Desafíos del profesional de Enfermería en el nexo salud y cambio climático / Challenges of the Nursing Professional within the Nexus between Health and Climate Change / Desafios para os enfermeiros no nexo entre saúde e mudança climática

La población mundial está enfrentando una de las mayores amenazas para la subsistencia de todas las especies. El cambio climático está afectando la salud de las personas y representa un reto para los profesionales de enfermería, quienes están llamados a trabajar con equipos transdisciplinarios para evaluar el impacto de este fenómeno en la salud humana, la promoción de entornos saludables, la mitigación y adaptación del sector salud, así como en la atención de la población afectada por los eventos climáticos extremos.

La população mundial está enfrentando uma das maiores ameaças à subsistência de todas as espécies. As mudanças climáticas estão afetando a saúde das pessoas e representam um desafio para os profissionais de enfermagem, que são chamados a trabalhar com equipes transdisciplinares para avaliar o impacto deste fenômeno na saúde humana, promover ambientes saudáveis, mitigar e adaptar o setor da saúde, assim como atender a população afetada por eventos climáticos extremos.

The world population is facing one of the greatest threats to the survival of all species. Climate change is affecting people's health and represents a challenge for the Nursing professionals who are called to work in transdisciplinary teams to evaluate the impact of this phenomenon on human health, to promote healthy environments, to mitigate and adapt the health sector, as well as its impact of the population affected by extreme weather events.

Situación epidemiológica de VIH a nivel global y nacional: Puesta al día / Epidemiological situation of HIV at global and national level: update

INTRODUCCIÓN: En las cuatro décadas de la epidemia por VIH, se han observado avances notables que han contribuido a una disminución progresiva en la incidencia de nuevas infecciones y en la mortalidad a nivel mundial. Sin embargo, no ha ocurrido lo mismo en Latinoamérica y en Chile. OBJETIVO: Esta revisión tiene como objetivo conocer la epidemiología actual a nivel global, latinoamericano y chileno. METODOLOGÍA: Se analizaron los informes epidemiológicos oficiales de infección por VIH emitidos por organismos nacionales e internacionales, más los estudios epidemiológicos nacionales. RESULTADOS: Se estima que 39 millones de personas viven con VIH en el mundo; no obstante, la mortalidad y la incidencia de nuevos casos han disminuido de forma notoria durante las últimas dos décadas, asociado a una expansión en al acceso a terapia antirretroviral en forma global. A diferencia del resto del mundo, América Latina presenta una tendencia de alza en las nuevas infecciones y Chile registra un aumento de 35% en nuevos casos durante los últimos 10 años, coincidiendo con un aumento en los flujos de migrantes que ha afectado a la región. Algunas estrategias preventivas como la profilaxis pre exposición se han implementa-do a un ritmo lento, tanto a nivel mundial, como latinoamericano. CONCLUSIONES: La epidemiología del VIH presenta características propias regionales y nacionales. En particular en Chile, diversos factores incluyendo déficit en políticas públicas de prevención y los recientes flujos migratorios han modelado nuestra actual epidemia. El desafío presente debe contemplar los esfuerzos multisectoriales para lograr los objetivos de ONUSIDA en esta década.

BACKGROUND: Over the course of the last four decades of global HIV epidemic, significant improvements have contributed to gradually reduce the frequency of new infections and global mortality rates. However, in Latin America particularly in Chile, new infections continue increasing. AIM: This review aims to comprehend the_epidemiology today on a worldwide, Latin American, and Chilean scale. METHODS: National epidemiology studies and official HIV reports from international and national organizations were reviewed. RESULTS: It is estimated that 39 million people live with HIV worldwide; however, mortality and the incidence of new cases have decreased markedly over the last two decades, associated with an expansion in access to antiretroviral therapy globally. In contrast to the rest of the world, Latin America shows an upward trend in new infections, with Chile registering a 35% increase in new cases over the last 10 years, coinciding with an increase in migratory flows that has occurred throughout the region. Some preventive strategies, such as pre-exposure prophylaxis, have been implemented at a slow pace, both globally and in Latin America. CONCLUSIONS: The epidemiology of HIV has regional and national characteristics. Specifically in Chile, several factors, including deficits in public prevention policies and recent migratory flows, have shaped our current epidemic. The present challenge must contemplate multisectoral efforts to achieve the UNAIDS objectives during this decade.

