Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 16.515
Filter
1.
Rev. Círc. Argent. Odontol ; 80(231): 14-18, jul. 2022. ilus
Article in Spanish | LILACS | ID: biblio-1391824

ABSTRACT

El granuloma piógeno es una lesión benigna, reactiva y multifactorial que resulta de le- siones repetitivas, microtraumatismos e irritación local en piel o mucosas y cambio hormonal. Cuando aparece en la cavidad oral tiene predilección por la encía vestibular, pero es importante que el odontólogo esté consciente y familiarizado con el hecho de que puede estar localizado en otras áreas anatómicas. Clínicamente se presenta como lesión hiperplásica altamente vascularizada, de tamaño generalmente no mayor a 2 cm, pediculada en la base o sésil y de lento crecimiento. Sin mostrar preferencia por edad o sexo, tiende a aparecer principalmente en encías, labios y mucosa oral, siendo muy pocos los casos reportados en el área lingual. Es por ello que, en este artículo, nos referimos a un caso de ubicación inusual, en conjunto con una revisión de la literatura (AU)


Pyogenic granuloma is a benign, reactive, and multifactorial lesion caused by repetitive injuries, microtrauma and local irritation on the skin or mucous membranes, and hormonal change. When it appears in the oral cavity, it has a predilection for the vestibular gingiva, but the dentist must be aware and familiar with the fact that it can be present in other anatomi- cal areas. Clinically, it is presented as a hyperplasic injury highly vascular-related, with a size generally no bigger than 2 cm, pedunculated in base or sessile, and slow in growth. Without showing any preference in age or gender, it tends to appear mainly on the gums, lips, and oral mucosae, with very few, reported cases in the lingual area. Therefore, in this study, we refer to a case of unusual localization with a literature review (AU)


Subject(s)
Humans , Female , Aged , Tongue/injuries , Granuloma, Pyogenic , Mouth Mucosa/injuries , Recurrence , Immunohistochemistry/methods , Granuloma, Pyogenic/surgery , Granuloma, Pyogenic/etiology , Diagnosis, Differential , Age and Sex Distribution
2.
Rev. bras. ortop ; 57(3): 462-466, May-June 2022. tab
Article in English | LILACS | ID: biblio-1388013

ABSTRACT

Abstract Objective To evaluate the functional outcome of patients submitted to arthroscopic Bankart repair in the long-term. Methods Retrospective evaluation of 41 patients (45 shoulders) operated between 1996 and 2009 followed-up for a mean period of 14.89 years. Functional scores were analyzed by the University of California, Los Angeles (UCLA) and Carter-Rowe scores, physical examination, and analysis of medical records. Results The Carter-Rowe score showed an average improvement of 46.11 points, with a final average of 85.89 points, and the UCLA score showed an average improvement of 31.33 points. Ten patients (22.22%) relapsed, with the number of preoperative dislocations being the most correlated factor. Conclusion It was demonstrated that the number of preoperative dislocations negatively influenced the failure rate.


Resumo Objetivo Avaliar o desfecho funcional dos pacientes submetidos ao reparo de Bankart artroscópico no longo prazo. Métodos Avaliação retrospectiva de 41 pacientes (45 ombros) operados entre 1996 e 2009 acompanhados por um período médio de 14,89 anos. Foram feitas análises das pontuações funcionais de University of California, Los Angeles (UCLA) e Carter-Rowe, exame físico e análises de prontuários. Resultados O escore Carter-Rowe apresentou melhora média de 46,11 pontos, com média final de 85,89 pontos, e o UCLA apresentou melhora de 31,33 pontos. Um total de 10 pacientes (22,22%) apresentou recidiva, sendo o número de luxações pré- operatórias o fator mais correlacionado. Conclusão Foi demonstrado que o número de luxações pré-operatórias influenciou negativamente na taxa de falha.


Subject(s)
Humans , Arthroscopy/rehabilitation , Recurrence , Shoulder/surgery , Retrospective Studies , Joint Instability/rehabilitation
3.
J. coloproctol. (Rio J., Impr.) ; 42(2): 107-114, Apr.-June 2022. tab, graf
Article in English | LILACS | ID: biblio-1394411

ABSTRACT

Background: Peritoneal carcinomatosis (PC) is a lethal regional progression in patients with colorectal cancer (CRC). Treatment with complete cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) achieves better local control than systemic palliative chemotherapy. Objectives: To assess the efficacy on the prognosis of CRS and HIPEC compared with CRS only and to identify possible clinicopathological factors associated with the recurrence of PC. Methods: The present retrospective study included all colorectal carcinoma cases with PC subjected to CRS with or without HIPC from January 2009 to June 2018 at the National Cancer Institute (NCI), Cairo University, Cairo, Egypt. The outcome is evaluated in terms of recurrence-free survival (RFS) and its predictors. Results: Out of the 61 patients, 45 patients (73.8%) underwent CRS plus HIPEC, and 16 (26.2%) underwent CRS alone. The 1-year RFS was 55.7%, with a median of 12 months. The risk factors for recurrence identified in the univariate analysis were T4 primary tumor, high-grade, positive lymphovascular invasion (LVI), positive extracapsular nodal spread, and patients treated with CRS only, without HIPEC. In the multivariate analysis, the independent risk factors for recurrence were high grade and patients treated with CRS only. Conclusion: T4 primary tumor, high grade, positive LVI, and positive extracapsular nodal spread seemed to be important predictors of recurrence following the treatment of PC. Our study also demonstrated that the addition of HIPEC to CRS improved the RFS. (AU)


