ABSTRACT
The main components of the gastric tumor stroma consist of cells in both the immune and non-immune microenvironments. The effectiveness of a series of therapeutic measures such as adjuvant chemotherapy is closely related to the composition of gastric tumor stroma. By analyzing the components in the gastric tumor stroma, we understand the characteristics of the constituents in the pathological structure of gastric cancer, and further explore the connection of each component of the stroma with pathological structure and regulatory mechanisms of stroma components on the occurrence and progression of gastric tumors. Combined with artificial intel-ligence technology to analyze the pathological features related to stroma components of tumor microenvironment, the dynamic changes of immune microenvironment and non-immune microen-vironment in gastric cancer are expected to reveal.
ABSTRACT
Resumen: Introducción: La Hidradenitis palmoplantar ecrina idiopática (HPPI) es una dermatosis neutrofílica infrecuente, que cursa con nódulos eritematosos dolorosos de comienzo brusco en regiones plantares o palmoplantares, en niños que no tienen otra enfermedad subyacente. Objetivo: Presentar un caso que ilustra las principales características clínicas e histológicas de la HPPI. Caso Clínico: Niña de 11 años evaluada por nódulos eritematovioláceos dolorosos en planta de pie derecho de 48 horas de evo lución y fiebre de hasta 38,2 °C, sin antecedentes de interés salvo hiperhidrosis y práctica intensa de ejercicio en los días previos. Ante la sospecha clínica de HPPI se realizó biopsia cutánea, que mostró infiltrado inflamatorio neutrofílico alrededor de glándulas sudoríparas ecrinas y abscesos de neutrófilos, confirmando el diagnóstico. Se indicaron antiinflamatorios no esteroidales orales y reposo, con resolución de las lesiones en 7 días. Conclusiones: Este caso demuestra los aspectos más importantes de la HPPI. Esta entidad en muchos casos es infradiagnosticada, dado que puede confundirse con otras patologías que también cursan con nódulos acrales dolorosos, pero tienen distintas implicacio nes patogénicas y terapéuticas. Identificar apropiadamente la HPPI permite evitar la alarma innece saria, tanto en pacientes y sus padres, como en los propios dermatólogos y pediatras.
Abstract: Introduction: Idiopathic Palmoplantar Eccrine Hidradenitis (IPPH) is a rare neutrophilic derma tosis, with painful erythematous nodules of sudden onset in the plantar or palmoplantar region, in children without other underlying diseases. Objective: To present a case that shows the main clinical and histological characteristics of this entity. Clinical Case: 11-year-old girl with a 48-hours history of painful erythematous-violaceous nodules on the right foot plant associated with fever of up to 38.2 °C, with no history of interest except hyperhidrosis and intense exercising on previous days. Given the clinical suspicion of IPPH, a skin biopsy was performed, which showed inflammatory neutrophil infiltration around eccrine sweat glands and neutrophilic abscesses, confirming the diagnosis. Oral NSAIDs and rest were prescribed, with resolution of the lesions in 7 days. Conclusions: This case demonstrates the most important aspects of this entity, in many cases underdiagnosed, since it can be confused with other pathologies that occur with painful acral nodules, but have different pathogenic and therapeutic implications. To properly identify the IPPH allows preventing an unnecessary alarm, both patients and their parents, as in dermatologists and pediatricians themselves.
Subject(s)
Humans , Female , Child , Hidradenitis/diagnosis , Foot Dermatoses/diagnosis , Hidradenitis/complications , Hidradenitis/pathology , Acute Pain/etiology , Foot Dermatoses/complications , Foot Dermatoses/pathologyABSTRACT
De Husserl a Ricoeur, constituyen temáticas que nos convocan hoy, aniversario de la publicación de Idea I Husserl, centenario del nacimiento de Ricoeur y de la publicación de la Psicopatología. ¿Qué importancia han tenido estos autores en la reflexión psicológica y psicopatológica? El recorrido que pasa por el describir, comprender y explicar en Dilthey y Jaspers hasta Binswanger, obliga sin embargo a realizar un giro, una torsión en el interpretar de Ricoeur. Se abren entonces senderos no marcados aún, "Holzwege" diría Heidegger, que nos lanzan a nuevas lecturas.
From Husserl's to Ricoeur's thought, there are topics that call for us today, anniversary of the publication of Husserl's Idea 1,100th anniversary of Ricoeur' birth and the publication of Jaspers' Psychopathology. What's the importance of these authors in Psychological and Psychopathological reflection? The tour goes through describing, understanding and explaining in Dilthey and Jaspers to Binswanger. It forces however to make a turn, a twisting in the interpreting of Ricoeur. Then, it opens paths not marked yet, "Holzwege", Heidegger would say, throwing us to new readings.