Efectividad de la terapia cognitivo conductual para trastorno obsesivo compulsivo en pacientes con trastorno del espectro autista: Artículo de revisión / Effectiveness of cognitive behavioral therapy for obsessive compulsive disorder in patients with autism spectrum disorde: Review article

La terapia cognitivo conductual (TCC), es el tratamiento de elección para el trastorno obsesivo compulsivo (TOC), principalmente la exposición con prevención de respuesta (EPR). En pacientes que presentan TOC co-ocurrente con trastorno del espectro autista (TEA) se cree que la TCC tendría un menor efecto debido al empobrecimiento de la comprensión de las propias emociones y de la rigidez cognitiva de estos pacientes. A través de la siguiente revisión se busca evaluar la efectividad de la TCC en pacientes que tengan TOC en asociación a TEA en niños, adolescentes y adultos. Métodos: Se realizó una búsqueda de artículos, de los últimos 10 años, que abordasen la efectividad de la TCC en niños, adolescentes o adultos con TOC y TEA en conjunto. Resultados: A pesar de que no todos los estudios concuerdan en sus resultados, la mayoría de éstos, indican que hay efectividad en la TCC en disminuir la sintomatología del TOC en pacientes con TEA co-ocurrente tanto en niños como en adolescentes y adultos. Existen terapias de TCC con ciertas adaptaciones que mejorarían los resultados de estos pacientes al personalizar su tratamiento, por lo que se incentiva al mayor desarrollo de este tipo de terapias. Conclusión: Los estudios revisados respaldan que a pesar de la rigidez que presentan los pacientes con TEA co-ocurrente, la TCC es efectiva para tratar TOC en niños, adolescentes y adultos, especialmente al realizar adaptaciones de esta.

The treatment of choice for obsessive compulsive disorder (OCD) is cognitive behavioral therapy (CBT), mainly exposure with response prevention (ERP). In patients with OCD co-occurring with autism spectrum disorder (ASD), it is believed that CBT should have a lesser effect due to the impoverishment of the understanding of their own emotions and the cognitive rigidity of these patients. The following review seeks to evaluate the effectiveness of CBT in patients who have OCD in association with ASD in children, adolescents and adults. Methods: A search was carried out for articles, from the last 10 years, that addressed the effectiveness of CBT in children, adolescents or adults with OCD and ASD together. Results: Although not all studies agree on their results, most of these indicate that CBT is effective in reducing OCD symptoms in patients with co-occurring ASD in children, adolescents and adults. There are CBT therapies with certain adaptations that would improve the results of these patients by personalizing their treatment, which is why the further development of this type of therapy is encouraged. Conclusion: The reviewed studies support that despite the rigidity that patients with co-occurring ASD present, CBT is effective to treat OCD in children, adolescents and adults, especially when making adaptations to it.

Estimulación cerebral profunda: tratamiento para pacientes con diagnóstico de trastorno obsesivo-compulsivo resistente / Deep brain stimulation: treatment for patients diagnosed with disorder obsessive-compulsive resistant

El trastorno obsesivo-compulsivo (TOC) afecta al 2% de la población general, llegando en ocasiones a causar un deterioro funcional severo y de la calidad de vida de las personas afectadas. Entre el 10 y el 30% de los pacientes con este trastorno no responde a los tratamientos recomendados: farmacológicos y terapia cognitivo-conductual. La Food and Drug Administration de los Estados Unidos (FDA) aprobó en el año 2008 la Estimulación cerebral profunda (ECP) para pacientes con TOC resistente a tratamiento. La ECP, utilizada frecuentemente para el tratamiento de la enfermedad de Parkinson refractaria, es una opción viable para los pacientes con TOC resistente, con efectos adversos poco frecuentes y transitorios. (AU)

