ABSTRACT
AbstractCoccidioidomycosis is a highly prevalent disease in the Western hemisphere. It is considered one of the most virulent primary fungal infections. Coccidioides species live in arid and semi-arid regions, causing mainly pulmonary infection through inhalation of arthroconidia although many other organs can be affected. Primary inoculation is rare. Since the first case of coccidioidomycosis was reported in 1892, the skin has been identified as an important target of this disease. Knowledge of cutaneous clinical forms of this infection is important and very useful for establishing prompt diagnosis and treatment. The purpose of this article is to provide a review of this infection, emphasizing its cutaneous manifestations, diagnostic methods and current treatment.
Subject(s)
Female , Humans , Male , Coccidioidomycosis/pathology , Dermatomycoses/pathology , Coccidioidomycosis/classification , Coccidioidomycosis/therapy , Dermatomycoses/therapy , Lung Diseases, Fungal/pathology , Lung Diseases, Fungal/therapy , Risk Factors , Skin/pathologyABSTRACT
A zigomicose é uma doença invasiva, que acomete tanto imunocompetentes como imunocomprometidos, dependendo do tipo da cepa. O diagnóstico é clínico e histopatológico, e o tratamento é baseado em antifúngico e em limpeza cirúrgica. O presente relato de caso é sobre um menino com zigomicose rinofacial invasiva com tratamento final bem-sucedido, após terapias antifúngicas e limpezas cirúrgicas.
Zygomycosis is an invasive disease that affects both immunocompetent and immunocompromised, depending on the type of strain. This disease diagnosis is clinical and histopathological, and its treatment is based on antifungal therapy and surgical cleaning. This paper reports a case of a boy with invasive zygomycosis rinofacial who final treatment was successful after underwent antifungal and surgical therapies.
Subject(s)
Humans , Male , Child , Paranasal Sinus Diseases/microbiology , Zygomycosis/pathology , Zygomycosis/therapy , Dermatomycoses/microbiology , Facial Dermatoses/microbiology , Paranasal Sinus Diseases/pathology , Paranasal Sinus Diseases/therapy , Tomography, X-Ray Computed , Amphotericin B/therapeutic use , Treatment Outcome , Dermatomycoses/pathology , Dermatomycoses/therapy , Facial Dermatoses/pathology , Facial Dermatoses/therapy , Immunocompetence , Antifungal Agents/therapeutic useABSTRACT
The antifungal activity of the ethanol and boiled water crude extracts of Acalypha wilkesiana leaves were investigated. Extracts were obtained from the leaves collected every 3 hrs within a 24 hrs rhythm or setting. All the crude extract had significant antifungal activity on all the fungi tested [Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger, Candida albicans, Microsporum audonii, Penicillium chrysogenum, Rhizopus sp., Trichoderma viride, and Trichophyton mentagrophyte]. There was a definite change in the antifungal activity of crude extracts of A. wilkesiana leaves harvested at different times of the day [3 am, 6 am, 9 am, 12 noon, 3 pm, 6 pm, 9 pm, 12 midnight]. The crude extracts of leaves harvested at 3 am had the highest zone of inhibition while the least inhibition was at 12 noon. The boiled water extract was more active as antifungal than the ethanol extract. The efficacy of the antifungal properties of the leaves harvested at 3 am is probably as good as the check antibiotics Fulcin and Nystatin. Preliminary phytochemical studies of the crude extracts reveal that the ethanol extracts contain cardiac-glycosides, saponins, steroid, and tannins. The boiled extract contains alkaloids, flavonoids cardiac-glycosides, phlobatannins, saponins, steroids and tannins. In this paper significance of the result is discussed
Subject(s)
Euphorbiaceae , Dermatomycoses/therapy , Dermatomycoses/prevention & control , Plants, Medicinal , Plant Extracts , Plant LeavesABSTRACT
Jorge Lobo's disease is a cutaneous and subcutaneous mycosis that affects patients in the Amazon region. The number of patients is relatively small, but the real situation of the disease as public health problem is not known, because Jorge Lobo's disease is not a notifiable disease. This study aims to report the clinical evolution in patients affected and to determine the prevalence and areas of occurrence of the disease. A retrospective study was carried out based on the analysis of the clinical records, which included a collection of photographs of patients in the Department of Sanitary Dermatology, in Rio Branco, and patients seen in the interior of the state. In a decade, in Rio Branco, 249 cases of the disease were reported, 30 were females and 219 males. Of these patients, 153 had localized lesions, 94 of them were on one ear, 55 had multifocal lesions and 41 had disseminated lesions. The average time between the onset of symptoms and diagnosis was 19 years. The average age at the time of diagnosis was 53 years, and ages ranged from 14 to 96 years.
