Research on kidney disease in the scriptures / Монголын эм зүй, эм судлал

Introduction@#Kidney disease is common in our country due to the four seasons and harsh climate. This article is discussed about the kidney health, causes, pathology and kidney on the relationship of other organs in traditional medicine.@*Methods@#The study was processed using analysis and synthesis methods.@*Results@#</br>1. The root nature of the five vital organs are included in the yang character organs which hot nature qualities in five elements. However, some of the five vital organs will be under the influence of that place, as they will be located in the place of the “badgan”, in the place of the “mkhris”, and in the place of the “rlung”. </br>2. Kidney disease is usually caused by falling from a height, hit and injured, lifting heavy things, jogging and twisting your back uncomfortably, sit for a long time in a damp place, water events excess, eating too sweets that are heavy and cold qualities. In medical practice, kidney disease is accompanied by heart disease and liver disease.@*Conclusion@#In according to traditional medicine main theory, kidneys are a solid vital organ that generates heat and warms the lower body because of the high blood flow through its, on the other hand they are cold character which are in the place of the “rlung”. The kidneys are functionally closely related to other organs therefore, to get sick the effects of disease on other organs.

Clinical and pathological features in children diagnosed with primary focal segmental glomerulosclerosis after repeated renal biopsy / 中华肾脏病杂志

Objective:To analyze the clinical and pathological characteristics in children diagnosed with primary focal segmental glomerulosclerosis (FSGS) after repeated renal biopsy.Methods:The clinicopathological data of children who ever experienced renal biopsy in Jinling Hospital from January 1, 2000 to December 31, 2020 were retrospectively reviewed. Clinical manifestations, pathological characteristics and treatment responses were analyzed.Results:Of the 34 enrolled patients, there were 22 males and 12 females. The median age of the first renal biopsy was 14 years old (1-18 years old), and the median interval between repeat renal biopsy and first renal biopsy was 6 months (1-151 months). Thirty-one showed nephrotic syndrome, of which 22 had microscopic hematuria, and 4 had elevated serum creatinine. Among the other 3 patients, 2 had hematuria and proteinuria, and 1 had proteinuria. In the first renal biopsy, 16 cases were diagnosed as minimal change disease, 14 cases were diagnosed as mesangial proliferative glomerulonephritis, 2 cases were diagnosed as IgA nephropathy, and 2 cases were diagnosed as IgM nephropathy. All 34 children showed poor responses to hormone and immunosuppressive therapies. The pathological features of the first renal biopsy in some patients were adhesion (2/34), decreased loop podocyte attachment (2/34), peripheral loop extension to the urinary pole (2/34), renal tubular reflux (4/34), capillary thrombosis (2/34) and IgM deposition (12/34).Conclusions:The initial diagnosis of FSGS is difficult, and the lesions are atypical and easily misdiagnosed. The patients have poor responses to hormone and immunosuppressive therapies. For patients with the pathological changes of adhesion, decreased loop podocyte attachment, peripheral loop extension to the urinary pole, renal tubular reflux, capillary thrombosis and IgM deposition, follow-up is required, and if necessary, repeat renal biopsy needs be performed to determine whether it is FSGS.

Therapeutic Role of Tangshenkang Granule () in Rat Model with Diabetic Nephropathy / 中国结合医学杂志

<p><b>OBJECTIVE</b>To evaluate the renal protective effect of Tangshenkang Granule () in a rat model of diabetic nephropathy (DN).</p><p><b>METHODS</b>Forty male Sprague-Dawley rats were randomly divided into control, DN, Tangshenkang and benazepril groups. DN model was established in the rats of DN, Tangshenkang and benazepril groups. Tangshenkang Granule solution and benazepril hydrochloride solution were intragastrically administered daily to the rats in the Tangshenkang and benazepril groups for 8 weeks, respectively. Urinary albumin and creatinine were detected. The albumin/creatinine (ACR) was calculated in addition to 24 h urinary protein (24-h UPr), serum creatinine (Scr), blood urea nitrogen (BUN), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and creatinine clearance rate (Ccr). Right kidneys were harvested for pathological observation using periodic acid-silver methenamine-Masson staining. The average glomerular diameter (DG), average glomerular (AG) and mesangial areas (AM) were measured. The thickness of glomerular basement membrane (TGBM) was detected using transmission electron microscope.</p><p><b>RESULTS</b>Compared with rats in the control group, rats in the DN group showed significantly decreased body weight, increased hypertrophy index, 24-h urinary volume, 24-h UPr, ACR, Scr, BUN, Ccr, blood lipids as well as renal pathological indices including DG, AG, AM, AM/AG and TGBM (P <0.05). Compared with the DN group, the weights of rats in the Tangshenkang and benazepril groups were significantly increased, and the renal hypertrophy indices were significantly decreased (P <0.05). The 24-h urinary volumes, ACR, 24-h UPr, Scr, BUN, Ccr, LDL, DG, AG, AM and TGBM were obviously decreased (P <0.05). Compared with the benazepril group, the Tangshenkang group showed significantly decreased levels of ACR, 24-h UPr, AG and AM (P <0.05).</p><p><b>CONCLUSIONS</b>Tangshenkang Granule decreased the urinary protein, attenuated the high glomerular filtration rate and improved lipid metabolism in DN rats, and prevented further injury induced by diabetic nephropathy.</p>

