ABSTRACT
Abstract: Periungual basal cell carcinoma is rare and needs to be differentiated from other common diseases that affect this region. Several factors are associated with the development of this tumor, and sun damage seems to play an important role in its pathogenesis. Dermoscopy of clinically indolent lesions on the nail unit can shorten the diagnostic process and avoid destructive treatment and functional damage.
Subject(s)
Humans , Female , Middle Aged , Skin Neoplasms/diagnostic imaging , Carcinoma, Basal Cell/diagnostic imaging , Carcinoma, Basosquamous/diagnostic imaging , Nail Diseases/diagnostic imaging , Skin Neoplasms/pathology , Carcinoma, Basal Cell/pathology , Carcinoma, Basosquamous/pathology , Dermoscopy , Nail Diseases/pathologyABSTRACT
SUMMARY Basosquamous carcinoma (BSC), as described in 1910, is a distinctive variety of skin cancer and its etiology and pathological characteristics have generated much controversy over the years. Currently, BSC is considered a basal cell carcinoma (BCC) subtype with aggressive behavior and greater tendency for recurrence and metastases. We present a clinical case recently reported in our unit.
RESUMO Carcinoma basoescamoso, conforme descrito em 1910, é uma variedade distinta de câncer de pele e sua etiologia e características patológicas têm gerado muita controvérsia ao longo dos anos. Atualmente, BSC é considerado um subtipo de carcinoma de células basais com comportamento agressivo e maior tendência para a recorrência e metástase. Nós apresentamos um caso clínico relatado recentemente em nossa unidade.
Subject(s)
Humans , Male , Skin Neoplasms/pathology , Skin Ulcer/pathology , Carcinoma, Basosquamous/pathology , Biopsy , Middle AgedABSTRACT
Collision tumors are characterized by the coexistence of two cancers in the same anatomical site and its pathogenesis remains controversial. Although uncommon, the association of basal cell carcinoma and melanocytic nevus is the most common among combinations of skin tumors. Even rarer is the association of two malignant tumors. We report a case of tumor collision representing melanoma and basosquamous cell carcinoma, a combination not previously described in the literature, since there are no reported cases of melanoma with this type of basal cell carcinoma.
.Subject(s)
Humans , Male , Middle Aged , Carcinoma, Basosquamous/pathology , Melanoma/pathology , Neoplasms, Multiple Primary/pathology , Skin Neoplasms/pathology , Carcinoma, Basosquamous/surgery , Dermoscopy , Diagnosis, Differential , Melanoma/surgery , Neoplasms, Multiple Primary/surgery , Skin Neoplasms/surgery , Treatment OutcomeABSTRACT
INTRODUCTION: Basaloid squamous cell carcinoma (BSCC) is a rare subtype of squamous cell carcinoma (SCC). Because of its rarity, both clinical and prognostic features of this variant are not well known. OBJECTIVE: In this study, we aimed to determine the frequency of BSCC and other SCC variants among all laryngeal SCC cases, and to determine clinical and prognostic features of BSCC variant. Study design: retrospective cohort study. Evidence level: Level 2b. MATERIAL AND METHODS: Records of the patients who had laryngeal SCC surgically treated at our institute between 2007 and 2013 were retrospectively reviewed. RESULTS: Among 198 subjects who had laryngeal SCC surgically treated, the frequency of the variants of SCC other than classical variant was 10.1% (20/198). The most common SCC variant was BSCC (6.6%). Eleven (84.6%) patients with BSCC were at an advanced stage at the presentation (p > 0.05). The 3-year overall survival and disease-free survival rates were 63% and 53% respectively. CONCLUSION: BSCC variant may be more common than previously reported. Since almost the half of patients experiences disease recurrence in the early period, multimodal treatment strategies should be employed at initial treatment, and a close follow-up is strongly recommended for this aggressive SCC variant. .
INTRODUÇÃO: O carcinoma escamoso basaloide (CEB) é um raro subtipo do carcinoma de célula escamosa (CCE). Em decorrência de sua raridade, os aspectos clínicos e prognósticos dessa variante não são bem conhecidos. OBJETIVO: Determinar a frequência de CEB e de outras variantes do CCE entre todos os casos de CCE da laringe, assim como os aspectos clínicos e prognósticos da variante CEB. MÉTODOS: Trata-se de um estudo de coorte retrospectivo. Nível de evidência: 2b Os registros dos pacientes tratados cirurgicamente para CCE de laringe em nossa instituição entre 2007 e 2013 foram retrospectivamente revisados. RESULTADOS: Foram anotados 198 pacientes tratados cirurgicamente para CCE de laringe. A frequência das variantes de CCE diferentes da variante clássica foi 10,1% (20/198). A variante de CCE mais comum foi CEB (6,6%). Por ocasião da apresentação inicial, 11 (84,6%) pacientes com CEB estavam em estágio avançado (p > 0,05). Os percentuais de sobrevida geral após três anos e de sobrevida livre da doença foram 63% e 53%, respectivamente. CONCLUSÃO: A variante CEB pode ser mais comum do que o informado anteriormente. Considerando que praticamente metade dos pacientes sofre recorrência da doença em seu período inicial, devem ser introduzidas estratégias terapêuticas multimodais no tratamento inicial; além disso, recomendamos enfaticamente um cuidadoso seguimento para essa agressiva variante do CCE. .
