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2.
rev.cuid. (Bucaramanga. 2010) ; 14(3): 1-14, 20230901.
Article in English | LILACS, BDENF, COLNAL | ID: biblio-1510105

ABSTRACT

Introduction: Serum vitamin D levels depend on sunlight, diet, and other factors. Objective: We aimed to determine serum vitamin D levels and evaluate their relationship with anthropometric indicators and lifestyle habits in apparently healthy volunteers. Materials and Methods: In this cross-sectional study (n=75), socio-demographic, anthropometric, and lifestyle habit-related data were collected. Serum vitamin D levels were determined with high performance liquid chromatography, food intake was measured by semiquantitative frequency and nutritional status was assessed by anthropometry. Chi-square test and also principal component analysis were used to analyze the relationship between some variables and vitamin D status. Spearman's test was used to determine correlations between quantitative variables. Results: 73% were women and 61% belonged to medium socio-economic level. Median vitamin D intake was 137 (83.1­227.3) IU/day. Based on body mass index (BMI), 44% individuals had overweight/obesity. The 68% exhibited deficient/insufficient vitamin D levels (Hypovitaminosis D). BMI classification and waist circumference (CW) were not related with vitamin D status; however, activities with higher sun exposure were highly related (p = 0.013). Sun exposure time explained variation in component 2 (16.60%), where most of the individuals with normal level were grouped. Sun exposure time was positively correlated with vitamin D status (r = 0.263; p = 0.023). Discussion: Excess weight and abdominal obesity are not always associated with hypovitaminosis D. Conclusions: The majority of individuals showed hypovitaminosis D but their status was not related with anthropometric indicators. A Sun exposure time was the only factor positively correlated with vitamin D status.


Introducción: Los niveles séricos de vitamina D dependen de la luz solar, la dieta y otros factores. Objetivo: Nuestro objetivo fue determinar los niveles séricos de vitamina D y evaluar su relación con indicadores antropométricos y estilos de vida en voluntarios aparentemente sanos. Materiales y métodos: En este estudio trasversal (n=75) se recogieron datos sociodemográficos, antropométricos y aquellos relacionados con hábitos y estilos de vida. La vitamina D se determinó por cromatografía liquida de alta eficiencia; la ingesta de alimentos, mediante frecuencia semicuantitativa, y el estado nutricional por antropometría. Para analizar la relación entre algunas variables y el estado de la vitamina D se usó la prueba de Chi cuadrado y también el análisis de componentes principales. Se empleó la prueba de Spearman para determinar la correlación entre variables cuantitativas. Resultados: El 73% eran mujeres y el 61% pertenecían a un estrato socioeconómico medio. La mediana de la ingesta de vitamina D fue de 137 (83,1­227,3) UI/día. Según el índice de masa corporal (IMC), el 44% de los individuos tenían sobrepeso/obesidad. El 68% mostro deficiencia/insuficiencia de vitamina D (hipovitaminosis D). La clasificación del IMC y la circunferencia abdominal no se relacionaron con el estado de la vitamina D; sin embargo, las actividades con una mayor exposición solar estuvieron altamente relacionadas (p=0,013). El tiempo de exposición solar explico la variación en el componente 2 (16,60%) donde se agruparon la mayoría de los individuos con niveles normales. El tiempo de exposición solar tuvo una correlación positiva con el estado de la vitamina D (r = 0,263; p = 0,023). Discusión: El exceso de peso y la obesidad abdominal no siempre se relacionan con la hipovitaminosis D. Conclusiones: La mayoría de los individuos presentaron hipovitaminosis D, pero su estado no se relacionó con los indicadores antropométricos. El tiempo de exposición al sol fue el único factor que se correlaciono positivamente con el estado de la vitamina D.