Aspectos anatomopatológicos do parasitismo por nematódeos da superfamília filarioidea em capivaras (hydrochoerus hydrochaeris) de vida livre no Centro-Oeste brasileiro / Anatomic pathology aspects of the parasitism by cruorifilaria tuberocauda in capybaras (hydrochoerus hydrochaeris) in midwestern Brazil

São descritos dois casos de parasitismo por Cruorifilaria tuberocauda em capivaras de vida livre no Distrito Federal, Brasil. Macroscopicamente, observou-se nas superfícies de corte dos rins espessamento acentuado de vasos das regiões cortical e córtico-medular. Microscopicamente, havia arterite proliferativa e granulomatosa acentuada associada a filarídeos intralesionais consistentes com Cruorifilaria tuberocauda. Esse é o primeiro relato do parasitismo por esse filarídeo em capivaras no Distrito Federal.

This report describes two cases of parasitism by Cruorifilaria tuberocauda in wild capybaras (Hydrochoerus hydrochaeris) from Distrito Federal, Brazil. Grossly, there was marked thickening of vessels wall of the cortical and corticomedullary regions of both kidneys. Microscopically, there was severe proliferative and granulomatous arteritis associated with intralesional filarids, consistent with Cruorifilaria tuberocauda. For the first time this filarid is reported parasitizing capybaras in Distrito Federal, Brazil.

Effect of TanshinoneⅡA on Renal Tumor Growth Factor-beta 1 and Nuclear Factor-kappa B in Diabetic Nephropathy Rats / 广州中医药大学学报

Objective To observe the effect of tanshinone ⅡA on renal transforming growth factor beta 1 (TGF-β1) and nuclear factor-kappa B (NF-κB) p65 mRNA and protein expression in diabetic nephropathy (DN) rats, thus to evaluate the therapeutic effect and mechanism of tanshinone ⅡA. Methods SD rats were used as the experimental animal. DN rat model was induced with 40 mg/kg of streptozocin ( STZ) . The rats were randomized into normal group, model group, and tanshinone ⅡA ( 10 mg·kg -1·d -1, im) group. On the experimental day 30, we examined the body weight, water in-take volume, 24-hour urine protein, fasting glucose ( Glu) , serum creatinine ( Cr) , blood urea nitrogen ( BUN) , total protein ( TP) and albumin ( Alb). Renal slices after periodic acid Schiff staining ( PAS) were used for the observation of renal pathology. Semi-quantitative reverse transcription polymerase chain reaction ( RT-PCR) was used for the detection of renal TGF-β1 and NF-κB p65 mRNA expression, and Western blotting method was used for the measurement of TGF-β1 and NF-κB p65 protein expression in rats of different groups. Results Compared with the normal group, body weight was decreased, water in-take volume and 24-hour urine protein were increased, serum Glu, Cr, and BUN levels were elevated, TP and Alb levels were decreased, renal pathological damage occurred, and renal TGF-β1 and NF-κB p65 mRNA and protein expressin were promoted in the model group (P<0.05 or P<0.01). Tanshinone ⅡA group had an effect on decreasing water in-take volume, 24-hour urine protein, serum levels of Glu, Cr and Bun, increasing TP and Alb levels, relieving renal pathological damage, and reducing the protein and mRNA expression of renal TGF-β1 and NF-κB p65 ( P<0.05 or P<0.01 compared with the model group). Conclusion Tanshinone ⅡA has protective effect on kidney probably through inhibiting renal TGF-β1 and NF-κB p65 expression in DN rats.

