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Rev. Hosp. Ital. B. Aires (2004) ; 37(2): 68-72, jun. 2017. ilus., tab.
Article in Spanish | LILACS | ID: biblio-1087152

ABSTRACT

La enfermedad injerto contra huésped es una entidad en la cual las células inmunológicas competentes de un tejido injertado reconocen y dañan antígenos presentes en el receptor del trasplante, que es incapaz de defenderse de ellas. Es una complicación frecuente del trasplante alogénico de médula ósea, y con menor frecuencia se produce luego de trasplantes de órganos sólidos o transfusiones de hemoderivados no irradiados. Se comunica el caso de una paciente de sexo femenino de 23 años, con leucemia linfoblástica aguda.y trasplante alogénico de médula ósea, que presentó una enfermedad injerto contra huésped con compromiso cutáneo y gastrointestinal dependiente de corticoides, con mejoría de los signos y síntomas cutáneos luego del tratamiento con infliximab y fotoféresis extracorpórea. (AU)


Graft versus host disease is an entity in which competent grafted immune cells recognize and damage tissue antigens present in the transplant recipient, who is unable to defend from them. It is one of the most serious complications in patients undergoing allogeneic bone marrow transplantation, although less frequently it may be associated with solid organ transplants or transfusions of not irradiated blood products. We report the case of a 23 year-old patient with acute lymphoblastic leukemia and allogeneic bone marrow transplantation, that presented graft versus host disease with skin and gastrointestinal involvement, dependent on corticosteroids, that showed improvement in signs and skin symptoms after treatment with infliximab and extracorporeal photopheresis. (AU)


Subject(s)
Humans , Female , Adult , Young Adult , Photopheresis , Graft vs Host Disease/drug therapy , Graft vs Host Disease/therapy , Signs and Symptoms , Transplantation, Homologous/adverse effects , Blood Transfusion , Methylprednisolone/administration & dosage , Prednisone/administration & dosage , Abdominal Pain , Ganciclovir/administration & dosage , Risk Factors , Organ Transplantation/adverse effects , Bone Marrow Transplantation/adverse effects , Tacrolimus/administration & dosage , Adrenal Cortex Hormones/adverse effects , Adrenal Cortex Hormones/therapeutic use , Cytomegalovirus Infections/diagnostic imaging , Diarrhea , Mucositis , Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications , Precursor Cell Lymphoblastic Leukemia-Lymphoma/radiotherapy , Febrile Neutropenia , Infliximab/therapeutic use , Degloving Injuries/drug therapy , Degloving Injuries/blood , Graft vs Host Disease/etiology , Graft vs Host Disease/mortality , Immunosuppressive Agents/adverse effects , Mycophenolic Acid/administration & dosage
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