Obsessive-compulsive disorder (OCD) affects 2% of the general population, sometimes resulting in severe impairment of functional capacity and quality of life of affected people. Between 10 and 30% of these patients do not respond to recommended treatments: pharmacological and cognitive behavioral therapy. In 2008, the FDA approved Deep Brain Stimulation (DBS) for patients with OCD resistant to treatment. DBS, frequently used for the treatment of refractory Parkinson's disease, is a viable option for the treatment of patients with resistant OCD, with infrequent and transient adverse effects. (AU)

Psychoactive substance abuse and dependence and its association with anxiety disorders: a population-based study of young adults in Brazil

Objective: To evaluate the association between abuse of and dependence on different psychoactive substances and the presence of anxiety disorders in a sample of young adults from a city in southern Brazil. Methods: Between 2007 and 2009, we carried out a cross-sectional, population-based study of individuals aged 18-24 years who lived in Pelotas, a city in southern Brazil. We evaluated anxiety disorders using the Mini International Neuropsychiatric Interview 5.0 (MINI), and use of psychoactive substances with the Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST 2.0/0MS). We used Fisher's exact test for univariate analysis, and Poisson regression models with robust variance for multivariable analysis. Results: The sample consisted of 1,560 young adults. The overall prevalence of abuse/dependence was 26.9% for alcohol, 24.9% for tobacco, and 7.3% for illicit substances. Individuals with agoraphobia had a 32% higher prevalence of tobacco abuse/dependence (prevalence ratio [PR] = 1.32 [95%CI 1.01-1.74]). Individuals with posttraumatic stress disorder (PTSD) or generalized anxiety disorder (GAD) had a 2.41-fold (95%CI 1.22-4.77) and 1.76-fold (95%CI 1.00-3.11) higher prevalence of illicit substance abuse/dependence, respectively. Conclusion: In this population-based sample, we found associations between GAD, PTSD, and increased prevalence of illicit substance abuse/dependence. In addition, individuals with agoraphobia seem to have increased tobacco abuse/dependence.

Clinical and familial profile of bipolar disorder with and without obsessive-compulsive disorder: an Indian study / Perfil clínico e familiar do transtorno bipolar com e sem transtorno obsessivo-compulsivo: estudo indiano

Abstract Introduction Comorbid obsessive-compulsive disorder (OCD) is common in bipolar disorder (BD). Clinical characteristics, functionality and familial pattern of this comorbidity are largely understudied. Objective To assess clinical profile, familial loading of psychiatric disorders and level of functioning in remitted BD patients who have comorbid OCD and to compare results with those of remitted BD patients without OCD. Methods Remitted BD-I subjects were assessed using the Structured Clinical Interview for DSM-IV Axis I Disorders, Global Assessment of Functioning Scale (GAF), Hamilton Depression Rating Scale (HDRS), Young Mania Rating Scale (YMRS), Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and Family Interview for Genetic Studies (FIGS). BD patients with and without OCD were compared. Group differences were analyzed using the chi-square test and the independent samples t test. Values <0.05 were considered statistically significant. Results Of the 90 remitted BD-I patients, 35.5% (n=32) had obsessive-compulsive symptoms/OCD. The BD-OCD group showed significantly lower GAF scores, higher rates of suicidal attempts, hospitalizations, manic and depressive episodes compared to the group with BD only (p<0.05). In addition, first and second-degree relatives had higher rates of BD-OCD and OCD, but not of BD. Conclusions BD-OCD is characterized by more severe BD, more dysfunction and higher familial loading of BD-OCD and OCD. Larger studies involving relatives of probands will help to confirm our findings and to delineate nosological status of BD-OCD comorbidity.

