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1.
Braz. j. biol ; 84: e245592, 2024. tab, graf
Article in English | LILACS, VETINDEX | ID: biblio-1355866

ABSTRACT

Abstract In recent years, the development of high-throughput technologies for obtaining sequence data leveraged the possibility of analysis of protein data in silico. However, when it comes to viral polyprotein interaction studies, there is a gap in the representation of those proteins, given their size and length. The prepare for studies using state-of-the-art techniques such as Machine Learning, a good representation of such proteins is a must. We present an alternative to this problem, implementing a fragmentation and modeling protocol to prepare those polyproteins in the form of peptide fragments. Such procedure is made by several scripts, implemented together on the workflow we call PolyPRep, a tool written in Python script and available in GitHub. This software is freely available only for noncommercial users.


Resumo Nos últimos anos, o desenvolvimento de tecnologias de alto rendimento para obtenção de dados sequenciais potencializou a possibilidade de análise de dados proteicos in silico. No entanto, quando se trata de estudos de interação de poliproteínas virais, existe uma lacuna na representação dessas proteínas, devido ao seu tamanho e comprimento. Para estudos utilizando técnicas de ponta como o Aprendizado de Máquina, uma boa representação dessas proteínas é imprescindível. Apresentamos uma alternativa para este problema, implementando um protocolo de fragmentação e modelagem para preparar essas poliproteínas na forma de fragmentos de peptídeos. Tal procedimento é feito por diversos scripts, implementados em conjunto no workflow que chamamos de PolyPRep, uma ferramenta escrita em script Python e disponível no GitHub. Este software está disponível gratuitamente apenas para usuários não comerciais.


Subject(s)
HIV Protease , Polyproteins , Software , Molecular Docking Simulation
2.
Braz. j. oral sci ; 21: e227903, jan.-dez. 2022. ilus
Article in English | LILACS, BBO | ID: biblio-1355005

ABSTRACT

Aim: To evaluate the accuracy and the validity of orthodontic diagnostic measurements, as well as virtual tooth transformations using a generic open access 3D software compared to OrthoAnalyzer (3Shape) software; which was previously tested and proven for accuracy. Methods: 40 maxillary and mandibular single arch study models were duplicated and scanned using 3Shape laser scanner. The files were imported into the generic and OrthoAnalyzer software programs; where linear measurements were taken twice to investigate the accuracy of the program. To test the accuracy of the program format, they were printed, rescanned and imported into OrthAnalyzer. Finally, to investigate the accuracy of editing capabilities, linear and angular transformation procedures were performed, superimposed and printed to be rescanned and imported to OrthoAnalyzer for comparison. Results: There was no statistically significant difference between the two groups using the two software programs regarding the accuracy of the linear measurements (p>0.05). There was no statistically significant difference between the different formats among all the measurements, (p>0.05). The editing capabilities also showed no statistically significant difference (p>0.05). Conclusion: The generic 3D software (Meshmixer) was valid and accurate in cast measurements and linear and angular editing procedures. It can be used for orthodontic diagnosis and treatment planning without added costs


Subject(s)
Software , Casts, Surgical , Imaging, Three-Dimensional , Models, Dental
3.
Aquichan ; 22(2): e2228, may. 13, 2022.
Article in English, Portuguese | LILACS, BDENF, COLNAL | ID: biblio-1372051

ABSTRACT

Objective: To adapt culturally the System Usability Scale to Brazilian Portuguese and assess its internal consistency and structural construct validity. Materials and methods: This methodological study of a measurement instrument's cultural adaptation included the initial translation, the translations' synthesis, the back-translation, the evaluation by a committee of eight experts, testinh with a sample of 100 students, who evaluated the usability of the WhatsApp application, and the evaluation of structural construct validity by exploratory factor analysis. Results: The judges validated the Brazilian version of the System Usability Scale in the second round. It was revealed that, following the structural construct validation, the version had a unidimensional structure and an acceptable level of reliability (Cronbach's alpha of 0.76). Besides, in the usability test, no suggestions for change were made. Conclusions: It is worth noting that the Brazilian version of this scale was semantically, idiomatically, conceptually, and culturally equivalent to the original English version and showed adequate reliability and structural construct validity.


Objetivo: realizar a adaptação cultural da System Usability Scale para a língua portuguesa do Brasil e avaliar a sua consistência interna e a validade estrutural de constructo. Materiais e método: trata-se de um estudo metodológico, de adaptação cultural de instrumento de medida, que contemplou a tradução inicial, a síntese das traduções, a retrotradução, a avaliação por comitê de oito especialistas, o teste com uma amostra de 100 estudantes, que avaliaram a usabilidade do aplicativo WhatsApp, e a avaliação da validade de constructo estrutural por análise fatorial exploratória. Resultados: validou-se a versão brasileira da System Usability Scale pelos juízes na segunda rodada. Revela-se que, após a validação de constructo estrutural, a versão apresentou estrutura unidimensional e nível aceitável de confiabilidade (alfa de Cronbach de 0,76). Acrescenta-se que, no teste de usabilidade, não houve sugestão de mudança. Conclusões: informa-se que a versão brasileira dessa escala apresentou equivalência semântica, idiomática, conceitual e cultural com a versão original em inglês, bem como adequada confiabilidade e validade de constructo estrutural.