Introdução: Os níveis séricos de vitamina D dependem da luz solar, da dieta e de outros fatores. Objetivo: Nosso objetivo foi determinar os níveis séricos de vitamina D e avaliar sua relação com indicadores antropométricos e hábitos de vida em voluntários aparentemente saudáveis. Materiais e métodos: Neste estudo transversal (n=75), foram coletados dados sociodemográficos, antropométricos e relacionados a hábitos de vida. Os níveis séricos de vitamina D foram determinados por cromatografia liquida de alto desempenho, a ingestão de alimentos foi medida por frequência semiquantitativa e o estado nutricional foi avaliado por antropometria. O teste do qui-quadrado e a análise de componentes principais foram utilizados para analisar a relação entre algumas variáveis e o estado da vitamina D. O teste de Spearman foi usado para determinar as correlações entre as variáveis quantitativas. Resultados: 73% eram mulheres e 61% pertenciam a um nível socioeconômico médio. A ingestão media de vitamina D foi de 137 (83,1-227,3) UI/dia. Com base no índice de massa corporal (IMC), 44% dos indivíduos tinham sobrepeso/obesidade. Os 68% apresentaram níveis deficientes/insuficientes de vitamina D (hipovitaminose D). A classificação do IMC e a circunferência da cintura (CW) não foram relacionadas ao status da vitamina D; entretanto, as atividades com maior exposição ao sol foram altamente relacionadas (p = 0,013). O tempo de exposição ao sol explicou a variação no componente 2 (16,60%), onde a maioria dos indivíduos com nível normal foi agrupada. O tempo de exposição ao sol foi positivamente correlacionado com o status de vitamina D (r = 0,263; p = 0,023). Discussão: O excesso de peso e a obesidade abdominal nem sempre estão associados com a hipovitaminose D. Conclusões: A maioria dos indivíduos apresentou hipovitaminose D, mas seu status não foi relacionado com indicadores antropométricos. O tempo de exposição ao sol foi o único fator positivamente correlacionado com o status da vitamina D.


Subject(s)
Sunlight , Vitamin D , Anthropometry , Healthy Volunteers , Life Style
3.
Actual. nutr ; 24(3): 205-214, Jul-Sept 2023. tab
Article in Spanish | LILACS, ARGMSAL, BINACIS | ID: biblio-1511570

ABSTRACT

Introducción: El déficit de vitamina D y la diabetes son dos situaciones prevalentes en todas las edades, regiones geográficas y niveles socioeconómicos. La presencia de receptores para 1,25(OH)2D y la existencia de la enzima 1-α-hidroxilasa en la célula beta ­que permite la síntesis del metabolito activo­ sugieren que la vitamina D juega un papel importante en dichas células y que su deficiencia podría ser un factor capaz de acelerar el inicio y la evolución de la enfermedad. Objetivos: Se realizó una revisión del tema vitamina D y Diabetes. A su vez, se analizó el rol de la vitamina D en la insulinorresistencia y en la DM2, así como en la autoinmunidad y la DM1. También se indagó en el estado actual sobre los efectos de la suplementación con vitamina D en la prevención, el control glucémico y la evolución de las complicaciones asociadas a esta enfermedad. Materiales y Métodos: Se realizó una búsqueda bibliográfica utilizando los buscadores PubMed, MEDLINE, Cochrane, Research Gate. Los criterios de búsqueda fueron "vitamin D", "vitamin D and diabetes", "vitamin D and supplementation". Conclusiones: Existe suficiente evidencia acerca de que los niveles séricos de 25(OH)D deberían alcanzar valores entre 30 y 50 ng/ml para influir en las funciones metabólicas. Se enfatiza en la importancia de incluir el dosaje de 25(OH)D en el control clínico de rutina. Teniendo en cuenta la escasa distribución de la vitamina D en los alimentos naturales, el bajo consumo de los alimentos fuente en la población argentina y las recomendaciones actuales de limitar la exposición al sol por el cáncer de piel, emerge como necesario contar con alimentos fortificados de consumo masivo, además de la leche


Introduction: Vitamin D deficiency and diabetes are two prevalent situations in all ages, geographic regions and socioeconomic levels. The presence of receptors for 1,25(OH)2D and the existence of the enzyme 1-α-hydroxylase in the beta cell ­which allows the synthesis of the active metabolite­ suggest that vitamin D plays an important role in these cells and that vitamin deficiency could be a factor that can accelerate the onset and progression of the disease. Objectives: The subject vitamin D and Diabetes was review. The role of vitamin D in insulin resistance and DM2, as well as autoimmunity and DM1, were analyze. We also evaluated the effects of vitamin D supplementation on prevention, glycemic control and evolution of associated complications. Materials and methods: A bibliographic search was carried out using the search engines PubMed, MEDLINE, Cochrane, Research Gate. The search criteria were "vitamin D", "vitamin D and diabetes", "vitamin D and supplementation". Conclusions: There is sufficient evidence that blood levels of 25(OH)D should reach values between 30 and 50 ng/ml to influence metabolic functions. The importance of including 25(OH)D dosage in routine clinical control is emphasized. Taking into account the scarce distribution of vitamin D in natural foods, the low consumption of source foods in the Argentine population and the current recommendations to limit sun exposure due to skin cancer, it emerges as necessary to have fortified foods for mass consumption, in addition to milk