Subject(s)
Humans , Male , Female , Middle Aged , Peritoneal Neoplasms/diagnosis , Colorectal Neoplasms , Cytoreduction Surgical Procedures/methods , Recurrence , Hyperthermic Intraperitoneal Chemotherapy , Neoplasm Staging
4.
Rev. Bras. Psicoter. (Online) ; 24(1): 107-123, jan-abr. 2022.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1371670

ABSTRACT

Os fatores associados ao suicídio são múltiplos e multifacetados e o tornam a consequência final de todo um processo. Neste trabalho, foi conduzida, a partir de duas bases de dados - Biblioteca Virtual da Saúde e PubMed -, uma revisão de estudos para identificar fatores associados à repetição de tentativas de suicídio entre os anos 2000 e 2020. Foram extraídas informações referentes à data de publicação, população, local, meios de coleta utilizados e fatores associados. Os dados foram posteriormente organizados em categorias de análise. No total, 23 estudos foram selecionados e revisados. Houve maior correspondência para repetição em pessoas que já haviam tentado suicídio. Transtorno mental e o uso abusivo de substâncias apareceram como segundo fator mais associado. Os resultados apontam a tentativa de suicídio como a variável mais associada a novas tentativas e a suicídios. Conclui-se, com base nos achados, que ações preventivas podem ter maior impacto se iniciadas antes da apresentação da primeira tentativa de suicídio.(AU)


The factors associated with suicide are multiple, multifaceted, and make it the ultimate consequence of an entire process. In this paper, a systematic review of studies was conducted on two data basis -Virtual Health Library and PubMed - with a view to identify factors associated with the repetition of suicide attempts between the years 2000 and 2020. Information regarding date of publication, population, place and means of collection used and associated factors were extracted. The data were later organized into categories of analysis. In total, 23 studies were selected and reviewed. There was greater correspondence for repetition in people who had already attempted suicide. Mental disorder and substance abuse appeared as the second most associated factor. The results indicate the suicide attempt as the variable most associated with new attempts and suicides. It is concluded, based on the findings, that preventive actions can have a greater impact if initiated before the presentation of the first suicide attempt.(AU)


Los factores asociados al suicidio son múltiples, multifacéticos y lo convierte en la consecuencia última de todo un proceso. En este articulo se realizó, en las bases de datos de la Biblioteca Virtual en Salud y PubMed, una revisión de estudios para identificar factores asociados a la repetición de intentos de suicidio entre los años 2000 y 2020. Se extrajo información sobre fecha de publicación, población, lugar, medio de recolección utilizado y factores asociados. Posteriormente, los datos se organizaron en categorías de análisis. En total, se seleccionaron y revisaron 23 estudios. Hubo mayor correspondencia por repetición en personas que ya habían intentado suicidarse. El trastorno mental y el abuso de sustancias aparecieron como el segundo factor más asociado. Los resultados indican el intento de suicidio como la variable más asociada a nuevos intentos y suicidios. Se concluye, con base en los hallazgos, que las acciones preventivas pueden tener un mayor impacto si se inician antes de la presentación del primer intento de suicidio.(AU)


Subject(s)
Recurrence , Suicide, Attempted
6.
Rev. Assoc. Med. Bras. (1992) ; 68(2): 165-169, Feb. 2022. tab
Article in English | LILACS | ID: biblio-1365335

ABSTRACT

SUMMARY OBJECTIVE: In this study, we evaluated the clinical characteristics and seasonal distribution of patients with primary spontaneous pneumothorax and examined the relationships between meteorological factors and pneumothorax development overall and in terms of first episode and recurrence. METHODS: The hospital records of 168 pneumothorax patients treated in our clinic between January 2016 and December 2020 were reviewed retrospectively. A cluster was defined as two or more patients with pneumothorax presenting within three consecutive days. Meteorological factors were compared between days with and without pneumothorax patients. This comparison was based on meteorological data from the day of symptom onset (D), the day before symptom onset (D1), and the difference between those days (D-D1). Meteorological data from the index day (D) were also compared between patients with first episode and recurrence of pneumothorax. RESULTS: The study included 149 (88.7%) men and 19 (11.3%) women. The mean age was 25.02±6.97 (range, 17-35; median, 26) years. Of note, 73 (43.4%) patients underwent surgery. The highest number of patients presented in November (n=19, 11.3%). In terms of season, most presentations occurred in autumn. Humidity was significantly lower on recurrence days compared with first episode (p=0.041). CONCLUSION: Our results indicated that meteorological factors (i.e., atmospheric pressure, humidity, wind speed, temperature, and precipitation) were not associated with pneumothorax development. By comparing the patients with first episode and recurrence, the humidity was significantly lower in the recurrence group.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Young Adult , Pneumothorax/etiology , Pneumothorax/epidemiology , Recurrence , Atmospheric Pressure , Weather , Retrospective Studies , Meteorological Concepts
7.
Psico USF ; 27(1): 1-15, jan.-mar. 2022. tab
Article in English | LILACS, INDEXPSI | ID: biblio-1376045

ABSTRACT

In Brazil, few studies have investigated the psychological aspects of childhood cancer. The aim of this article was to compare the psychological adjustment of children with cancer from different survival perspectives with that of children without cancer, besides examining potential risk factors. The sample consisted of 179 participants (6-14 years-old) recruited in two Brazilian public hospitals and three schools, and divided in three groups (relapsed, survivors and control). Children answered orally the self-reported Behavior Assessment Scale for Children, the Revised Children's Manifest Anxiety Scale and Piers-Harris' Self-Concept Scale. No differences were found between groups regarding school and clinical maladjustment, personal adjustment, emotional symptoms and self-concept. Findings also showed positive associations between psychological maladjustment and gender, younger age, lower household income, single parenthood and lower levels of parental education. Conclusions indicate that children with cancer adapt well to the disease and do not present more psychological problems than controls (AU).