Objetivo: realizar la adaptación cultural de la System Usability Scale al idioma portugués, variante brasileña, y evaluar su consistencia interna y su validez de constructo estructural. Materiales y métodos: se trata de un estudio metodológico de adaptación cultural de un instrumento de medición, que contempló traducción inicial, síntesis de traducciones, retrotraducción, evaluación por ocho expertos, prueba con una muestra de 100 estudiantes, quienes evaluaron la usabilidad de la aplicación WhatsApp, y evaluación de la validez de constructo estructural mediante análisis factorial exploratorio. Resultados: los expertos en la segunda ronda validaron la versión brasileña de la System Usability Scale. Se reveló que, luego de la validación de constructo, la versión presentó una estructura unidimensional y un nivel aceptable de confiabilidad (alfa de Cronbach de 0,76). Además, en la prueba de usabilidad, no hubo sugerencia de cambio. Conclusiones: se informa que la versión brasileña de la escala presentó equivalencia semántica, idiomática, conceptual y cultural con la versión original en inglés, así como una confiabilidad y validez de constructo estructural adecuadas.


Subject(s)
Translating , Software , Evaluation of Research Programs and Tools , Mobile Applications , Data Accuracy
4.
Lima; Perú. Ministerio de Salud. Dirección General de Intervenciones Estratégicas en Salud Pública. Dirección de Prevención y Control de la Discapacidad. Oficina General de Tecnologías de la Información. Instituto Nacional de Rehabilitación; 1 ed; Mar. 2022. 18 p. ilus.
Monography in Spanish | LILACS, LIPECS, MINSAPERU | ID: biblio-1362130

ABSTRACT

El Ministerio de Salud, a través de la Dirección de Prevención y Control de la Discapacidad conjuntamente con la Oficina General de Tecnologías de la Información, han propiciado un Proyecto de Desarrollo e Implementación del Sistema de Software, denominado HIS-DISCAP WEB, en su finalidad de contribuir a generar condiciones que faciliten el acceso de las Personas con Discapacidad, a los procesos para la evaluación, calificación y certificación de la discapacidad


Subject(s)
Software , Certification , Disabled Persons , Information Technology
5.
Rev. ADM ; 79(1): 12-19, ene.-feb. 2022. ilus, graf
Article in Spanish | LILACS | ID: biblio-1361307

ABSTRACT

El objetivo del presente estudio fue medir la curvatura vestíbulo-lingual de los conductos de las raíces mesiales de primeros molares inferiores en personas adultas del estado de Chihuahua, por medio de la técnica de tomografía computarizada de haz cónico (CBCT, por sus siglas en inglés) y usando el software de análisis 3D EndoTM (Dentsply/Sirona USA). Se llevó a cabo la medición por dos observadoras, empleando dos métodos diferentes, Schneider y 3D EndoTM (Dentsply/Sirona USA). Los resultados obtenidos tuvieron valores mayores a los 100 grados con la técnica 3D EndoTM y a los 20 grados con la técnica de Schneider. No se detectó una diferencia estadística significativa al comparar los diferentes conductos entre sí (AU)


The objective of the present study was to measure the vestibule-lingual curvature of the ducts of the mesial roots of lower first molars, of adults from the state of Chihuahua. Using the cone beam computed tomography (CBCT) technique and using the 3D analysis software EndoTM (Dentsply/Sirona USA). The measurement was carried out by two observers using two different methods, Schneider and 3D EndoTM (Dentsply/Sirona USA). The results obtained had values greater than 100 degrees with the 3D EndoTM technique and at 20 degrees with the Schneider technique. No statistically significant difference was detected when comparing the different ducts with each other (AU)


Subject(s)
Humans , Dental Pulp Cavity , Cone-Beam Computed Tomography , Molar , Software , Data Interpretation, Statistical , Imaging, Three-Dimensional , Mexico
6.
Article in Chinese | WPRIM | ID: wpr-928888

ABSTRACT

The chemical characterization analysis of a medical device often results in chemical substances with unknown toxicities. While identification of each individual toxicity could result in a time-consuming hurdle with tremendous labor and financial burden, quantitative structure-activity relationship (QSAR) is of great significance for toxicity risk assessment of such chemical substances. By establishing quantitative relationship between the molecular structures or active groups of similar chemical compounds with their biological activities, QSAR can be utilized to predict the toxicity of such target compounds with significantly reduced cost and time. In this article, the authors generally summarized the mechanisms of QSAR approaches, current applications of QSAR modeling in the field of medical device, an introduction of the characteristics of publicly and commercially-available QSAR software, and briefly explored future trends of QSAR modeling in medical device toxicological risk assessment. The utilization of QSAR would undoubtedly further advance the toxicological risk assessment of medical devices.