A doença de Jorge Lobo é micose cutânea e subcutânea que afeta pessoas na região Amazônica. O número de pacientes é relativamente pequeno, no entanto, a real prevalência da doença como problema de saúde pública é pouco conhecida. A doença de Jorge Lobo não é de notificação compulsória. Este estudo teve como objetivo determinar a prevalência, as áreas de ocorrência da doença de Jorge Lobo, além de sua evolução clínica. Um estudo retrospectivo foi desenvolvido com base na análise de prontuários de pacientes, incluindo documentação fotográfica dos mesmos, que foram atendidos no Departamento de Dermatologia Sanitária em Rio Branco e no interior do Estado. Foram registrados 249 casos em uma década em Rio Branco, 30 mulheres e 219 homens. Do total 153 apresentavam lesões localizadas, 94 lesões em apenas uma orelha, 55 lesões multifocais e 41 lesões disseminadas. A média de tempo entre o início dos sintomas e o diagnóstico foi de 19 anos. A média de idade no momento do diagnóstico foi de 53 anos, e as idades variaram de 14 a 96 anos.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Dermatomycoses/epidemiology , Brazil/epidemiology , Dermatomycoses/pathology , Dermatomycoses/therapy , Disease Reservoirs/microbiology , Prevalence , Retrospective Studies , Young AdultABSTRACT
A feo-hifomicose subcutânea é uma doença causada por fungos demáceos que acomete principalmente indivíduos imunocomprometidos e geralmente cursa com lesões localizadas nos membros inferiores. Os autores relatam um caso de feo-hifomicose subcutânea em um paciente imunocompetente, com localização atípica - na hemibolsa escrotal esquerda -, tratado com sucesso com fluconazol sistêmico associado à excisão cirúrgica.
Subcutaneous phaeohyphomycosis is a disease caused by dematiaceous fungi that develops mainly in immunocompromised patients. Lesions are generally located on the lower limbs. The present report describes a case of phaeohyphomycosis in an immunocompetent patient in whom a subcutaneous abscess was located in an unusual site, on the left hemiscrotum. The abscess was treated successfully with oral fluconazole associated with surgical excision.
Subject(s)
Humans , Male , Middle Aged , Dermatomycoses/microbiology , Exophiala/isolation & purification , Genital Diseases, Male/microbiology , Scrotum/microbiology , Antifungal Agents/therapeutic use , Dermatomycoses/diagnosis , Dermatomycoses/therapy , Fluconazole/therapeutic use , Genital Diseases, Male/diagnosis , Genital Diseases, Male/therapyABSTRACT
El Querion de Celsus es una patología micótica, inflamatoria y supurativa localizada habitualmente en la nuca, cuero cabelludo o en la barba pero que también puede aparecer en áreas de piel lampiña. Presentamos el caso de una paciente femenina de 25 años de edad, quien al ingresar al Hospital Universitario Ruíz y Páez de Ciudad Bolívar, presentaba múltiples lesiones pustulares, pruriginosas y dolorosas a nivel genital, lográndose aislar en ellas el dermatofito Trichophyton rubrum. La paciente recibió tratamiento a base de itraconazol y prednisona, presentando en poco tiempo mejoría evidente de su clínica de ingreso. Por tanto concluimos que se trataba de una presentación atípica del Querion de Celsus.
Subject(s)
Humans , Adult , Female , Dermatomycoses/diagnosis , Dermatomycoses/therapy , Vulvar Diseases/pathology , GynecologyABSTRACT
El granuloma tricofítico de Majocchi es una infección causada por hongos dermatofitos que invaden dermis profunda y tejido celular subcutáneo. Existen pocos reportes de esta entidad. Se han descripto diferentes características clínicas de acuerdo al estado inmune del paciente. Presentamos el caso de una paciente de 8 años de edad con múltiples nódulos ligeramente dolorosos, en cuero cabelludo y cara, de 6 meses de evolución, que había sido tratada con corticoides tópicos y sistémicos. El estudio anatomopatológico evidenció abundantes estructuras micóticas con formación de granulomas en dermis profunda. Se estableció el diagnóstico de granuloma tricofítico de Majocchi y se inició terapia antimicótica con itraconazol, 5 mg/kg/día, con mejoría clínica parcial a la cuarta semana de tratamiento
Trichophytic Majocchi granuloma is an infection by dermatophytes which invade deep dermis and fat. There are few reports about this disease. Some clinical features have been described depending on immune state of patients. We present a case in an 8 years old girl with tenderness nodules in scalp and face of 6 months of evolution, who had been previously treated with topical and systemic steroids. Histological findings showed many fungal structures and a dermal granulomatous inflammatory infiltrate in deep dermis. Diagnosis of trichophytic Majocchi granuloma was done and initiated anti fungal therapy with itraconazole 5 mg/kg once a day with partial improvement at the fourth week of treatment
Subject(s)
Humans , Female , Child , Arthrodermataceae , Dermatomycoses/diagnosis , Dermatomycoses/therapy , Granuloma , Trichophyton , Tinea/diagnosisABSTRACT
Cutaneous mucormycosis is a rare fungal infection in children. It is commonly found in immunocompromised children. Early diagnosis is difficult and requires a very high degree of suspicion. Recommended mainstay of treatment has been amphotericin B and extensive surgical debridement which may at times require amputation if limb is involved. The authors share their experience of two cases of successfully treated cutaneous mucormycosis.
