La endoftalmitis endógena por Candida, un marcador pronóstico / Endogenous Candida endophthalmitis, a prognostic marker

La candidiasis es la causa más común de endoftalmitis endógena. La afectación ocular se produce entre los 3 y los 15 días siguientes a la fungemia. Las dos formas características de presentación son la coriorretinitis candidiásica, que afecta a la coroides y a la retina sin afectar claramente al vítreo, y la endoftalmitis candidiásica, con presencia de lesiones vítreas redondeadas, de aspecto algodonoso (perlas vítreas), características de esta infección. Los síntomas visuales precoces más habituales son la visión borrosa y los flotadores. Se recomienda entonces realizar fondo de ojo en las 2 primeras semanas del diagnóstico de candidemia para prevenir complicaciones oculares y usar la afectación ocular como indicador de probable infección fúngica invasiva. La anfotericina B, el fluconazol, el voriconazol, el posaconazol y el ravuconazol, así como las equinocandinas entre las que se encuentran la caspofungina han demostrado su utilidad en el tratamiento de la coriorretinitis, pero la efectividad disminuye en los casos de afectación vítrea si no se asocian a vitrectomía(AU)

Candidiasis is the most common cause of endogenous endophthalmitis. Ocular damage occurs within 3 and 15 days after fungemia. The two characteristic forms of presentation are Candida chorioretinitis, affecting the choroid and the retina with no clear impact on the vitreous, and Candida endophthalmitis, with the presence of rounded cottony vitreous lesions (vitreous pearls), characteristic of this infection. The most common early visual symptoms are blurred vision and floaters. It is thus recommended to perform funduscopy within the first two weeks after the candidemia diagnosis to prevent ocular complications and use the ocular damage as an indicator of probable invasive fungal infection. Amphotericin B, fluconazole, voriconazole, posaconazole and ravuconazole, as well as echinocandins, among them caspofungin, have proven useful in the treatment of chorioretinitis, but effectiveness is lower in vitreous damage cases when they are not associated to vitrectomy(AU)

Hallazgos en el fondo de ojo de boxeadores cubanos activos asintomáticos / Funduscopy findings in Cuban active asymptomatic boxers

Objetivo: determinar los hallazgos del fondo de ojo en los boxeadores cubanos activos asintomáticos en dos grupos de estudio. Métodos: se efectuó un estudio observacional descriptivo y transversal en los boxeadores de la preselección nacional de boxeo, a quienes se les realizó un fondo de ojo anual, con pupila dilatada y oftalmoscopia binocular indirecta con depresión escleral, en el Servicio de Vítreo-Retina del Instituto Cubano de Oftalmología "Ramón Pando Ferrer". Se tomaron dos grupos, el primero comprendido entre los años 1995 y 2000 (115) y el segundo grupo después de formar parte de la franquicia de los domadores de Cuba en los años 2015 - 2016 (38), donde se realizaron cambios en el estilo de la competencia. Resultados: en los dos grupos estudiados la agudeza visual sin corrección fue mayor de 0,8. En ambos grupos se observó un aumento de la visibilidad de las fibras a nivel del vítreo periférico. Más de la mitad de los ojos de los atletas tenían una retina normal. El desprendimiento de retina se presentó en 1,3 y 2,6 por ciento, respectivamente. Existían lesiones en la retina periférica pero la frecuencia fue baja. No existieron diferencias significativas en ambos grupos. El tratamiento más frecuente realizado en los ojos con lesiones retinales en los dos grupos fue la fotocoagulación focal con láser de argón. Conclusiones: el chequeo anual oftalmológico de los boxeadores garantiza un diagnóstico precoz y un tratamiento oportuno profiláctico o quirúrgico. Así se alarga la vida profesional activa de los boxeadores y se mantiene una buena calidad de vida al concluir su vida deportiva(AU)

Objective: determine funduscopy findings in Cuban active asymptomatic boxers from two study groups. Methods: across-sectional observational descriptive study was conducted with boxers from the national boxing trial team, who underwent annual funduscopy with dilated pupils and indirect binocular ophthalmoscopy with scleral depression at the Vitreous-Retina Service of Ramón Pando Ferrer Cuban Institute of Ophthalmology. Two groups were formed: one corresponding to the period 1995-2000 (115) and the other after being part of the Cuban Domadores (Tamers) team in 2015-2016 (38), when changes were made to competition styles. Results: in the two groups studied, uncorrected visual acuity was above 0.8. In both an increase was observed in the visibility of peripheral vitreous fibers. More than half of the athletes' eyes had a normal retina. Retinal detachment was present in 1.3 percent and 2.6 percent, respectively. There were lesions on the peripheral retina, but their frequency was low. No significant differences were found in the groups. The most common treatment indicated in the two groups for eyes with retinal lesions was argon laser focal photocoagulation. Conclusions: annual ophthalmological examination of boxers ensures early diagnosis and timely prophylactic or surgical treatment with the purpose of lengthening their active professional life and maintaining a good quality of life upon retirement(AU)