Subject(s)
Quantitative Structure-Activity Relationship , Risk Assessment , Software
7.
Article in Chinese | WPRIM | ID: wpr-928880

ABSTRACT

Aiming at the current situation of performance testing of hemodialysis extracorporeal circulation tubing, which has slow efficiency, inaccurate measurement, and inconvenient testing, a portable detection system for testing the performance of hemodialysis extracorporeal circulation tubing is designed. The system mainly includes a hardware system and a software system. The hardware system uses STM32F407 single-chip microcomputer as the core to design the driving control of the roller pump; the software system uses the C++ real-time operating system, and the flow detection data is transmitted to the upper computer through RS485 communication and displayed. Experimental showed that the system detects the accuracy and the stability of the flow rate. It has the characteristics of stability and high precision. The relative error of the experimental measurement is within the range of ±10%. The weight of the whole machine is 2 kg, which improves the efficiency by 50% compared with the traditional detection method.


Subject(s)
Computers , Equipment Design , Extracorporeal Circulation , Microcomputers , Renal Dialysis , Software
8.
Article in Chinese | WPRIM | ID: wpr-928861

ABSTRACT

Advances in digital pathology technology have enabled pathologists and laboratory physicians to perform quick, easy, accurate and reproducible analysis of digital images of tissues and cells with the aid of electronic screens and software tools, rather than relying solely on traditional optical microscopy observations. The conventional clinical cytology testing practice is to be replaced by a digital workflow, which includes both digital imaging and image analysis. This article provides an overview of the basic principles of digital pathology techniques, the advances of development of device in cytology digital pathology, and their clinical applications in bone marrow morphology, and existing problems and prospects of digital pathology application in hematology.


Subject(s)
Bone Marrow , Image Processing, Computer-Assisted , Microscopy , Software , Technology
9.
Article in English | WPRIM | ID: wpr-928655

ABSTRACT

: To design and develop a Wechat applet for intelligent health management of metabolic syndrome. Based on the needs and requirements of individuals undergoing health check-up, patients with metabolic syndrome and medical workers, a Wechat applet for metabolic syndrome management was designed and developed, which involving health data collection, health risk prediction, health management knowledge base fusion and intelligent recommendation, data privacy and security. The platform consists of three user ports: individuals undergoing health check and patients with metabolic syndrome, the medical workers and the system administrators. The main functions of the platform included metabolic syndrome risk prediction, intelligent recommendation of health management strategies, health behavior record and supervision, experts' consultation and health knowledge guide. The Wechat applet developed in this study can be used for metabolic syndrome risk prediction for general population, and health management for patients with metabolic syndrome, which helps them to enhance health management awareness and health behavior adherence.


Subject(s)
Humans , Metabolic Syndrome/therapy , Software
10.
Article in Chinese | WPRIM | ID: wpr-928152

ABSTRACT

Based on the combination of ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF) and Waters UNIFI software, the chemical constituents of the classic prescription Xiaochengqi Decoction were qualitatively analyzed and identified. The UPLC conditions are as follows: Acquity HSS T3 reverse phase column(2.1 mm ×100 mm, 1.8 μm), column temperature of 30 ℃, mobile phase of 0.1% formic acid aqueous solution(A)-acetonitrile(B), and flow rate of 0.3 mL·min~(-1). High-resolution MS data of Xiaochengqi Decoction were collected in ESI~(+/-) modes by Fast DDA. The structures of the chemical constituents were tentatively characterized or identified by UNIFI software according to the retention time of reference standards and characteristic fragment ions in MS profile, and literature data. A total of 233 components in Xiaochengqi Decoction were identified, with 93 from wine-processed Rhei Radix et Rhizoma, 104 from bran-processed Aurantii Fructus Immaturus, and 36 from ginger-processed Magnoliae Officinalis Cortex. These 233 components included anthraquinones, flavonoids, lignans, alkaloids, coumarins, and phenylethanoid glycosides. The result provided experimental evidence for the further study on establishment of quality standard and product development of the formula.


