Correlación entre los estadios de maduración ósea de las vértebras cervicales y los estadios de formación del canino mandibular / Correlação entre os estágios de maturação óssea das vertebras cervicais e os estágios de formação do mandibular canino / Correlation between the skeletal maturation of the cervical vertebrae and stage of mandibular canine calcification

Resumen: La evaluación de la maduración ósea es de gran importancia en la toma de decisiones con respecto al plan de tratamiento de diferentes maloclusiones que pueden depender del pico de crecimiento mandibular. El objetivo de este estudio fue evaluar la correlación entre las etapas de calcificación del canino mandibular permanente observadas en la radiografía panorámica con los estadíos de maduración cervicales observados en la radiografía cefálica lateral. Materiales y Métodos: Se realizó un estudio descriptivo, transversal y correlacional, evaluando los estadios de maduración ósea de las vértebras cervicales utilizando el método de Baccetti, y los estadios de desarrollo del canino mandibular utilizando las etapas descritas por Demirjian. La muestra estuvo conformada por radiografías panorámicas y cefálicas laterales de 81 sujetos (hombres y mujeres) con una edad comprendida entre los 9 y los 14 años. Las variables fueron comparadas mediante estadística inferencial utilizando tablas de contingencia y la pruebas Chi2 de Pearson. Resultados: La correlación entre la maduración dental y cervical para el género masculino fue de 0,689 y para el femenino de 0,690 p<0,001. Las etapas F y G observadas en el canino mandibular coincidieron con las etapas CS1 y CS3 de maduración respectivamente. Conclusión: se observó que las etapas de formación radicular del canino mandibular presentan relación con las etapas de maduración cervical siendo útil su determinación para inferir cercanía del pico de crecimiento prepuberal.

Resumo: A avaliação da maturação óssea é de grande importância na tomada de decisões quanto ao plano de tratamento das diferentes maloclusões que podem depender do pico de crescimento mandibular. O objetivo deste estudo foi avaliar a correlação entre as etapas de calcificação de caninos mandibulares permanentes observados na radiografia panorâmica com os estágios de maturação cervical observados na radiografia cefálica lateral. Materiais e Métodos: Foi realizado um estudo descritivo, transversal e correlacional, avaliando os estágios de maturação óssea das vértebras cervicais pelo método de Baccetti e os estágios de desenvolvimento dos caninos inferiores pelas etapas descritas por Demirjian. A amostra foi composta por radiografias cefálicas panorâmicas e laterais de 81 indivíduos (homens e mulheres) com idade entre 9 e 14 anos. As variáveis foram comparadas por estatística inferencial por meio de tabelas de contingência e testes Chi2 de Pearson. Resultados: A correlação entre a maturação dentária e cervical para o gênero masculino foi de 0,689 e para o feminino, 0,690 p <0,001. As etapas F e G observadas no canino inferior coincidiram com as etapas CS1 e CS3 de maturação, respectivamente. Conclusão: observou-se que os estágios de formação radicular do canino inferior estão relacionados aos estágios de maturação cervical, sendo sua determinação útil para inferir a proximidade do pico de crescimento pré-púbere.

Abstract: Orthodontic treatment plan decisions may rely on establishing the timing of the mandibular growth peak, thus the evaluation of skeletal maturation is of importance. The aim of this study was to determine the correlation between the stages of permanent mandibular canine calcification observed in the panoramic radiography with the cervical maturation stages observed in the lateral cephalic radiography. Materials and Methods: A descriptive, cross-sectional and correlational study was performed evaluating the stages of bone maturation of the cervical vertebrae using the Baccetti method, and the stages of development of the mandibular canine using the stages described by Demirjian. The sample consisted of panoramic and lateral cephalic radiographs, obtained from 81 subjects (men and women) with ages between 9 and 14 years. The variables were compared using inferential statistics using contingency tables and Pearson's Chi2 tests. Results: The correlation between dental and skeletal maturation found for the males was 0.689 and for females, 0.690 (p <0.001). The F and G stages observed in the mandibular canine coincided with the stages CS1 and CS3 maturation respectively. Conclusion: Dental formation stages for the mandibular canine are related to cervical maturation stages and may be useful to infer timing of prepuberal growth peak.

Parto pré-termo espontâneo sem rotura de membranas: intervenções para evitar o parto pré-termo / Spontaneous preterm birth without rupture of membranes: interventions to prevent preterm birth

A prematuridade é uma síndrome com múltiplos fatores de risco e cuja causa permanece desconhecida, mas, independentemente da etiologia, a parturição converge para uma via final comum de esvaecimento, dilatação e encurtamento do colo uterino. Do ponto de vista hormonal, o responsável por esse processo é a progesterona. A prevenção de quadros de prematuridade pode basear-se em tratamentos medicamentosos como a administração diária de comprimidos de progesterona; intervenções cirúrgicas para a contenção da cérvice uterina com fios inabsorvíveis mantidos até o termo, a cerclagem cervical; e o pessário cervical, dispositivo de silicone que envolve e inclina o colo uterino, evitando sua abertura. Para propor qualquer intervenção profilática ou terapêutica, a avaliação ultrassonográfica via transvaginal no segundo trimestre gestacional desempenha papel crucial. Apresentamos neste terceiro e último artigo da série sobre parto pré-termo espontâneo as intervenções terapêuticas e o rastreamento do colo uterino.(AU)