Resumo Introdução Transtorno obsessivo-compulsivo (TOC) comórbido é comum no transtorno bipolar (TB). Características clínicas, funcionalidade e história familiar dessa comorbidade são pouco estudadas. Objetivo Avaliar o perfil clínico, a carga familiar de transtornos psiquiátricos e o nível de funcionalidade em pacientes com TB em remissão que apresentam TOC comórbido e comparar os resultados com aqueles obtidos em pacientes com TB em remissão sem TOC. Métodos Indivíduos com TB-I em remissão foram avaliados usando a Entrevista Clínica Estruturada para o DSM-IV- Transtornos do Eixo I, Escala de Avaliação Global do Funcionamento, Escala de Depressão de Hamilton, Escala de Mania de Young, Escala Obsessivo-Compulsiva de Yale-Brown e Entrevista Familiar para Estudos Genéticos. Pacientes com TB com e sem TOC foram comparados. Diferenças entre os grupos foram analisadas usando o teste do qui-quadrado e o teste t para amostras independentes. Valores <0,05 foram considerados estatisticamente significativos. Resultados Dos 90 pacientes com TB-I em remissão, 35,5% (n=32) tinham sintomas obsessivo-compulsivos/TOC. O grupo com TB-TOC mostrou escores significativamente mais baixos na Escala de Avaliação Global do Funcionamento, maiores taxas de tentativas de suicídio, hospitalizações, episódios maníacos e depressivos quando comparado ao grupo com apenas TB (p<0,05). Além disso, familiares de primeiro e segundo grau mostraram maiores níveis de TB-TOC e TOC, mas não de TB. Conclusões TB-TOC se caracteriza por TB de maior gravidade, mais disfunção e maior carga familiar de TB-TOC e TOC. Estudos maiores envolvendo familiares de probandos ajudarão a confirmar nossos achados e a delinear o status nosológico de TB-TOC comórbidos.

Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates

Objective: In obsessive-compulsive disorder (OCD), symmetry-related symptoms may be important. Although clinical correlates of symmetry-related symptoms have been identified in OCD, few data exist on genetic associations. Animal studies indicate involvement of dopamine in symmetry-related behavior, suggesting this may be relevant to analogous symptoms in OCD. Alterations in dopamine may also reflect environmental influences. However, the association of symmetry-related symptomatology, early adversity, and polymorphisms in dopaminergic genes has not been investigated in OCD. Methods: Clinical information and polymorphisms in key dopaminergic genes were compared between OCD patients with primary symmetry symptoms and those without. Results: OCD patients with primary symmetry symptoms comprised 46.6% (n=210) of the sample (n=451), and were older (p < 0.01), had longer illness duration (p < 0.01), higher OCD severity scores (p = 0.01), and greater comorbidity (p < 0.01) than those without. In Caucasians (n=343), genotype frequency differed significantly between groups for ANKK1 rs1800497, with more OCD patients with symmetry symptoms being homozygous for the A2 (CC) genotype (χ2 = 7.296; p = 0.026). Conclusion: Symmetry symptoms have some distinct clinical features and may represent a marker of severity in OCD. However, clinical associations, in combination with the association found with the ANKK1 rs1800497 A2 variant, suggest that primary symmetry symptoms may represent a distinctive clinical and psychobiological profile.

Functional Gastrointestinal Disorders in Young Military Men

BACKGROUND/AIMS: To estimate the prevalence and evaluate the associated psychological factors of functional gastrointestinal disorders (FGIDs) in males in their twenties who are currently enrolled in military service. METHODS: A total of 1,073 men in the Korean army were asked to complete questionnaires based on the Rome III criteria and Symptom Checklist-90-revised (SCL-90R). The prevalence of FGIDs was estimated, and the associated psychological factors were evaluated. RESULTS: A total of 967 men participated. The total prevalence of FGIDs was 18.5% (age-adjusted prevalence, 18.1%; 95% confidence interval [CI], 15.3% to 20.8%). The total SCL-90R scores were higher in men with FGIDs than men without FGIDs (24 [interquartile range, 13 to 44] vs 13 [5 to 28], p<0.001) and higher in men with overlapping syndromes than in those with single FGIDs (31 [18 to 57] vs 14 [5.75 to 29], p<0.001). Somatization (odds ratio [OR], 1.141; 95% CI, 1.09 to 1.20; p<0.001), obsessive-compulsive behaviors (OR, 1.084; 95% CI, 1.03 to 1.14; p=0.002) and depression (OR, 0.943; 95% CI, 0.90 to 0.99; p=0.020) were identified as independent predictive factors for FGIDs. CONCLUSIONS: FGIDs are common among men in their twenties who are fulfilling their military duty. Somatization and obsessive-compulsive features from the tense atmosphere are associated with the development or progression of FGIDs. Patients who exhibit overlapping syndromes require greater attention given their more severe psychopathology.