Subject(s)
Chromatography, High Pressure Liquid/methods , DDT/analogs & derivatives , Drugs, Chinese Herbal/chemistry , Mass Spectrometry , Rhizome/chemistry , Software
11.
Dental press j. orthod. (Impr.) ; 27(1): e2219388, 2022. tab, graf
Article in English | LILACS, BBO | ID: biblio-1364782

ABSTRACT

ABSTRACT Introduction: Currently, no method is considered effective for the evaluation of digital models in the Certification Examination of the Brazilian Board of Orthodontics (BBO), considering the parameters of the currently used manual method. Objective: Thus, the aim of this study is to verify the reliability of an evaluation method for digital models that could be used in the BBO exam, compared to the gold standard. Methods: Measurements were performed by five previously calibrated examiners. Samples of ten sets of plaster models of the final phase of orthodontic treatment were measured using a manual method (Objective Grading System, OGS). These models were digitized using a 3D scanner and exported to Geomagic Qualify software, in which the measurements were made with the proposed digital method. These measurements were repeated using five models, after fifteen days. The intra-examiner performance with this method was analyzed with a paired t-test, whereas the inter-examiner analysis was carried out with analysis of variance and Tukey's test. To compare the manual and digital methods, a paired t-test and Pearson's correlation analysis were performed. Results: A statistically significant difference was found. The results showed that, when compared to the manual method, the digital method was effective in measuring the OGS in four of the seven variables studied: Marginal Ridge, Overjet, Occlusal Contact, and Interproximal Contact. The variables Alignment, BL inclination, and Occlusal Relationship showed a great amount of dispersion in the findings. Conclusion: Further studies are needed to develop an adequate digital methodology that can be used for all OGS variables.


RESUMO Introdução: Ainda não há um método considerado eficaz para análise dos modelos digitais no exame do Board Brasileiro de Ortodontia (BBO), considerando-se os parâmetros do método manual atual. Objetivo: Assim, o presente estudo objetiva verificar a confiabilidade de um método de avaliação em modelos digitais para o exame do BBO, comparando com o padrão-ouro. Métodos: As medições foram realizadas por 5 examinadores, previamente calibrados. A amostra de 10 pares de modelos de gesso da fase final do tratamento ortodôntico foi medida no método manual (Sistema Objetivo de Avaliação, SOA). Os modelos foram digitalizados por meio de um scanner 3D e exportados para o software Geomagic Qualify, onde foram feitas as medidas no método digital proposto. As medidas foram refeitas em 5 modelos após 15 dias. A análise intraexaminador desse método foi realizada por meio do teste t pareado; já a interexaminadores, feita com ANOVA e teste de Tukey, sendo encontrada diferença estatisticamente significativa. Para a comparação dos métodos manual e digital, foram utilizados o teste t pareado e a correlação de Pearson. Resultados: Uma diferença estatisticamente significativa foi encontrada. Os resultados mostraram que, comparada ao método manual, a metodologia digital mostrou-se eficaz para medição do SOA em quatro das sete variáveis estudadas: Margem interproximal, Sobressaliência, Contato oclusal e Contato interproximal. As variáveis Alinhamento, Inclinação V-L e Relação oclusal mostraram muita dispersão nos achados. Conclusão: Mais estudos são necessários para o desenvolvimento de uma metodologia digital adequada em todas as variáveis do SOA.


Subject(s)
Orthodontics , Software , Pilot Projects , Reproducibility of Results , Models, Dental
13.
Rev. Esc. Enferm. USP ; 56: e20210396, 2022. tab, graf
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1356725

ABSTRACT

Abstract Objectives: to identify the contents and characteristics of videos posted on YouTube that deal with Iramuteq software use as a tool to assist qualitative research and discuss the contribution of this social network to dissemination of knowledge, especially in the context of the COVID-19 pandemic. Method: this is an exploratory-descriptive study with a qualitative approach, carried out with YouTube videos, collected in June 2021 and subjected to thematic analysis. Results: a total of 43 videos on the researched topic were identified, with the majority (69.76%) published from 2020-2021. As for content, five categories were identified. Conclusion: the videos explain about Iramuteq installation, the textual corpus preparation, the errors identified by users and methods to correct them, the lexical analysis developed by the program and how to use it. The content is presented in a theoretical and practical way through the software interface presentation. Thus, YouTube's contribution to developing teaching and disseminating knowledge is observed, both because it constitutes itself as a source for research and because it fosters dialogues between researchers, especially in a pandemic context.


RESUMEN Objetivos: identificar los contenidos y características de los videos publicados en la red social YouTube que abordan el uso del software Iramuteq como herramienta para ayudar a la investigación cualitativa y discutir la contribución de esta red social a la difusión del conocimiento, especialmente en el contexto de la pandemia de COVID-19. Método: estudio exploratorio-descriptivo con abordaje cualitativo, realizado con videos de YouTube, recolectados en junio de 2021 y sometidos a análisis temático. Resultados: se identificaron 43 videos sobre el tema investigado, la mayoría (69,76%) publicados en el período 2020-2021. En cuanto al contenido, se identificaron cinco categorías. Conclusión: los videos explican sobre la instalación de Iramuteq, la preparación del corpus textual, los errores identificados por los usuarios del software y los métodos para corregirlos, el análisis léxico desarrollado por el programa y cómo utilizarlo. El contenido se presenta de forma teórica y práctica a través de la presentación de la interfaz del software. Así, se observa la contribución de YouTube al desarrollo de la docencia y la difusión del conocimiento, tanto porque se constituye como fuente de investigación como porque provoca diálogos entre investigadores, especialmente en un contexto pandémico.


