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1.
Article in Chinese | WPRIM | ID: wpr-975166

ABSTRACT

ObjectiveTo investigate the mechanism of Magnolia officinalis cortex for constipation-type irritable bowel syndrome(IBS-C) rats before and after sweating. MethodIBS-C rat model was established by gavage of ice water, and rats were randomly divided into the blank group, model group, mosapride group(1 mg·kg-1), M. officinalis cortex group(10 g·kg-1) and sweated M. officinalis cortex group(10 g·kg-1). The changes of body weight, fecal number and fecal water content of rats were observed, 16S rRNA sequencing was used to detect the structural changes of fecal intestinal flora in rats, the levels of 5-hydroxytryptamine(5-HT) and substance P(SP) in colonic tissues of rats were determined by enzyme-linked immunosorbent assay(ELISA). ResultCompared with the model group, the fecal water content and fecal number of mosapride group, M. officinalis cortex group and sweated M. officinalis cortex group were significantly increased(P<0.05). At the phylum level, the top four species of flora abundance were Firmicutes, Bacteroidetes, Spirochaetes and Proteobacteria. Compared with the blank group, the proportion of Firmicutes in the model group was significantly reduced(P<0.05), while the proportion of Spirochaetes was significantly increased(P<0.05). Compared with the model group, the proportion of Firmicutes and Spirochaetes in M. officinalis cortex group and sweated M. officinalis cortex group tended to be similar to that in the blank group, and the proportion of Spirochaetes in sweated M. officinalis cortex group was lower than that of M. officinalis cortex group. At the family level, the top four species of flora abundance were Lactobacillaceae, S24_7, Ruminococcaceae, Bacteroidaceae, compared with the blank group, the proportion of Lactobacillaceae in the model group decreased significantly(P<0.05), and its proportion in the M. officinalis cortex group and sweated M. officinalis cortex group increased significantly after administration(P<0.05), and the flora structure of the two groups tended to be similar to that of the blank group. At the genus level, the top four species of flora abundance were Lactobacillus, Unspecified_S24_7, Bacteroides and Treponema. Compared with the blank group, the proportion of Lactobacillus in the model group decreased significantly(P<0.05), while the proportion of Treponema increased significantly(P<0.05). Compared with the model group, ratio of bacterial structure of Lactobacillus and Treponema in the M. officinalis cortex group and sweated M. officinalis cortex group tended to be similar to those in the blank group, indicating that M. officinalis cortex could restore the intestinal microbial structure of IBS-C rats before and after sweating. Compared with the model group, the 5-HT content in mosapride group was significantly reduced(P<0.05), the contents of 5-HT and SP in the M. officinalis cortex group and sweated M. officinalis cortex group were significantly increased(P<0.01), and the sweated M. officinalis cortex group was higher than the M. officinalis cortex group. ConclusionM. officinalis cortex can play a therapeutic role on IBS-C rats by regulating 5-HT pathway and intestinal flora structure before and after sweating.

2.
Article | IMSEAR | ID: sea-226288

ABSTRACT

Knowledge of Ayurveda is based on specific fundamental principles. Dosha, Dhatu, Mala, Srotasa are some among them. Malas are the waste products which primarily generate after digestion of food. While Srotasa are the channels or pathways in the human body which carries Dosha, Dhatu, Mala and Mana. Sveda (sweat) is one of the waste product which forms after digestion of food or in the process of metabolism of adipose tissue. Formation, transportation and elimination of Sveda is carried out by Sveadavaha Srotasa and it helps to regulate body temperature, maintain skin moisture and excrete toxic substance from body. Detail description of concept Sveda, Svedavaha Srotasa, its normal mechanism, importance in manifestation of various diseases and its application in treatment is described in Ayurvedic texts. Thinking of this fact, for better acknowledgment of these concepts and its role in the practice this comprehensive review has been done.

