ABSTRACT
The localization of carcinoembryonic antigen (CEA) in malignant epithelial ovarian tumours was studied using immunohistochemistry. The tissue included in the study consisted of 38 ovarian cancers : 14 mucinous adenocarcinomas, 23 serous adenocarcinomas and 1 endometroid carcinoma. Peroxidase-antiperoxidase staining technique using monoclonal antibodies to CEA was used on routinely fixed paraffin embedded tissues. CEA positivity was observed in all (100%) mucinous adenocarcinomas whereas only one case of serous cyst a denocarcinoma (4.3%) was weakly positive. The only case endometroid carcinoma encountered showed patchy CEA positivity.
Subject(s)
Adenocarcinoma, Mucinous/immunology , Antibodies, Monoclonal , Carcinoembryonic Antigen/metabolism , Carcinoma, Endometrioid/immunology , Cystadenocarcinoma, Serous/immunology , Female , Humans , Immunohistochemistry , Ovarian Neoplasms/immunologyABSTRACT
Thirty six cases of carcinoma breast were subjected to the assessment of CMI status by estimating different T lymphocyte parameters. The mean TPLC, T% and TTC in case of carcinoma were 1955/mm3 blood, 41% and 825/mm3 blood respectively which are evidently depressed than that of controls. This depression is progressive and clinical stage related, the least being in stage I and the most being in stage IV. The infiltrating varieties revealed a significant depression of T lymphocyte values than the non-infiltrating ones. Among the infiltrating types, IDC (T-38.9%) and Muc. Ca (T-29.1%) revealed most significant depression, thereby indicating worst prognosis. Six cases of IDCS, 2 cases of Medullary Ca and a solitary case of comedo Ca revealed a significant lymphocyte infiltration into the tumour cell mass proper. There was a depressed lymphocyte values but of lesser magnitude indicating a better prognosis. 6 cases without metastasis (clinical St. I) showed a lesser degree of depressed CMI than the cases with metastasis.