RESUMO Objetivos: identificar os conteúdos e características dos vídeos postados na rede social YouTube que tratam do uso do software Iramuteq como ferramenta para auxiliar as pesquisas qualitativas e discutir a contribuição desta rede social para a difusão do conhecimento, especialmente no contexto da pandemia de COVID-19. Método: estudo exploratório-descritivo de abordagem qualitativa, realizado com vídeos do YouTube, coletados em junho de 2021 e submetidos à análise temática. Resultados: foram identificados 43 vídeos sobre a temática pesquisada, sendo a maioria (69,76%) publicado no período de 2020-2021. Quanto ao conteúdo, identificaram-se cinco categorias. Conclusão: os vídeos explanam sobre a instalação do Iramuteq, o preparo do corpus textual, os erros identificados por usuários do software e métodos para corrigi-los, as análises lexicais desenvolvidas pelo programa e como utilizá-lo. O conteúdo é apresentado de forma teórica e prática por meio da apresentação da interface do software. Assim, observa-se a contribuição do YouTube para o desenvolvimento do ensino e difusão do conhecimento, tanto por constituir-se como uma fonte para pesquisa como também por suscitar diálogos entre pesquisadores, especialmente em um contexto de pandemia.


Subject(s)
Software , Qualitative Research , Teaching , Social Media , COVID-19
14.
Rev. cuba. inform. méd ; 13(2): e433, 2021. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1357288

ABSTRACT

La aplicación Sistema para la Gestión de Personas Aisladas (SGPA-UCI) fue desarrollada para informatizar el proceso de ingreso, pruebas de PCR y egreso de personas aisladas en el centro de aislamiento instalado en la Universidad de las Ciencias Informáticas (UCI), como parte del enfrentamiento a la Covid-19 en Cuba. Para el desarrollo de la aplicación se utilizó Symfony como framework de desarrollo y para el monitoreo de los datos, se diseñaron tableros con el empleo de Grafana. La solución informática facilitó la gestión de más de 10 mil personas aisladas en el centro de aislamiento, en un período de aproximadamente 6 meses, obteniendo los datos primarios de las personas y facilitando el proceso de ingreso, preparación de PCR, procesamiento de resultados recibidos y proceso de egreso. El sistema para la gestión de personas aisladas permitió el proceso de seguimiento a las personas en el centro de aislamiento UCI-MINSAP durante el enfrentamiento a la pandemia Covid-19(AU)


The System for the Management of Isolated Persons (SGPA-UCI) application was developed to computerize the process of admission, PCR tests and discharge of isolated people in the isolation center created in the University of Computer Sciences (UCI), as part of the confrontation with Covid-19 in Cuba. For the development of the application, Symfony was used as a development framework and for data monitoring, dashboards were designed using Grafana. The computer solution simplified the management of more than 10 thousand people isolated in the isolation center, in a period of approximately 6 months, obtaining the primary data of the people and facilitating the process of admission, preparation of PCR, processing of received results and exit process. The system for the management of isolated people allowed the process of monitoring people in the UCI-MINSAP isolation center during the confrontation with the Covid-19 pandemic(AU)


Subject(s)
Humans , Patient Isolation , Programming Languages , Software , Environmental Monitoring , COVID-19 , Cuba
15.
Rev. cuba. inform. méd ; 13(2): e447, 2021. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1357286

ABSTRACT

Introducción: el entorno virtual de aprendizaje como modalidad de educación a distancia, se ha convertido en una necesidad para las universidades pues aprovecha los avances de las tecnologías de la informática y las comunicaciones para garantizar un aprendizaje dinámico, en el cual el estudiante es un ente activo. Ante la contingencia epidemiológica de la COVID-19, cobra gran importancia para garantizar la continuidad del proceso docente. Objetivo: relatar la experiencia del entorno virtual de aprendizaje en la asignatura Genética médica, para estudiantes del cuarto semestre de la carrera de Medicina de la Facultad Finlay-Albarrán, durante el período de enfrentamiento a la pandemia de la COVID-19. Material y Métodos: se aplicó un diseño de paradigma cualitativo, del nivel investigativo exploratorio, en el que se realiza un estudio de caso. Resultados: en la primera etapa se utilizó la modalidad del aprendizaje mixto, previa creación del entorno virtual de aprendizaje en la plataforma Moodle. En ella se aplicaron la mayoría de sus herramientas informáticas como el foro de discusión, el chat, el examen tipo test, entre otros. En la segunda etapa, se aplicó la modalidad e-learning y se creó un grupo WhatsApp para darle continuidad al proceso. En la tercera etapa se re-estableció la modalidad presencial, haciendo énfasis en la integración de los conocimientos desde la perspectiva del tema 8. Conclusión: la educación a distancia virtual, garantizó la continuidad del proceso docente de la asignatura Genética médica durante el periodo de emergencia epidemiológica por la COVID-19(AU)