Clinical characteristics and Oxford classification of IgA nephropathy patients with hyperuri-cemia / 临床与实验病理学杂志

Purpose To investigate the clinical characteristics and Oxford classification of IgA nephropathy patients with hyperurice-mia. Methods 151 IgA nephropathy patients confirmed by renal biopsy in 2013 were analyzed retrospectively. The patients were di-vided into the two groups:IgA nephropathy patients with or without hyperuricemia. Morphological changes were evaluated with Oxford classification scoring system and Lee’s grades. A comparative analysis of clinical manifestations and pathological injuries was performed between the two groups. Results Incidence of hyperuricemia in IgA nephropathy patients was 48. 3% and was more common in young men. Hypertension was associated with hyperuricemia. Oxford classification of IgA nephropathy patients with hyperuricemia was pre-dominant M1E0S1T0 and Lee’s grades presented with grade Ⅲ. The outstanding histopathologic features with higher plasma uric acid levels indicated higher tubulointerstitial chronicity, higher glomerular sclerosis ratio, accompanied by a decline in glomerular filtration rate. There was no significant difference of vascular lesions. Conclusions The prevalence of hyperuricemia in IgA nephropathy pa-tients is high. Oxford classification shows IgA nephropathy with hyperuricemia are associated with more severe tubulointerstitial lesions and lower GFR.

Effect of Modified Qinghao Biejia Decoction on Th17 Cells and Renal Pathology of MRL/lpr Mice with Lupus Nephritis / 广州中医药大学学报

Objective To observe the effect of modified Qinghao Biejia Decoction ( QBD) on Th17 cells and renal pathology of MRL/lpr mice with spontaneous systemic lupus erythematosus. Methods Thirty-two female MRL/lpr mice aged 8 to 10 weeks were divided into 4 groups: model group, Chinese medicine group, prednisone group, and combination group, 8 mice in each group. Eight female C57BL/6 mice aged 8 to 10 weeks served as normal control. Mice in Chinese medicine group were given concentrated solution of modified QBD (19.25 g·kg-1·d-1), mice in the prednisone group were given water solution of prednisone acetate (8.75 mg·kg-1·d-1) , mice in the combination group were given the above two kinds of medicine, and mice in the model group and normal control group were given physiological saline. After medication for 7 weeks, spleens and kidneys in all of the groups were taken out for the experiment. Th17 cells in splenic mononuclear cell suspension were detected by flow cytometry, the pathological changes of renal tissue were observed under light microscope, and activity index (AI) of renal tissue in lupus nephritis mice was scored. Results The proportion of Th17 cells in the model group was significantly higher than that of normal control group ( P<0.05) . The proportion of Th17 cells in Chinese medicine group and combination group was lower than that of the model group ( P<0.05) , and prednisone group had higher proportion of Th17 cells than Chinese medicine group ( P<0.05) . Compared with the model group, pathological changes of renal tissue were relieved, and AI scores were decreased in Chinese medicine group, the prednisone group and the combination group ( P<0.05) . Except for the normal control group , AI scores in all groups were positively correlated with the proportion of Th17 cells ( r=0.77, P<0.01) . Conclusion Modified QBD can inhibit the expression of Th17 cells and improve the pathological changes of MRL/lpr mice with lupus nephritis.

Effects of Yishen Tongluo Decoction on Renal Transforming Growth Factor-β1 and CollagenⅣmRNA Expression in Membranous Nephropathy Rats / 广州中医药大学学报

Objective To observe the effects of Yishen Tongluo Decoction (YTD) on the renal mRNA expression of transforming growth factor-β1 ( TGF-β1) and collagen Ⅳ ( ColⅣ) in membranous nephropathy ( MN) rats. Methods SD rats were randomly divided into normal group, model group, benazepril group (in the dosage of 10 mg·kg-1·d-1) , YTD group ( in the dosage of 20 g·kg-1·d-1) . The rats in various groups were given intragastric administration of corresponding agents. At the end of the fourth week, 24-hour urinary protein quantity, albumin ( ALB) , total protein ( TP) , triglyceride ( TG) , total cholesterol ( TC) , blood urea nitrogen ( BUN) , and creatinine (Cr) levels were observed. The mRNA expression levels of TGF-β1 and ColⅣ in renal tissue of rats were detected by immunofluorescence method, electron microscopy and real-time polymerase chain reaction (PCR) method. Results In the model group, urinary protein quantity in rats was increased, serum levels of TP and ALB were significantly lowered, serum levels of TC and TG were significantly increased, renal pathological changes were present, and mRNA expression levels of TGF-β1 and ColIV in renal tissue were up-regulated (P0.05) . Conclusion The therapeutic mechanism of YTD for MN is probably related with the inhibition of mRNA expression of TGF-β1 and ColⅣin renal tissue.