No Brasil, poucos estudos investigaram os aspectos psicológicos do câncer infantil. O objetivo deste artigo foi comparar o ajustamento psicológico de crianças com câncer com diferentes perspectivas de sobrevivência com o de crianças sem câncer, além de examinar potenciais fatores de risco. A amostra consistiu em 179 participantes (6-14 anos de idade) recrutados em dois hospitais públicos e três escolas brasileiras. As crianças responderam oralmente à Escala de Avaliação Comportamental para Crianças, à Escala de Ansiedade Manifesta para Crianças Revisada e à Escala de Autoconceito Piers-Harris. Não foram constatadas diferenças entre os grupos com relação ao desajustamento clínico e escolar, ajustamento pessoal, sintomas emocionais e autoconceito. Os resultados também mostraram associações positivas entre o desajustamento psicológico e gênero, menor idade, menor renda, famílias monoparentais e menor nível educacional parental. As conclusões indicam que crianças com câncer se adaptam bem à doença e não apresentam mais problemas psicológicos que as do grupo controle (AU).


Na Brasil, pocos estudios han investigado los aspectos psicológicos del cáncer infantil. El objetivo de este artículo fue comparar el ajuste psicológico de niños na cáncer na diferentes perspectivas de supervivencia na el de niños sin cáncer, además de examinar los posibles factores de riesgo. La muestra consistió en 179 participantes (6-14 años de edad) reclutados en dos hospitales públicos y tres escuelas brasileñas. Los niños contestaron oralmente a la Escala de Evaluación del Comportamiento del Niño, la Escala Revisada de Ansiedad Manifiesta en Niños y la Escala de Autoconcepto de Piers-Harris. No se constataron diferencias entre los grupos con respeto al desajuste clínico y escolar, el ajuste personal, los síntomas emocionales y el autoconcepto. Los resultados también mostraron asociaciones positivas entre el desajuste psicológico y el género, la menor edad, la menor renta, las familias monoparentales y el nivel educativo parental más bajo. Las conclusiones señalan que niños con cáncer se adaptan bien a la enfermedad y no presentan más problemas psicológicos que los del grupo de control (AU).


Subject(s)
Humans , Male , Female , Child , Adolescent , Recurrence , Adaptation, Psychological , Emotional Adjustment , Behavior Rating Scale , Cancer Survivors , Neoplasms/psychology
8.
Braz. dent. sci ; 25(2): 1-8, 2022. tab, ilus
Article in English | LILACS, BBO | ID: biblio-1370878

ABSTRACT

Objective: To evaluate the treatment outcome of enucleation and peripheral ostectomy with the use of Carnoy's solution for management of Odontogenic keratocyst. Material and Methods: 17 patients with OKC who reported from 2011 to 2015 were included. All the cases were treated by enucleation and peripheral ostectomy of 0.5mm followed by Carnoy's solution cauterization for 4 minutes. All patients were followed up for 4-5 years. Results: All the cases were followed-up by using serial panoramic radiography and clinical evaluation at regular intervals. No recurrence was reported in any of the cases. Conclusion: Treatment of Odontogenic keratocyst by enucleation and 0.5mm of peripheral ostectomy, followed by Carnoy's solution cauterization for 4 minutes is an effective treatment with zero recurrence rates for five years of follow-up (AU)


Objetivo: Avaliar o resultado do tratamento de enucleação e osteotomia periférica com o uso de solução de Carnoy para o manejo do ceratocisto odontogênico (OKC). Material e Métodos: 17 pacientes com OKC com acompanhamento de 2011 a 2015 foram incluídos. Todos os casos foram tratados através da enucleação e osteotomia periférica de 0,5 mm, seguido da cauterização com solução de Carnoy por 4 minutos. Todos os pacientes foram acompanhados por 4-5 anos. Resultados: Todos os casos foram acompanhados por meio de séries de radiografias panorâmicas e avaliação clínica em intervalos regulares. Nenhuma recorrência foi reportada em nenhum dos casos. Conclusão: O tratamento de ceratocisto odontogênico por meio da enucleação e osteotomia periférica de 0,5mm, seguido da cauterização com solução de Carnoy por 4 minutos é um tratamento efetivo com zero taxa de recorrência em um acompanhamento de 5 anos. (AU)


Subject(s)
Humans , Osteotomy , Recurrence , Radiography, Panoramic , Odontogenic Cysts
9.
Psico (Porto Alegre) ; 53(1): 37279, 2022.
Article in English | LILACS | ID: biblio-1367635

ABSTRACT

This study sought to identify the Social Representations of Obesity among 15 individuals who underwent bariatric surgery through the Roux-en-Y Gastric Bypass (RYGB) method and were subjected to Argon Plasma Coagulation (APC) due to weight relapse. Data were collected through interviews and analyzed via Descending Hierarchical Classification. Obesity was associated with physical limitations and difficulties in social relationships. Prejudice and difficulty in changing habits are associated with the choice to undergo surgical treatment and to weight relapse. The suffering that goes along with obesity and the difficulty in changing habits seem to be associated with the search for surgical help.


Este estudo procurou identificar as representações sociais da obesidade entre 15 indivíduos submetidos à cirurgia bariátrica pelo método Bypass Gástrico em Y de Roux (RYGB) e submetidos à Coagulação por Plasma de Argônio (APC) devido à recidiva de peso. Os dados foram coletados através de entrevistas e analisados por meio da Classificação Hierárquica Descendente. A obesidade foi associada a limitações físicas e dificuldades nas relações sociais. Preconceito e dificuldades na mudança de hábitos estão associados à escolha de se submeter a tratamento cirúrgico e à recidiva de peso. O sofrimento que acompanha a obesidade e a dificuldade de mudar hábitos parecem estar associados à busca de ajuda cirúrgica.