Research progress on global health competency and its models / 中华预防医学杂志

At present, the research on Global Health Competencies is mainly conducted in the field of the establishment of competency models and application of indicators. This review summarizes the research progress of the Global Health Competency and its models, and focuses on cutting-edge research from the aspects of target audience, purpose, content, classical model, methods and future development. The competency model is suggested to be adjusted and updated according to the practices of different countries and regions. The research and funding of the competency model in the field of public health is suggested to be strengthened, and the global health and diplomacy are suggested to be combined to enrich and improve the competency model. Finally, this review aims to promote Global Health Competencies research in China, especially to improve the global health talent training system and relevant policies in further research.

Research progress on global health competency and its models / 中华预防医学杂志

At present, the research on Global Health Competencies is mainly conducted in the field of the establishment of competency models and application of indicators. This review summarizes the research progress of the Global Health Competency and its models, and focuses on cutting-edge research from the aspects of target audience, purpose, content, classical model, methods and future development. The competency model is suggested to be adjusted and updated according to the practices of different countries and regions. The research and funding of the competency model in the field of public health is suggested to be strengthened, and the global health and diplomacy are suggested to be combined to enrich and improve the competency model. Finally, this review aims to promote Global Health Competencies research in China, especially to improve the global health talent training system and relevant policies in further research.

Development of an online nursing leadership program for global health in the Western Pacific Region

@#<strong>BACKGROUND AND OBJECTIVE</strong><p>Global health highlights the transnational determinants, issues, and possible solutions for improving health outcomes. Addressing global health issues requires population-based approaches coupled with individualized healthcare across settings, including strategies for achieving health equity. Designing and implementing global health solutions requires competent nurse leaders who can facilitate multi-disciplinary collaborations, engage in policy development, and lead advocacies that support the global health agenda. Thus, this paper examined the stakeholder perspectives that informed the development of a leadership program on global health for nurse leaders in the Western Pacific Region (WPR).</p><strong>METHODS</strong><p>The study used a descriptive qualitative approach to generate key recommendations for a context-appropriate, multi-country capacity-building program for nurse leaders on global health. The Analysis Design, Development, Implementation, and Evaluation (ADDIE) model and reflexive approach were employed to guide the development of the training design. Twenty-five nurse leaders from World Health Organization Collaborating Centers (WHO-CC) in the Western Pacific participated. Qualitative data were collected from participant feedback and post-activity sessions throughout program implementation.</p><strong>RESULTS</strong><p>Thematic analysis of stakeholder data revealed that the program (1) capitalized on equipping nurse leaders with the concepts related to global health and developing competencies in leadership, policy engagement, and advocacy; (2) ensured learning strategies by having participants from varied contexts and experiences; and (3) reflected on the strengths and limitations of the use of the online platform.</p><strong>CONCLUSION</strong><p>This paper contributed to the growing literature on global health and programs that support addressing global health issues. The findings underscored the urgent need to capacitate nurses in leadership positions who contribute to addressing emerging issues in global health. The paper recommended improvements in the design and implementation of the Global Health Nursing Leadership Program to engage more nurse leaders across the region and enhance content and delivery.</p>

Governança em rede: um estudo de caso sobre a Rede Global de Bancos de Leite Humano durante a pandemia de covid-19 / Network governance: a case study on the Global Network of Human Milk Banks during the covid-19 pandemic