Preterm birth is a syndrome with multiple risk factors, with unknown etiology. Parturition converges to a final path with uterine cervix effacement, dilation and shortening and progesterone is the hormone responsible for this process. Preterm birth prevention relies on daily administration of progesterone pills; cerclage as a surgical intervention; or cervical pessary, a vaginal silicone device that enfolds and deflects the cervix, avoiding its opening. To propose any of these interventions it is crucial to evaluate the cervix during the second trimester by transvaginal ultrasound. Here, in the third and last article regarding preterm birth without membrane disruption, we present therapeutic interventions and ultrasound screening.(AU)

Parto pré-termo espontâneo sem rotura de membranas: prevalência, fatores de risco e o papel do colo uterino / Spontaneous preterm birth without premature rupture of membranes: prevalence, risk factors and the role of the cervix

Cerca de 15 milhões de prematuros nascem por ano globalmente. Em 2015 ocorreram mais de 4 milhões de mortes de crianças menores de 5 anos, e as complicações da prematuridade são a principal causa de óbito em neonatos. O parto pré-termo é uma síndrome em que múltiplas etiologias convergem para uma via final única, e os fatores de risco mais importantes são antecedente de prematuridade e gestação gemelar. O colo uterino tem a função de manter a gestação desde a concepção até o parto, e seu processo de amadurecimento gera esvaecimento, dilatação e encurtamento, num continuum que pode compreender desde quadros de insuficiência cervical até o parto pré-termo espontâneo sem rotura de membranas. Este primeiro artigo, da série de três, descreve a prevalência da prematuridade, seus fatores de risco e o papel do colo uterino no processo de parturição.(AU)

Around 15 million preterm births happen globally. In 2015 over 4 million deaths in children under 5 years of age died and preterm birth complications is the leading cause in neonates. Preterm birth is a multiple etiology syndrome, in which various causes converge to a single parturition path. The most important risk factors are multiple gestation and obstetrical history of preterm birth. Uterine cervix is responsible for pregnancy maintenance from conception to birth, and its remodeling process generates effacement, dilation and shortening in a continuum that comprises conditions from cervical insufficiency to preterm birth without membrane disruption. This is a first article, of a series of three, describing preterm birth prevalence, risk factors and uterine cervix role in parturition.(AU)

Comprimento de colo uterino ao ultrassom transvaginal como preditor de risco do parto pré-termo espontâneo / Ultrasound cervical lenght predicting risk for spontaneous preterm birth

O encurtamento do colo uterino é parte da via final comum da parturição seja a termo ou pré-termo. A identificação precoce do comprimento cervical encurtado ao ultrassom transvaginal no segundo trimestre gestacional pode atuar como preditor de risco de prematuridade. Desde a década de 1990, vários estudiosos dedicaram-se a estabelecer parâmetros de referência para as medidas de colo uterino entre 16 e 24 semanas e até hoje o limite mais consensualmente aceito é de 25 mm. Especialistas são favoráveis à triagem universal, mas diretrizes internacionais são controversas quanto à investigação em casos sem antecedente de parto pré-termo, além de diversos estudos apresentarem que há custo-efetividade no rastreamento universal. Neste artigo, discutimos criticamente os parâmetros apresentados por estudos históricos e balizadores de conduta, a custo-efetividade e os guidelines internacionais. Propomos ainda uma reflexão ao pré-natalista, sugerindo a individualização da conduta perante os dados de cada gestante específica.(AU)

Cervical shortening is the final path of parturition, regardless if it is term or preterm. Precocious identification of a shortened cervix by transvaginal ultrasound during the second gestational trimester can act as a risk predictor of prematurity. Since the 1990´s decade, numerous studies established reference ranges for cervical length measurement between 16 to 24 gestational weeks and the most accepted cutoff limit is 25 mm. Experts indicate universal screening, however international guidelines are controversial, even in cases without a history of preterm birth, furthermore, many studies demonstrated cost-effectiveness about the universal screening of cervical length in middle gestation. In this article we discuss historical reference ranges, cost- -effectiveness, and international guidelines. We propose critical thinking and suggest individualized management according to specific characteristics of each patient.(AU)

Relación de la edad cronológica con la maduración ósea cervical mediante el método de Baccetti / Relationship of the chronological age with cervical bone maturation through the Baccetti method