Subject(s)
Vitamin D Deficiency , Diabetes Mellitus , Vitamin D
4.
Arch. latinoam. nutr ; 73(3): 222-232, sept 2023.
Article in Spanish | LILACS, LIVECS | ID: biblio-1518453

ABSTRACT

Los trastornos autoinmunes representan una familia de al menos 80 condiciones diferentes que surgen de una respuesta aberrante del sistema inmunológico resultando finalmente en la destrucción de tejidos y órganos específicos del cuerpo. Es importante destacar que durante las últimas tres décadas los estudios epidemiológicos han proporcionado evidencia de un aumento constante en la incidencia y prevalencia de trastornos autoinmunes. En los últimos años, varios estudios han demostrado que la vitamina D y los ácidos grasos poliinsaturados (AGPs) omega-3 ejercen propiedades inmunomoduladoras y antiinflamatorias sinérgicas que pueden aprovecharse positivamente para la prevención y el tratamiento de trastornos autoinmunes. En este sentido, el reciente ensayo clínico denominado VITAL (ensayo de vitamina D y omega 3); un estudio a gran escala, aleatorizado, doble ciego, controlado con placebo encontró que la suplementación conjunta de vitamina D y AGPs omega-3 (VIDOM) puede reducir la incidencia de enfermedades autoinmunes. En esta revisión de la literatura, resumimos los mecanismos moleculares detrás de las propiedades inmunomoduladoras y antiinflamatorias de la vitamina D y los AGPs omega-3, así como la posible interacción bidireccional entre el metabolismo de la vitamina D y el metabolismo de los AGPs omega-3 que justifica la co- suplementación VIDOM en trastornos autoinmunes(AU)


Autoimmune disorders represent a family of at least 80 different conditions that arise from an aberrant immune system response, which ultimately results in the destruction of specific body tissues and organs. It is important to highlight that during the last three decades epidemiological studies have provided evidence of a steady increase in the incidence and prevalence of autoimmune disorders. In recent years, several studies have shown that vitamin D and omega-3 polyunsaturated fatty acids (PUFAs) exert synergistic immunomodulatory and anti-inflammatory properties that can be positively harnessed for the prevention and treatment of autoimmune disorders. In this sense, the recent clinical trial called VITAL (Vitamin D and Omega 3 trial) - a large, randomized, double-blind, placebo- controlled study - found that co-supplementation of vitamin D and omega-3 PUFAs (VIDOM) can reduce the incidence of autoimmune diseases. In this literature review, we summarize the molecular mechanisms behind the immunomodulatory and anti-inflammatory properties of vitamin D and omega-3 PUFAs, as well as the possible bidirectional interaction between vitamin D metabolism and omega-3 PUFA metabolism that justifies VIDOM co- supplementation in autoimmune disorders(AU)


Subject(s)
Autoimmune Diseases , Vitamin D , Fatty Acids, Omega-3 , Epidemiology , Immunomodulation
5.
Rev. ADM ; 80(1): 36-40, ene.-feb. 2023. ilus, tab
Article in Spanish | LILACS | ID: biblio-1511548

