Effect of Mushao Composition on ?-EP and CCK-8 in Caudex Dorsalis of Rats with Pain after Fracture Operation / 中国中医药信息杂志

Objective To study the effect of Mushao composition on ?-EP and CCK-8 in the caudex dorsalis of rats with pain after fracture operation,and explore its mechanism.Methods The male Wistar rats were randomly divided into control group,model group,Mashao composition group and tramadol group.The Brennan model was adopted.The level of the ?-EP and CCK-8 were determined by the method of radioimmunity.Results Compared with model group,Mushao composition could increase level of ?-EP in the caudex dorsalis,while decrease level of CCK-8.Conclusion Mushao composition could increase the content of ?-EP and reduce the content of CCK-8,so to analgesia in rats model of pain after fracture operation.