Introducción: Es importante valorar el momento ideal en el que se producen los cambios tanto biológicos como estructurales en el crecimiento y desarrollo de los maxilares, para identificar en qué momento se inicia del crecimiento puberal en los pacientes jóvenes y corregir las alteraciones tanto dentarias como esqueléticas que se puedan presentar. Objetivo: Evaluar los estadios de maduración de las vértebras cervicales mediante el análisis propuesto por Baccetti y su relación con la edad cronológica y el sexo, en radiografías laterales de individuos de 8 a 14 años. Metodología: Estudio transversal, retrospectivo y descriptivo. Se evaluaron 280 radiografías laterales (140 de varones y 140 de mujeres). Un evaluador calibrado evaluó los estadios de maduración esquelética e identificó 6 de ellas. Se evaluó el pico de crecimiento de los individuos desde la segunda a la cuarta vértebra cervical en las radiografías y luego se relacionó con la edad y el sexo de los individuos. Se utilizaron las pruebas de asociación de Chi cuadrado p < 0,05. Resultados: En las edades de 11 y 12 años se observó que las mujeres tenían mayor grado de madurez que los varones; sin embargo, para apreciar mejor los resultados, se reagruparon según los estadios: 1 con 2, 3 con 4 y 5 con 6, y se encontraron diferencias estadísticamente significativas entre ellos (p < 0,001). Conclusiones: Existe asociación en el diagnóstico del pico de crecimiento y la maduración ósea de los pacientes según su edad cronológica, con una clara diferencia entre varones y mujeres, lo que evidencia que el método de Baccetti se pueda emplear de manera confiable en la población estudiada. (AU)

Introduction: In Orthodontics, it is important to assess the ideal moment where changes occur, both biological and structural in relation to the growth and development of the jaws, thus identifying, at what time, the onset of pubertal growth in young patients and substantiate their dental correction as skeletal, achieving a positive result through its planning and application, correcting its discrepancies or alterations that may occur. Objective: To evaluate the stages of maturation of the cervical vertebrae through the analysis proposed by Baccetti and its relationship with chronological age according to age and sex, on lateral head X-rays of individuals aged 8 to 14 years. Methodology: This was a crosssectional, retrospective, descriptive study. 280 lateral head X-rays were evaluated (140 men and 140 women). A trained and calibrated evaluator evaluated the stages of skeletal maturation with the method proposed by Baccetti, identifying 6 stages. The peak of growth of the individuals was evaluated through the second to the fourth cervical vertebra on radiographs and then related to the chronological age and sex of the individuals. Chi square association tests were used p < 0.05. Results: In the ages of 11 and 12, it is observed that women have a greater degree of maturity than men, however, in order to better appreciate the results, they were regrouped according to the stages of maturity of cervical vertebrae 1 with 2, 3 with 4 and 5 with 6 and statistically significant differences were found between the stages of maturation of the cervical vertebrae according to age and sex (p < 0.001). Conclusions: There is an association in the diagnosis of peak growth and bone maturation of patients according to their chronological age, producing a clear difference between men and women, which shows that the Baccetti method can be used reliably in the population studied. (AU)

Inadequate adherence to the recommendations regarding labor induction as a trigger of cesarean section in women with singleton term pregnancy. A descriptive study / Cumplimiento inadecuado de las recomendaciones para el proceso de la inducción del trabajo de parto como desencadenante de la cesárea en mujeres con embarazo simple a término. estudio descriptivo

ABSTRACT Objective: To describe the characteristics of the labor induction process associated with the excess number of cesarean sections in women subjected to this intervention. Materials and methods: Descriptive historical cohort that included pregnant women without a history of previous cesarean section, with singleton term pregnancy and cephalic presentation who were subjected to labor induction in a Level III complexity hospital in Medellín, Colombia, during the time period between May 2015 and October 2016. Consecutive sampling was used. Measured variables were maternal age, parity, gestational age, indication for labor induction, cervical favorability, time of induction, quality of uterine activity achieved, type of delivery, and time point during induction when the decision of cesarean section was made. The clinical practice guidelines of international organizations of the specialty and the new guidelines arising from the 2012 proposal of limiting the first cesarean section were used in order to define adherence to the recommendations for induction. Results: Of the 2402 births, 289 which met the inclusion criteria were selected. Cesarean section was performed in 48% of the women subjected to induction, 60.8% nulliparous and 32.1% multiparous. Of those with unfavorable cervix, 72.2% received oxytocin for cervical maturation. Of the women subjected to delivery induction, 108 (37%) underwent cesarean section due to a diagnosis of failed induction. This was considered inadequate in all of them, given that the diagnosis was made before reaching a dilatation of 6 cm in 88 (81.5%), with intact membranes in 67 (62%), with no uterine activity in 42 (38.9%), with poor quality uterine activity in 23 (21.3%) and in 55 (61%) who did not have at least 24 hours of latent phase before undergoing cesarean section. Conclusion: Failure to adhere to the recommendations for adequate induction was found, added to an incorrect diagnosis of failed induction.