ABSTRACT

Introducción: la vitamina D es una hormona que se sintetiza por células de la piel mediante la luz ultravioleta (UV) y se obtiene a través de la dieta. La relación que se establece entre la deficiencia de vitamina D y el fracaso en injertos óseos o implantes se basa en las alteraciones inmunológicas e inflamatorias debido al vínculo que existe con la inmunidad innata y adaptativa. Objetivo: identificar los factores que se presentan en el periodonto cuando existen niveles bajos de vitamina D y se realizan tratamientos periodontales como injertos óseos e implantes. Material y métodos: se realizó la búsqueda primaria de artículos en bases de datos PubMed y Google Académico (en español e inglés), de acuerdo con las palabras claves: deficiencia, vitamina D, implantología y oseointegración. Resultados: la vitamina D afecta y predispone al rechazo de injertos, ausencia de oseointegración en implantes debido a la inmunomodulación. Conclusión: el éxito del tratamiento se vuelve predecible cuando se encuentran niveles óptimos de vitamina D en conjunto con técnicas de abordaje quirúrgico correctas que permitan generar una integración ideal de los tejidos periodontales (AU)


Introduction: vitamin D is a hormone that is synthesized by skin cells using UV light and consumed through the diet. The relationship established between vitamin D deficiency and the failure of bone grafts or implants is based on immunological and inflammatory alterations due to the intimate link with innate and adaptive immunity. Objective: to identify the factors that occur in the periodontium when there are low levels of vitamin D and periodontal treatments such as bone grafts and implants are performed. Material and methods: a search for articles was carried out in PubMed and Google Scholar (Spanish and English). Results: vitamin D affects and predisposes to graft rejection, absence of osseointegration in implants due to immunomodulation. Conclusion: the success of the treatment becomes predictable when optimal levels of vitamin D are found together with the correct surgical approach techniques that allow the generation of an ideal integration of the periodontal tissues.(AU)


Subject(s)
Vitamin D Deficiency/complications , Osseointegration/physiology , Dental Implantation, Endosseous/adverse effects , Vitamin D/metabolism , Bone Transplantation/adverse effects
6.
Braz. j. biol ; 83: 1-5, 2023. tab
Article in English | LILACS, VETINDEX | ID: biblio-1468939

ABSTRACT

Serum toxic metals have been implicated in development of many diseases. This study investigated the association between blood levels of lead and cadmium with abnormal bone mineral density (BMD) and incidence of osteoporosis. Sixty Saudi male adults age matching were assigned into two groups: A healthy control group (n = 30) and osteoporosis patients diagnosed according to T-score (n = 30). Serum calcium, vitamin D, osteocalcin, lead, cadmium were measured. Osteoporotic group showed a highly significant elevation of blood lead and cadmium levels compared to the control group (p <0.001). BMD was negatively correlated with serum osteocalcin level compared with control. There was a significant negative correlation between the cadmium and lead levels (r=-0.465 and p-value = 0.01) and calcium (p < 0.004). Our findings suggested that high cadmium and lead were negative correlated to BMD and increased the risk factor for osteoporosis.


Os metais tóxicos do soro têm sido implicados no desenvolvimento de muitas doenças. Este estudo investigou a associação entre os níveis sanguíneos de chumbo e cádmio com densidade mineral óssea anormal (DMO) e incidência de osteoporose. Sessenta adultos sauditas do sexo masculino com idades iguais foram divididos em dois grupos: um grupo de controle saudável (n = 30) e pacientes com osteoporose diagnosticados de acordo com o T-score (n = 30). Cálcio sérico, vitamina D, osteocalcina, chumbo, cádmio foram medidos. O grupo osteoporótico apresentou elevação altamente significativa dos níveis de chumbo e cádmio no sangue em comparação ao grupo controle (p < 0,001). A DMO foi negativamente correlacionada com o nível de osteocalcina sérica em comparação com o controle. Houve correlação negativa significativa entre os níveis de cádmio e chumbo (r = -0,465 ep = 0,01) e cálcio (p < 0,004). Nossos achados sugeriram que cádmio e chumbo elevados foram correlacionados negativamente à DMO e aumentaram o fator de risco para osteoporose.