Introduction: the virtual learning environment as a distance education modality has become a necessity for universities, which takes advantage of advances in information technology and communications to guarantee dynamic learning, in which the student is an active entity. Given the epidemiological contingency of the COVID-19 pandemic, it is of great importance to guarantee the continuity of the teaching process. Objective: to report the experience of the virtual learning environment in the subject of Medical Genetics for the fourth semester students of the Medicine career at the Finlay-Albarrán Faculty that was developed during the period of confrontation with the COVID-19 pandemic. Material and Methods: a qualitative paradigm design of the exploratory research level was applied, in which a case study is carried out. Results: in the first stage, the blended learning modality was used, after creating the virtual learning environment on the Moodle platform; most of its computer tools were applied, such as the discussion forum, the chat, multiple choice exam, among others. In the second stage, the e-learning modality was applied and a WhatsApp group was created to give continuity to the process. In the third stage, the face-to-face modality was re-established, emphasizing the integration of knowledge from the perspective of topic 8. Conclusion: virtual distance education guaranteed the continuity of the teaching process of the subject of medical genetics during the period epidemiological emergency of COVID-19(AU)


Subject(s)
Humans , Young Adult , Software , Telemedicine , Education, Distance/methods , COVID-19 , Genetics, Medical/education , Software Design
16.
Rev. cuba. inform. méd ; 13(2): e413, 2021. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1357282

ABSTRACT

El uso de las aplicaciones informáticas facilita en la actualidad el quehacer de los docentes en la educación médica superior. El objetivo fue confeccionar una aplicación con soporte en dispositivos móviles y computadoras como herramienta para el aprendizaje de la Epidemiología Bucal en la carrera de Estomatología. Se realizó un estudio de desarrollo tecnológico en la Universidad de Ciencias Médicas de Granma, de septiembre del 2018 a junio del 2019. Para la confección de la aplicación se identificaron como etapas de trabajo la búsqueda y recopilación de información, selección de herramientas y el diseño. Se validó el producto mediante criterio de expertos en la materia. La efectividad de la utilización del producto se evaluó mediante una prueba pedagógica a los estudiantes que integraron la muestra. La aplicación mostró un diseño claro y atractivo. Ofrece una libre navegación donde se puede llegar, rápido y fácilmente al contenido deseado. En su totalidad los expertos evaluaron el producto de muy adecuado, y todos los usuarios emitieron el criterio de bien en los indicadores medidos. Se concluyó que la herramienta confeccionada permitió al estudiante de estomatología interactuar con los contenidos de la asignatura Epidemiología Bucal, considerándose útil como material de apoyo a la docencia(AU)


The use of computer applications currently facilitates the work of teachers in higher medical education. The objective was to create an application with support for mobile devices and computers as a tool for learning Oral Epidemiology in Stomatology. A study of technological development was carried out at the University of Medical Sciences of Granma, from September 2018 to June 2019. For the preparation of the application, the search and collection of information, selection of tools and design were identified as work stages. The product was validated by the criteria of experts in the field. The effectiveness of use of the product was evaluated by means of a pedagogical test to the students who made up the sample. The application showed a clear and attractive design. It offers free navigation where you can quickly and easily reach the desired content. In its entirety, the experts evaluated the product as very adequate, and all users gave the criterion of good in the measured indicators. It was concluded that the tool allowed the stomatology student to interact with the contents of the subject Oral Epidemiology, considering it useful as a teaching support material(AU)


Subject(s)
Humans , Male , Female , Medical Informatics Applications , Software , Education, Dental , Mobile Applications
17.
Estud. pesqui. psicol. (Impr.) ; 21(4): 1541-1560, dez. 2021.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1359832

ABSTRACT

A análise de dados qualitativos tem sido auxiliada por diferentes programas computacionais (e.g., Alceste, Iramuteq, TXM, Lexico). O Iramuteq é um software gratuito que auxilia o tratamento de dados textuais e oferece diferentes possibilidades de análise baseadas na estatística de texto, ou lexicometria. O artigo buscou apresentar essa abordagem e oferecer fundamentos teórico-metodológicos para o uso do Iramuteq em pesquisas qualitativas. O texto discorre sobre os princípios da lexicometria e apresenta as características, potencialidades e limites das diferentes técnicas de tratamento lexical viabilizadas pelo Iramuteq: Estatísticas Textuais Clássicas, Análise de Especificidades, Análise de Similitude, Análise Fatorial por Correspondência, Classificação Hierárquica Descendente (método Reinert - Alceste), Nuvem de Palavras e Análise Prototípica de evocações livres. Espera-se que o trabalho possa estimular a utilização crítica e contextualizada do Iramuteq em pesquisas qualitativas, assim como contribuir para a formação de estudantes de pós-graduação e pesquisadores da psicologia e áreas afins que possam se beneficiar do uso da ferramenta em seus estudos. (AU)