Neuropsychological Correlates for Obsessive Slowness.

Aim : To assess the cognitive functioning of a group of patients with OCD and a group of matched normal controls. Method : Patients of OCD were screened for selection criteria. They were assessed on Wisconson Card Sorting Test (WCST) and Continuous Performance Test (CPT) for neuro-cognitive impairments and compared the same with matched controls. Conclusions : On WCST, clinical group performed poorly, which is statistically significant. On CPT, the patient groups made significantly more wrong responses, more missed responses and took more time to respond, which is statistically significant.

Tricotilomanía: abordaje diferenciado según la franja etaria en la infancia / Trichotillomania: differentiated approach depending on the age group in children

Introducción: La tricotilomanía se caracteriza por áreas de alopecia causadas por la tracción de cabellos realizada por el mismo paciente y es más frecuente en edades pediátricas. No obstante, existen pocos trabajos sobre esta enfermedad. Este estudio tiene como objetivo delinear las características clínicas y evolutivas de la tricotilomanía en un grupo de niños Resultados: Hubo 47 casos de tricotilomanía, de los cuales 32 (68%) fueron niñas. Se observó una mayor predisposición en el género femenino luego de los 5 años (mientras en las menores de 5 años el 56% estuvo afectada, en las mayores de 5 años el porcentaje se elevó al 76%). La edad media de inicio fue de 6 años, variando entre los 7 meses y los 11 años. La presencia de factores precedentes como cambios en la dinámica familiar, problemas psicológicos y enfermedades se determinó en 29 pacientes y fue más común en los niños mayores de 5 años. La región parieto-temporal fue la más afectada y las pestañas y cejas las menos comprometidas. En el 74% de los casos se inició tratamiento con placebo y se obtuvo una buena respuesta...

Introduction: Trichotillomania is characterised by alopecic areas caused by patients pulling out their hair. There are few works on this disease in the pediatric age group. The aim of this study is to delineate the clinical characteristics and evolution of trichotillomania in childhood.Results: There were 47 cases, 32 (68%) girls, with a higher difference between genders was observed over the age of 5 (of the group of under 5, 56% were while over this age they represented the 76%). Median age at onset was 6 years, ranging from 7 months to 11 years. Prior factors such as changes in family dynamics, psychological problems and diseases occurred in 29 patients, more current in the over 5 years old. The parieto-temporal region was the most affected and eyelashes and eyebrows the least removed. Placebo treatment was instituted in 74% with good response...

Impact of Eating Psychopathology, Obsessive-Compulsion and Depression on Self-Harm Behavior in Patients with Eating Disorders

PURPOSE: The purpose of the study was to investigate psychological factors such as eating psychopathology, depression, and obsessive-compulsion that might influence self-harm behavior in patients with eating disorders. METHODS: Patients with eating disorders (n=135) who visited "M" clinic for eating disorders participated in the study. Data were collected from March to August 2007 using the Eating Disorder Inventory-2, Beck Depression Inventory, Maudsley Obsessional-Compulsive Inventory, and Self-Harm Inventory (SHI). RESULTS: The participants scored high on self-harm as well as on depression and obsessive-compulsion. On the SHI, a high frequency of self harm behavior such as 'torturing self with self-defeating thoughts', 'abused alcohol', 'hit self', and 'suicide attempt' were found for the participants. There were significant correlations between most eating psychopathology variables, depression, obsessive-compulsion, and self-harm behavior. 'Interoceptive awareness' (eating psychopathology), depression, and 'checking' (obsessive-compulsion) were significant predictors of self-harm behavior. CONCLUSION: Future interventions for patients with eating disorders should focus on assessing the possibility of self-harm and suicidal attempts, especially in those patients with high levels of eating psychopathology, depression, or obsessive-compulsion. Early intervention for depression and obsessive-compulsion could contribute to preventing self-harm and suicide in patients with eating disorders.