RESUMEN Objetivo: describir las características del proceso de inducción del trabajo de parto relacionadas con el exceso de cesáreas en las mujeres a quienes se les realiza este procedimiento. Materiales y métodos: cohorte histórica descriptiva en la que se incluyeron las gestantes sin antecedente de cesárea, con embarazo único, a término y presentación cefálica, sometidas a inducción del trabajo de parto en un hospital de tercer nivel de complejidad, en Medellín, Colombia, en el periodo de mayo de 2015 a octubre de 2016. Se excluyeron mujeres con feto muerto antes de la inducción. Muestreo consecutivo. Se midieron: edad materna, paridad, edad gestacional, indicación de la inducción del trabajo de parto, favorabilidad del cérvix, tiempo de la inducción, calidad de la actividad uterina lograda, tipo de parto, momento de la inducción en que se decide la cesárea. Para definir el cumplimiento de las recomendaciones de inducción se tuvieron como referencia las guías de práctica clínica de organizaciones internacionales de la especialidad y las nuevas directrices generadas en la propuesta de reducción de la primera cesárea del año 2012. Se utilizó estadística descriptiva. Resultados: de 2402 nacimientos se seleccionaron 289 que cumplieron con los criterios de inclusión. Se realizó cesárea al 48 % de las gestantes, a 60,8 % de las nulíparas y a 32,1 % de las multíparas sometidas a inducción. El 72,2 % de las que tenían cérvix desfavorable recibieron oxitocina como método de maduración cervical. A 108 (37 %) de las mujeres llevadas a inducción de parto se les realizó cesárea por diagnóstico de inducción fallida que se consideró inadecuado en todas ellas, ya que el diagnóstico se realizó antes de alcanzar 6 cm de dilatación en 88 (81,5 %), con membranas íntegras en 67 (62 %), sin actividad uterina en 42 (38,9 %), con actividad uterina de mala calidad en 23 (21,3 %) y 55 (61 %), no tuvieron al menos 24 horas de fase latente antes de realizar la cesárea. Conclusión: se encontró falta de cumplimiento de las recomendaciones para una adecuada inducción que lleva a un diagnóstico errado de inducción fallida.

Evening Primrose (Oenothera biennis) Oil in Management of Female Ailments

Oenothera biennis with the common name of “evening primrose” is containing a valuable fixed oil with commercial name of EPO. Evening primrose oil has two types of omega-6-fatty acid including linoleic acid (60%–80%) and γ-linoleic acid (8%–14%). Essential fatty acids are considered as essential compounds for body health, especially among women. The aim of this study was to evaluate the efficacy of evening primrose oil in the management of women ailments. The document was prepared by investigation in scientific articles of electronic resources (Google Scholar, PubMed, Science Direct, Wiley, Scopus, and Springer) by keywords of evening primrose oil and women. The results of our investigations showed that evening primrose oil has been the subject of several clinical studies, including premenstrual syndrome (PMS), hot flash, mastalgia, fibroadenomas, gestational diabetes, cervical ripening, and dilation. The major clinical studies are focused on mastalgia, followed by PMS. The results of studies confirmed the evening primrose oil's efficacy in women health, but the immediate response should not be expected from it, therefore, it should be regularly used up to 4 or 6 months.

Evaluation of isosorbide-5-mononitrate as a cervical ripening agent prior to induced abortion in contrast to misoprostol- a randomized controlled trial

OBJECTIVE: To determine whether vaginal application of 40 mg isosorbide-5-mononitrate (ISMN) has a comparable cervical ripening efficacy to and lesser side effects than 400 µg misoprostol in women scheduled for the first trimester induced abortion using a manual vacuum aspirator (MVA). METHODS: We conducted a prospective randomized open- label study in 70 women at 6–12 weeks of pregnancy at the R G Kar Medical College and Hospital, Kolkata, India, over a period of two years from 2015 to 2017. Forty milligrams of ISMN and 400 µg misoprostol were vaginally applied for cervical priming. The primary outcome measure was the cervical response assessed by the passage of the appropriate and largest sized MVA cannula through the internal os without resistance, at the beginning of the procedure. RESULTS: The base line cervical dilatation was found to be significantly higher in the misoprostol group than in the ISMN group (7.65±1.38 vs. 6.9±1.26 mm; P=0.025, 95% confidence interval, −1.4046 to −0.953). However, when the women were sub-analyzed based on parity, there was no statistically significant difference in the same parameters among the multigravid women. The need for further cervical dilatation was significantly higher in the ISMN group when the primigravid women were compared, although the multigravid women responded favorably to ISMN. CONCLUSION: In the primigravid women, misoprostol appears to exert a higher efficacy as a cervical ripening agent in contrast to ISMN. However, ISMN can be used in multigravid women for the same purpose as in this group, misoprostol did not show any significant improvement in efficacy over ISMN.