O estudo investigou a forma de governança praticada pela Rede Global de Bancos de Leite Humano (rBLH-Global), com ênfase no contexto da doação de leite humano durante o início da pandemia de covid-19. Identificou-se que, embora já houvesse indicações anteriores da governança compartilhada, revelou-se que sua abordagem em rede é profundamente influenciada por sua estrutura, princípios compartilhados e relações estabelecidas. Os elementos clássicos de governança, juntamente com as três dimensões do capital social, ofereceram uma fundamentação sólida para analisar essa forma de governança com base nos quatro fatores-chave de eficácia da governança em rede de Provan e Kenis (2008). Dentre os resultados, observou-se que a rBLH-Global demonstra: processos democráticos e descentralizados na formação de diretrizes; padrões uniformes de qualidade e segurança; resiliência e adaptabilidade durante crises; uma estrutura descentralizada; e liderança distribuída. O estudo validou que a rBLH-Global atua sob a forma de governança compartilhada, uma interação altamente horizontalizada entre os membros da rede, enfatizando relações mútuas, interdependência e decisões coletivas. Observou-se que o capital social da Rede permite a eficácia dessa forma adotada mesmo com um grande número de membros. O estudo também destacou percepções de profissionais de saúde e mulheres-mães doadoras de bancos de leite humano de diferentes países membros da rBLH-Global, revelando alto grau de confiança, consenso de objetivos, interdependência em competências e cooperação mútua. Conclui-se que a rBLH-Global, por sua governança compartilhada, prosperou durante os desafios da pandemia. Recomendações futuras incluem ampliar o escopo de análise para outros atores, estudos comparativos e explorar lições aprendidas para futuras crises. A pesquisa destaca a relevância das opiniões de profissionais de saúde e mulheres-mães doadoras para avaliação da governança, sugerindo a complementaridade destas perspectivas em estudos subsequentes.

The study investigated the form of governance practiced by the Global Network of Human Milk Banks (rBLH-Global), with an emphasis on the context of human milk donation during the beginning of the covid-19 pandemic. It was identified that, although there were previous indications of shared governance, it was revealed that its network approach is deeply influenced by its structure, shared principles and established relationships. The classical elements of governance, together with the three dimensions of social capital, provided a solid foundation for analyzing this form of governance based on Provan and Kenis' (2008) four key factors of network governance effectiveness. Among the results, it was observed that rBLH-Global demonstrates: democratic and decentralized processes in the formation of guidelines; uniform quality and safety standards; resilience and adaptability during crises; a decentralized structure; and distributed leadership. The study validated that rBLH-Global operates under shared governance, a highly horizontal interaction between network members, emphasizing mutual relationships, interdependence and collective decisions. It was observed that the social capital of the Network allows the effectiveness of this adopted form even with a large number of members. The study also highlighted perceptions of health professionals and women donors from human milk banks from different member countries of rBLH-Global, revealing a high degree of trust, consensus of objectives, interdependence in skills and mutual cooperation. It is concluded that rBLH-Global, due to its shared governance, prospered during the challenges of the pandemic. Future recommendations include expanding the scope of analysis to other actors, comparative studies, and exploring lessons learned for future crises. The research highlights the relevance of the opinions of health professionals and female donor mothers for evaluating governance, suggesting the complementarity of these perspectives in subsequent studies.

Asociación entre las tendencias de búsqueda en internet con el número de casos confirmados por la viruela símica: estudio multinacional en diez países / Association between internet search trends and the number of confirmed monkeypox cases: a multinational study in ten countries

INTRODUCCIÓN: La viruela símica es una infección zoonótica que se ha distribuido por todo el mundo. La búsqueda de información en internet refleja el interés y concientización de la población acerca de salud. OBJETIVO: Determinar la asociación entre el volumen relativo de búsquedas en internet con el número de casos confirmados por la viruela símica en diez países. MÉTODOS: Se realizó un estudio obser- vacional, analítico, retrospectivo, utilizando la herramienta Google Trends (GT™) para encontrar el volumen relativo búsqueda (VRB) sobre viruela símica desde 01 de enero al 31 de agosto del 2022 usando términos de búsqueda en el idioma oficial de los 10 países con mayor número de casos en dichas fechas, registrado por Our World in Data. Para establecer la relación lineal entre el VRB con los nuevos de casos por día se usó el coeficiente de correlación de Pearson con un nivel de significancia (p ≤ 0,05). RESULTADOS: Se encontró un coeficiente de correlación de Pearson fuerte en Brasil (Rp = 0,562,p = 0,001), y débil en países como Alemania (Rp = 0,281, p = 0,004), Estados Unidos de Norteamérica (Rp = 0,255, p = 0,008), España (Rp = 0,122, p = 0,213), Perú (Rp = 0,120, p = 0,333), Canadá (Rp = 0,116, p = 0,238), Francia (Rp = 0,095, p = 0,335), Reino Unido (Rp = 0,085, p = 0,362), Portugal (Rp = 0,024, p = 0,805) y Países Bajos (Rp = 0,067, p = 0,497). CONCLUSIÓN: Nuestro estudio evidencio que el VRB presento una relación positiva con el número de nuevos casos de viruela símica. Asimismo, se observo un coeficiente de correlación fuerte en Brasil, y en el resto de países fue débil.