Este estudio buscó identificar las representaciones sociales de la obesidad entre 15 individuos que se sometieron a cirugía bariátrica utilizando el método de bypass gástrico Roux-en-Y (RYGB) y que se sometieron a coagulación con plasma de argón (APC) debido a una recaída en el peso. Los datos fueron recolectados a través de entrevistas y analizados utilizando la Clasificación Jerárquica Descendente. La obesidad se asoció con limitaciones físicas y dificultades en las relaciones sociales. Los prejuicios y las dificultades para cambiar los hábitos están asociados con la opción de someterse a un tratamiento quirúrgico y una recaída del peso. El sufrimiento que acompaña a la obesidad y la dificultad para cambiar los hábitos parecen estar asociados con la búsqueda de ayuda quirúrgica.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Recurrence , Bariatric Surgery , Argon Plasma Coagulation , Interpersonal Relations , Obesity
10.
Acta Paul. Enferm. (Online) ; 35: eAPE02822, 2022. tab
Article in Portuguese | LILACS, BDENF | ID: biblio-1364229

ABSTRACT

Resumo Objetivo Analisar os fatores relacionados à recidiva de erisipela em adultos e idosos. Métodos Estudo de coorte retrospectivo com 235 adultos e idosos admitidos em um hospital com diagnóstico de erisipela entre 2012 e 2019. Investigaram-se fatores sociodemográficos e clínicos relacionados a maior chance de recidiva de erisipela no período por meio de análises uni e bivariada, com p<0,05 considerado significativo. Resultados A prevalência de recidiva de erisipela foi de 25,5% (n=60). Os fatores significativamente associados à recidiva foram insuficiência venosa (p= 0,002; OR= 2,597; IC= 1,4-4,7) e uso de penicilina (p< 0,000; OR= 7,042; IC= 2,5-19,7). Conclusão a insuficiência venosa se associa a chance duas vezes maior de recidiva de erisipela e o uso de penicilina se associa a risco sete vezes maior para sua recidiva.


Resumen Objetivo Analizar los factores relacionados con la recidiva de erisipela en adultos y adultos mayores. Métodos Estudio de cohorte retrospectivo con 235 adultos y adultos mayores ingresados en un hospital con diagnóstico de erisipela entre 2012 y 2019. Se investigaron factores sociodemográficos y clínicos relacionados con una mayor probabilidad de recidiva de erisipela en el período mediante análisis uni y bivariados, con p<0,05 considerado significativo. Resultados La prevalencia de recidiva de erisipela fue del 25,5 % (n=60). Los factores significativamente asociados con la recidiva fueron insuficiencia venosa (p= 0,002; OR= 2,597; IC= 1,4-4,7) y uso de penicilina (p< 0,000; OR= 7,042; IC= 2,5-19,7). Conclusión La insuficiencia venosa está relacionada con una probabilidad dos veces mayor de recidiva de erisipela, y el uso de penicilina está relacionado con un riesgo siete veces mayor de recidiva.


Abstract Objective To analyze factors related to erysipelas recurrence in adults and older adults. Methods Retrospective cohort study with 235 adults and older adults admitted to a hospital diagnosed with erysipelas between 2012 and 2019. Sociodemographic and clinical factors related to a greater chance of erysipelas recurrence in the period were investigated through uni and bivariate analyses, with p<0.05 considered significant. Results The prevalence of erysipelas recurrence was 25.5% (n=60). Factors significantly associated with recurrence were venous insufficiency (p= 0.002; OR= 2.597; 95%CI= 1.4-4.7) and use of penicillin (p< 0.000; OR= 7.042; 95%CI= 2.5-19.7). Conclusion venous insufficiency is associated with a twice greater chance of erysipelas recurrence and the use of penicillin is associated with a seven times greater risk for its recurrence.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Erysipelas/diagnosis , Erysipelas/epidemiology , Recurrence , Retrospective Studies , Cohort Studies , Electronic Health Records
11.
Rev. Col. Bras. Cir ; 49: e20223063, 2022. tab, graf
Article in English | LILACS | ID: biblio-1365386

ABSTRACT

ABSTRACT Objective: to describe the use of the robotic platform in inguinal hernia recurrence after a previous laparoscopic repair. Methods: patients with recurrent inguinal hernias following a laparoscopic repair who have undergone robotic transabdominal preperitoneal between December 2015 through September 2020 were identified in a prospectively maintained database. Outcomes of interest included demographics, hernia characteristics, operative details and rates of 30-day surgical site occurrence, surgical site occurrences requiring procedural interventions, surgical site infection and hernia recurrence were abstracted. Results: nineteen patients (95% male, mean age 55 years, mean body mass index 28) had 27 hernias repaired (N=8 bilateral). Average operative time was 168.9 ± 49.3min (range 90-240). There were two intraoperative complications all of them were bleeding from the inferior epigastric vessel injuries. Three SSOs occurred (N=2 seromas and N=1 hematoma. After a median 35.7 months follow-up (IQR 13-49), no recurrence has been diagnosed. One patient developed chronic postoperative inguinal pain. Conclusions: on a small number of selected patients and experienced hands, we found that the use of the robotic platform for repair of recurrent hernias after prior laparoscopic repair appears to be feasible, safe and effective despite being technically demanding. Further studies in larger cohorts are necessary to determine if this technique provides any benefits in recurrent inguinal hernia scenario.


