ABSTRACT
Nitric oxide donors proved to have gastroprotective effect experimentally but the clinical applicability of this effect is limited by pharmaceutical nature of these drugs. Transdermal nitroglycerine adhesive patches [TNAP] is a safe clinically used preparation provide a continuous administration of NO with constant rate the aim of this study is to evaluate the effect of [TNAP] on ethanol induced gastric ulcer in rats and the possible underlying mechanisms. TNAP caused significant improvement in ethanol, 90%, induce gastric ulcers in rats. This improvement is represented by significant reduction of Ulcer index [56%], volume of gastric secretion [40%], titrable acidity [67%], peptic activity [62%], mucin concentration in gastric secretion [36%] and vascular Permeability expressed as [g Evans blue/g. tissue [47.6c1] compared with rats received 1 ml/rat ethanol P.O. TNAP release 20-25 micro g/cm3/h for 2 hours [400-1000 micro g/rat as surface area of TTS-5 used in this work is 10 cm[3]] proved to have gastroprotective effect against ethanol 90% [Topical acute injury]. This gastroprotective may be mediated by reduction of acid secretion and peptic activity, reversal of ethanol induced inhibition of mucin binding protein and vascular damage