3.
São Paulo med. j ; 140(2): 284-289, Jan.-Feb. 2022. tab
Article in English | LILACS | ID: biblio-1366054

ABSTRACT

Abstract BACKGROUND: Primary hyperhidrosis is a condition characterized by excessive sweating, inconsistent with the needs for thermoregulation. OBJECTIVE: To assess the effectiveness and the change in the quality of life of patients undergoing bilateral VATS (video-assisted thoracoscopic sympathectomy) for treatment of hyperhidrosis, in a large case series. DESIGN AND SETTING: Cohort study conducted in a tertiary hospital specializing in hyperhidrosis located in São Paulo, Brazil. METHODS: A total of 2,431 patients who underwent surgery consisting of bilateral video-assisted thoracoscopic sympathectomy between January 2000 and February 2017 were retrospectively assessed in an outpatient clinic specializing in hyperhidrosis. The patients underwent clinical and quality of life assessments on two occasions: firstly, prior to surgery, and subsequently, one month after the operation. The presence or absence of compensatory hyperhidrosis (CH) and general satisfaction after the first postoperative month were also evaluated. RESULTS: All the patients operated had poor or very poor quality of life before surgery. In the postoperative period, an improvement in the quality of life was observed in more than 90% of the patients. Only 10.7% of the patients did not present CH, and severe CH occurred in 22.1% of the patients in this sample. CONCLUSION: Bilateral VATS is a therapeutic method that decreases the degree of sweating more than 90% of patients with palmar and axillary hyperhidrosis. It improves the quality of life for more than 90% of the patients, at the expense of development of CH in approximately 90% of the patients, but not intensely.


Subject(s)
Humans , Thoracic Surgery, Video-Assisted/adverse effects , Thoracic Surgery, Video-Assisted/methods , Hyperhidrosis/surgery , Hyperhidrosis/etiology , Quality of Life , Sympathectomy/adverse effects , Sympathectomy/methods , Brazil , Retrospective Studies , Cohort Studies , Treatment Outcome , Patient Satisfaction
4.
Article in Chinese | WPRIM | ID: wpr-928051

ABSTRACT

In this study, we employed Q Exactive to determine the main differential metabolites of Magnoliae Officinalis Cortex du-ring the "sweating" process. Further, we quantified the color parameters and determined the activities of polyphenol oxidase(PPO), peroxidase(POD), and tyrosinase of Magnoliae Officinalis Cortex during the "sweating" process. Gray correlation analysis was performed for the color, chemical composition, and enzyme activity to reveal the effect of enzymatic reaction on the color of Magnoliae Officinalis Cortex during the "sweating" process. Magnoliae Officinalis Cortex sweating in different manners showed similar metabolite changes. The primary metabolites that changed significantly included amino acids, nucleotides, and sugars, and the secondary metabolites with significant changes were phenols and phenylpropanoids. Despite the different sweating methods, eleven compounds were commonly up-regulated, including L-glutamic acid, acetylarginine, hypoxanthine, and xanthine; six compounds were commonly down-re-gulated, including L-arginine, L-aspartic acid, and phenylalanine. The brightness value(L~*), red-green value(a~*), and yellow-blue value(b~*) of Magnoliae Officinalis Cortex kept decreasing during the "sweating" process. The changes in the activities of PPO and POD during sweating were consistent with those in the color parameter values. The gray correlation analysis demonstrated that the main differential metabolites such as amino acids and phenols were closely related to the color parameters L~*, a~* and b~*; POD was correlated with amino acids and phenols; PPO had strong correlation with phenols. The results indicated that the color change of Magnoliae Officinalis Cortex during "sweating" was closely related to the reactions of enzymes dominated by PPO and POD. The study analyzed the correlations among the main differential metabolites, color parameters, and enzyme activities of Magnoliae Officinalis Cortex in the "sweating" process. It reveals the common law of material changes and ascertains the relationship between color changes and enzymatic reactions of Magnoliae Officinalis Cortex during "sweating". Therefore, this study provides a reference for studying the "sweating" mechanism of Magnoliae Officinalis Cortex and is of great significance to guarantee the quality of Magnoliae Officinalis Cortex.