BACKGROUND: Smallpox is a zoonotic infection that has been distributed worldwide. The search for information on the Internet reflects the interest and awareness of the population about health. AIM: To determine the correlation between the relative volume of internet searches and the number of confirmed cases of smallpox in ten countries. METHODS: An observational, analytical, retrospective study was conducted using the Google Trends (GT™) tool to find the relative search volume (RSV) on monkeypox from January 1 to August 31, 2022 using search terms in the official language of the 10 countries with the highest number of cases on those dates, as recorded by Our World in Data. To establish the relationship between RSV and new cases per day, Spearman's correlation was used with a significance level (p ≤ 0.05). RESULTS: A. strong Pearson correlation coefficient was found in Brazil (Rp = 0.562, p = 0.001), and weak in countries like Germany (Rp = 0.281, p = 0.004), United States (Rp = 0.255, p = 0.008), Spain (Rp = 0. 122, p = 0.213), Peru (Rp = 0.120, p = 0.333), Canada (Rp = 0.116, p = 0.238), France (Rp = 0.095, p = 0.335), United Kingdom (Rp = 0.085, p = 0.362), Portugal (Rp = 0.024, p = 0.805) and Netherlands (Rp = 0.067, p = 0.497). CONCLUSION: Our study showed that RSV had a positive relationship with the number of new cases of smallpox. Also, a strong correlation coefficient was observed in Brazil, while the rest of the countries showed a weak correlation coefficient.

Odontología sostenible y sustentable / Sustainable dentistry

Introducción: la periodontitis es una enfermedad infecciosa multifactorial asociada a un biofilm de microorganismos patógenos. Objetivo: el objetivo del trabajo fue establecer la prevalencia de Porphyromonas gingivalis en pacientes con periodontitis y relacionarla con la severidad de la enfermedad. Material y métodos: participaron 45 pacientes, sistémicamente saludables, con edades entre 35 y 65 años. El grado de periodontitis se definió según los criterios de Papapanou y colaboradores. Como grupo control, se incluyeron 20 sujetos de ambos sexos sin periodontitis y sin enfermedades sistémicas. Se tomaron muestras de fluido gingival en dos sitios más profundos. Porphyromonas gingivalis se detectó por PCR (reacción en cadena de la polimerasa). Resultados: la frecuencia relativa de periodontitis fue de 13.3% grado I, 46.7% grado II y 40% grado III. El sexo masculino presentó periodontitis grado III 72.2% y grado II 52.3%. El grado I se registró con mayor frecuencia en el sexo femenino, 66.7%. La prevalencia de Porphyromonas gingivalis en la población con periodontitis fue de 44.4%. Se obtuvieron diferencias estadísticamente significativas entre los grados de severidad de periodontitis y la presencia de Porphyromonas gingivalis (p = 0.0002, α = 5%). Conclusión: la periodontitis predominó en el sexo masculino. La prevalencia de Porphyromonas gingivalis en la población con periodontitis crónica fue de 44.4% y su presencia está relacionada con la severidad (AU)