RESUMO Objetivo: descrevemos nossa experiência com uso da plataforma robótica no tratamento das recidivas operadas previamente por laparoscopia, mantendo assim uma proposta minimamente invasiva a esses pacientes, apesar de haver uma predileção pela via anterior e aberta nestes casos. Métodos: foram incluídos pacientes submetidos a hernioplastia inguinal robótica transabdominal pré-peritoneal como tratamento de recidiva e que foram operados previamente por laparoscopia, entre dezembro de 2015 e setembro de 2020 e mantidos em uma base de dados ambulatorial prospectiva. Variáveis de interesse incluíram dados demográficos, características herniárias, detalhes operatórios, ocorrências do sítio cirúrgico em 30 dias (com ou sem necessidade de intervenção), infeção do sítio cirúrgico, tempo de seguimento e taxa de recidiva. Resultados: dezenove pacientes (95% masculino, média de idade de 55 anos, média de índice de massa corporal 28kg/m2) e 27 hérnias operadas (N=8 bilaterais). Média de tempo cirúrgico 168.9±49.3 min (variando 90-240). N=2 complicações intraoperatórias por lesão de vasos epigástricos inferiores. N=2 seromas e N=1 hematoma foram identificados no pós-operatório; N=1 paciente apresentou dor crônica pós operatória. Após um tempo de seguimento médio de 35.7 meses (intervalo entre quartis 13-49), nenhuma recidiva foi diagnosticada. Conclusões: o uso da plataforma robótica parece ser seguro e efetivo no tratamento das recidivas operadas previamente laparoscopia, nesse pequeno grupo de pacientes selecionados, apesar de requerer expertise em cirurgia robótica. Outros estudos com maiores casuísticas são necessários para estabelecer o papel desta técnica no cenário das hérnias inguinais recidivadas.


Subject(s)
Humans , Male , Female , Laparoscopy/methods , Robotic Surgical Procedures/methods , Hernia, Inguinal/surgery , Recurrence , Surgical Mesh , Retrospective Studies , Treatment Outcome , Herniorrhaphy/methods , Groin , Middle Aged
12.
Rev. latinoam. enferm. (Online) ; 30: e3569, 2022. tab, graf
Article in Portuguese | LILACS, BDENF | ID: biblio-1376959

ABSTRACT

Resumo Objetivo: analisar os fatores associados ao insucesso do Transplante de Células-Tronco Hematopoiéticas (TCTH) em pacientes submetidos ao retransplante de Células-Tronco Hematopoiéticas (RCTH). Método: estudo quantitativo do tipo caso-controle para avaliar pacientes submetidos ao RCTH. Para tanto, utilizou-se amostra pareada de dois controles para cada caso (2:1). O grupo caso foi constituído pelos prontuários de saúde com todos os pacientes que foram submetidos ao RCTH (28) e o grupo controle (56) incluiu pacientes que receberam apenas um transplante. Três variáveis nortearam o pareamento: sexo, diagnóstico e tipo de transplante. Resultados: vinte e quatro (85,71%) pacientes do grupo caso receberam retransplante devido a recidiva da doença e quatro (14.29%) devido a falha do enxerto. Uma diferença estatística foi encontrada na análise entre os pacientes que não usaram o ácido ursodesoxicólico, analgésicos opioides ou imunossupressores. A necessidade de um RCTH entre aqueles que usaram estes medicamentos de forma inapropriada foi 16,12, 12,79 e 4,5 vezes maior, respectivamente, do que entre os que as usaram corretamente. Conclusão: houve uma diferença relacionada ao motivo que levou ao retransplante e os indivíduos analisados. A conclusão é que a razão preditiva para retransplante nesta amostra foi a recidiva da doença.


Abstract Objective: to analyze the factors associated with the failure of Hematopoietic Stem Cell Transplantation (HSCT) in patients undergoing Hematopoietic Stem Cell Retransplantation (HSCR). Method: this study implemented a quantitative approach and was a case-control type which addressed patients undergoing HSCR. To do so, a paired sample of two controls was used for each case (2:1). The case group consisted of the medical records of all patients who underwent HSCR (28) and the control group (56) of those who underwent only one transplant. Three variables guided the pairing: gender, diagnosis and type of transplant. Results: a total of 24 (85.71%) patients in the case group were re-transplanted due to disease relapse and four (14.29%) due to graft failure. There was a statistical difference in the analysis between patients who did not use ursodeoxycholic acid, opioid analgesics and immunosuppressants. The need for HSCR among those who used these medications inappropriately was 16.12, 12.79 and 4.5 times more likely, respectively, than those who used them correctly. Conclusion: there was a difference regarding the reasons which led to the retransplantation and the analyzed subjects, and this study concluded that the predictive reason for retransplantation in the studied sample was disease relapse.


Resumen Objetivo: analizar los factores asociados con el fracaso del Trasplante de Células Madre Hematopoyéticas (TCMH) en pacientes sometidos al Retrasplante de Células Madre Hematopoyéticas (RCMH). Método: estudio cuantitativo de tipo caso-control que abordó pacientes sometidos al RCMH. Para esto, se utilizó una muestra pareada de dos controles para cada caso (2:1). El grupo caso estuvo formado por los registros médicos de todos los pacientes que fueron sometidos al RCMH (28) y el grupo control (56) por los que fueron sometidos a un solo trasplante. Tres variables guiaron el emparejamiento: género, diagnóstico y tipo de trasplante. Resultados: un total de 24 (85.71%) pacientes en el grupo caso fueron retransplantados debido a la recaída de la enfermedad y 4 (14.29%) por el fracaso del injerto. Hubo una diferencia estadística en el análisis entre los pacientes que no usaron ácido ursodesoxicólico, analgésicos opioides e inmunosupresores. La necesidad de RCMH entre los que usaron estos medicamentos de manera inapropiada se encontraba 16,12 - 12,79 y 4,5 veces más probable, respectivamente, que aquellos que los usaron correctamente. Conclusión: hubo diferencia en cuanto a las razones que llevaron al retrasplante de los sujetos analizados. Este estudio concluyó que la razón predictiva del retrasplante, en la muestra estudiada, fue la recidiva de la enfermedad.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Recurrence , Reoperation , Hematopoietic Stem Cells , Retrospective Studies , Hematopoietic Stem Cell Transplantation
13.
Article in English | WPRIM | ID: wpr-929071