Subject(s)
Magnolia/chemistry , Quality Control , Sweating
5.
Einstein (Säo Paulo) ; 20: eRC5795, 2022.
Article in English | LILACS | ID: biblio-1360403

ABSTRACT

ABSTRACT Hyperhidrosis is characterized by excessive sweating and it affects almost 5% of the population. The affected age group is wide, and it can affect from children to elderlies. There are two types of hyperhidrosis: generalized and focal. Treatment depends on the symptoms presented. In more severe cases, radiofrequency sympatholysis and bilateral thoracic sympathectomy are the options. However, recurrence is possible or the postoperative appearance of conditions called compensatory hyperhidrosis or reflex hyperhidrosis. We describe two cases of patients treated with Cannabidiol who had significant and unexpected improvement of hyperhidrosis. The first patient received Cannabidiol specific for public presentations at work, and the second patient had a diagnosis of autism spectrum disorder. The hyperhidrosis improved in both patients immediately after using Cannabidiol.


Subject(s)
Humans , Child , Cannabidiol/therapeutic use , Autism Spectrum Disorder , Hyperhidrosis/drug therapy , Sympathectomy , Treatment Outcome , Patient Satisfaction
6.
Kampo Medicine ; : 398-401, 2022.
Article in Japanese | WPRIM | ID: wpr-986408

ABSTRACT

We report a case of a 49-year-old woman who presented with 6-month period menopausal syndrome including excessive sweating and hot flushes in her face, chest and back. She was also frustrated with her sons, but she reflected on her own anger and wondered why she got so irritated with them. We prescribed yokukansan to her and her all symptoms improved one month later. We need to differentiate between yokukansan and kamishoyosan in the treatment of menopausal syndrome and irritation, and it may be useful to evaluate the detail of irritation in selecting formula.

7.
Medicina (B.Aires) ; 81(1): 54-61, mar. 2021. graf
Article in Spanish | LILACS | ID: biblio-1287241

ABSTRACT

Resumen La hiperhidrosis es un trastorno caracterizado por la producción excesiva de sudor por las glándulas sudoríparas ecrinas que influye negativamente en las actividades sociales, laborales y fundamentalmente en la calidad de vida. Se divide en primaria o secundaria. La primaria es una enfermedad benigna caracterizada por una excesiva sudoración con mayor frecuencia en palmas, plantas, axilas y cara. Su incidencia es del 1% de la población y su causa es desconocida. La mayoría de los tratamientos médicos no logran un buen control sintomático y frecuentemente son transitorios. La simpaticotomía torácica bilateral videoasistida se ha vuelto el tratamiento de elección en pacientes muy sintomáticos. En el período de 1998 a 2018 se realizaron 174 simpaticotomias bilaterales videoasistidas por hiperhidrosis primaria, de las cuales 102 cumplieron los criterios de inclusión. Se excluyeron a 72 pacientes. El 20.5% fueron hombres y el 79.5% mujeres con una edad media de 29.22 años. En cuanto a la localización fue palmoplantar axilar en un 50.9%, axilar en un 23.5%, palmoplantar en un 10.7%, palmar en un 7.8%, palmoaxilar 6.8% y facial 5.8%. Los pacientes con sudoración palmar presentaron 94.9% de mejoría, axilar 84.51%, plantar 46.25% y facial 84% respectivamente. El post operatorio arrojó una media de internación de 1.1 días. Como efecto no deseado, se presentó sudoración compensatoria en 53 casos y complicaciones postoperatorias en 18 casos. Concluimos que es una técnica segura, que resuelve de manera significativa la sudoración, mejorando la calidad de vida.