Bilateral atypical optic neuritis associated with tuberculosis in an immunocompromised patient

A 27 year-old lady, presented with sudden loss of vision in the right eye for a week. It was followed by poor vision in the left eye after 3 days. It involved the whole entire visual field and was associated with pain on eye movement. She was diagnosed to have miliary tuberculosis and retroviral disease 4 months ago. She was started on anti-TB since then but defaulted highly active anti-retroviral therapy (HAART). On examination, her visual acuity was no perception of light in the right eye and 6/120 (pinhole 3/60) in the left eye. Anterior segment in both eyes was unremarkable. Funduscopy showed bilateral optic disc swelling with presence of multiple foci of choroiditis in the peripheral retina. The vitreous and retinal vessels were normal. Chest radiography was normal. CT scan of orbit and brain revealed bilateral enhancement of the optic nerve sheath that suggest the diagnosis of bilateral atypical optic neuritis. This patient was managed with infectious disease team. She was started on HAART and anti-TB treatment was continued. She completed anti-TB treatment after 9 months without any serious side effects. During follow up the visual acuity in both eyes was not improved. However, funduscopy showed resolving of disc swelling and choroiditis following treatment.

Clinical Features of Ocular Toxoplasmosis in Korean Patients

We report here the records of 10 consecutive Korean patients (10 eyes) with ocular toxoplasmosis which showed the typical clinical manifestations with seropositivity for Toxoplasma gondii specific IgG antibodies by micro-ELISA between 2006 and 2010. Nine patients were males and 1 was female; their age was 50.5+/-13.8 years. The most common accompanying signs were vitritis (100%), anterior uveitis (70%), and scattered white deposit (80%). Pre-existing retinochoroidal scar was found in 1 (10%) patient. All patients received antiparasitic chemotherapy and systemic corticosteroid treatment, which resolved the presenting attack and recovered the visual acuity better than initial one in 9 patients and worse in 1. Optic atrophy, cataract, and retinal neovascularization were observed during the follow-up period and recurrence was detected in 3 eyes (30%) 6 to 20 months after the initial attack. In Korea, although rarely detected and reported, ocular toxoplasmosis needs more attention in clinical field of retinal diseases.

Age and Gender Specific Reference Value of Ocular Torsion by Using Funduscope in Korean / 대한평형의학회지

BACKGROUND AND OBJECTIVES: Ocular torsion may be a result of vestibulopathy. The funduscopy is the most reliable method of measuring an ocular torsion. However, the reference value of ocular torsion in Korean is available at only limited ages. Therefore, we analyzed the angle of ocular torsion more age-specific than previous study. MATERIALS AND METHODS: We used the fundus photograph of health check-up visitor. And age and sex specific average angle of ocular torsion was measured. RESULTS: The right and left average angle of ocular torsion were 7.7+/-3.6degrees, 5.3+/-3.0degrees, respectively. In addition, there was no significant difference in age or sex specific angle of ocular torsion. CONCLUSION: This result might give an aid to evaluating the function of otolithic organ by measurement of ocular torsion.

Risk factors of ocular involvement in children with mitochondrial respiratory chain complex defect / 소아과

PURPOSE: Mitochondrial dysfunction can present with various symptoms depending on the organ it has affected. This research tried to analyze the ophthalmologic symptoms and ophthalmologic examination (OE) results in patients with mitochondrial disease (MD). METHODS: Seventy-four patients diagnosed with mitochondrial respiratory chain complex defect with biochemical enzyme assay were included in the study. They were divided into 2 groups based on the OE results by funduscopy and were analyzed on the basis of their clinical features, biochemical test results, morphological analysis, and neuroimaging findings. RESULTS: Thirty-seven (50%) of the 74 MD patients developed ophthalmologic symptoms. Abnormal findings were observed in 36 (48.6%) patients during an OE, and 16 (21.6%) of them had no ocular symptoms. Significantly higher rates of prematurity, clinical history of epilepsy or frequent apnea events, abnormal light microscopic findings in muscle pathology, diffuse cerebral atrophy in magnetic resonance imaging, and brainstem hyperintensity and lactate peaks in magnetic resonance spectroscopy were noted in the group with abnormal OE results. CONCLUSION: Although the ophthalmologic symptoms are not very remarkable in MD patients, an OE is required. When the risk factors mentioned above are observed, a more active approach should be taken in the OE because a higher frequency of ocular involvement can be expected.