 to Jun., 2011. RESULTS: The incidence of nosocomial infections in the paralytic patients was high, and most of the infections were found in lower respiratory tract and urinary tract. The main pathogens were gram-negative bacteria,but the pathogens were highly resistant with significant cross resistance. CONCLUSION: It is important for clinical treatment to monitor the drug resistance of bacteria and optimize antibiotics therapy according to antimicrobial susceptibility test and PK/PD theories. Copyright 2012 by the Chinese Pharmaceutical Association.