Vía de finalización en pacientes con segunda inducción al trabajo de parto en el Hospital Nacional prof. A. Posadas / Postterm pregnancy in patients with second labour induction - Author's experience

The labour induction is an intervention to initiate artificially the uterine contractions to produce the effacement and dilatation of the uterine cervix until the child-birth is achieved. It is indicated when the benefit of the termination of the pregnancy for the mother and the child is greater than its continuation. It is perfored in more or less the 20 % of the women. In our institution the rate oscillates in around the 9 % of the cases. It is understand as an successful induction the termination of the labour through the vaginal delivery. The methods for labour induction more commonly used at present are mechanical and pharmacological. Between the first group we can find the Hamilton maneuver and the amniotomy. And between the pharmacologicals we find the oxytocine. These elements are considered in the article

Vía de finalización en inducciones de embarazos postérmino, según score de Bishop / Induction of postterm pregnancies according to Bishop score

Objetivo: Determinar la vía de finalización en embarazos pos término de mujeres que fueron internadas para inducción al trabajo de parto y establecer la relación entre la vía de finalización y Bishop de comienzo. Pacientes y métodos: Estudio Observacional, Descriptivo, Transversal, de 2013 a 2014. La población se identificó del SIP de aquellas pacientes con embarazo mayor a 41 semanas internadas para inducción. Test de Fisher exacto o Chi cuadrado para evaluar la siginficancia estadística p=0.05. Resultados: De 197 pacientes, la media fue de 24 años. El 21% comenzó la inducción con Bishop entre 0 y 3 puntos, 59.5% entre 4 y 6 puntos. 13 pacientes recibieron una segunda inducción tras la primera fallida. El 67.5% de las inducciones finalizaron por parto vaginal, 32.5% cesárea. De las mujeres con score 0-3 puntos el 61,5% finalizaron por cesárea, para el segundo grupo (Bishop 4-6) el 71.8% de las inducciones finalizó por parto vaginal, encontrándose una significancia estadística en estas relaciones, test de Fisher=0.000. Conclusiones: Podríamos relacionar el score de Bishop de comienzo de inducción con la vía de finalización y si bien se han encontrado gran porcentaje de partos vaginal con score de 4 en adelante, el 61.5% de las mujeres que pertenecían al grupo de 0-3 finalizaron por la vía quirúrgica por lo que podría recomendarse la maduración cervical previa inducción en este grupo de como estatregia para la reducción de la tasa de cesáreas en inducciones por 41 semanas.

The aim of this report was to present an evaluation of induction of postterm pregnancies according to the ´Bishop score in women admitted for labor induction. Labor induction is an intervention in order to iniciate artificially the uterine contractions to produce the effacement and the dilatation of the uterine cervix and to end with a birth. At present we have three main methods for induction, oxytocin, prostaglandins and amniotomy. The pregnancy chronologically prolongued refers to that simple gestation that reaches or overcomes the 294 days since the date of the last menstruation. It is known that the pregnancies chronologically prolongued are associated with a rise of the maternal and perinatal morbimortality, and therefore, since they are diagnosed. It is mandatory the management toward a minimization of the risks. For these reasons, it is recommended, in the case of a prolonged pregnancy, to consider beneficial to begin the parturition for security reasons for the mother and the fetus. ´These considerations are referred in the article

Anaphylactic shock to vaginal misoprostol: a rare adverse reaction to a frequently used drug

Misoprostol is widely used in daily practice for induction of labor and cervical dilatation prior to intrauterine procedures, including dilatation and curettage or hysteroscopy. Anaphylactic shock to intravaginal misoprostol can occur not only in pregnant women, as reported in 2 previous cases, but also in a non-pregnant, perimenopausal woman, as in the case described herein. A 49-year-old woman received vaginal misoprostol for cervical ripening prior to hysteroscopic myomectomy and experienced anaphylactic shock. Two 400 μg doses of misoprostol 6 hours apart caused uncontrolled shaking and high fever followed by shock. In conclusion, the possibility of anaphylactic shock should be considered in patients with sudden hypotension following misoprostol administration. Prompt identification and management are crucial to prevent morbidity and mortality following an anaphylactic shock to misoprostol.

Inducción al parto en mujeres con score de Bishop desfavorable / LABOUR INDUCTION IN WOMEN WITH UNFAVOURABLE BISHOP'S SCORE

Objetivo: Primario: Determinar vía de finalización del embarazo en mujeres con score de Bishop desfavorable con maduración cervical previa, en relación con aquellas sin maduración, en el Hospital Nacional Posadas, 01/01/2015- 31/12/2015. Secundarios: Establecer indicación de inducción y cesárea; frecuencia de inicio de trabajo de parto y de segunda inducción; resultados perinatales y presencia de complicaciones puerperales. Material y Método: Estudio observacional, descriptivo, transversal. La población fue identificada a partir del SIP. Se realizó un relevamiento de las historias clínicas. Se incluyeron mujeres embarazadas con indicación de inducción al parto, embarazo único a partir de 24 semanas, feto vivo y score de Bishop desfavorable. Las variables se presentan como medidas de frecuencia y tendencia central. Las comparaciones se realizaron a través de Fisher exact test y Chi2 , p valor<=0.05. Resultados: En el periodo estudiado acontecieron 3312 nacimientos de fetos vivos, de los cuales 310 correspondieron a inducciones. El 46% presentaban score de Bishop desfavorable (N=141). El 33% recibió maduración cervical (n=46), de las cuales 56% finalizó por parto vaginal, en comparación con un 39% de las que no la recibieron (n=95) (p=0.04). El 85% de aquellas mujeres que recibieron maduración cervical inició trabajo de parto, frente al 68% de las que no la recibieron (p=0.03). Discusión: Determinamos la importancia de la maduración cervical para el éxito de inducciones con score de Bishop desfavorable. Consideramos de importancia la disponibilidad del mismo a nivel público, para garantizar el acceso de las mujeres a todas las herramientas disponibles para un nacimiento seguro