Avaliação da intoxicação aguda induzida por atrazina em espécie da ictiofauna do pantanal mato-grossense, pacu (Piaractus mesopotamicus), com o emprego de biomarcadores morfológicos / Morphological biomarkers for assessing acute toxicity of atrazine in pacu (Piaractus mesopotamicus) fingerlings, a freshwater species from the Brazilian pantanal wetland

Atrazina é um herbicida muito usado em agricultura intensiva e encontrado com alta freqüência em recursos hídricos na região do Pantanal Mato-grossense. Assim, devido aos riscos que a atrazina pode trazer à ictiofauna da região, foi proposta deste trabalho determinar a CL50 da atrazina em alevinos de pacu (Piaractus mesopotamicus). A determinação da CL50 em 96 h em sistema estático, realizada em duplicata, foi conduzida em aquários de vidro com 8 peixes cada, de peso médio de 5,06±0,31g, avaliando-se as seguintes concentrações nominais de atrazina: 0; 13,2; 17,6; 22,0; 26,4; 30,8; 35,2; 39,6 mg L-1, realizando-se também análise comportamental e análise anatomopatológica. Experimento de intoxicação aguda foi realizado em duplicata, nas mesmas condições do anterior, com a concentração da CL50 obtida (28,58 mg L-1), sendo empregados 6 exemplares de peso médio 6,68±0,36g. Amostras hepáticas e mesonéfricas foram colhidas e processadas para análise de microscopia de luz (ML), realizando-se nestas amostras análise semi-quantitativa das alterações encontradas, e para análise de microscopia eletrônica de transmissão (MET). Quanto à avaliação comportamental, foram observados nos grupos tratados: o escurecimento da pigmentação da pele, várias alterações na intensidade do movimento, perda de equilíbrio e presença da ação de boquejamento. Na avaliação anatomopatológica, foram observadas nos grupos tratados: dilatação da região ventral, exoftalmia, protrusão labial, hiperemia no opérculo e em todas as nadadeiras, presença de ar e/ou água no estômago e ascite sanguinolenta...

Exposure to atrazine caused darkening of the skin, alterations in the intensity of movements, loss of balance and an increase in the frequency of gasping. Anatomopathological assessment revealed dilation of the ventral region, exophthalmia, lip protrusion, skin hyperemia in the opercular region and in all fins, the presence of air and/or water in the stomach, and bloody ascites after the herbicide exposition. The histopathological analysis revealed the typical hepatic and renal morphology for the specie, in control group. Several histopathological changes were observed in exposed fish, but the changes most significant were: in liver, the presence of hyaline inclusions in the cytoplasm of hepatocytes, and proximal tubule (PT) degeneration in the kidney. The ultrastructure showed that the atrazine caused several membrane alterations suggestive of oxidative stress and lipid peroxidation...

Cytoprotective role of heme oxygenase-1 upregulation in progressive renal disease / Papel citoprotetor da indução da heme oxigenase-1 na lesão renal progressiva

Objective: This study evaluated the ability of heme oxygenase-1 to prevent or reverse renal fibrosis. Methods: Sprague-dawley male rats were submitted to unilateral ureteral obstruction and divided into groups: non-treated and hemin. Biochemical and histological analyses were performed. We also conducted RT-PCR to verify the expression of heme oxygenase-1, MCP-1, IL1-beta, IL-6, TNF-alfa, COL-I, COL-III, PAI-1 and fibronectin mRNA. Results: heme oxygenase-1 expression significantly increased in treated animals. The non treated group showed significantly higher levels of proteinuria than the Hemin group. The protein/urinary creatinine ratio in obstructed pelvis was also higher in non treated group, which also showed greater albuminuria and higher percentage of fibrosis when compared to the Hemin group. The expression of pro-inflammatory and pro-fibrotic molecules was significantly higher in the non treated group. Conclusions: The treatment induced the expression of heme oxygenase-1, preventing the installation of fibrosis and even limiting its progression.

