Subject(s)
Humans , Female , Adult , Skin/drug effects , Tretinoin/adverse effects , Chemexfoliation/adverse effects , Blister/chemically induced , Keratolytic Agents/adverse effects , Time Factors , Patch Tests , Blister/drug therapy , Treatment Outcome , Erythema/chemically induced , Erythema/drug therapy , FaceABSTRACT
Retinoic acid is a widely used drug in the treatment of cystic acné. It has teratogenic effects that depend on the gestational period in which it is used. We report a seven months of female whose mother was exposed to retinoic acid in both pregestational and gestational periods. She had a retardation of psychomotor development and a brain MRI showed frontal atrophy and a malformation of the posterior fossa. We discuss the mechanisms ofthe teratogenic effeets of retinoic acid.
Subject(s)
Female , Humans , Infant , Pregnancy , Abnormalities, Drug-Induced , Abnormalities, Multiple/chemically induced , Craniofacial Abnormalities/chemically induced , Isotretinoin/adverse effects , Keratolytic Agents/adverse effects , Teratogens , Acne Vulgaris/drug therapy , Atrophy/chemically induced , Cranial Fossa, Posterior/abnormalities , Cranial Fossa, Posterior/drug effects , Frontal Lobe/abnormalities , Frontal Lobe/drug effects , Maternal Exposure/adverse effects , Prenatal Exposure Delayed Effects/chemically induced , Psychomotor Disorders/chemically induced , Tretinoin/adverse effectsABSTRACT
OBJECTIVE: Evaluate and compare the efficacy, safety, and tolerability of coal tar (10% LCD, liquor carbonis detergens), with betamethasone valerate in the therapy of large plaque-type psoriasis. MATERIAL AND METHOD: Patients with stable, mild to moderate plaque psoriasis at the Department of Medicine, Lerdsin General Hospital, Bangkok, Thailand were randomized for treatment with either coal tar (10% LCD) cream or betamethasone valerate cream (0.1%). All patients entered a 2 week wash-out period followed by the creams being applied twice daily until completion at 6 weeks. The patient severity of psoriasis was assessed using the modified Psoriasis Area and Severity Index (PASI) score at baseline and after 2, 4, and 6 weeks of treatment. RESULT: At the end of the trial, the mean reduction of the PASI score from baseline was 38.39% with the coal tar group and 69.36% with the betamethasone valerate group. The mean percentage of the PASI score reduction was statistically significant in both groups but the betamethasone valerate group was significantly superior to the coal tar group. Both drugs' adverse effects were limited to mild irritation localized to the skin without systemic side effects. The Betamethasone valerate cream was safe, effective, and well-tolerated while the coal tar cream was described as messy, malodorous, and with a tendency to staining clothes. CONCLUSION: The investigator's overall assessment of the treatment response at completion of the trial demonstrated that the betamethasone valerate group achieved significantly greater clearance and marked improvement compared with the coal tar group.
Subject(s)
Adult , Aged , Anti-Inflammatory Agents/adverse effects , Betamethasone Valerate/adverse effects , Chronic Disease/drug therapy , Coal Tar/adverse effects , Disease Progression , Female , Health Status Indicators , Humans , Keratolytic Agents/adverse effects , Male , Middle Aged , Psoriasis/drug therapy , Thailand , Treatment OutcomeABSTRACT
A case of psoriasis presented with sudden simultaneous bilateral sudden sensorineural hearing loss after taking oral acitretin. Audiogram showed bilateral symmetrical sensorineural hearing loss. Her symptom improved after a short course of prednisolone. It is suggested that acitretin may affect hearing acuity.
Subject(s)
Acitretin/adverse effects , Adult , Female , Hearing Loss, Bilateral/chemically induced , Hearing Loss, Sensorineural/chemically induced , Humans , Keratolytic Agents/adverse effects , Psoriasis/drug therapyABSTRACT
El objetivo de éste trabajo es dar a conocer a los dermatólogos no introducidos en el tema, en qué consiste un peeling, indicaciones, contraindicaciones y tipos de peeling con ácido tricloroacético al 35 por ciento, ya que consideramos que es importante conocer bien la técnica y los cuidados pre y posoperatorios para minimizar los efectos secundarios. Se hace una revisión de los probables efectos secundarios que pueden aparecer y se comenta su manejo en la experiencia personal de los autores. Los peelings químicos representan un avance en el tratamiento del envejecimiento cutáneo, pero debemos conocer bien el manejo del paciente, ya que la finalidad de un peeling es simepre mejorar la calidad de la piel