Esquizofrenia con síntomas obsesivos compulsivos o el grupo de las Esquizofrenias Esquizoobsesivas: características clínicas y pronósticas / Schizophrenia with obsessive-compulsive symptoms or the group of schizo-obsessive schizophrenias: clinical characteristics and prognosis

Este trabajo es una revisión bibliográfica crítica de lo publicado a la fecha acerca de la Esquizofrenia Esquizoobsesiva o el grupo de las Esquizofrenias Esquizoobsesivas, en el cual se repasan las características clínicas, neuropsicológicas y pronósticas. Se discute además la replicabilidad de los hallazgos publicados y se propone un esquema nosológico de integración.

Obsessive-compulsive symptoms (OCS) have been observed in a substantial proportion of schizophrenic patients. In this paper, the rate of occurrence of OCS and OCD in schizophrenic patients, and also the interrelationship between OCS and schizophrenic symptoms, depressive symptoms, cognitive function and age are reviewed. The author proposes to use the term "group of schizo-obsessive disorders" and proposes an integrate classification system.

Family burden, quality of life and disability in obsessive compulsive disorder: an Indian perspective.

BACKGROUND: Obsessive compulsive disorder (OCD) is a psychiatric disorder that often tends to run a chronic course. The lifetime prevalence of OCD is around 1-3%, which is twice as prevalent as schizophrenia and bipolar disorder. AIM: To asses the family burden, quality of life (QoL) and disability in patients suffering from at least moderately ill OCD and then to compare them with schizophrenia patients of comparable severity. SETTINGS AND DESIGN: We recruited 70 consecutive subjects (OCD=35, schizophrenia=35) who met study criteria between March 2005 and March 2006 from the psychiatric services of the National Institute of Mental Health and Neuro Sciences, Bangalore, India. MATERIALS AND METHODS: The severity of illness was rated using the Clinical Global Impression-Severity (CGI-S). Instruments used in the current study were the Family Burden Schedule, the World Health Organization (WHO) QoL (Bref) and the WHO - Disability Assessment Schedule (DAS). STATISTICAL ANALYSIS: The Fisher's exact test/chi-square test was used to compare categorical variables and the independent sample t test was used to analyze continuous variables. Analysis of covariance (ANCOVA) was used to compare the groups after controlling for potential confounding variables. Pearson's correlation was used for correlation analysis. RESULTS: Overall family burden, financial burden and disruption of family routines were significantly higher in schizophrenia patients compared to OCD although the groups did not differ with respect to other domains of family burden. On the WHO QoL, OCD patients were comparable to schizophrenia patients with respect to the psychological and social domains. On the WHO - DAS, both the groups were similar in all the domains except getting around. CONCLUSION: Severe OCD is associated with significant disability, poor QoL and high family burden, often comparable to schizophrenia. Therefore, there is an urgent need to increase the sensitivity among healthcare professionals to recognize and treat OCD.

Qualidade de vida em indivíduos com transtorno obsessivo-compulsivo: revisão da literatura / Quality of life in individuals with obsessive-compulsive disorder: a review

OBJETIVO: O transtorno obsessivo-compulsivo acomete entre 1,6 a 3,1 por cento da população. Em virtude de uma maior compreensão do sofrimento associado aos sintomas, aumentaram os estudos e o interesse no bem-estar geral e na qualidade de vida dos portadores. MÉTODO: Foi realizada uma revisão bibliográfica de trabalhos que investigaram a qualidade de vida em portadores de transtorno obsessivo-compulsivo. A busca foi feita nas bases de dados Medline, SciELO e PsychoInfo, utilizando como palavras-chave quality of life e obsessive-compulsive disorder. Foram selecionados 27 artigos que abordaram o tema, sendo descritas as áreas mais afetadas pelo transtorno, bem como a sua relação com a qualidade de vida foram descritas. Também foram apresentados efeitos de tratamentos na qualidade de vida dos pacientes. RESULTADOS: Os relacionamentos sociais e familiares, seguidos pelo desempenho ocupacional (capacidade para trabalhar e estudar), foram as áreas mais afetadas pelo transtorno e, apesar de melhorarem com tratamento, permanecem insatisfatórios. As obsessões foram associadas a prejuízos mais significativos na qualidade de vida do que as compulsões (rituais). CONCLUSÕES: Apesar das limitações, os estudos mostram evidências do comprometimento da qualidade de vida de indivíduos com transtorno obsessivo-compulsivo, sendo este comparável ao de pacientes com esquizofrenia. Pesquisas futuras com diferentes delineamentos são necessárias para estabelecer resultados mais consistentes.