Introduction: periodontitis is a multifactorial infectious disease associated with a biofilm of pathogenic microorganisms. Objective: the objective of the work was to establish the prevalence of Porphyromonas gingivalis in patients with periodontitis and relate it to the severity of the disease. Material and methods: 45 systemically healthy patients, aged between 35 and 65 years old, participated. The degree of periodontitis was defined according to the criteria of Papapanou et al. As a control group, 20 patients of both sexes without periodontitis and without systemic diseases were included. Gingival fluid samples were taken from two deeper sites. Porphyromonas gingivalis was detected by PCR (polymerase chain reaction). Results: the relative frequency of periodontitis was 13.3% grade I, 46.7% grade II and 40% grade III. The male sex presented periodontitis grade III 72.2% and grade II 52.3%. Grade I was recorded more frequently in the female sex, 66.7%. The prevalence of Porphyromonas gingivalis in the population with periodontitis was 44.4%. Statistically significant differences were obtained between the degrees of severity of periodontitis and the presence of Porphyromonas gingivalis (p = 0.0002, α = 5%). Conclusion: periodontitis predominated in males. The prevalence of Porphyromonas gingivalis in the population with chronic periodontitis was 44.4% and its presence is related to severity (AU)

Medicina Integrativa en Chile: Hacia una visión más global de la salud de las personas / Integrative Medicine in Chile: Towards a more global vision of people's health

La Organización Mundial de la Salud ha definido salud como un estado de completo bienestar físico, mental y social, no solo como la ausencia de enfermedad. La medicina integrativa considera la articulación de diferentes prácticas y sistemas médicos, como las terapias mente-cuerpo, las terapias manuales, la medicina energética, los sistemas completos y los estilos de vida saludables, que permite ampliar la comprensión de los procesos de salud y enfermedad, junto con dar herramientas concretas en este abordaje, centrado en la persona más que en la enfermedad. En Chile, el Ministerio de Salud planteó la incorporación de las medicinas alternativas y complementarias a través del decreto 42, reglamentándolas como auxiliares a la atención tradicional, normando las condiciones de los recintos donde se realizan y regulando hasta el momento el ejercicio de la acupuntura, la homeopatía y la naturopatía. Existen múltiples barreras para la implementación de unidades de medicina integrativa, como la percepción de que son costosas, poco efectivas y que muchas veces existe resistencia por parte de los equipos de salud. Para su avance es importante ir incorporando la disciplina en los currículums de las carreras de la salud, el consensuar taxonomías y resultados a evaluar, no perder de vista que el tronco de la atención en salud se encuentra en la atención primaria y generar un mayor desarrollo de la evidencia asociada a su uso, sobre todo a nivel local, incorporando de manera más rutinaria el informar también sobre sus potenciales efectos adversos.

The World Health Organization has defined health as a state of complete physical, mental and social well-being, not just the absence of disease. Integrative medicine considers the articulation of different medical practices and systems such as mind-body therapies, manual therapies, energy medicine, whole systems and healthy lifestyles, allowing focusing on the cause of diseases and giving concrete tools to focus on the person rather than just the disease. In Chile, the Ministry of Health proposed incorporating alternative and complementary medicines through Decree 42, regulating them as auxiliary to traditional care, the conditions of practice for the exercise of acupuncture, homeopathy, and naturopathy. There are multiple barriers to implementing integrative medicine units, such as the perception that they are expensive and ineffective and, frequently, the resistance of health teams. For its advancement, it is essential to gradually incorporate this discipline in health careers curricula, agree on taxonomies and outcomes, and maintain sight that the core of health care is at the primary level. It is also necessary to generate evidence on the use of integrative medicine, especially at the local level, incorporating its practice more routinely and reporting on its potential adverse effects.

Cursos en línea abiertos y masivos: oportunidad de aprendizaje sobre salud global en Latinoamérica / Massive open online courses: learning opportunities about global health for Latin American countries