Abstract Hyperhidrosis is a disorder consisting of excessive sweating through the different body sweat glands, which produces a negative impact socially and in work-related activities in those that suffer this condition. There are primary and secondary forms. The primary form is a benign condition with excessive sweating mainly in palms, soles of feet, axillae and face. It affects a 1% of the population, and its cause is unknown. Most medical treatments are unsuccessful, and at best, transitory. In patients who are very troubled by the condition, videoassisted bilateral thoracic sympathicotomy has become the elective treatment. In the period ranging from 1998 to 2018, 174 procedures were undertaken for primary hyperhidrosis, of which 102 satisfied the inclusion criteria. 72 patients were excluded. A 20.5% were males, and 79.5% were females, with an average age of 29.22 years at surgery. As to localization of sweating, a 50.9% was palmar-plantar-axillary, 23.5% axillary, 10.7% palmarplantar, 7.8% palmar, 6.8% palmar-axillary, and a 5.8% facial. Those patients with palmar sweating showed a 94.9% improvement, those with axillary sweating a 88.51%, with plantar a 46.25% and those with facial sweating a 84% improvement. The average admission time was 1.1 days. As an undesired effect, compensatory sweating occurred in 53 cases and postoperative complications in 18 cases. We conclude this is a safe technique, that diminishes sweating significantly, improving patient's quality of life.


Subject(s)
Humans , Male , Female , Adult , Quality of Life , Hyperhidrosis/surgery , Sympathectomy , Treatment Outcome , Thoracic Surgery, Video-Assisted
8.
Article in Chinese | WPRIM | ID: wpr-888178

ABSTRACT

The present study aimed to explore the mechanism of the sweating of Dipsacus asper on content changes of triterpene sa-ponins by detecting the total triterpene saponins and the index component asperosaponin Ⅵ in the crude and sweated D. asper, and analyzing the differentially expressed proteins by isobaric tags for relative and absolute quantification(iTRAQ) combined with LC-MS/MS. After sweating, the content of total triterpene saponins decreased manifestly, while that of asperosaponin Ⅵ increased significantly. As revealed by the iTRAQ-LC-MS/MS analysis, 140 proteins with significant differential expression were figured out, with 50 up-regulated and 90 down-regulated. GO analysis indicated a variety of hydrolases, oxido-reductases, and transferases in the differential proteins. The results of activity test on two differentially expressed oxido-reductases were consistent with those of the iTRAQ-LC-MS/MS analysis. As demonstrated by the analysis of enzymes related to the triterpene saponin biosynthesis pathway, two enzymes(from CYP450 and UGT families, respectively, which are involved in the structural modification of triterpene saponins) were significantly down-regulated after sweating. The findings suggested that sweating of D. asper presumedly regulated triterpene saponins by affecting the expression of downstream CYP450 s and UGTs in the biosynthesis pathway of triterpene saponins of D. asper.


Subject(s)
Humans , Chromatography, Liquid , Dipsacaceae , Saponins , Sweating , Tandem Mass Spectrometry , Triterpenes
9.
Article in Chinese | WPRIM | ID: wpr-887938

ABSTRACT

Magnoliae Officinalis Cortex, a common Chinese medicinal in clinic, should undergo "sweating" process in producing area according to Chinese Pharmacopoeia, which affects its genuineness and quality. In light of the concept and research mode of quality marker(Q-marker) for decoction pieces, the active components of Magnoliae Officinalis Cortex pieces which altered significantly before and after "sweating" were identified in this study. The main pharmacodynamic material basis was clarified by pharmacodynamic, pharmacokinetic and drug property research, followed by the prediction of Q-markers of Magnoliae Officinalis Cortex before and after "sweating", for better improving its quality standard.


Subject(s)
Drugs, Chinese Herbal , Magnolia
10.
Article | IMSEAR | ID: sea-194998

ABSTRACT

Swedanam is a therapy which alleviates stiffness, heaviness, coldness & that which brings out sweating from the system is sudation therapy. The perspiration brought about by the sudation therapy is more than the normal. Conventionally the sudation therapy is just understood as the steam bath, but sudation in Ayurveda is something more as a treatment & as a daily routine. Swedana drugs by Ushna and Tikshnaguna are capable of penetrating the microcirculatory channels (Srotas) where they activate the sweat glands to produce mores heat. Swedana Karma hastens this process by increasing the permeability of capillary and bringing the morbidities into an extracellular fluid by dilating and clearing the channels of the body. Swedanakarma maintains the thermoregulation system of the body by maintaining quilibrium between core temperature (temp. inside the body) and shell temperature (skin temp).