Objectives: Primary: To determine the mode of birth in women with unfavorable Bishop score with prior cervical ripening, compare to those without maduration, Posadas National Hospital, 01/01 / 2015-31 / 12/2015. Secondary: To establish inductions and cesarean section indications; begin labour active phase frecuency and second induction frecuency; perinatal outcomes and puerperal complications. Patients and methods: Observational, descriptive, cross-sectional study. The population was identified from SIP. A survey of medical records was performed. Inclusion criteria were labour induction, after 24 weeks, live fetus and unfavorable Bishop score. The variables are presented as measures of frequency and central tendency. Comparisons were made by Fisher exact test and Chi2 , p value <= 0.05. Results: 3312 births of live fetuses, of which 310 were inductions. 46% had unfavorable Bishop score (N=141). 33% received cervical ripening (n=46), 56% vaginal delivery , compared with 39% cesarean section (n=95) (p=0.04). 85% of women who received cervical ripening, began with labour active phase, compared with 68% of those who did not (p=0.03).Discussion: We determine the importance of cervical ripening for successful inductions with unfavorable Bishop score. We consider important the availability of the public level, to ensure access of women to all available tools for a safe birth.

The effectiveness of evening primrose oil gel capsule as a cervical ripening agent during labor induction as measured by bishop score on term singleton pregnant patients / Philippine Journal of Obstetrics and Gynecology

BACKGROUND: Pre-induction of labor cervical ripening increases success of labor induction when there is unfavorable cervix. Evening primrose oil soft gel capsule contains linoleic and gamma-linolenic acid, which are precursors of prostaglandins E1 andE2.OBJECTIVE: To measure the effectiveness of evening primrose oil capsule as a cervical ripening agent by measuring the Bishop score before and 4 hours after intravaginal insertion of six capsules.METHODS: A quasi-experimental cross-sectional study was conducted from the period of May to July 2016 involving labor induction patients with a Bishop score ?4, an intact amniotic sac and a Biophysical profile score of 10/10 or 8/8.RESULTS: Thirteen patients had an average age of 27±6 years, and a mean age of gestation of 40±1 weeks. Seven patients (54%) were nulliparous, 2 (15%) were primiparous and 4 (31%) were multiparous. Seven patients (54%) had hypertension, 1 (8%) had diabetes mellitus, 5 (38%) had post-term pregnancies. A paired t-test was done to check for statistically significant changes in the Bishop score. Change in the Bishop score from baseline to 4 hours after insertion of evening primrose oil capsules was statistically significant (p=0.001). Eleven patients (85%) had improvement in the Bishop score after 4 hours, 4 (31%) of which had a clinically significant change in the Bishop score (?4). Specifically, there were statistically significant changes in the dilatation (p=0.027), effacement (p=0.006) and consistency (p=0.002). The mean birth weight of deliveries was 3192±351 grams. Nine patients (69%) underwent primary low segment cesarean section, six (46%) of which for nonreassuring fetal status, 2 (15%) for arrest in cervical dilatation, and 1 (8%) for intraamnionic infection. Four patients (31%) successfully delivered vaginally.CONCLUSION: Results showed a positive effect on the Bishop score during cervical ripening although further studies are needed to establish direct correlation.

The effectiveness of evening primrose oil gel capsule as a cervical ripening agent during labor induction as measured by bishop score on term singleton pregnant patients / Philippine Journal of Obstetrics and Gynecology