Introducción. Los cursos en línea, masivos y abiertos, brindan la oportunidad de formar profesionales e investigadores en Latinoamérica sobre salud global. Objetivos. Determinar la oferta global de los cursos en línea, masivos y abiertos, sobre salud global y conocer las características de su contenido. Materiales y métodos. Se examinaron las plataformas especializadas en cursos en línea, masivos y abiertos, para recopilar aquellos sobre salud global. La búsqueda no tuvo restricción de tiempo y se realizó por última vez en noviembre de 2021. La estrategia de búsqueda solo incluyó el descriptor "global health". Posteriormente, se obtuvieron las características del curso, su contenido y el dominio abordado de salud global. Estos datos fueron analizados descriptivamente, y se reportaron frecuencias absolutas y relativas. Resultados. La estrategia de búsqueda identificó 4.724 cursos en línea, masivos y abiertos. De ellos, solo 92 estaban relacionados con salud global. La mayoría de estos cursos (n=44; 47,8 %) se ofrecieron mediante la plataforma Coursera. Más de la mitad de los cursos (n=50; 54,4 %) fueron realizados por instituciones de Estados Unidos y en idioma inglés (n=90; 97,8 %). La mayor parte de los cursos se centró en la "globalización de la salud y la asistencia sanitaria" (n=24; 26,1 %), seguido de los dominios "fortalecimiento de capacidades" (n=16; 17,4 %), "carga global de enfermedad" y "determinantes sociales y ambientales de la salud" (n=15; 16,3 %). Conclusiones. Se encontró una importante oferta de cursos en línea, masivos y abiertos, sobre salud global. Estos cursos abordaron las competencias de la salud global que se requieren para los profesionales sanitarios.

Introduction. Massive open online courses provide the opportunity to train health professionals and researchers from Latin America in global health. Objective. To determine the global offer of massive open online courses in global health and the characteristics of their content. Material and methods. We examined massive open online course platforms to compile the global health offerings. The search had no time restriction and was last conducted in November, 2021. The search strategy only included the descriptor "global health". We obtained the characteristics of the courses, their content, and the global health domain covered. These data were analyzed using descriptive statistics, reporting absolute and relative frequencies. Results. Our search strategy identified 4,724 massive open online courses. Of these, only 92 were related to global health. Most of these courses (n=44; 47.8%) were offered through Coursera. More than half (n=50; 54.4%) of the MOOCs were conducted by U.S.A. institutions and in English language (n=90; 97.8%). Most courses focused on "globalization of health and healthcare" (n=24; 26.1%), followed by the domains "capacity building" (n=16; 17.4%), "global burden of disease" and "social and environmental determinants of health" (n=15; 16.3%). Conclusions. We found a high offer of massive open online courses on global health. These courses covered the global health competencies required for health professionals.

Global incidence and mortality of renal cell carcinoma in 2020 / 中华流行病学杂志

Objective: To analyze the global epidemiology of renal cell carcinoma (RCC) in 2020. Methods: The incidence and mortality data of RCC in the cooperative database GLOBOCAN 2020 of International Agency for Research on Cancer of WHO and the human development index (HDI) published by the United Nations Development Programme in 2020 were collated. The crude incidence rate (CIR), age-standardized incidence rate (ASIR), crude mortality rate (CMR), age-standardized mortality rate (ASMR) and mortality/incidence ratio (M/I) of RCC were calculated. Kruskale-Wallis test was used to analyze the differences in ASIR or ASMR among HDI countries. Results: In 2020, the global ASIR of RCC was 4.6/100 000, of which 6.1/100 000 for males and 3.2/100 000 for females and ASIR was higher in very high and high HDI countries than that in medium and low HDI countries. With the rapid increase of age after the age of 20, the growth rate of ASIR in males was faster than that in females, and slowed down at the age of 70 to 75. The truncation incidence rate of 35-64 years old was 7.5/100 000 and the cumulative incidence risk of 0-74 years old was 0.52%. The global ASMR of RCC was 1.8/100 000, 2.5/100 000 for males and 1.2/100 000 for females. The ASMR of males in very high and high HDI countries (2.4/100 000-3.7/100 000) was about twice that of males (1.1/100 000-1.4/100 000) in medium and low HDI countries, while the ASMR of female (0.6/100 000-1.5/100 000) did not show significant difference. ASMR continued to increase rapidly with age after the age of 40, and the growth rate of males was faster than that of females. The truncation mortality rate of 35-64 years old was 2.1/100 000, and the cumulative mortality risk of 0-74 years old was 0.20%. M/I decreases with the increase of HDI, with M/I as 0.58 in China, which was higher than the global average of 0.39 and the United States' 0.17. Conclusion: The ASIR and ASMR of RCC presented significant regional and gender disparities globally, and the heaviest burden was in very high HDI countries.