ABSTRACT

As a group of nonspecific inflammatory diseases affecting the intestine, inflammatory bowel disease (IBD) exhibits the characteristics of chronic recurring inflammation, and was proven to be increasing in incidence (Kaplan, 2015). IBD induced by genetic background, environmental changes, immune functions, microbial composition, and toxin exposures (Sasson et al., 2021) primarily includes ulcerative colitis (UC) and Crohn's disease (CD) with complicated clinical symptoms featured by abdominal pain, diarrhea, and even blood in stools (Fan et al., 2021; Huang et al., 2021). UC is mainly limited to the rectum and the colon, while CD usually impacts the terminal ileum and colon in a discontinuous manner (Ordás et al., 2012; Panés and Rimola, 2017). In recent years, many studies have suggested the lack of effective measures in the diagnosis and treatment of IBD, prompting an urgent need for new strategies to understand the mechanisms of and offer promising therapies for IBD.


Subject(s)
Chronic Disease , Colitis, Ulcerative/therapy , Crohn Disease/epidemiology , Diarrhea , Homeodomain Proteins , Humans , Inflammatory Bowel Diseases , Mesenchymal Stem Cells/cytology , MicroRNAs , RNA, Long Noncoding , Recurrence , Umbilical Cord/cytology
14.
Article in English | WPRIM | ID: wpr-929047

ABSTRACT

At present, endometriosis remains a worldwide health burden, with the main symptoms of dysmenorrhea, chronic pelvic pain, and infertility, markedly reducing the quality of life (de Ziegler et al., 2010). Although there is no proof that the disease is associated with high mortality, this disorder can significantly contribute to the deterioration of women's general well-being (McPeak et al., 2018). The main current treatment for endometriosis is surgery to remove endometriotic lesions; however, the recurrence rate following surgical treatment is as high as 21.5% at two years and 40.0%‍-‍50.0% at five years post-surgery (Koga et al., 2015). To prevent recurrence, adjuvant treatment with drugs after surgery is recommended to prolong relapse-free intervals. However, it is inconvenient for patients to continuously use such medications in terms of adverse effects and cost (Turk, 2002).


Subject(s)
Endometriosis/pathology , Endometrium/pathology , Female , Humans , Ki-67 Antigen/metabolism , Quality of Life , Recurrence , Telomerase/metabolism , Up-Regulation
15.
Article in Chinese | WPRIM | ID: wpr-928663

ABSTRACT

OBJECTIVE@#To analyze the efficacy of children with B-cell acute lymphoblastic leukemia (B-ALL) without prognostic fusion genes treated by CCLG-ALL 2008, and investigate the related factors affecting the recurrence of the patients.@*METHODS@#B-ALL patients without prognostic fusion genes treated by the protocol of CCLG-ALL 2008 in our hospital from March 2008 to December 2012 were retrospectively analyzed. Follow-up time was ended in August 31, 2019. The median follow-up time was 92 months (range 0-136 months). Kaplan-Meier was used to detect the RFS, and COX multivariate regression analysis was employed to identify the independent factors affecting the recurrence of the patients.@*RESULTS@#There were 140 males and 99 females enrolled in this study. The ratio of male to female was 1.41∶1. The median age was 4.4 years old and the median number of WBC at initial stage was 4.98×109/L. There were 77 cases relapsed during the observation while 162 without relapsed, 16 cases lost to follow-up and 72 cases died. The recurrence and mortality rate was 32.22% and 30.1%, respectively, in which 45 cases died of recurrence (62.5% of the total deaths). Univariate analysis showed that the age≥6 years old, WBC >100×109/L, the bone marrow blasts on day 15≥25%, the bone marrow minimal residual disease (MRD) at week 12 >10-4, and the higher risk were the main factors affecting the recurrence of the patients (P<0.05). Multivariate COX regression analysis showed that age≥6 years old, WBC >100×109/L, bone marrow MRD >10-4 at the 12th week were the independent risk factors affecting recurrence of the patients.@*CONCLUSION@#Age, initial WBC, and bone marrow MRD at the 12th week were correlated with recurrence in children with B-ALL without prognostic fusion genes, which can be used as prognostic indices of recurrence risk in clinical.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols , Child , Child, Preschool , Disease-Free Survival , Female , Humans , Male , Neoplasm, Residual , Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics , Prognosis , Recurrence , Retrospective Studies
16.
Arch. pediatr. Urug ; 92(2): e305, dic. 2021. tab
Article in Spanish | LILACS, BNUY, UY-BNMED | ID: biblio-1278305

ABSTRACT

Las afecciones respiratorias agudas son la primera causa de consulta e ingreso hospitalario en los meses de invierno, y entre ellas el asma ocupa un lugar preponderante. El salbutamol es un broncodilatador con eficacia demostrada en las exacerbaciones y se utiliza de primera línea en el tratamiento. El objetivo de la presente comunicación es analizar dos casos clínicos de niños asmáticos que presentaron efectos adversos al salbutamol y requirieron el ingreso en la Unidad de Terapia Intensiva. Se propone revisar los efectos adversos del salbutamol empleado en crisis asmáticas y analizar las alternativas terapéuticas en esta enfermedad. Los síntomas de los efectos secundarios pueden confundirse con los causados por la propia enfermedad, por lo que puede usarse el fármaco de modo excesivo y es importante conocer el perfil posológico y caracterizar los posibles efectos secundarios en los pacientes para usar de manera racional y segura este medicamento.