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Carcinoma, Basosquamous/pathology , Carcinoma, Squamous Cell/pathology , Laryngeal Neoplasms/pathology , Cohort Studies , Carcinoma, Basosquamous/mortality , Carcinoma, Squamous Cell/mortality , Disease-Free Survival , Laryngeal Neoplasms/mortality , Neoplasm Staging , Prognosis , Retrospective StudiesABSTRACT
Basosquamous carcinoma is a relatively rare cutaneous tumour that shares some characteristics of both basal cell and squamous cell carcinoma. Currently most dermatologists consider that it represents a subtype of basal cell carcinoma with a more aggressive behaviour. The clinical presentation is non-specific and in general the diagnosis is made after the histopathological studies. The prevalence is higher in male patients, during the seventh decade and it tends to appear on sun exposed areas. Many authors compare its behaviour with squamous cell carcinoma. We present the case of a 44 years old male patient with a history of chronic arsenic exposure that presented a firm tumor in the left inguinal region and the biopsy showed basosquamous carcinoma with lymphatic involvement. This case shows an atypical presentation because of its localization and the appearance 20 years before the mean age reported in the literature. This could be explained by chronic environmental arsenic exposure, a well known risk factor for the development of cutaneous tumours.
El carcinoma basoescamoso es una neoplasia cutánea relativamente rara que reúne características de carcinoma basocelular y espinocelular. Actualmente la mayoría de los dermatólogos reconocen que este es un subtipo del carcinoma basocelular con comportamiento muchísimo más agresivo. Su presentación clínica es inespecífica y en general su diagnóstico se realiza sólo después de la biopsia. Predomina en pacientes de sexo masculino durante la séptima década de la vida y tiende a aparecer en regiones fotoexpuestas. Muchos autores igualan su comportamiento al del carcinoma espinocelular. Se presenta el caso de un paciente, de sexo masculino, de 44 años de edad, con antecedente de exposición a arsénico medioambiental crónica, que presentó aumento de volumen, duro en la región inguinal izquierda, cuya biopsia fue compatible con carcinoma basoescamoso con compromiso linfático. El caso de nuestro paciente muestra una presentación atípica por su localización y por la aparición 20 años antes de la media de edad reportada en la literatura. Esto podría ser explicado por la exposición crónica a arsénico, conocido factor de riesgo para carcinogénesis cutánea.
Subject(s)
Humans , Male , Adult , Arsenic/adverse effects , Carcinoma, Basosquamous/chemically induced , Carcinoma, Basosquamous/pathology , Skin Neoplasms/chemically induced , Skin Neoplasms/pathology , Carcinoma, Basosquamous/surgery , Environmental Exposure , Lymphatic Metastasis , Skin Neoplasms/surgeryABSTRACT
Carcinoma basoescamoso é um tumor raro com características de tumor de células basais e escamosas interligados por uma área de transição. Tem sido descrito como um tumor agressivo com possibilidade de metástases à distância, o que difere substancialmente do carcinoma basocelular. Propomos neste relato a descrição de um caso de evolução crônica e das consequências do abandono do tratamento por causa do prognóstico reservado deste tipo de tumor de comportamento agressivo.
Basosquamous carcinoma is a rare tumor with features of both basal cell and squamous cell carcinoma, linked by a transition area. It is a rare epithelial neoplasm with a tendency for local recurrence. It also has a high incidence of distant metastasis, a condition that differentiates it from the basal cell carcinoma. In this case, the slow course of the infiltrative lesion associated to patient non-compliance to treatment led to a poor prognosis.
Subject(s)
Humans , Male , Middle Aged , Carcinoma, Basosquamous/pathology , Orbital Neoplasms/pathology , Patient Compliance , Carcinoma, Basosquamous/therapy , Disease Progression , Orbital Neoplasms/therapyABSTRACT
Basaloid squamous cell carcinoma (BSCC) is a high grade variant of Squamous Cell Carcinoma with a predilection for the aero-digestive tract. The typical microscopic features of carcinoma with a basaloid pattern in intimate association with a squamous component helps in diagnosis of this tumour. There are few reports in the Indian literature and we report three cases, including one in the sinonasal region. This study discusses the differential diagnosis of BSCC, as recognition of this tumour may have therapeutic implications.