11.
Rev. méd. Chile ; 148(1): 54-59, Jan. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1094206

ABSTRACT

Background: Sudomotor dysfunction may appear in early stages of diabetic neuropathy. Aim: To evaluate the diagnostic capacity of the Neuropad test, based on the detection of sudomotor dysfunction, as an early indicator of diabetic neuropathy. Material and Methods: In Forty-two type 2 diabetic patients, the Neuropad test was compared with the 10 g monofilament test (proposed in the technical orientation of diabetic foot of the Ministry of Health of Chile), deep and thermal sensitivity. Results: The surface sensitivity assessed with a brush had a sensitivity and specificity of 18.8 and 100% respectively when compared with the 10 g monofilament. When compared with the Neuropad, the figures were 9 and 100%, respectively. Pain perception sensitivity and specificity were 13 and 100% respectively when compared with the 10 g monofilament. The figures were 6 and 100%, when compared with the Neuropad. Thermal discrimination had a sensitivity and specificity of 88 and 33% respectively when compared with the 10 g monofilament. The figures were 75 and 25% respectively when compared with the Neuropad. The deep sensitivity evaluated with a 128 Hz tuning fork had a sensitivity and specificity of 31 and 100% respectively when compared with the 10 g monofilament. The figures were 16 and 31% respectively when compared with the Neuropad. The Neuropad had a sensitivity and specificity of 94 and 29% respectively were compared with the 10 g monofilament. Conclusions: Neuropad had a good diagnostic yield for the early detection of sudomotor dysfunction.


Subject(s)
Humans , Diabetic Foot , Diabetes Mellitus, Type 2 , Diabetic Neuropathies , Chile , Diagnostic Tests, Routine
12.
Palliative Care Research ; : 355-359, 2020.
Article in Japanese | WPRIM | ID: wpr-843001

ABSTRACT

We encountered a case where opioids were effective for excessive sweating caused by secondary generalized hyperhidrosis associated with cancer. ​​A 64-year-old woman diagnosed with metastatic renal cell carcinoma was admitted to the palliative care unit with right hip pain caused by bone metastasis and sudden excessive sweating. An increased dose of fentanyl transdermal patch provided pain relief. Excessive sweating seemed to have occurred due to neoplastic fever initially, but antipyretic analgesics and steroids were ineffective. Prophylactic use of immediate-release oxycodone provided excessive sweating relief. Finally, we consider that hypothalamus and fentanyl transdermal patch were involved in excessive sweating. Opioids may suppress sweating by acting on the hypothalamus.

13.
Article in Japanese | WPRIM | ID: wpr-873950

ABSTRACT

  Using healthy volunteers, we examined the influence of emulsified oil and a low concentration of CO2 gas on cutaneous blood flow in the forearm. The forearm of each subject was immersed in 25 liters of warm water containing either 10 ppm emulsified oil or 60 ppm CO2 gas or both. Forearm cutaneous blood flow was measured for 20 minutes. Emulsified oil had no effect on cutaneous blood flow, whereas CO2 gas caused a gradual and significant increase. When CO2 gas was used with emulsified oil, cutaneous blood flow was significantly increased in comparison to CO2 alone, suggesting that emulsified oil enhances the vasodilation caused by CO2. We then prepared bath salts releasing CO2 and emulsified oil, and tested for their influence on sweating function in sixteen healthy adults. Each subject bathed daily 10 minutes either in tap water (control group) or in tap water dissolving bath salts releasing CO2 and emulsified oil (bath-salts group) at 40°C for successive 14 days. A sweating test was performed before and after the session of bathing. In the bath-salts group, the baseline tympanic temperature after successive bathing tended to be lower than that before successive bathing. Although the rise of body temperature during the heat exposure was not different between the groups, sweating rate was significantly greater after successive bathing. The analysis of the rate of sweat expulsion suggested that the greater sweat rate after the successive bathing is mediated by the central mechanism for sweating. Such changes were not observed in the control group. Thus, successive bathing using bath salts that release CO2 and emulsified oil may have a beneficial effect on sweating function.