Subject(s)
Dermatomycoses/therapy , Humans , Infant , Infant, Newborn , Male , Mucormycosis/therapyABSTRACT
Se realizó una Investigación de tipo transversal clínico-micológico en 464 pacientes con onicopatías referidos al laboratorio de Micología del Hospital "Dr. Rafael González Plaza", U.C., en el período 1993-1996 confirmándose mediante exámenes directo y cultivo, etiología micótica en 296 (63.79 por ciento) y descartándose en 168 (36,21 por ciento). En las onicopatías micóticas encontramos que el mayor número de casos pertenecían al grupo de edades entre 45-54 años (26,35 por ciento), sexo femenino (76,35 por ciento), profesión amas de casas (42,57 por ciento) procedentes del Estado Carabobo (93,91 por ciento), localización de las lesiones en ambas manos (23,31 por ciento) y de menos de un año de evolución (32,09 por ciento). Se determinaron onicopat¡as dermatofíticas, tinea unguim en 150 pacientes (50,68 por ciento) aislándose dos especies: T. rubrum (82,67 por ciento) y T. mentagrophytes (17,33 por ciento), perteneciendo el (25,81 por ciento) al grupo entre 45 - 54 años producidos por T. rubrum y (30,77 por ciento) al grupo entre 35 - 44 por T. mentagrophytes, siendo las características predominantes por ambas: sexo femenino (60,67 por ciento), profesionales (32 por ciento), localización en ambos pies (47,33 por ciento), dos años de evolución (25,33 por ciento), afectación de varias uñas (62 por ciento) y forma clínica Distal subungueal (76 por ciento). De la forma clínica leuconiquia superficial solo encontramos 3 casos producidos por T. rubrum
Subject(s)
Humans , Male , Female , Middle Aged , Candidiasis , Dermatomycoses/diagnosis , Dermatomycoses/therapy , Onychomycosis/diagnosis , Paronychia/diagnosis , Nails/injuries , Nails/pathology , Mycology , VenezuelaABSTRACT
An open label trial of Lamisil [Terbinafine] 500 mg daily for 16 weeks was conducted on 20 patients with Onychomycosis due to candida. Of these, 15 patients could complete the trial. Total number of target nails infected was 21. The follow-up period was from 16 to 52 weeks. At 16 weeks, 71% cases showed clinical improvement and 67% had mycological cure. Thirty-three percent had complete cure at 52 weeks. The results show that Terbinafine is effective against candida but requires a longer duration of treatment. The drug was well tolerated
Subject(s)
Candidiasis/therapy , Terbinafine , Dermatomycoses/therapyABSTRACT
El liquen estriado infantil es una dermatosis papulosa lineal, a veces hipocrómica y descamativa, más frecuentemente en la infancia que en otras épocas de la vida.Se hizo una revisión de 55.000 Historias Clínicas de pacientes atendidos en los Servicios de Dermatología del Hospital de Niños" Dr. Ricardo Gutierrez" y del Hospital de Niños de San Isidro, entre enero de 1986 y octubre de 1993. Se encontraron 151 casos (0,27 porciento del total de consultas), más de la mitad con presentación en verano y el resto repartido entre las otras estaciones.El 54,9 porciento se vio entre año y los cuatro años de edad y el 62,9 porciento del total fueron niñas. La localización fue unilateral en el 88,7 porciento y más frecuente en miembros inferiores.Salvo tres pacientes que refirieron prurito leve, la enfermadad fue asintomática y la involución se produjo en un lapso de dos meses a dos años, la mayoría sin secuelas, salvo cinco pacientes que presentaron hipopigmentación residual
Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Adolescent , Dermatomycoses/diagnosis , Dermatomycoses/therapy , Histamine H1 Antagonists/therapeutic useABSTRACT
Os autores registram caso de hialo-hifomicose subcutanea por Acremonium recifei em paciente branca, imunocompetente, natural da Bahia, com historia de traumatismo no dorso da mao direita. A lesao era indolor, com edema, inflamacao, presenca de fistulas, secrecao seropulenta, e ausencia de graos. O exame histopatologico mostrou hifas septadas hialinas pela hematoxilina-eosina...