Qualitative data analysis has been aided by various computer programs (e.g., Alceste Iramuteq, TXM, Lexicon). Iramuteq is a free software that helps the treatment of textual data and offers different possibilities of analysis based on text statistics, or lexicometry. This paper aims to present this approach and provide theoretical and methodological foundations for the use of Iramuteq in qualitative research. The text discusses the principles of lexicometry and presents the characteristics, potentialities and limits of the different lexical treatment techniques made possible by Iramuteq: Classic Textual Statistics, Specificity Analysis, Similitude Analysis, Factorial Analysis by Correspondence, Descending Hierarchical Classification (Reinert's method - Alceste), Word Cloud and Prototypical Analysis of free evocations. It is expected that the work can stimulate the critical and contextualized use of Iramuteq in qualitative research, as well as contribute to the training of graduate students and researchers in psychology and related fields who can benefit from the use of the tool in their studies. (AU)


El análisis de datos cualitativos ha sido ayudado por diferentes programas de computadora (e.g., Alceste, Iramuteq, TXM, Lexico). Iramuteq es un software gratuito que ayuda al procesamiento de datos textuales y ofrece diferentes posibilidades de análisis basadas en estadísticas de texto o lexicometría. El artículo buscó presentar este enfoque y ofrecer fundamentos teóricos y metodológicos para el uso de Iramuteq en la investigación cualitativa. El texto analiza los principios de la lexicometría y presenta las características, potencialidades y límites de las diferentes técnicas de tratamiento léxico de Iramuteq: Estadística Textual Clásica, Análisis de Especificidad, Análisis de Similitud, Análisis Factorial por Correspondencia, Clasificación Jerárquica Descendente (método Reinert - Alceste), Nube de Palabras y Análisis Prototípico de evocaciones libres. Se espera que el trabajo pueda estimular el uso crítico y contextualizado de Iramuteq en la investigación cualitativa, así como contribuir a la capacitación de estudiantes graduados e investigadores en psicología y campos relacionados que puedan beneficiarse del uso de la herramienta en sus estudios. (AU)


Subject(s)
Qualitative Research , Methodology as a Subject , Software
18.
Rev. cuba. oftalmol ; 34(3): e924, 2021. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1352021

ABSTRACT

Objetivo: Determinar los factores relacionados con los resultados visuales finales de la mejor agudeza visual en pacientes con trauma ocular a globo abierto en zona I, ingresados en el Instituto Cubano de Oftalmología "Ramón Pando Ferrer", entre junio de 2016 y junio de 2017. Métodos: Se realizó un estudio observacional, descriptivo, longitudinal y prospectivo a una muestra de 35 pacientes. Las variables estudiadas fueron edad, sexo, ocupación, ojo afectado, lugar del accidente, agente causal, localización, tamaño, forma de la herida, tiempo de evolución, mecanismo de producción, mejor agudeza visual inicial y final, alteraciones oculares asociadas, tratamiento médico realizado y complicaciones, para las cuales se creó una base de datos automatizada con SPSS (versión 21.0 para el sistema operativo Windows). Resultados: La mayoría de los pacientes se ubicaron en las categorías 3 y 4 del puntaje del trauma ocular. Más de la mitad mejoró su agudeza visual a los tres meses del trauma. Mientras mayor era la agudeza visual inicial y mayor la categoría del puntaje del trauma ocular, mayor fue la agudeza visual final. Esta última tuvo una relación directa con la agudeza visual inicial y con la presencia de hernia de iris y de hemovítreo. Conclusiones: A pesar de los avances en las clasificaciones y en el tratamiento del trauma ocular a globo abierto en zona I, persiste la pérdida o disminución visual en un número importante de pacientes, por lo que las medidas encaminadas a la prevención del trauma ocular deben fortalecerse(AU)


Objective: Determine the factors related to final best visual acuity results in patients with zone 1 open globe ocular trauma admitted to Ramón Pando Ferrer Cuban Institute of Ophthalmology from June 2016 to June 2017. Methods: An observational prospective longitudinal descriptive study was conducted of a sample of 35 patients. The variables analyzed were age, sex, occupation, affected eye, place of the accident, causative agent, location, wound size and shape, time of evolution, production mechanism, best initial and final visual acuity, associated ocular alterations, medical treatment indicated and complications, all of which were processed into a database with the software SPSS version 21.0 for Windows. Results: Most patients were classed as categories 3 and 4 on the ocular trauma scale. Visual acuity improvement was observed in more than half of the patients three months after the trauma. The greater the initial visual acuity and the higher the ocular trauma score, the greater was the final visual acuity. The latter was directly proportional to initial visual acuity and the presence of iris hernia and hemovitreous. Conclusions: Despite the progress achieved in the classification and treatment of zone 1 open globe ocular trauma, visual loss or reduction persists in a considerable number of patients, pointing to the need of enhancing the measures aimed at preventing ocular trauma(AU)