14.
Rev. Pesqui. (Univ. Fed. Estado Rio J., Online) ; 12: 1283-1289, jan.-dez. 2020. tab
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1140980

ABSTRACT

Objetivo: Avaliar a prevalência e o impacto da hiperidrose primária nas atividades e qualidade de vida dos profissionais de enfermagem de um hospital público. Métodos: estudo transversal com 363 profissionais de enfermagem de um Hospital Referência em Urgência e Emergência de Sergipe, Brasil. Utilizou-se questionário de critérios diagnósticos, qualidade de vida e sobre o impacto da hiperidrose primária nas atividades laborais. Resultados: a prevalência da hiperidrose primária foi de 11%, com a piora em situação de estresse em 27 (68%) dos profissionais e três (8%) referiram comprometimento nas atividades diárias. Todas as limitações foram referidas na execução de procedimentos de enfermagem, sendo as mais citadas avaliação escrita por 37 profissionais (93%) e utilização de equipamentos de proteção individual por 31 (79%). Conclusão: a hiperidrose primária teve alta prevalência nos profissionais de enfermagem com comprometimento negativo na qualidade de vida dos portadores, mesmo quando em grau leve e moderado


Objective: The study's main purpose has been to assess both the prevalence and impact of primary hyperhidrosis on the activities and quality of life of nursing professionals working in a public hospital. Methods: It is a crosssectional study with 363 nursing professionals from a Public Referral Hospital for Urgent and Emergency Care in the Sergipe State, Brazil. There was used a questionnaire addressing diagnostic criteria, quality of life and the impact of primary hyperhidrosis on work activities. Results: There was found a primary hyperhidrosis prevalence of 11% in nursing professionals, worsening under stress in 27 (68%) of the professionals, and three (8%) reported impairment in daily activities. All limitations were mentioned to be happening in the implementation of nursing procedures, the most cited being written assessment by 37 professionals (93%), and the use of personal protective equipment by 31 (79%). Conclusion: Primary hyperhidrosis had a high prevalence in nursing professionals ultimately producing a negative impact on bearer's quality of life, even when mild or moderate


Objetivo: Evaluar la prevalencia y el impacto de la hiperhidrosis primaria en las actividades y la calidad de vida de los profesionales de enfermería en un hospital público. Métodos: estudio transversal con 363 profesionales de enfermería de un hospital de referencia en urgencias y emergencias en Sergipe, Brasil. Se utilizó un cuestionario sobre criterios diagnósticos, calidad de vida y sobre el impacto de la hiperhidrosis primaria en las actividades laborales. Resultados: la prevalencia de hiperhidrosis primaria fue del 11%, con empeoramiento bajo estrés en 27 (68%) de los profesionales y tres (8%) informaron deterioro en las actividades diarias. Todas las limitaciones se mencionaron en la implementación de los procedimientos de enfermería, siendo la evaluación escrita más citada por 37 profesionales (93%) y el uso de equipos de protección personal por 31 (79%). Conclusión: la hiperhidrosis primaria tuvo una alta prevalencia en profesionales de enfermería con un deterioro negativo en la calidad de vida de los pacientes, incluso cuando era leve y moderada


Subject(s)
Humans , Male , Female , Quality of Life , Hyperhidrosis , Nursing, Team , Sweating , Sickness Impact Profile
15.
Med. interna Méx ; 35(3): 454-459, may.-jun. 2019. tab, graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1154820

ABSTRACT

Resumen: Se comunica el caso de una paciente de 61 años de edad que tuvo hipertensión arterial descontrolada (220/110 mmHg) concomitante con palpitaciones, diaforesis, dolor precordial, cefalea y disnea a pesar de fármacos antihipertensivos, con lesiones nodulares en la piel del cuello, las clavículas, los antebrazos, la región anterior del tórax y el abdomen.


Abstract: This paper reports the case of a 61-year-old female patient who presented uncontrolled hypertension (220/110 mmHg) associated with palpitations, sweating, chest pain, headache and dyspnea despite antihypertensive drugs, with nodular skin lesions in neck, clavicles, forearms, anterior chest and abdomen.