Subject(s)
Humans , Female , Aged , Acremonium/classification , Antifungal Agents/therapeutic use , Dermatomycoses/therapy , Dermatomycoses/diagnosisSubject(s)
Humans , Dermatomycoses/diagnosis , Skin Diseases, Parasitic/diagnosis , Skin Diseases, Bacterial/diagnosis , Communicable Diseases/diagnosis , Dermatomycoses/therapy , Skin Diseases, Parasitic/therapy , Furunculosis/diagnosis , Furunculosis/drug therapy , Skin Diseases, Bacterial/therapyABSTRACT
Se estudiaron 40 pacientes de tiña del cuerpo y de la ingle para probar la eficacia y tolerancia del fluconazol a dosis de 150 mg semanalmente, de una a cuatro semanas. Los pacientes fueron estudiados clínica y micológicamente y por exámenes de laboratorio clínico. Los resultados mostraron un 87.5 por ciento de curación, 10 por ciento de falla terapéutica y un paciente no evaluable. El mayor índice de curación se obtuvo con 3 dosis. No se observaron efectos adversos
Subject(s)
Adolescent , Adult , Middle Aged , Dermatomycoses/therapy , Fluconazole/administration & dosage , Tinea/therapyABSTRACT
Sao registrados tres casos de feo-hifomicose subcutanea em transplantados renais provocados pela Exophiala jeanselmei (Langeron) McGinnis et Padhye 1977, fungo demacio capaz, tambem, de produzir raramente eumicetoma de graos pretos. Este fungo, segundo KWON-CHUNG&BENNETT, 1992 e antigenicamente muito heterogeneo, sendo identificados ate o presente momento tres sorotipos com subgrupos dentro de cada um deles....
Subject(s)
Humans , Male , Female , Middle Aged , Dermatomycoses/therapy , Kidney Transplantation , Cyclosporins/therapeutic use , Dermatomycoses/microbiology , Immunosuppression Therapy/adverse effectsABSTRACT
Se trataron 28 pacientes con dermatomicosis en áreas limitadas del cuerpo, con crema dermatológica de ketoconazol al 2 por ciento. La aplicación tópica fue de una vez al día y se proporcionó información sobre habitos y cuidado de la piel. Se obtuvo respuesta satisfactoria en el 92,8 por ciento de los pacientes y efectos colaterales en 2 pacientes (7,1 por ciento). Los agentes etiológicos más frecuentes fueron el T. rubrum 46,4 por ciento y Cándida 28,5 por ciento. Las lesiones más rebeldes al tratamiento fueron las interdigitales de pie producidas por T. rubrum. La crema de ketoconazol demostró ser una buena alternativa en este tipo de tratamiento.
Subject(s)
Humans , Male , Female , Dermatomycoses/etiology , Dermatomycoses/therapy , Ketoconazole , Ketoconazole/therapeutic use , MycosesABSTRACT
Resumo:Oleos essenciais de Annona crassiflora (araticum) Cymbopogon citratus (capim santo), Cinnamomum zeylanicum (canela), Ocimum gratissimum (alfavaca), Protium heptaphyllum (almiscar), Xylopia frutescens (embiriba vermelha) foram ensaiados contra várias cepas e Microsporum canis, Trichophyton rubrum, trchophyton mentagrophytes e Epidermophyton floccosum isolados de pacientes com dermatofitoses. Essas plantas säo popularmente utilizadas no nordeste brasileiro para tratamento de infecçöes da pele e seus anexos, causadas por bactérias, vírus e fungos. Cinco dos óleos essenciais ensaiados mostraram excelente atividade antifúngica inibindo fortemente o crescimento e 81 (por cento) das cepas estudadas. O óleo de P. heptaphyllum foi completamente inativo (au)
Subject(s)
Animals , Plants, Medicinal/therapeutic use , Skin , Trichophyton/drug effects , Dermatomycoses/therapy , Epidermophyton/drug effects , Antigens, Fungal , Ocimum basilicum/therapeutic use , Oils, Volatile/therapeutic useABSTRACT
De 949 casos estudiados entre 1976 y 1986 en el Instituto de Medicina Tropical "Daniel A. Carrión", Univ. San Marcos, se presentan 482 con diagnóstico etiológico de alguna Dermatomicosis con el objetivo principal de aclarar la relación entre el aspecto clínico y el etiológico. Asimismo, se señalan las variantes epidemiológicas y clínicas, los medios de diagnóstico utilizados y el tratamiento que tentativamente se ha aplicado