Subject(s)
Humans , Software , Visual Acuity , Eye Injuries/etiology , Accidents , Epidemiology, Descriptive , Prospective Studies , Longitudinal Studies , Observational Studies as Topic
19.
Rev. habanera cienc. méd ; 20(4): e3211, 2021. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1289629

ABSTRACT

Introducción: El tratamiento inicial de la cervicalgia por degeneración de los discos intervertebrales es conservador, pero en caso de fallo la discectomía es la opción quirúrgica habitual, sustituyendo el disco por un injerto óseo u otra estructura que cumpla total o parcialmente las funciones del primero. El Servicio de Neurocirugía del Hospital General Camilo Cienfuegos de Cuba ha diseñado un nuevo modelo de prótesis de disco intervertebral cervical para tratar esta enfermedad. Objetivo: Evaluar el desempeño mecánico de la prótesis diseñada a través del método de los elementos finitos bajo las cargas habituales de la columna cervical. Material y Métodos: Se realizó un estudio experimental mediante la simulación numérica, según el método de los elementos finitos, sometiendo la prótesis a las cargas axiales recomendadas por las normas ASTM F2423-11e ISO 18192-1.2011 mediante el software Free CAD 0.18. Resultados: Los mayores esfuerzos soportados por la prótesis en la posición neutral, flexión anterior y flexión lateral fueron de 28.79 MPa, 52.29 MPa y 55.59 MPa respectivamente. La prótesis no sufrió ninguna fractura al no sobrepasar los valores anteriores al límite elástico del material que la constituye. La mayor deformación descrita fue de 1 m. Conclusiones: La mayor concentración de esfuerzos en la prótesis se ubicó en el punto de contacto de la cavidad prismática de la pieza superior al hacer contacto con el prisma de la pieza inferior. El dispositivo diseñado no sufrió ninguna deformación significativa ni se fracturó ante las cargas aplicadas(AU)


Introduction: The initial treatment of cervicalgia due to degeneration of the intervertebral discs is conservative, but in case of failure, discectomy is the usual surgical option, replacing the disc with a bone graft or another structure that fully or partially fulfills the functions of the former. The Neurosurgery Service of the Camilo Cienfuegos General Hospital in Cuba has designed a new cervical intervertebral disc prosthesis model to treat this disease. Objective: To evaluate the mechanical performance of the prosthesis designed through the finite element method under the usual loads of the cervical spine. Material and Methods: An experimental study was carried out using numerical simulation according to the finite element method, subjecting the prosthesis to the axial loads recommended by ASTM F2423-11e ISO 18192-1.2011 standards using Free CAD 0.18 software. Results: The greatest efforts supported by the prosthesis in the neutral position, anterior flexion and lateral flexion were 28.79 MPa, 52.29 MPa and 55.59 MPa, respectively. The prosthesis did not suffer any fracture as it did not exceed the values ​prior to the elastic limit of the material that constitutes it. The greatest deformation described was 1 956;m. Conclusions: The highest concentration of efforts in the prosthesis was located at the point of contact of the prismatic cavity of the upper part when making contact with the prism of the lower part. The designed device did not undergo any significant deformation or fracture at the applied loads(AU)


Subject(s)
Software , Bone Transplantation , Hospitals, General
20.
Int. braz. j. urol ; 47(4): 843-855, Jul.-Aug. 2021. tab, graf
Article in English | LILACS | ID: biblio-1286781

ABSTRACT

ABSTRACT Objective: Interstitial cystitis (IC)/bladder pain syndrome (BPS) is a chronic inflammatory disease that can cause bladder pain and accompanying symptoms, such as long-term urinary frequency and urgency. IC/BPS can be ulcerative or non-ulcerative. The aim of this study was to explore the core genes involved in the pathogenesis of ulcerative IC, and thus the potential biomarkers for clinical treatment. Materials and Methods: First, the gene expression dataset GSE11783 was downloaded using the Gene Expression Omnibus (GEO) database and analyzed using the limma package in R to identify differentially expressed genes (DEGs). Then, the Database for Annotation, Visualization and Integrated Discovery (DAVID) was used for Gene Ontology (GO) functional analysis, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) was used for pathway enrichment analysis. Finally, the protein-protein interaction (PPI) network was constructed, and key modules and hub genes were determined using the STRING and Cytoscape software. The resulting key modules were then analyzed for tissue-specific gene expression using BioGPS. Results: A total of 216 up-regulated DEGs and 267 down-regulated genes were identified, and three key modules and nine hub genes were obtained. Conclusion: The core genes (CXCL8, CXCL1, IL6) obtained in this study may be potential biomarkers of interstitial cystitis with guiding significance for clinical treatment.


Subject(s)
Humans , Cystitis, Interstitial/genetics , Software , Gene Expression Profiling , Protein Interaction Maps/genetics , Gene Ontology
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