@#<p style="text-align: justify;"><strong>BACKGROUND</strong>: Pre-induction of labor cervical ripening increases success of labor induction when there is unfavorable cervix. Evening primrose oil soft gel capsule contains linoleic and gamma-linolenic acid, which are precursors of prostaglandins E1 andE2.<br /><strong>OBJECTIVE:</strong> To measure the effectiveness of evening primrose oil capsule as a cervical ripening agent by measuring the Bishop score before and 4 hours after intravaginal insertion of six capsules.<br />METHODS: A quasi-experimental cross-sectional study was conducted from the period of May to July 2016 involving labor induction patients with a Bishop score ?4, an intact amniotic sac and a Biophysical profile score of 10/10 or 8/8.<br /><strong>RESULTS:</strong> Thirteen patients had an average age of 27±6 years, and a mean age of gestation of 40±1 weeks. Seven patients (54%) were nulliparous, 2 (15%) were primiparous and 4 (31%) were multiparous. Seven patients (54%) had hypertension, 1 (8%) had diabetes mellitus, 5 (38%) had post-term pregnancies. A paired t-test was done to check for statistically significant changes in the Bishop score. Change in the Bishop score from baseline to 4 hours after insertion of evening primrose oil capsules was statistically significant (p=0.001). Eleven patients (85%) had improvement in the Bishop score after 4 hours, 4 (31%) of which had a clinically significant change in the Bishop score (?4). Specifically, there were statistically significant changes in the dilatation (p=0.027), effacement (p=0.006) and consistency (p=0.002). The mean birth weight of deliveries was 3192±351 grams. Nine patients (69%) underwent primary low segment cesarean section, six (46%) of which for nonreassuring fetal status, 2 (15%) for arrest in cervical dilatation, and 1 (8%) for intraamnionic infection. Four patients (31%) successfully delivered vaginally.<br /><strong>CONCLUSION:</strong> Results showed a positive effect on the Bishop score during cervical ripening although further studies are needed to establish direct correlation.</p>

Associação entre a idade óssea determinada pelas vértebras cervicais e estágios de desenvolvimento de formação dentária / Association between bone age determined by cervical vertebrae and dental formation development stages

A proposta deste estudo foi verificar a associação entre estágios de formação radicular de caninos e primeiros pré-molares em radiografias panorâmicas e a idade óssea determinada por meio da 3ª vértebra cervical em telerradiografias em norma lateral e buscar uma alternativa à determinação da idade esquelética, utilizando-se apenas uma variável de análise vértebra C3 ou Índice Nolla, dispensando-se uma segunda comprovação por meio da radiografia carpal. A pesquisa deu-se através da análise de telerradiografias e radiografias panorâmicas de 122 pacientes, com idades entre 8 e 12 anos de idade, com calibração Kappa de 100% de confiabilidade. Pela amostra analisada, pôde-se concluir que a utilização de forma isolada dos estágios de maturação esquelética é compatível com os índices de correlação positivos apresentados para a maturação vertebral. No entanto, houve uma baixa correlação entre os estágios de maturação radicular dentária pela escala de Nolla e os estágios de maturação vertebral. (AU)

The aim of this study was to verify the association between dental root formation stages of canines and first premolars in panoramic radiographies and the bone age determined by means of the third cervical vertebra in lateral teleradiography, as well as to seek for an alternative to determine skeletal age using a single analysis variable - C3 vertebra or Nolla Index eliminating the require for a second validation through carpal radiography. The research consisted on the analysis of teleradiography and panoramic radiography of 122 patients, aged between 8 and 12, with 100% Kappa calibration reliability. Through the sample analyzed, it was possible to conclude that the isolated use of skeletal maturation is compatible with the positive correlation coefficients presented for vertebral maturation. However, Nolla scale showed low correlation between the stages of dental root maturation and vertebral maturation.(AU)

Intracervical foley catheter balloon versus oxytocin infusion as pre-induction cervical ripening agent in live term pregnancies with unfavorable cervices / Philippine Journal of Obstetrics and Gynecology

OBJECTIVE: The purpose of this study was to evaluate the effectiveness and safety as well as maternal and fetal outcome of intracervical Foley catheter balloon versus oxytocin infusion as pre-induction cervical ripening agents in live term pregnancies with unfavorable cervices.METHODS: Forty-two patients who fulfilled the induction criteria were randomized to 2 groups. Group 1= intracervical balloon catheter and Group 2= oxytocin infusion. Both groups were compared as to: insertion/infusion to active phase interval, induction to delivery interval, uterine hyperstimulation, pain intensity, delivery and fetal outcome. Analysis of data collected was done using Indepedent T-test.RESULTS: Statistical analysis showed no significant difference as to insertion/infusion to active phase interval (p 0.814) and induction to delivery interval (p 0.264) between the balloon and oxytocin groups. By percentage comparison, both groups have comparable results in the mode of delivery, likelihood of cesarean section and good fetal outcome. Statistical significance was observed with regards to absence of uterine hyperstimulation (p 0.036) and absence of pain (p 0.000) in favor of the balloon group.CONCLUSION: By percentage comparison, intracervical Foley catheter balloon and oxytocin were both effective and safe in achieving cervical dilatation. The Foley catheter showed statistical significance in terms of absence of uterine hyperstimulation and pain. Foley catheter is readily available and affordable. It may be considered as a good alternative to oxytocin.