Subject(s)
Carcinoma, Basosquamous/pathology , Carcinoma, Squamous Cell/pathology , Esophageal Neoplasms/pathology , Humans , Laryngeal Neoplasms/pathology , Male , Maxillary Sinus Neoplasms/pathology , Middle AgedABSTRACT
Basaloid squamous cell carcinoma (BSCC) is an aggressive distinct variant of squamous cell carcinoma that mandates recognition as a separate entity owing to the difference in its clinical behaviour. Histologically this tumor can mimic other neoplasms like adenoid cystic carcinoma, neuroendocrine carcinoma and basal cell adenocarcinoma. BSCC occurs most commonly in older men and has a site predilection for the upper aero-digestive tract. We report a case of basaloid squamous cell carcinoma for its relative rarity, which was diagnosed in a 52 year old woman, with a brief review of literature.
Subject(s)
Carcinoma, Basosquamous/pathology , Carcinoma, Squamous Cell/pathology , Diagnosis, Differential , Female , Humans , Middle Aged , Mouth Floor/pathology , Mouth Neoplasms/pathologyABSTRACT
Four cases of Marjolin's Ulcer developing in a chronic venous ulcer are presented. Three were moderately differentiated squamous cell carcinoma while the fourth was a base-squamous cell carcinoma. The average age at presentation was 80 years and the interval from time of development of chronic venous ulceration to appearance of neoplasm was from four to thirty years. Lower extremity was involved in all the cases. This paper also reviews the literature and provides a treatment plan to optimize care and assure patient survival
Subject(s)
Humans , Male , Female , Chronic Disease , Carcinoma, Basosquamous/pathology , Carcinoma, Squamous Cell/pathology , Cicatrix/pathologyABSTRACT
El epitelioma basocelular metatípico es un tumor frecuente cuya ubicación nosológica aún permanece en discusión. Aparece en edades más tardías que el epitelioma basocelular con el cual comparte aspectos clínicos. El comportamiento biológico se asemeja más al carcinoma espinocelular. La incidencia de metástasis y el índice de recurrencia total son muy superiores al del epitelioma basocelular. Histológicamente, se describe un patrón por sectores, con células basaloides distintas a las del epitelioma basocelular típico, y proliferación escamosa. Se comentan las distintas corrientes de pensamiento actuales con respecto a su clasificación
Subject(s)
Humans , Male , Aged , Carcinoma, Basosquamous/diagnosis , Head and Neck Neoplasms/pathology , Carcinoma, Basosquamous/pathology , Head and Neck Neoplasms/complicationsABSTRACT
Basaloid Squamous Carcinoma (BSC) is an uncommon aggressive neoplasm occurring in the upper aerodigestive tract. Lung as a primary site has only recently been reported. A combination of microscopic features is required to make a diagnosis and to differentiate it from other more common malignancies in these sites. Three cases of BSC including one in the lung are reported. There are no prior published reports of this neoplasms in Indian literature. The study highlights the typical microscopic features and the diagnostic difficulties which may be encountered.
Subject(s)
Aged , Carcinoma, Basosquamous/pathology , Diagnosis, Differential , Esophageal Neoplasms/pathology , Humans , Laryngeal Neoplasms/pathology , Lung Neoplasms/pathology , Male , Middle AgedABSTRACT
Hombre de 68 años, con diagnóstico clínico patológico de carcinoma cuniculatum bilateral. Es interesante este caso por lo poco frecuente de su presentación intertriginosa y bilateral
Subject(s)
Humans , Male , Aged , Carcinoma, Basosquamous/pathology , Foot Dermatoses/pathology , Skin Neoplasms/pathology , Biopsy , Skin Neoplasms/physiopathologyABSTRACT
Los carcinomas no melanóticos son los tumores malignos mas comunes que afectan a la raza humana. El diagnóstico precoz y el tratamiento oportuno de estas lesiones habitualmente llevan a la curación. En este artículo se revisan los carcinomas basocelular y escamoso de la piel, destacando la importancia de los agentes carcinógenos y la significación de las lesiones premalignas cutáneas. Se mencionan las características clínicas de estos cánceres y se analizan los tipos de biopsias que se practican. Se hace referencia a los tratamientos quirúrgico y radiante de estas neoplasias y a los factores que influyen en su pronóstico