ABSTRACT
A tuberculose é uma das doenças mais antigas do mundo. Os fatores de vulnerabilidade social, individual, programática, permitem que a tuberculose fique em latência por vários anos no indivíduo. Objetivo: Analisar, por meio de dados secundários, incidência e protocolo de infecção latente de tuberculose no município de São Paulo. Método: Trata-se de revisão sistemática da literatura. Em 29 de agosto de 2023, com a busca no Descritores em ciências da saúde: Tuberculose AND Infecção Latente, foram encontrados 4.527 artigos, após aplicação dos filtros: Base de dados LILACS e MEDLINE, texto completo, em Português, 2018 a 2023, restaram 38 documentos que foram submetidos ao checklist PRISMA. Resultados: Restaram 16 artigos que embasaram os resultados e a discussão. Conclusão: Iniciativas, como a busca ativa de comunicantes de tuberculose, devem ser construídas a partir de estratégias propostas em conjunto com pesquisadores e gestores alinhados ao Ministério da Saúde.(AU)
Tuberculosis is one of the oldest diseases in the world. Social, individual and programmatic vulnerability factors allow tuberculosis to remain latent for several years in the individual. Objective: To analyze, using secondary data, the incidence and protocol of latent tuberculosis infection in the city of São Paulo. Method: This is a systematic literature review. On August 29, 2023, 4,527 articles were found after applying the filters in the Health Sciences Descriptors: Tuberculosis AND Latent Infection: LILACS and MEDLINE database, full text, in Portuguese, 2018 to 2023, 38 documents remained that were submitted to the PRISMA checklist. Results: 16 articles were found to support the results and discussion. Conclusion: Initiatives, such as the active search for tuberculosis communicants, should be built on strategies proposed jointly with researchers and managers in line with the Ministry of Health.(AU)
La tuberculosis es una de las enfermedades más antiguas del mundo. Factores sociales, individuales y programáticos de vulnerabilidad permiten que la tuberculosis permanezca latente por varios años en el individuo. Objetivo: Analizar, a partir de datos secundarios, la incidencia y el protocolo de infección tuberculosa latente en el municipio de São Paulo. Método: Se trata de una revisión sistemática de la literatura. El 29 de agosto de 2023, fueron encontrados 4.527 artículos después de la aplicación de los filtros en los Descriptores de Ciencias de la Salud: Tuberculosis E Infección Latente: Base de datos LILACS y MEDLINE, texto completo, en portugués, 2018 a 2023, permanecieron 38 documentos que fueron sometidos a la lista de verificación PRISMA. Resultados: Quedaron 16 artículos, que constituyeron la base de los resultados y la discusión. Conclusión: Iniciativas como la búsqueda activa de comunicantes de tuberculosis deben construirse a partir de estrategias propuestas conjuntamente por investigadores y gestores en consonancia con el Ministerio de Salud.(AU)
Subject(s)
Tuberculosis , Latent InfectionABSTRACT
Abstract Heart transplantation (HT) is an established treatment for patients with advanced heart failure (HF). Chagas disease (CD), caused by the Trypanosoma cruzi (T.cruzi) is an important cause of HF in Latin America. Considering CD is a chronic infectious disease, the use of immunosuppressive therapy after HT can reactivate T. cruzi infection and compromise outcomes. Early diagnosis and treatment of this complication is extremely important, which requires knowledge, experience, and a high degree of suspicion by transplant physicians. Furthermore, with the international immigration of people, CD is no longer exclusive to Latin America, since a large number of immigrants with T. cruzi infection are living in non-endemic countries. This phenomenon represents not only a new global epidemiological problem, but also a challenge for transplant teams. This review aims to discuss the peculiarities of HT in the context of CD, with a focus on reactivation of the infection, clinical manifestations, etiological treatment of T. cruzi and differential diagnosis with allograft rejection, among HT recipients.
Subject(s)
Chagas Cardiomyopathy/surgery , Graft Rejection/prevention & control , Heart Transplantation/adverse effects , Heart Transplantation/methods , Immunosuppression Therapy/adverse effects , Latent Infection/prevention & controlABSTRACT
El Ministerio de Salud, a través del Programa Nacional de Tuberculosis y Enfermedades Respiratorias (PNTYER), a fin de dar respuesta al Plan Estratégico Nacional Multisectorial de Tuberculosis y al Plan Quinquenal de Salud a través de la ejecución del Modelo de atención integral en salud con enfoque familiar y comunitario, emite la primera edición de los Lineamientos técnicos para la atención de personas con infección latente por tuberculosis, contribuyendo al desarrollo de las acciones integrales de forma transversal a través del Sistema Nacional Integrado de Salud (SNIS) y Dirección General de Centros Penales para la búsqueda, diagnóstico y tratamiento de personas con infección latente por TB, utilizando métodos diagnósticos disponibles y la adaptación de esquemas de tratamiento acordes a las directrices de la Organización Mundial de la Salud (OMS) de 2018
The Ministry of Health, through the National Tuberculosis and Respiratory Diseases Program (PNTYER), in order to respond to the National Multisectoral Tuberculosis Strategic Plan and the Five-Year Health Plan through the execution of the Comprehensive Health Care Model with family and community approach, issues the first edition of the Technical Guidelines for the care of people with latent tuberculosis infection, contributing to the development of comprehensive actions in a transversal manner through the National Integrated Health System (SNIS) and the General Directorate of Centers. Penalties for the search, diagnosis and treatment of people with latent TB infection, using available diagnostic methods and the adaptation of treatment schemes according to the 2018 World Health Organization (WHO) guidelines
Subject(s)
Tuberculosis , Latent Infection , Attention , DiagnosisABSTRACT
La reactivación de la enfermedad de Chagas en pacientes HIV/sida con bajos recuentos de LTCD4 es un problema que complica el manejo de ambas infecciones. Se dispone actualmente de dos fármacos antichagá-sicos con eficacia debidamente documentada en pacientes no coinfecta-dos. Sin embargo, existe poca evidencia y experiencia clínica en cuanto a la eficacia y la seguridad del tratamiento integral en este grupo de pa-cientes susceptibles de sufrir distintos efectos adversos a fármacos y con altas tasas de mortalidad a corto y mediano plazo. En el presente artículo se describen las consideraciones (en especial las que atañen a la poten-ciación de efectos adversos y la posibilidad de interacciones farmacoló-gicas), que deben tenerse en cuenta acerca del tratamiento antirretrovi-ral, antichagásico y anticonvulsivante conjunto y los esquemas terapéu-ticos más adecuados para pacientes coinfectados
Reactivation of Chagas Disease in patients HIV/AIDS with low counts LTCD4 is a problem that complicates management of both infections. There are currently two antiparasitic drugs properly documented efficacy in patients non-co-infected patients. However, there is little evidence and clinical experience regarding the efficacy and safety of an integral treatment in this group of patients, who are susceptible of suffering diverse adverse drug reactions and who have high mortality rates both in the short and long-term. In this article we describe the considerations (especially those related to adverse effects and possibility of pharmacological interactions) that must be taken into account during the combined antiretroviral, antichagasic and anticonvulsant treatment, as well as the most convenient treatment for patients described co-infected.