Acute respiratory conditions are the first cause of consultation and hospital admission in the Winter months, being asthma the most important. Salbutamol is a bronchodilator with proven efficacy in exacerbations used first-line in treatment. The objective of this paper is to analyze two clinical cases of asthmatic children who presented adverse effects to salbutamol and required admission to the Intensive Care Unit. It is proposed to review the adverse effects of salbutamol used in asthmatic crises and to analyze therapeutic alternatives in this disease. Symptoms of side effects can be confused with those caused by the disease itself, determining the excessive use of this drug, thus, it is important to know the dosage profile and characterize the possible side effects to make rational and safe use of this drug.


As doenças respiratórias agudas são a primeira causa de consultas e internações nos meses de inverno e a asma ocupa é a mais importante. O salbutamol é um broncodilatador com eficácia comprovada nas exacerbações e é usado como tratamento de primeira linha. O objetivo desta comunicação é analisar dois casos clínicos de crianças asmáticas que apresentaram efeitos adversos ao salbutamol e necessitaram de internação em Unidade de Terapia Intensiva. Propõe-se revisar os efeitos adversos do salbutamol utilizado na crise asmática e analisar as alternativas terapêuticas nessa doença. Os sintomas de efeitos colaterais podem ser confundidos com os causados pela própria doença, determinando o uso excessivo desse medicamento, sendo importante conhecer o perfil posológico e caracterizar os possíveis efeitos colaterais nos pacientes para fazer um uso racional e seguro desse medicamento.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Acidosis, Lactic , Bronchodilator Agents/adverse effects , Albuterol/adverse effects , Hyperglycemia/chemically induced , Hypokalemia/chemically induced , Psychomotor Agitation/etiology , Recurrence , Asthma/drug therapy , Tachycardia/chemically induced , Tremor/chemically induced , Hallucinations/chemically induced
17.
J. coloproctol. (Rio J., Impr.) ; 41(4): 406-410, Out.-Dec. 2021. tab, ilus
Article in English | LILACS | ID: biblio-1356446

ABSTRACT

Background: Fistula-in-ano is one of the most common clinical condition encountered in a surgical outpatient department. Many treatment modalities have been described with variable outcomes but gold standard surgical treatment is yet to be agreed upon. The aim of the present study is to evaluate the treatment outcomes of ligature of intersphincteric fistula tract (LIFT) technique in the treatment of simple and complex fistula-in-ano with the primary objective of recurrence rate and broad objective of other postoperative complications during the period of study and after long-term follow-up. Methods: It is a retrospective study of prospectively collected data from the patients who havebeen operated for fistula-in-ano using the LIFT technique at our institute from February 2018 to March 2020 and followed-up until September 2020. Results: A total of 56 patients with fistula-in-ano were treated with the LIFT procedure during the study period, of which 20 patients had simple fistula and 36 had complex fistula. A success rate of 83% was obtained with completely healed fistulas in 46 patients. No patient developed postoperative incontinence. Conclusion: Ligature of intersphincteric fistula tract is an effective treatmentmodality for fistula-in-ano with less procedure-related morbidity, but it is associated with a higher recurrence rate in simple fistula than in complex fistula. (AU)


Subject(s)
Humans , Male , Female , Rectal Fistula/surgery , Rectal Fistula/therapy , Anal Canal/surgery , Recurrence
18.
Article in Portuguese | LILACS | ID: biblio-1353076

ABSTRACT

Objetivo: Averiguar a efetividade da utilização da cirurgia de MOHS no manejo de tumores cutâneos tipo não melanoma em comparação a outros métodos de terapia. Métodos: O estudo consiste em uma revisão sistemática, cuja coleta de artigos ocorreu nas bases de dados MEDLINE, PubMed Central (PMC), LILACS e SciELO, utilizando os termos "Cirurgia de MOHS", "Câncer de pele", "Ensaio clínico", excluindo "melanoma". Resultados: Do total de 132 artigos identificados, foram considerados elegíveis 11. A análise dos artigos demonstrou que a CMM, comparada a outros métodos, apresentou resultados estéticos melhores, além de menor grau de complicações em tumores recorrentes e um custo/benefício variável com o país onde foi feita operação. A CMM também apresentou menores índices de recorrência em todos os estudos. Conclusão: No geral, a cirurgia de MOHS se mostrou um método terapêutico promissor. No entanto, existem ainda poucos estudos comparativos sobre a eficácia da CMM e os que existem se concentram em poucas regiões do mundo. (AU)


Objective: Evaluating the effectiveness of using MOHS surgery in the management of non-melanoma skin tumors compared to other therapy methods. Methods: The study consists of a systematic review, whose search for articles was performed using databases MEDLINE, PubMed Central (PMC), LILACS and SciELO, using the terms "MOHS surgery", "Skin cancer", "Clinical trial", excluding "melanoma". Results: from a total of 132 identified articles, 11 were considered eligible. The analysis of the articles showed that MMS, compared to other methods, presented better cosmetic results, in addition to a lower grade of complications in recurrent tumors and a variable cost/benefit according to the country where the surgery was performed. MMS also had lower recurrence rates in all studies. Conclusion:Overall, MOHS surgery has shown promising therapeutic results. However, there are still few comparative studies on the effectiveness of MMS and those that exist are concentrated in a few regions of the world. (AU)


Subject(s)
Humans , Recurrence , Skin Neoplasms , Effectiveness , Mohs Surgery , Costs and Cost Analysis , Melanoma
19.
Enferm. foco (Brasília) ; 12(4): 767-772, dez. 2021. tab
Article in Portuguese | LILACS, BDENF | ID: biblio-1353330

