ABSTRACT
A infecção pelo vírus herpes simples tipo 2 (HSV-2) é frequente em pacientes infetados pelo vírus de imunodeficiência adquirida (VIH). Nestes casos, o herpes genital pode ter uma apresentação clínica atípica. As variantes hipertróficas e vegetantes são pouco habituais. Os autores relatam um caso de herpes hipertrófico perianal em paciente infetada pelo VIH, com resposta insatisfatória ao aciclovir e valaciclovir, tratado eficazmente com imiquimod tópico. O herpes genital hipertrófico é, frequentemente, refratário aos tratamentos antivirais. Na nossa experiência, o imiquimod é um tratamento eficaz, seguro e bem tolerado que deverá ser considerado na abordagem terapêutica destes pacientes.
Herpes simplex virus type 2 (HSV-2) infections are frequent in HIV (human immunodeficiency virus) infected patients. In those cases, genital herpes may have an atypical clinical presentation. Hypertrophic and vegetating variants are unusual. The authors describe a case of hypertrophic perianal herpes in an HIV patient with unsatisfactory response to acyclovir and valacyclovir, successfully treated with imiquimod. Hypertrophic genital herpes cases are frequently refractory to antiviral treatments. In our experience, imiquimod is an efficient, safe and well tolerated treatment that should be considered in therapeutic approach of these patients.
Subject(s)
Female , Humans , Middle Aged , Aminoquinolines/therapeutic use , Antiviral Agents/therapeutic use , HIV Infections , HIV-1 , Herpes Genitalis/drug therapy , /isolation & purification , Acyclovir/therapeutic use , Anal Canal/virology , HIV Infections/complications , Herpes Genitalis/etiology , Herpes Genitalis/pathologyABSTRACT
La holoprosencefalia es la malformación prosencefálica más frecuente; su etiología es heterogénea y en ocasiones se asocia alteraciones genéticas e infecciones virales. Se presenta el caso de una paciente de 27 años de edad, IIG, IP, 1 Aborto, con embarazo de 27 semanas + 4 días, amenaza de parto pretérmino, holoprosencefalia y antecentes de herpes genital durante el primer trimestre.
Holoprosencephaly is the more frequent prosencephalic malformation. The etiology is heterogeneous an d some times is associated with genetic alterations and uterine viral infections. We present a pregnant 27 old year patient with 27 weeks and 4 days, preterm labor and genital herpes infection on the first trimester.
Subject(s)
Humans , Adult , Female , Pregnancy , Herpes Genitalis/pathology , Holoprosencephaly/ethnology , Holoprosencephaly/genetics , Nervous System Malformations/pathology , Virus Diseases/pathology , Abortion , Obstetric Labor, PrematureABSTRACT
Os autores discorrem sobre os fatores predisponentes das vulvovaginites na infância e adolescência. Informam sobre a grande incidência dessa patologia nesta faixa etária. Relatam sobre a importância dos hábitos de higiene na gênese e no tratamento das infecçöes vaginais e vulvares. Discorrem sobre os meios diagnósticos dessa patologia e indicam os tratamentos mais eficazes.
Subject(s)
Humans , Female , Child , Adolescent , Vulvovaginitis/pathology , Trichomonas vaginalis/pathogenicity , Vulvovaginitis/diagnosis , Vulvovaginitis/etiology , Vulvovaginitis/physiopathology , Vulvovaginitis/microbiology , Vulvovaginitis/drug therapy , Candida albicans/pathogenicity , Herpes Genitalis/pathology , Gardnerella vaginalis/pathogenicity , Candidiasis, Vulvovaginal/pathology , Sexually Transmitted Diseases/pathology , Trichomonas Infections/pathologyABSTRACT
1. Light and electron microscopy have been used to characterize echovirus 19 and herpes simplex type 2 infection of human placenta tissue in vitro. Immunofluorescence, autoradiography and virus adsorption were used to determine virus replication in this system. 2. Placental tissue was permissive to echovirus 19. Trophoblast cells were lysed with liberation of mature virions. However, during the 48-h period of observation, few cells were damaged and the trophoblastic structure was maintained. 3. HSV-2 infection in placental tissue was aborted although trophoblastic cells allowed virus adsorption, penetration and uncoating. A characteristic cytopathic effect was observed in infected trophoblastic cells in spite of the abortive infection
Subject(s)
Humans , Female , Herpes Genitalis/pathology , Echovirus Infections/pathology , Placenta/microbiology , Enterovirus B, Human/isolation & purification , Enterovirus B, Human/physiology , Fluorescent Antibody Technique , Herpesvirus 2, Human/isolation & purification , Herpesvirus 2, Human/physiology , Microscopy, Electron , Placenta/cytology , Pregnancy , Trophoblasts/microbiology , Trophoblasts/ultrastructure , Virus ReplicationSubject(s)
Humans , Female , Amniotic Fluid/microbiology , Herpes Genitalis/microbiology , Immunoglobulins/analysis , Pregnancy Complications, Infectious/microbiology , Simplexvirus/isolation & purification , Adult , Amniotic Fluid/immunology , Antibodies, Viral/analysis , Chile/epidemiology , English Abstract , Follow-Up Studies , Herpes Genitalis/epidemiology , Herpes Genitalis/immunology , Herpes Genitalis/pathology , Pregnancy , Placenta/pathology , Pregnancy Complications, Infectious/epidemiologyABSTRACT
Lesiones de Herpes simplex fueron observadas en 9 de 84 pacientes (10,7%) con SIDA atendidos en el centro venereológico del Servicio de Dermatología, Hospital Universitario de Caracas. 5 pacientes con formas clínicas recurrentes y 4 con herpes simplex crónico perianal. La citología y la histología revelaron los cambios celulares e histopatológicos característicos de la infección herpética. En 3 pacientes con herpes simplex crónico, los cultivos confirmaron infección por virus Herpes simplex tipo 2, y la microscopia electrónica reveló núcleo de células epiteliales y partículas de virus papiloma dentro del citoplasma. El estudio demuestra la relativa frecuencia de lesiones herpéticas en pacientes con SIDA y la utilidad de la prueba de Tzanck para detectar los cambios celulares típicos asociados con la infección
Subject(s)
Adult , Humans , Male , Female , Herpes Genitalis/pathology , Herpes Simplex/pathology , Simplexvirus/pathology , Acquired Immunodeficiency Syndrome/pathologyABSTRACT
É apresentada uma revisäo das publicaçöes mais recentes sobre o herpes, com ênfase às relaçöes com a toco-ginecologia