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Rev. chil. obstet. ginecol ; 80(5): 414-420, ago. 2015. ilus, tab
Article in Spanish | LILACS | ID: lil-764074

ABSTRACT

Cáncer epitelial de ovario es una enfermedad altamente letal. Constituye la quinta causa de muerte por cáncer en mujeres a nivel mundial. El subtipo histológico más frecuente es el carcinoma seroso de alto grado. Este es el responsable de la alta letalidad de la enfermedad. Se presenta evidencia que respalda el origen tubario de este tipo histológico desde lesiones precursoras. A partir de estos datos se ha establecido que el cáncer tradicionalmente conocido como cáncer ovárico seroso de alto grado, el cáncer de trompa de Falopio y el carcinoma peritoneal primario, corresponden a una misma entidad nosológica: cáncer seroso pélvico de alto grado. Se revisa además la evidencia disponible para establecer que la salpingectomía podría constituir una medida de prevención para este tipo de cáncer.


Epithelial ovarian cancer is a highly lethal disease. It is the 5th cause of cancer death in women worldwide. The most common histologic subtype is the high-grade serous carcinoma. This is the responsible for the high lethality of the disease. Evidence supporting the tubal origin of this histological type from precursor lesions is presented. From these data it has been established that cancer traditionally known as serous high-grade ovarian cancer, cancer of the fallopian tube and primary peritoneal carcinoma, correspond to a single disease entity: pelvic serous high-grade cancer. We also check the available evidence to establish that the salpingectomy could be a preventive measure for this type of cancer.


Subject(s)
Humans , Female , Ovarian Neoplasms/etiology , Ovarian Neoplasms/pathology , Fallopian Tubes/pathology , Carcinoma, Ovarian Epithelial/etiology , Carcinoma, Ovarian Epithelial/pathology , Ovarian Neoplasms/genetics , Ovarian Neoplasms/prevention & control , Tumor Suppressor Protein p53 , Fallopian Tubes/surgery , Salpingectomy , Neoplasm Grading , Carcinogenesis , Carcinoma, Ovarian Epithelial/genetics , Carcinoma, Ovarian Epithelial/prevention & control
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