ABSTRACT
A major goal of mineral nutrition research is to provide information of feed zinc (Zn) utilization efficiency and gross Zn requirements as affected by changing rearing conditions. This can be achieved only by applying precise experimental models that acknowledge the basic principles of Zn metabolism. This review article summarizes the most important aspects of Zn homeostasis in monogastric species, including molecular aspects of Zn acquisition and excretion. Special emphasis is given to the role of the skeleton as well as the exocrine pancreas for animal Zn metabolism. Finally, we discuss consequences arising from these physiological principles for the experimental design of trials which aim to address questions of Zn requirements and bioavailability.
Subject(s)
Animals , Humans , Animal Feed , Animal Nutritional Physiological Phenomena , Biological Availability , Diet , Genotype , Homeostasis , Minerals/metabolism , Pancreas, Exocrine/metabolism , Trace Elements , Zinc/metabolismABSTRACT
La insuficiencia pancreática (IP) exocrina se manifiesta cuando el páncreas ha perdido alrededor del 98% de sus glándulas. La fibrosis quística (FQ) es la causa más común de IP en los niños, entre el 85% y 90% de ellos requerirá tratamiento con enzimas pancreáticas. La monitorización de la eficacia debe realizarse fundamentalmente observando la respuesta nutricional del paciente y la consistencia de la deposiciones. Se debe reconocer que la respuesta inadecuada al tratamiento en la mayoría de los casos está relacionada con la baja adherencia o la inadecuada toma de las enzimas.
Pancreatic insufficiency (PI) occurs when the exocrine páncreas has lost about 98% of their glands. Cystic fibrosis (CF) is the most common cause of PI in children, between 85% and 90% of them require treatment with pancreatic enzymes. The monitoring of efficacy should primarily be looking at the patient's nutritional response and consistency of stools. If should be recognized tha the inadequate response to treatment in most cases is related to poor adherence or inadequate making enzymes.