ABSTRACT
The most common mixed glioma encountered in routine surgical practice is oligoastrocytoma (OA); however, its is currently considered a vanishing entity. The 2016 classification of the World Health Organization (WHO) discourages the diagnosis of tumors as mixed glioma. The recommendations are that diffuse gliomas, including those withmixed or ambiguous histological features, should be subjected tomolecular testing. Dual-genotype OAs are not yet a distinct entity or variant in the classification. We report a case ofmixed glioma: a pleomorphic xanthoastrocytoma (PXA)mixed with an oligodendroglioma. The immunohistochemistry (IHC) pattern of isocitrate dehydrogenase 1 (IDH1) negativity with retained nuclear expression of the alpha-thalassemia x-linked intellectual disability syndrome (ATRX) protein, and 1p19q co-deletion negativity in both the components enabled its identification as a mixed glioma rather than a collision tumor. To the best of our knowledge, the case herein presented is the fourth case of PXA with oligodendroglioma. Out of the other three reported cases, only one was of a collision tumor with a dual genotype, and the other two showed similar molecular signatures in both components. The present article discusses the histological, immunohistochemical and molecular features of the aforementioned case.
Subject(s)
Humans , Male , Adult , Oligodendroglioma/surgery , Astrocytoma/surgery , Brain Neoplasms/therapy , Neoplasms, Multiple Primary/surgery , Oligodendroglioma/pathology , Oligodendroglioma/diagnostic imaging , Astrocytoma/pathology , Temporal Lobe/surgery , Aconitate Hydratase/genetics , Chromosomes, Human, Pair 1 , Chromosomes, Human, Pair 19 , Chromosome Deletion , Telomerase/genetics , Craniotomy/methodsABSTRACT
Anaplastic oligodendrogliomas (AOs) correspond to 23% of all oligodendrogliomas. They correspond to a tumor with malignant histological characteristics, focal or diffuse, associated with a worse prognosis. In the present case report, we describe the case of a 30-year-old female submitted to resection of a right parietal lesion whose histology showed to be an AO. She underwent complementary treatment with chemotherapy and radiotherapy according to the Roger Stupp protocol. Four years after the initial diagnosis, there was tumor recurrence within the superior sagittal sinus, with no evidence of recurrence elsewhere. In the literature, we have found no similar published case reinforcing the rarity of this condition.
Subject(s)
Humans , Female , Adult , Oligodendroglioma/surgery , Oligodendroglioma/complications , Oligodendroglioma/radiotherapy , Oligodendroglioma/diagnostic imaging , Superior Sagittal Sinus/abnormalitiesABSTRACT
Anaplastic Oligodendroglioma / Anaplastic Oligoastrocytoma [AO/AOA] is a WHO Grade-III primary brain tumor. These tumors comprise about 5 - 10% of all gliomas, which make them the third most common primary brain tumors after glioblastoma multiforme and astrocytomas. For many years standard of treatment remained Maximum Safe Resection [MSR] followed by Radiotherapy [RT]. These tumors have also been known to be sensitive to alkylator-based chemotherapy particularly the subset having 1p/19q co-deletion signature. There is robust data showing that these tumors are responsive to chemotherapy in recurrent or progressive setting. Recently, up front chemotherapy has been added to standard post-surgery RT. It has been found that subset of AO/AOA having 1p/19q co-deletion responded very well to the addition of chemotherapy. This substantial benefit in terms of median Overall Survival [OS] and median Progression Free Survival [PFS] have intrigued the personalized treatment of AO/AOA on the basis of molecular signature markers
Subject(s)
Humans , Oligodendroglioma/surgery , Astrocytoma/surgery , Astrocytoma/therapy , Brain Neoplasms , Oligodendroglioma/radiotherapy , Oligodendroglioma/prevention & control , Oligodendroglioma/classification , Oligodendroglioma/diagnosis , Radiotherapy , Antineoplastic AgentsABSTRACT
Os astrocitomas e oligodendrogliomas supratentoriais dos adultos são tumores infrequentes. Analisamos retrospectivamente 23 pacientes com este tipo de neoplasia que foram operados entre 1986 e 2002. Não ocorreu nenhum óbito no pós-operatório. A sobrevida de 5 e 10 anos de todo o grupo foi 67 e 30 por cento respectivamente, semelhante a outras experiências. Em 14 pacientes obtivemos a remoção completa da lesão (60,8 por cento) e em 9 (39,2 por cento) ocorreu remoção parcial do tumor. No subgrupo da ressecção total do tumor, 89 por cento sobreviveram 5 anos e 45 por cento alcançaram 10 anos de sobrevida, em contraste com o subgrupo da remoção parcial em que somente 35 por cento alcançaram os 5 anos de sobrevida e nenhum, 10 anos. Devido aos efeitos deletérios da radioterapia, nós preferimos prescrevê-la apenas nos casos de recorrência tumoral.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Glioma/surgery , Supratentorial Neoplasms/surgery , Astrocytoma/diagnosis , Astrocytoma/surgery , Disease-Free Survival , Glioma/diagnosis , Magnetic Resonance Imaging , Oligodendroglioma/diagnosis , Oligodendroglioma/surgery , Retrospective Studies , Supratentorial Neoplasms/diagnosisABSTRACT
A case of a patient operated on twice for a temporoparietal anaplastic oligondendroglioma, followed by radiotherapy, is reported. Although no intracranial recurrence has happened, a biopsyproven extracranial cervical lymphnode metastasis was diagnosed 15 months later. Surgical manipulation of the primary lesion by lymphatic and/or blood vessel invasion seem to be the main suspected factors in the development of CNS tumors metastasis in the head and neck region.
