ABSTRACT
Hemophagocytic syndrome (HPS) has been associated with infections, hematological malignancies and autoimmune conditions. Malaria is rarely reported to cause HPS. We report a case of an 11-month-old infant with fever, hepatosplenomegaly, pancytopenia, high serum ferritin, hypertriglyceridemia, and bone marrow hemophagocytosis, consistent with hemophagocytic syndrome. Gametocytes of plasmodium falciparum were identified on bone marrow aspiration. Rapid recovery was observed after treatment with antimalarials.
Subject(s)
Antimalarials/administration & dosage , Bone Marrow/parasitology , Bone Marrow/pathology , Humans , Infant , Lymphohistiocytosis, Hemophagocytic/diagnosis , Lymphohistiocytosis, Hemophagocytic/etiology , Malaria, Falciparum/complications , Malaria, Falciparum/drug therapy , Malaria, Falciparum/pathology , Male , Microscopy , Plasmodium falciparum/cytology , Treatment OutcomeABSTRACT
Characteristics of primary and recrudescent Plasmodium falciparum infections were evaluated in 25 children who did not recover after amodiaquine (AQ) treatment. Recrudescence was detected by a thick blood smear and confirmed by polymerase chain reaction. Over half of recrudescent events occurred after 14 days of initiation of treatment and were associated with relatively low asexual parasitaemia. We examined the gametocyte sex ratio (GSR) in these children and in age and gender-matched controls that had AQ-sensitive (AQ-S) infections (n = 50). In both AQ-S and AQ-resistant (AQ-R) infections, the GSR was female-biased pre-treatment and became male-biased by the third day after treatment initiation. However, gametocyte males persisted after this period in children with AQ-R infections. AQ-recrudescent infections are relatively low (25 of 612.4 percent) in children from this endemic area.
Subject(s)
Animals , Child , Child, Preschool , Female , Humans , Infant , Male , Amodiaquine/therapeutic use , Antimalarials/therapeutic use , Malaria, Falciparum/drug therapy , Plasmodium falciparum/drug effects , Acute Disease , Case-Control Studies , Drug Resistance , Malaria, Falciparum/parasitology , Malaria, Falciparum/prevention & control , Nigeria , Parasitemia/parasitology , Plasmodium falciparum/cytology , Recurrence , Sex Ratio , Time FactorsABSTRACT
Les auteurs proposent un colorant cytologique polychrome a base de fichsine; bleu de methylene et d'eosine. De realisation rapide selon un protocole simple; cette coloration permet une bonne differenciation des structures nucleaires et cytoplasmiques. Le NEO-FME est indique pour la recherche et l'identification des plasmodiums sp dans le sang et pour la realisation de la formule leucocytaire. La rapidite de sa mise en oeuvre (3 a 4 mn) permet un gain de temps inestimable entre examen du patient et decision therapeutique; d'ou son importance dans l'amelioration du pronostic vital