Objetivo: Este estudo avaliou a capacidade da heme oxigenase-1 em prevenir ou reverter o quadro de fibrose renal. Métodos: Ratos Sprague-dawley machos foram submetidos a UUO e divididos nos grupos: não-tratados e Hemin. Avaliou-se a função renal, fez-se análise histológica e realizou-se RT-PCR para verificar expressão de heme oxigenase-1, MCP-1, IL1-beta, IL-6, TNF-alfa, COL-I, COL-III, PAI-1 e Fibronectina. Resultados: Houve expressão significativamente maior de heme oxigenase-1 nos animais tratados. O grupo não tratado apresentou níveis significativamente maiores de proteinúria em relação ao grupo Hemin. O índice proteína/creatinina urinária da pelve obstruída também foi maior no grupo não tratado, que apresentou ainda maior albuminúria e maior porcentagem de fibrose em relação ao grupo Hemin. A expressão de moléculas pró-inflamatórias e pró-fibróticas foi significativamente maior no grupo não tratado. Conclusões: O tratamento induziu a expressão de heme oxigenase-1, evitando a instalação da fibrose e mesmo limitando sua progressão.

Influences of Bis(maltolato) oxovanadium in kidney morphology in spontaneously hypertensive rats / 吉林大学学报(医学版)

Objective To study the effects of Bis(maltolato) oxovanadium(BMOV) on renal structure of spontaneously hypertensive rats(SHRs) and its mechanism.Methods Thirty-six SHRs were divided into three groups at random: blank group,Nifedipine group and BMOV group.The light microscope and electron microscope were used to examine the pathologic changes of the kidney in rats.Results The rat glomerular mesangial expansion was found and the lumen of glomeruler capillary nearly closed in bland group,while in BMOV group the pathological changes mentioned above were unobvious.Conclusion BMOV may have protective effects on kidney in SHRs.

Relationship between Serum Platelet Derived Growth Factor-BB and IgA Nephropathy in Children / 实用儿科临床杂志

Objective To investigate the clinicopathologic relationship between serum platelet derived growth factor-BB(PDGF-BB)and IgA nephropathy in children.Methods The level of serum PDGF-BB was detected by double antibody enzyme linked immunosorbent assay(ELISA) in 15 cases healthy children and 30 cases IgA nephropathy.According to patholgical degree constituted by WHO in 1982,the IgA nephropathy group divided into 5 degrees:Ⅰ,Ⅱ,Ⅲ,Ⅳ,Ⅴ(Ⅰ,Ⅱ were light patholgic change group;Ⅲ,Ⅳ were moderate patholgic change group;Ⅴ was severe patholgic change group).The serum PDGF-BB in IgA nephropathy group and none-IgA nephropathy group,and in different renal pathology type IgA nephropathy group were analyzed.Data were analyzed by using SAS 6.12 software.Results The level of serum PDGF-BB were(247.35?55.79) ng/L in control group and(869.16?200.73) ng/L in IgA nephropathy group.It was higher in IgA nephropathy group than in control group,the difference was significant(P

Effect of Tongmai Oral Liquid on Renal Pathological Feature and Tumor Growth Factor ?_1 in Rats with Experimental Diabetic Nephropathy / 广州中医药大学学报

Objective To observe the effect of Tongmai Oral Liquid(TOL) on renal pathological feature and tumor growth factor ?1(TGF-?1) in rats with experimental diabetic nephropathy(DN).Methods Forty SD male rats were used for the experiment.Of which,8 were in the normal group,and the other rats were given one-dose intraperitoneal injection of streptozocin(STZ),and were fed with high-fat forage every other day.The normal group received one-dose intraperitoneal injection of aseptic citric acid-sodium citrate buffer and routine forage.After feeding for 4 weeks,the rat models of DN were randomized into the model group and TOL group,which were given normal saline and TOL(2.5 g?kg-1?d-1) respectively,and the two groups were still fed with high-fat forage.After treatment for 6 weeks,the rats were executed and the pathological features and ultrastructure of renal tissue were observed under light microscope and electron microscope respectively.Mean glomerular area(MGA),mean extracellular matrix area(MMA),and the thickness of glomerular basement membrane(GBM) as well as the ratio of MMA/MGA were measured.Meanwhile,the expression of tumor growth factor ?1(TGF-?1) was detected by immunohistochemical method.Results In TOL group,the pathological features such as broadened mesentery,thick basement membrane and vacuolar degeneration in the renal tubular epithelium were relieved,MMA/MGA ratio was decreased,GBM became thin,and the expression of TGF-?1 was strong mainly in renal tubular and interstitial region while weak in glomeruli,and its area density and integral optimal density were decreased as compared with the model group(P

