ABSTRACT
The authors present a clinical and farmacological evaluation of the effect and safety of N-acetylcysteine in chronic obstructive diseases. The N-actylcysteine (NAC) is a sulphorated amino acid employed as an mucolytic agent. The efficacy and tolerability of oral NAC as compared with other agents was determined, in the mucolytic treatment on mucus hypersecretion and in the management of respiratory tract fluids and sputums from cigarette smokers, and also as a bronchial mucus fluidifying agent. A sistematic review and analysis of the effect of NAC and its effectiveness. In the treatment of acute respiratory disorders in children was determined
Subject(s)
Humans , Acetylcysteine/therapeutic use , Acetylcysteine/pharmacology , Bromhexine/pharmacology , Respiratory Mucosa/physiopathology , Mucus/drug effectsABSTRACT
Nasal mucus clearance (NMC) was studied in seventy patients with chronic maxillary sinusitis. Forty-five patients were treated with oral administration of bromhexine tablets along with oral antibiotics and nasal decongestants. Twenty-five patients received the same treatment but without bromhexine to evaluate the results. NMC was also studied in hundred healthy controls.
Subject(s)
Bromhexine/pharmacology , Chronic Disease , Female , Humans , Male , Maxillary Sinusitis/drug therapy , Mucus/metabolism , Nasal Mucosa/drug effectsABSTRACT
Foram estados, em 21 pacientes portadoras de Síndrome de Sjögren primária ou secundária, a influência da bromohexine sobre os níveis de lisozima da secreçäo lacrimal, teste de rosa bengala e sintomas oculares. Realizamos estudo cego com administraçäo de placebo (um comprimido por dia) e bromohexine (um comprimido de 48 mg por dia), durante 2 períodos consecutivos de 3 semanas (21 dias), com avaliaçöes do nível de lisozima lacrimal, sintomas oculares e teste de rosa bengala no dia antecedente ao ínicio do tratamento e após o uso de placebo (22§) e de bromohexine (44§ dia). Näo houve influência estatisticamente significante da bromohexine sobre os parâmetros analisados
Subject(s)
Humans , Bromhexine/pharmacology , Tears , Muramidase/analysis , Sjogren's Syndrome/drug therapy , TearsABSTRACT
Faz-se uma revisäo sobre mucolíticos, principalmente, sobre a Bromexine. Discute-se suas propriedades farmacológicas e seu perfil de prescriçäo em nosso meio