ABSTRACT
This paper reports the overall effects of three lectins, extracted from Canavalia brasiliensis, Dioclea violacea, and D. grandiflora, on BALB/c mice popliteal draining lymph nodes. These lectins have presented high stimulatory capacity on lymph node T cells. Additionally, they were able to induce apoptosis and inflammation (frequently associated with high endothelial venule necrosis). The data presented here suggest that the Diocleinae lectins studied can stimulate in vivo T cell activation and apoptosis, as well as present important side effects
Subject(s)
Animals , Mice , Male , Female , Apoptosis/drug effects , Fabaceae/chemistry , Lectins/pharmacology , Lymph Nodes/drug effects , Lymphocyte Activation/drug effects , Amino Acid Sequence , Cell Count , Endothelium/blood supply , Fabaceae/genetics , Inflammation/chemically induced , Lymph Nodes/pathology , Mice, Inbred BALB C , Necrosis , Receptors, Interleukin-2/metabolism , Venules/pathologyABSTRACT
Objetivo: Alertar os pediatras para uma doença decorrente do uso de ervas consideradas inócuas. Métodos: Descriçä de um caso de hipertensäo porta de início súbito, secundária à Doença Veno-Oclusiva Hepátiaca em um paciente de 2 anos e 5 meses, proveniente de Cruz Alta, RS, após uso crônico de chás de "maria-mole" (Senecio brasiliensis), que contém alcalóides pirrolizidínicos, sabidamente hepatotóxicos. após tratamento adequado, apresentou recuperaçäo clínica e laboratorial completa e hoje encontra-se assintomático. Conclusöes: A prevençäo dessa doença depende da sua divulgaçäo entre médicos e populaçäo em geral, bem como do conhecimento dos efeitos tóxicos de muitos chás.
Subject(s)
Humans , Male , Child, Preschool , Hepatic Veno-Occlusive Disease/chemically induced , Hepatic Veno-Occlusive Disease/complications , Hypertension, Portal/etiology , Pyrrolizidine Alkaloids/adverse effects , Ascites/etiology , Hepatomegaly/etiology , Venules/pathologyABSTRACT
Testicular biopsies of 38 infertile males with varicocele were examined for vascular changes. Endothelial prominence, intimal fibrosis and increased amount of collagen in the media were present in veins, venules and capillaries. The small vessels were thickened with the deposition of homogeneous bluish pink material. The material stained green on Van Geison stain. The vascular changes were bilateral even in patients of unilateral varicocele. The severity of these changes was not related to tubular morphology.