ABSTRACT
Objective To expore the correlation between resting heart rate(RHR)and carotid atheroscle-rosis in middle-aged and elderly hypertention. Methods A total of 1043 middle-aged and elderly essential hyper-tention were selected and divided into 3 groups according to the RHR:< 70(Group A,n = 406),70～79(Group B,n=364),and≥80 beats/min(Group C,n=273). The patients′fasting blood-glucose(FBG),blood lipids, homocysteine (Hcy) and serum creatinine (SCr) levels were measured. Carotid artery intima-media thickness (CAIMT) and carotid artery diameter (CADIA) were measured by ultra-sonography ,and carotid artery plaques were investigated. Bi-variate correlation analysis was adopted to analyze the correlation between RHR and CAIMT , CADIA. Logistic regression analysis was employed to analyze the influential factors in carotid artery plaques. Mean-while,sub-group analysis of different ages was performed. Results The detection rates of carotid artery plaques in the Group A,B and C were 59.1％,63.7％and 69.6％respectively. Differences in detection rates of carotid artery plaques among 3 groups showed statistical significance(P<0.05). RHR(OR 1.165,95％CI 1.094～1.482,P=0.037) was a risk factor of carotid artery plaques. Significant positive correlations were found between RHR and CAIMT ,CADIA (r = 0.115 ,0.123;P = 0.005 ,0.003). Conclusions RHR was closely related with carotid artery plaques,CAIMT,and CADIA in middle-aged and elderly hypertention. RHR can be recognized as a predic-tive factor of carotid atherosclerosis in middle-aged and elderly hypertention.
ABSTRACT
Objective To expore the correlation between resting heart rate(RHR)and carotid atheroscle-rosis in middle-aged and elderly hypertention. Methods A total of 1043 middle-aged and elderly essential hyper-tention were selected and divided into 3 groups according to the RHR:< 70(Group A,n = 406),70～79(Group B,n=364),and≥80 beats/min(Group C,n=273). The patients′fasting blood-glucose(FBG),blood lipids, homocysteine (Hcy) and serum creatinine (SCr) levels were measured. Carotid artery intima-media thickness (CAIMT) and carotid artery diameter (CADIA) were measured by ultra-sonography ,and carotid artery plaques were investigated. Bi-variate correlation analysis was adopted to analyze the correlation between RHR and CAIMT , CADIA. Logistic regression analysis was employed to analyze the influential factors in carotid artery plaques. Mean-while,sub-group analysis of different ages was performed. Results The detection rates of carotid artery plaques in the Group A,B and C were 59.1％,63.7％and 69.6％respectively. Differences in detection rates of carotid artery plaques among 3 groups showed statistical significance(P<0.05). RHR(OR 1.165,95％CI 1.094～1.482,P=0.037) was a risk factor of carotid artery plaques. Significant positive correlations were found between RHR and CAIMT ,CADIA (r = 0.115 ,0.123;P = 0.005 ,0.003). Conclusions RHR was closely related with carotid artery plaques,CAIMT,and CADIA in middle-aged and elderly hypertention. RHR can be recognized as a predic-tive factor of carotid atherosclerosis in middle-aged and elderly hypertention.