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Indian J Physiol Pharmacol ; 1990 Oct; 34(4): 277-8
Article in English | IMSEAR | ID: sea-106581

ABSTRACT

The study was designed to demonstrate the interaction between verapamil and glybenclamide on blood glucose in rabbits. Glybenclamide (0.05 mg/kg, po) induced hypoglycaemia was observed 1 h after treatment and persisted till 3 h. Verapamil (8 mg/kg, sc) per se produced hyperglycaemia which lasted for 2 1/2 hr. Concurrent administration of verapamil was found to impair significantly the hypoglycaemic response of glybenclamide.


Subject(s)
Animals , Blood Glucose/metabolism , Drug Interactions , Female , Glyburide/antagonists & inhibitors , Male , Rabbits , Verapamil/pharmacology
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