ABSTRACT

Objetivos: Identificar, descrever e analisar a Infecção do Trato Urinário e sua recorrência em internação. Caracterizar os aspectos sociodemográficos, laboratoriais e clínicos dos idosos com ITU. Método: Estudo transversal com delineamento descritivo, abordagem quantitativa do tipo analítica, realizada nos prontuários eletrônicos dos idosos que foram internados no ano de 2017 e reinternaram em 2018, na unidade de Geriatria de um hospital de ensino. Na estatística foi usado Teste Exato de Fisher, considerado p<0,05. Resultados: Dos 1.835 prontuários, foram selecionados 550 (29,97%) idosos, destes, foram investigados 121 (22%) com ITU. A maioria foi do sexo masculino com idade entre 80 e 89 anos. Dentre eles, 51,2% usaram algum tipo de sonda vesical e 52,9% usaram frauda. Os exames alterados foram os de creatinina, Proteina-C-Reativa, urina I (proteínas e leucócitos), além de urocultura positiva para Escherichia Coli. Dos 121 pacientes investigados, 50,4% tiveram reinternação por Infecção urinária, destes, 42,6% morreram e, dos que não tiveram recorrência, foram 18,3% óbitos (p= 0,00054).Conclusão: O idoso tem predisposição maior para adquirir infeção urinária, além de apresentar recidivas, principalmente os que fazem uso de sonda vesical e fralda, o que ocasiona aumento da frequência de hospitalizações, do estadiamento no hospital e da mortalidade. (AU)


Objective: Analyze the Urinary Tract Infection and its recurrence in hospitalization in the elderly, characterizing the sociodemographic, laboratory and clinical aspects. Methods: Cross sectional study with descriptive design, quantitative approach of an analytical type, carried out on the electronic medical records of the elderly who were hospitalized in 2017 and readmitted in 2018, in the Geriatrics unit of a teaching hospital. Fisher's exact test was used in statistics, considered p <0.05. Results: Of the 1,835 records, 550 (29.97%) elderly were selected, of these, 121 (22%) with Urinary Tract Infection were investigated. The majority were male aged between 80 and 89 years. Among them, 51.2% used some type of bladder catheter and 52.9% used fraud. The altered tests were those of creatinine, C-Reactive Protein, urine I (proteins and leukocytes), in addition to positive urine culture for Escherichia Coli. Of the 121 patients investigated, 50.4% had readmission for urinary tract infection, of these, 42.6% died and, of those who did not have recurrence, 18.3% died (p = 0.00054). Conclusion: The elderly is predisposed greater to acquire urinary infection, in addition to relapses, especially those who use a bladder catheter and diaper, which causes an increase in the frequency of hospitalizations, hospital stay and mortality. (AU)


Objetivo: Analizar la Infección del Tracto Urinario y su recurrencia en la hospitalización del anciano, caracterizando los aspectos sociodemográficos, de laboratorio y clínicos. Métodos: Estudio transversal con diseño descriptivo, abordaje cuantitativo de tipo analítico, realizado sobre la historia clínica electrónica de los ancianos que fueron hospitalizados en 2017 y readmitidos en 2018, en la unidad de Geriatría de un hospital universitario. En estadística se utilizó la prueba exacta de Fisher, considerada p <0,05. Resultados: De las 1.835 historias clínicas, se seleccionaron 550 (29,97%) ancianos, de estos se investigaron 121 (22%) con Infección del Tracto Urinario. La mayoría eran hombres de entre 80 y 89 años. Entre ellos, el 51,2% utilizó algún tipo de sonda vesical y el 52,9% utilizó fraude. Las pruebas alteradas fueron las de creatinina, proteína C reactiva, orina I (proteínas y leucocitos), además de urocultivo positivo para Escherichia Coli. De los 121 pacientes investigados, el 50,4% tuvo reingreso por infección del tracto urinario, de estos, el 42,6% falleció y, de los que no presentaron recidiva, falleció el 18,3% (p = 0,00054). Conclusión: Los ancianos tienen mayor predisposición a adquirir urinaria infección, además de recaídas, especialmente en quienes utilizan sonda vesical y pañal, lo que provoca un aumento en la frecuencia de hospitalizaciones, estancia hospitalaria y mortalidad. (AU)


Subject(s)
Old Age Assistance , Recurrence , Urinary Tract , Cross Infection
20.
Rev. ADM ; 78(5): 283-290, sept.-oct. 2021. ilus
Article in Spanish | LILACS | ID: biblio-1348323

ABSTRACT

Los cambios en la vida, así como también en el campo de la Odontología, deben ser para mejorar siempre en todos los aspectos posibles. Y muchos de los cambios recientes en la Odontología Restauradora están encaminados a la utilización de materiales estéticos para remplazo de restauraciones metálicas previas, sin generar certeza total de ser mejores opciones. Esto ha generado un marcado incremento en la tendencia a practicar, más enfáticamente, el remplazo de restauraciones previas (AU)


Changes in life, as so in the field of Dentistry, should always be for the improvement on most possible aspects. Many of the recent changes in Restorative Dentistry are focus on the use of cosmetic materials to replace previous metallic restorations, without total certainty of being better options. This has generated a marked increase in the tendency to practice, more emphatically, the replacement of previous restorations (AU)


Subject(s)
Humans , Male , Female , Dental Restoration Failure , Dental Caries/therapy , Dental Materials , Dental Restoration, Permanent , Recurrence , Metal Ceramic Alloys , Esthetics, Dental , Conservative Treatment
SELECTION OF CITATIONS
SEARCH DETAIL