OBJECTIVE: Obsessive-compulsive disorder affects between 1.6 and 3.1 percent of the population. Due to the distress caused by obsessive-compulsive disorder leading to disability as well as the prevalence of the disease, there has been an increase in the number of studies focusing on the general well-being of patients by assessing quality of life. METHOD: A literature review of the studies that investigated the quality of life of patients with obsessive-compulsive disorder was performed. The search was carried out in the following database: Medline, SciELO and PsychoInfo, and the following key-words were used "quality of life" and "obsessive-compulsive disorder". Twenty-seven articles about the topic were selected. The results from this study describe the areas most severely affected by the disorder as well as the relationship between obsessive-compulsive disorder and quality of life. In addition, the effects of the treatment on the patients' quality of life are presented. RESULTS: The social and familial relationships and the occupational performance (capacity to work and study) were the areas most severely affected by the disorder, and, although there was an improvement with the treatment, these areas remain at a poor level of performance. The obsessions were associated with the most significant impairment of the quality of life if compared to the compulsions (rituals). CONCLUSIONS: Results from the selected studies suggest that obsessive-compulsive disorder patients have an impairment of quality of life. The level of impairment is similar to that of schizophrenic patients. Future studies with different designs are necessary so that more consistent results can be established.

Neurological soft signs in obsessive-compulsive disorder.

BACKGROUND: Neurological soft signs (NSSs) are defined as abnormal motor or sensory findings, including involuntary movements, a variety of dispraxia, difficulties in performing rapid alternating movements, difficulties in two-point discrimination, and graphesthesia in a person without a neurological disorder which can be determined as its focus. AIMS: to investigate the relationship of NSSs with obsessive-compulsive disorder (OCD). SETTINGS AND DESIGN: This study was designed in the Psychiatry Polyclinic of Ondokuz Mayis University Hospital. After signing an informed consent form, all the subjects were divided into 2 groups: (1) the patient group and (2) the control group. MATERIAL AND METHODS: Thirty consecutive patients presenting with DSM-IV OCD were included in this study. The control group consisted of 30 healthy subjects without a psychiatric/neurological disorder. All subjects underwent a physical and neurological examination for soft signs (PANESS). STATISTICAL ANALYSIS USED: The Mann-Whitney U test was used for statistical analysis of data. RESULTS: It was seen that graphesthesia, two-point discrimination, and total PANESS scores were significantly higher in the group with OCD than the control group. In other NSSs, there was no significant difference between the patient and control groups. CONCLUSIONS: Unlike some studies, in the present study, the difference between the groups in graphesthesia compared to other NSSs was significant. The results of this preliminary study suggest that there is a relationship between NSSs and OCD. We think that NSSs may point to a structural brain abnormality in patients with OCD.

Basal ganglia hemorrhagic ablation associated with temporary suppression of obsessive-compulsive symptoms

Currently, basal ganglia (BG) are considered regulators of motor and emotional activity. It's operationality encompass Obsessive Compulsive Disorder (OCD). The case of a patient suffering with severe OCD is described of note, his symptoms disappeared following a hemorrhage of the left BG. However, once the hemorrhage was reabsorbed his symptoms returned. It is possible that lesions affecting cerebral OCD association circuits may influence the evolution of obsessive-compulsive symptoms