16.
Article in Chinese | WPRIM | ID: wpr-1008413

ABSTRACT

Magnolia Officinalis Cortex has been used as a traditional Chinese herb for thousands of years in China. According to Chinese Pharmacopoeia,the processing of Magnolia Officinalis Cortex needs " sweating" or " Fahan",which was a special drying process and considered to be an important symbol for high quality and genuine medicinal materials. In this unique processing mode,Magnolia Officinalis Cortex's microbial community structure may be changed,but little is known about microbial diversity during the " sweating". In this study,to analyze the change and its change rules of microbial community of Magnolia Officinalis Cortex in the whole process of " sweating",and find out the microbial community that affects the quality of Magnolia Officinalis Cortex in the process of its " sweating",and provide a basis for further research on the microbial transformation of Magnolia Officinalis Cortex,MiSeq highthroughput sequencing was used to evaluate the microbial diversity of natural " sweating" of Magnolia Officinalis Cortex. In this research,334 genera fungi and 674 genera bacteria were identified. The dominant species weren' t obvious during the early stage of " sweating". Candida was the dominant fungal species( 45. 01%-71. 93%) during the medium " sweating" stage. Aspergillus is the dominant fungal species( 45. 83%-95. 51%) during the late stage of " sweating". Moreover,Enterobacter and Klebsiella were the primary bacterial genus( ≥56. 05%) during the middle and late stages of " sweating". In addition,the predominant bacteria in the process of " sweating" included Bacillus,Deinococcus,Sphingomonas,Hymenobacter and Jatrophihabitans. In conclusion,the microbial diversities and the main dominant fungi and bacteria in the process of " sweating" of Magnolia Officinalis Cortex were initially determined. It was also found that the metabolism of Aspergillus and Candida may be related to the character formation,which were sweet odor and brown inner surface after " sweating". The results provide a theoretical basis for the study of the influence of different microorganisms on the excellent traits formation of " sweating" Magnolia Officinalis Cortex.


Subject(s)
Chemistry, Pharmaceutical/methods , China , High-Throughput Nucleotide Sequencing , Magnolia/microbiology , Microbiota
17.
Article in Japanese | WPRIM | ID: wpr-758282

ABSTRACT

  Using healthy volunteers, we examined the influence of emulsified oil and a low concentration of CO2 gas on cutaneous blood flow in the forearm. The forearm of each subject was immersed in 25 liters of warm water containing either 10 ppm emulsified oil or 60 ppm CO2 gas or both. Forearm cutaneous blood flow was measured for 20 minutes. Emulsified oil had no effect on cutaneous blood flow, whereas CO2 gas caused a gradual and significant increase. When CO2 gas was used with emulsified oil, cutaneous blood flow was significantly increased in comparison to CO2 alone, suggesting that emulsified oil enhances the vasodilation caused by CO2. We then prepared bath salts releasing CO2 and emulsified oil, and tested for their influence on sweating function in sixteen healthy adults. Each subject bathed daily 10 minutes either in tap water (control group) or in tap water dissolving bath salts releasing CO2 and emulsified oil (bath-salts group) at 40°C for successive 14 days. A sweating test was performed before and after the session of bathing. In the bath-salts group, the baseline tympanic temperature after successive bathing tended to be lower than that before successive bathing. Although the rise of body temperature during the heat exposure was not different between the groups, sweating rate was significantly greater after successive bathing. The analysis of the rate of sweat expulsion suggested that the greater sweat rate after the successive bathing is mediated by the central mechanism for sweating. Such changes were not observed in the control group. Thus, successive bathing using bath salts that release CO2 and emulsified oil may have a beneficial effect on sweating function.