Subject(s)
Humans , Male , Adult , Brain Neoplasms/pathology , Lymph Nodes/pathology , Lymphatic Metastasis , Head and Neck Neoplasms/secondary , Oligodendroglioma/pathology , Parietal Lobe/pathology , Temporal Lobe/pathology , Anaplasia , Brain Neoplasms/surgery , Neck , Oligodendroglioma/surgery , Parietal Lobe/surgery , Temporal Lobe/surgeryABSTRACT
Säo poucos os estudos sobre gliomas <
Subject(s)
Humans , Male , Adult , Brain Neoplasms/surgery , Cysticercosis/surgery , Oligodendroglioma/surgery , Brain Neoplasms/diagnosis , Craniotomy , Cysticercosis/cerebrospinal fluid , Cysticercosis/diagnosis , Oligodendroglioma/diagnosis , Magnetic Resonance SpectroscopyABSTRACT
Oa autores apresentam 24 casos de doentes portadores de oligodendrogliomas e revisam aspectos relacionados a classificaçäo, quadro clínico, comportamento de oligodendrofliomas e revisam aspectos relacionados a classificaçäo, quadro clínico, comportamento biológico, patologia e tratamento desta neoplasia
Subject(s)
Child , Adolescent , Adult , Middle Aged , Humans , Male , Female , Brain Neoplasms , Oligodendroglioma , Brain Neoplasms , Brain Neoplasms/pathology , Brain Neoplasms/surgery , Follow-Up Studies , Oligodendroglioma , Oligodendroglioma/pathology , Oligodendroglioma/surgery , Postoperative Care , Prognosis , Reoperation , Retrospective StudiesABSTRACT
Os autores, após minudente pesquisa bibliográfica, levantaram 43 casos de oligodendroglioma na fossa posterior. Destes, só dois eram de localizaçäo no ângulo ponto cerebelar. Os autores acrescentam mais um caso desta patologia, nesta rara localizaçäo, chamando a atençäo para sua evoluçäo comprovada durante 16 anos
Subject(s)
Humans , Adult , Male , Cerebellopontine Angle , Cerebellar Neoplasms , Oligodendroglioma , Cerebellar Neoplasms/surgery , Oligodendroglioma/surgery , Tomography, X-Ray ComputedABSTRACT
Os autores apresentam 2 casos de oligodendrogliomaa localizado primariamente dentro dos ventrículos laterais. Clinicamente manifestaram-se por sinais de hipertensäo intracraniana, o que é mais comum nestes casos, associado à sindrome hemiparkinsoniana em 1. O diagnóstico foi feito através da tomografia. Os pacientes foram operados, havendo extirpaçäo total da lesäo. Na revisäo da literatura, ficou patente a raridade deste tipo de glioma no interior dos ventriculos cerebrais
Subject(s)
Adult , Humans , Male , Cerebral Ventricle Neoplasms , Oligodendroglioma/radiotherapy , Oligodendroglioma/surgery , Tomography, X-Ray ComputedABSTRACT
Se da a conocer y se revisa la literatura en un caso de "Oligodendroglioma Bifrontal Gigante" de un enfermo de 34 años, que se habría expresado clínicamente por un episodio convulsivo generalizado. Las radiografías del cráneo mostraron calcificaciones irregulares que nos permitieron efectuar un diagnóstico pre-operatório de presunción. Las arteriografías carotídeas muestran el cacácter bilobulado del tumor. El estudio histopatológico mostró las características del Oligodendroglioma. La resección radical del tumor produjo la mejoría del enfermo, que recibió además radioterapia. El paciente se encuentra actualmente, dos años después de la operación, asintomático y sin indicios de recidiva ni de metastasis