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Mem. Inst. Oswaldo Cruz ; 111(2): 106-113, Feb. 2016. tab, graf
Article in English | LILACS | ID: lil-772612

ABSTRACT

The influence of different infectious agents and their association with human papillomavirus (HPV) in cervical carcinogenesis have not been completely elucidated. This study describes the association between cytological changes in cervical epithelium and the detection of the most relevant aetiological agents of sexually transmitted diseases. Samples collected from 169 patients were evaluated by conventional cytology followed by molecular analysis to detect HPV DNA, Chlamydia trachomatis, herpes simplex virus 1 and 2,Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis, andTreponema pallidum, besides genotyping for most common high-risk HPV. An association between cytological lesions and different behavioural habits such as smoking and sedentariness was observed. Intraepithelial lesions were also associated with HPV and C. trachomatis detection. An association was also found between both simple and multiple genotype infection and cytological changes. The investigation of HPV and C. trachomatisproved its importance and may be considered in the future for including in screening programs, since these factors are linked to the early diagnosis of patients with precursor lesions of cervical cancer.


Subject(s)
Adolescent , Adult , Female , Humans , Middle Aged , Young Adult , Cervix Uteri/microbiology , Chlamydia trachomatis/isolation & purification , DNA, Viral/isolation & purification , Papillomaviridae/isolation & purification , Squamous Intraepithelial Lesions of the Cervix/microbiology , Uterine Cervical Neoplasms/prevention & control , Carcinogenesis , Coinfection , Cross-Sectional Studies , Cytopathogenic Effect, Viral , Cervix Uteri/pathology , Chlamydia Infections/complications , Chlamydia Infections/epidemiology , Early Detection of Cancer/methods , Epithelium/virology , Genotype , Genotyping Techniques , Herpesvirus 1, Human/isolation & purification , /isolation & purification , Molecular Typing , Mycoplasma genitalium/isolation & purification , Neisseria gonorrhoeae/isolation & purification , Papillomaviridae/classification , Papillomavirus Infections/complications , Papillomavirus Infections/epidemiology , Risk Factors , Treponema pallidum/isolation & purification , Trichomonas vaginalis/isolation & purification , Uterine Cervical Neoplasms/microbiology
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