18.
Article in English | WPRIM | ID: wpr-758110

ABSTRACT

  A person regulates body temperature by outside and inside heat from change of environmental temperature. One of the inside heats includes drinking water. However, the effect of drinking water temperature on body temperature is not clear. The purpose of this study was to examine how water temperature influences the change in body temperature. The study participant were 13 men (average age, 21.3 ± 0.8 years), and they drank water at 3°C, room temperature, and 60°C; in addition, one more task was not to drink water. We measured tympanic temperature using a thermometer, skin blood flow using a laser Doppler flow meter, and sweating rate using the capsule ventilation method. The mean skin temperature was measured at seven body points with a thermistor and calculated. Tympanic temperature of drinking water at 3°C and 60°C was significantly in comparison with other conditions. As for skin blood flow between water temperature at 60°C and 3°C, sweating rate between water temperature at 60°Cand other conditions, and mean skin temperature between water temperature at 3°C and other conditions significant differences were recognized. It is thought that the response to early change to drinking water at different temperatures is by responses of thermo-receptors and subsequently by the thermal energy of the drinking water.

19.
Article in Chinese | WPRIM | ID: wpr-774574

ABSTRACT

Based on metabolomics,the effect of Magnolia officinalis before and after " sweating" on gastrointestinal motility disorder( rat) was compared. To study the mechanism of M. officinalis " sweating" increased the efficacy and reduced the toxicity. The rat model of gastrointestinal motility disorder was established by intraperitoneal injection of L-arginine. Pharmacodynamic indexes were relative residual rate of gastric pigment and intestinal propulsion ratio in rats. LC-MS metabolomics and multivariate statistical analysis were used to screen and identify biomarkers associated with gastrointestinal motility disorders,and MetPA database was used to analyze related metabolic pathways. The results showed that M. officinalis could improve gastrointestinal motility disorder whether it " sweating" or not,and the effect of " sweating" M. officinalis was stronger than that of " no sweating" M. officinalis. The metabolites of the experimental groups could be distinguished distinctly,and 15 different compounds and 17 related pathways were identified preliminarily. The mechanism of M. officinalis might be to improve gastrointestinal motility disorder by increasing the content of L-glutamate in the metabolic pathway of alanine,aspartate and glutamate and protecting gastrointestinal barrier. Before " sweating",M. officinalis could reduce taurine through metabolism of taurine and taurine and biosynthetic pathway of primary bile acid,increase the content of deoxycholic acid in glycine goose,and increase the risk of liver and kidney injury. After " sweating",M. officinalis could enhance gastrointestinal motility by increasing the contents of L-tryptophan and serotonin in the tryptophan pathway,and avoid the production of harmful metabolites to achieve synergistic and detoxifying effect.


Subject(s)
Animals , Rats , Gastrointestinal Motility , Magnolia , Metabolomics , Sweating , Tandem Mass Spectrometry
20.
Article in English | WPRIM | ID: wpr-762768

ABSTRACT

BACKGROUND: Parotidectomy is the treatment of choice in many parotid tumors. Due to the extensive nature of the procedure, unfavorable complications such as gustatory sweating, surgical site depression are common. Various techniques using fascia, muscle or AlloDerm have been developed but debate still remains regarding its availability and affordability. We applied a newly developed acellular dermal matrix (Insuregraf) to the parotidectomy field to act as a physical barrier and to provide adequate filling effect for prevention of functional and aesthetic complications. METHODS: From March 2010 to March 2017, 30 patients with parotid tumors underwent superficial parotidectomy. Twenty patients underwent only superficial parotidectomy. Ten patients had Insuregraf applied to the surgical site after superficial parotidectomy. We evaluated the incidence of Frey’s syndrome, surgical site depression, and patient satisfaction rate in both groups. RESULTS: The incidence of Frey’s syndrome was lower in the Insuregraf group (0 vs. 2). Surgical site depression was also lower in the Insuregraf group (2 vs. 20). Satisfaction score for facial contour in Insuregraf group was 9.2 out of 10, which was comparable to 6.2 out of 10 in the control group. CONCLUSION: Application of Insuregraf after superficial parotidectomy is an effective surgical procedure to prevent complications such as Frey’s syndrome and surgical site depression. This technique is affordable and safe with no immune reactions. Above all this surgical method should be considered as an option for patients who are concerned about the contour of the face after surgery.


Subject(s)
Humans , Acellular Dermis , Architectural Accessibility , Collagen , Depression , Facial Asymmetry , Fascia , Incidence , Methods , Parotid Neoplasms , Patient Satisfaction , Sweating, Gustatory
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