Jiuqiang Naoliqing affords protection to vital organs of spontaneous hypertension rats / 中国康复理论与实践

@#ObjectiveTo investigate the Jiuqiang Naoliqing's (JNQ) histological influence on hearts, brains and kidneys of spontaneous hypertension rats (SHR). MethodsThe rats were randomly divided into four groups: Wistar control group, SHR group, higher dose JNQ treated SHR group(0.530 g/kg) and lower dose JNQ treated SHR group(0.265 g/kg). The treatment lasted five weeks, and the rats' blood pressure were monitored through tail pulse. After the perfusion procedure, rats' hearts, brains and kidneys were rapidly removed in low temperature condition and stored in 10% formalin solution of 4 ℃.Then routine sections were obtained and the slides were stained with HE.ResultsBefore treatment, the blood pressure of SHR groups were distinctly higher than that of the control group(P<0.01), nevertheless, no obvious blood pressure downgrade were observed after three week and five week treatment. Histopathologic study showed: in SHR group,heart with hypertrophic cardiac muscle, proliferative arterial wall and strictured lumina; Cortex with angiostenosis, proliferative vascular wall and large perivascular space; Glomerulus atrophy with hyaline degeneration. These pathologic changes got respective alleviation after five week treatment of JNQ, particularly in higher dose group.ConclusionSHR who got five week treatment of JNQ didn't gain obvious blood pressure downgrade. But the treatment did good to their vital organs and can obviously alleviate hearts, brains and kidneys' pathologic changes.

Effect of Zaojiangtang Tablet on Streptozotocin-Induced Diabetes and Pathological Change of Kidney / 广州中医药大学学报

0.05 compared with group B);ZT and Youjiangtang Tablets had similar effect in promoting the synthesis of hepatic glucose and the release of serum insulin(P

Nefropatia na infância: estudo morfológico / Nefropathy in childhood: a morphological study

O presente trabalho analisou 992 biópsias de pacientes menores de 16 anos de idade no período de 1980 a 1994. As biópsias de pacientes do sexo feminino representaram 47,08% do total. As indicações clínicas para a biópsia mais frequentemente encontradas foram síndrome nefrótica, síndrome nefrítica e hematúria isolada. As glomerulopatias proliferativas representaram o diagnóstico anatomopatológico mais comum. O diagnóstico morfológico mais freqüentemente associado com a síndrome nefrótica foi a glomeruloesclerose focal e segmentar e aquele mais relacionado à hematúria isolada foi a glomerulopatia proliferativa por IgA.

In the present paper 992 renal biopsies of patients under 16 years of age were analysed in the period of 1980 though 1994. Biopsies of female patients accounted for 47,08% of all biopsies. The most freguent clinical conditions that prompted the biop- sies were nephrotic syndrome, hematuria as a sole symptom and nephritic syndrome. The proliferative glomerulopathies were found to be the most common pathologycal diagnosis. The mor- hological diagnosis most freguently associated with nephrotic syndrome was focal and segmental glomerulosclerosis and the one most often related to hematuria as a sole symptom was IgA proliferative glomerulosclerosis.

A Subacute Toxicological Study on Radix Rhododentri Mollis / 中药新药与临床药理

Sixteen dogs were allocated to 4 groups in equal number and were fed with Rad ix Rhod od end ri Mollis 0.170, 0.345 and 1.420 g/kg for three months respectively, with one group as control. The results showed that Rad ix Rhod od end ri Mollis can cause focal necrosis, edema, ballooning degeneration and fatty degeneration of liver cells. It can also increase the permeability of glomerulus, and cause edema and even ballooning degeneration of renal tubular epithelial cells. Biochemical analysis showed that GPT and BUN apparently increased. Urine analysis showed that qualitative examination of protein, epithelial cells, white and red blood cells were all positive. It is considered that long-term administration of Rad ix Rhod od end ri Mollis can cause functional and structural damage of liver and kidney, and timely suspension of the drug and treatment may render the damage.