Introduction for One Health Joint Plan of Action (2022-2026) / 中华流行病学杂志

Four organizations, including the Food and Agriculture Organization of the United Nations, the United Nations Environment Programme, WHO, and the World Organization for Animal Health, recently launched a new One Health Joint Plan of Action (2022-2026) which was the first time that the Quadripartite had issued a joint action plan on One Health. The action plan aimed to address the health challenges in the human, animal, plant, and environment, focusing on improving capabilities in six action tracks including One Health capacities, emerging and re-emerging zoonotic diseases, neglected tropical and vector-borne diseases, food safety, antimicrobial resistance and environment. This introduction will give an overview and brief translation of the background, content, and the plan's value, to help readers understand the joint action plan quickly.

Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China / 医学前沿

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported at the end of 2019 as a worldwide health concern causing a pandemic of unusual viral pneumonia and many other organ damages, which was defined by the World Health Organization as coronavirus disease 2019 (COVID-19). The pandemic is considered a significant threat to global public health till now. In this review, we have summarized the lessons learnt during the emergence and spread of SARS-CoV-2, including its prototype and variants. The overall clinical features of variants of concern (VOC), heterogeneity in the clinical manifestations, radiology and pathology of COVID-19 patients are also discussed, along with advances in therapeutic agents.

Crises contemporâneas: retrocessos sociais, políticas de saúde e desafios democráticos / Contemporary crisis: social regressions, health policies, and democratic challenges

Resumo No contexto da globalização, é recorrente a menção às crises contemporâneas da democracia, da ciência, econômico-sociais, sanitárias e ambientais. No Brasil, essas crises se agravam em função da estrutura histórico-social que carrega profundos problemas não resolvidos, bem como em função de governos que têm desgastado as instituições nacionais que foram arduamente reconstruídas no processo de redemocratização do país. Neste editorial, refletimos sobre o contexto de crise nacional experimentado no Brasil nos últimos anos, situando retrocessos sociais resultantes de políticas neoliberais e conservadoras levadas à cabo pelos últimos dois mandatários do governo federal, e posicionando alguns desafios a serem enfrentados pelo país, a partir de um movimento de retomada da democracia.

Abstract In the context of globalization, mentioning contemporary democracy, science, social-economic, sanitary, and environmental crises is recurrent. In Brazil, these crises have worsened due to historical-cultural structures that carry deep unresolved problems and due to governments that have worn down the national institutions that were reconstructed with hard work during its re-democratization process. In this editorial, we reflect on the national crisis context experienced in Brazil in the last years, situating social regressions resulting from neoliberal and conservative policies carried out by the last two heads of the federal government and placing some challenges to be faced by the country beginning by a movement to retrieve democracy.

Covid-19 como tema de memória, verdade e justiça: entrevista com Deisy Ventura / Covid-19 as an issue of memory, truth, and justice: an interview with Deisy Ventura

Resumo Entrevista com Deisy Ventura, professora titular da Faculdade de Saúde Pública da Universidade de São Paulo, que discute a dimensão política da pandemia de covid-19 no Brasil. A pesquisadora se tornou uma das principais referências no assunto por seu amplo conhecimento de direito internacional com foco em saúde. Na entrevista, ela apresenta reflexões relacionadas à saúde global, além de discutir a gestão da pandemia no país e suas implicações para os direitos humanos. De acordo com a pesquisadora, houve no Brasil uma política governamental sistemática de disseminação do vírus, e a pandemia deveria ser tratada como uma questão de memória, verdade e justiça.

Abstract This interview with Deisy Ventura, professor at the Faculty of Public Health of the Universidade de São Paulo, discusses the political dimension of the covid-19 pandemic in Brazil. She has become a leading reference on the subject due to her extensive knowledge of international law, with a focus on health. In this interview, Deisy Ventura offers some reflections on global health and discusses the handling of the pandemic in Brazil and its human rights implications. According to Ventura, the Brazilian government had a systematic policy for the spread of the virus, and the pandemic should be treated as a matter of memory, truth, and justice.