ABSTRACT
The pretibial myxedema is a manifestation of Graves' disease characterized by accumulation of glycosaminoglycans in the reticular dermis. The dermopathy is self-limiting but in some cases may cause cosmetic and functional damage. Conventional treatment is use of topical steroids under occlusive dressing, however the intralesional application has shown good results. We present a case of pretibial myxedema treated with single injection of intralesional corticosteroid.
.Subject(s)
Humans , Male , Young Adult , Adrenal Cortex Hormones/administration & dosage , Graves Disease/drug therapy , Leg Dermatoses/drug therapy , Myxedema/drug therapy , Triamcinolone/administration & dosage , Biopsy , Graves Disease/pathology , Injections, Intralesional/methods , Leg Dermatoses/pathology , Myxedema/pathology , Treatment OutcomeABSTRACT
Grave's disease is an autoimmune disease of thyroid gland and pretibial myxedema occurs in 4% of these patients. We present a 50-year-old man with Grave's disease who was referred with nonpitting, edematous, erythematous plaques on legs and feet that became elephantiasic. Biopsy of skin revealed granular material deposition in dermis with splitting of collagen fibers. This is a rare presentation of pretibial myxedema that presented in this case
Subject(s)
Humans , Male , Elephantiasis/diagnosis , Elephantiasis/pathology , Graves Disease/complications , Graves Disease/diagnosis , Graves Disease/pathology , Myxedema/diagnosis , Myxedema/etiology , Myxedema/pathologySubject(s)
Humans , Male , Female , Adult , Middle Aged , Myxedema/diagnosis , Triamcinolone Acetonide/therapeutic use , Administration, Topical , Hyperthyroidism/complications , Injections, Intralesional , Mucinosis, Follicular/diagnosis , Mucinosis, Follicular/drug therapy , Myxedema/drug therapy , Myxedema/pathologySubject(s)
Humans , Male , Female , Middle Aged , Diagnosis, Differential , Leg Dermatoses/etiology , Myxedema/drug therapy , Azathioprine/therapeutic use , Chronic Disease , Exophthalmos , Hyaluronoglucosaminidase/therapeutic use , Hyperthyroidism/complications , Leg Dermatoses/drug therapy , Leg Dermatoses/pathology , Mucins , Myxedema/diagnosis , Myxedema/pathology , Osteoarthropathy, Secondary Hypertrophic/pathology , Thyroid Diseases , Triamcinolone Acetonide/therapeutic useABSTRACT
Por largo tiempo la patogénesis del mixedema pretibial fue un misterio. Investigaciones recientes han corroborado la naturaleza autoinmune del padecimiento y han señalado el papel importante de citoquinas en la expresión de moléculas HLA-DR en su fisiopatología. Como se sospechaba, el fibroblasto es la célula blanco efectora
Subject(s)
Fibroblasts/cytology , Fibroblasts/metabolism , Glycosaminoglycans , Glycosaminoglycans/metabolism , Leg Dermatoses/pathology , Myxedema/immunology , Myxedema/pathologyABSTRACT
Se presenta una paciente con exoftalmia, mixedema pretibial e infiltración de los dedos de las manos que en el extremo distal adoptan la forma de palillo de tambor con uñas en vidrio de reloj. Sa analizan las características clínicas, histopatológicas y radiológicas y se efectúa una revisión de la literatura de este raro síndrome
Subject(s)
Exophthalmos/etiology , Hyperthyroidism/complications , Leg Dermatoses/etiology , Myxedema/pathology , Osteoarthropathy, Secondary Hypertrophic/etiology , Elephantiasis/complications , Imidazoles/analogs & derivatives , Imidazoles/therapeutic use , Myxedema/drug therapy , Myxedema/etiology , Osteoarthropathy, Secondary Hypertrophic/physiopathology , Osteoarthropathy, Secondary Hypertrophic , Prednisone/therapeutic use , Propranolol/therapeutic use , Thyroiditis, Autoimmune/complications , Triamcinolone Acetonide/therapeutic useABSTRACT
Os autores fazem uma breve bibliográfica sobre o líquen mixedematoso, entidade relativamente rara. A seguir, apresentam um caso desta dermatose em paciente do sexo masculino em que o diagnóstico clínico se confirmou pelos achados histopatológicos