Role of vaginal estradiol pretreatment combined with vaginal misoprostol for cervical ripening before operative hysteroscopy in postmenopausal women

OBJECTIVE: To assess the efficacy and safety of vaginal misoprostol after a pretreatment with vaginal estradiol to facilitate the hysteroscopic surgery in postmenopausal women. METHODS: In this observational comparative study, 35 control women (group A) did not receive any pharmacological treatment,26 women (group B) received 25 µg of vaginal estradiol daily for 14 days and 400 µg of vaginal misoprostol 12 hours before hysteroscopic surgery, 32 women (group C) received 400 µg of vaginal misoprostol 12 hours before surgery. RESULTS: Demographic data were well balanced and all variables were not significantly different among the three groups. The study showed a significant difference in the preoperative cervical dilatation among the group B (7.09±1.87 mm), the group A (5.82±1.85 mm; B vs. A, P=0.040) and the group C (5.46±2.07 mm; B vs. C, P=0.007). The dilatation was very easy in 73% of women in group B. The pain scoring post surgery was lower in the group B (B vs. A, P=0.001; B vs. C, P=0.077). In a small subgroup of women with suspected cervical stenosis, there were no statistically significant differences among the three groups considered. No complications during and post hysteroscopy were observed. CONCLUSION: In postmenopausal women the pretreatment with oestrogen appears to have a crucial role in allowing the effect of misoprostol on cervical ripening. The combination of vaginal estradiol and vaginal misoprostol presents minor side effects and has proved to be effective in obtaining satisfying cervical dilatation thus significantly reducing discomfort for the patient.

Intravaginal Misoprostol for Cervical Ripening and Labor Induction in Nulliparous Women: A Double-blinded, Prospective Randomized Controlled Study / 中华医学杂志(英文版)

<p><b>BACKGROUND</b>In China, no multicenter double-blinded prospective randomized controlled study on labor induction has been conducted till now. This study is to evaluate the efficacy and safety of intravaginal accurate 25-μg misoprostol tablets for cervical ripening and labor induction in term pregnancy in nulliparous women.</p><p><b>METHODS</b>This was a double-blinded, prospective randomized controlled study including nulliparous women from 6 university hospitals across China. Subjects were randomized into misoprostol or placebo group with the sample size ratio set to 7:2. Intravaginal 25-μg misoprostol or placebo was applied at an interval of 4 h (repeated up to 3 times) for labor induction. Primary outcome measures were the incidence of cumulative Bishop score increases ≥3 within 12 h or vaginal delivery within 24 h. Safety assessments included the incidences of maternal morbidity and adverse fetal/neonatal outcomes.</p><p><b>RESULTS</b>A total of 173 women for misoprostol group and 49 women for placebo were analyzed. The incidence of cumulative Bishop score increases ≥3 within 12 h or vaginal delivery within 24 h was higher in the misoprostol group than in the placebo (64.2% vs. 22.5%, relative risk [RR]: 2.9, 95% confidence interval [CI]: 1.4-6.0). The incidence of onset of labor within 24 h was significantly higher in the misoprostol group than in the placebo group (48.0% vs. 18.4%, RR: 2.6, 95% CI: 1.2-5.7); and the induction-onset of labor interval was significantly shorter in the misoprostol group (P = 0.0003). However, there were no significant differences in the median process time of vaginal labor (6.4 vs. 6.8 h; P = 0.695), incidence (39.3% vs. 49.0%, RR: 0.8, 95% CI: 0.4-1.5) and indications (P = 0.683) of cesarean section deliveries, and frequencies of maternal, fetal/neonatal adverse events between the groups.</p><p><b>CONCLUSION</b>Intravaginal misoprostol 25 μg every 4 h is efficacious and safe in labor induction and cervical ripening.</p>

Clinical study of Jiawei Bazhen decoction combined with oxytocin for cervical ripening of qi and blood deficiency type of pregnant women / 中国中药杂志

To study preliminarily the effect of Jiawei Bazhen decoction combined with oxytocin in promoting cervical ripening of full-term pregnancy women who were in the deficiency of qi and blood type through the syndrome differentiation of traditional Chinese medicine (TCM). 180 patients that met the inclusion criteria of the study were randomly divided into three groups: the control group(oxytocin group), the treatment group (Jiawei Bazhen decoction combined with oxytocin group), the blank control group (expected and observation group). Cervical maturity score (Bishop score), vaginal and cervical secretions fetal fibronectin (FFN), the result of induced labor, the result of mother and baby were observed in each group before and after treatment. The result comes out that the cervical Bishop score of pregnant women for treatment group were significantly higher than the control group and blank control group after treatment (P < 0.05). The FFN of pregnant women for the treatment group were significantly different from the control group and blank control group after treatment (P < 0.05). The pregnancy outcome of the three groups: the labor rate and rate of vaginal delivery of the treatment group were higher than the other two groups, and the difference was statistically significant (P < 0.05). The cesarean section rate of the treatment group was significantly lower than the other two groups, the difference was also statistically significant (P < 0.05). The three groups did not appear the phenomenon of neonatal asphyxia. Jiawei Bazhen decoction combined with oxytocin is effective in producing cervical ripening and induce labor. It is convenient, safe and reliable, for it is no obvious adverse effects on mother and fetus, but effective in reducing the rate of cesarean section, and playing a positive role in promoting natural delivery.