Subject(s)
Male , Humans , Adult , Lead/toxicity , Cadmium/toxicity , Osteocalcin/analysis , Osteoporosis/blood , Vitamin D/analysis
9.
Article in English | WPRIM | ID: wpr-984452

ABSTRACT

Introduction@#In the Philippines, hypertensive diseases of pregnancy belong in the top three causes of maternal mortality and complicate up to 10% of pregnancy worldwide. In relation with this, proper interventions must be given during the prenatal check-up to prevent occurrence that may cause feto-maternal mortality and morbidity. During prenatal check-up, pregnant women are given vitamin and mineral supplementations. Vitamin D has an association of having a risk for preeclampsia. Receptors of Vitamin D and 1-a hydroxylase are both expressed in the decidua and trophoblast cells. The active form of Vitamin D affects the transcription and function of genes associated with angiogenesis, invasion of the placenta, and normal implantation. The mechanisms mentioned are all involved in the pathophysiology of preeclampsia.@*Objectives@#The primary outcome of this study is to determine the association of Vitamin D supplementation in preeclampsia. Specifically, this study aims to compare the following secondary outcomes: Maternal outcomes (complication of gestational diabetes mellitus and underwent cesarean delivery) and fetal outcomes (preterm delivery and birth weight).@*Methodology@#Meta-analysis and systematic review of eight randomized controlled trials.@*Results@#Vitamin D reduced the risk of preeclampsia (risk ratio [RR] 0.45, 95% confidence interval [CI] 0.30–0.69; P = 0.0002). No significant difference on risk of gestational diabetes mellitus (RR 0.84, 95% CI 0.48–1.48) and risk of preterm delivery (RR 0.71, 95% CI 0.49–1.03). Results showed that newborns of mothers who had no Vitamin D supplementation had a higher birthweight (P = 0.010). No significant difference on cesarean section rate (RR 1.12, 95% CI 0.87–1.45).@*Conclusion@#Evidence suggests that Vitamin D supplementation can reduce the risk of preeclampsia. This study encourages obstetricians in our country to add Vitamin D supplementation as prenatal medication to prevent preeclampsia, thereby reducing maternal morbidity and mortality.


Subject(s)
Pre-Eclampsia , Vitamin D
10.
Article in English | WPRIM | ID: wpr-984393

ABSTRACT

Objectives@#This study aimed to compare the severity of COVID-19, inflammatory parameters and clinical outcomes among patients with normal and subnormal levels of Vitamin D.@*Methodology@#This is a retrospective cohort study of 135 patients admitted in a tertiary hospital for COVID-19. Patients were grouped according to their Vitamin D level. Primary outcome measure was the composite of all-cause mortality and morbidity. Other outcome measures determined were the comparison among the groups on the severity of COVID-19 infection, changes in inflammatory parameters, length of hospital stay and duration of respiratory support.@*Results@#There was a significant trend of higher ICU admission (p=0.024), mortality (p=0.006) and poor clinical outcome (p=0.009) among the Vitamin D deficient group. No significant difference was found for most of the inflammatory parameters, duration of hospital stay and respiratory support. Overall, patients with deficient, but not insufficient Vitamin D level had 6 times higher odds of composite poor outcome than those with normal Vitamin D (crude OR=5.18, p=0.003; adjusted OR=6.3, p=0.043).@*Conclusion@#The inverse relationship between Vitamin D level and poor composite outcome observed in our study suggests that low Vitamin D may be a risk factor for poor prognosis among patients admitted for COVID-19.


Subject(s)
Vitamin D , Vitamin D Deficiency , COVID-19
11.
Article in English | WPRIM | ID: wpr-984373

ABSTRACT

Objective@#To determine the association between serum 25-hydroxyvitamin D (25(OH)D) and measures of glycemic control, hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG), in adult patients with diabetes mellitus.@*Methodology@#This is an analytical cross-sectional study of 270 patients with diabetes admitted to a tertiary hospital. Serum 25(OH)D levels were categorized as follows: sufficient (>30 ng/mL), insufficient (20 to 30 ng/mL), and deficient (<20 ng/mL). The correlation of HbA1c and FPG with serum 25(OH)D and other variables was determined using Spearman’s rho (ρ) coefficient. The risk factors associated with HbA1c ≥7% and FPG ≥126 mg/dL were determined using logistic regression analysis to generate crude and adjusted odds ratios. The null hypothesis was rejected at 0.05 α-level of significance.@*Results@#The median serum 25(OH)D was 18.92 (range 3.56–56.3) ng/mL. Ninety percent (245 patients) had vitamin D levels below 30 ng/mL. This study showed that vitamin D level is significantly but weakly correlated with patient’s age (ρ=0.339) and duration of diabetes (ρ=0.147), whereas it had inverse correlations with BMI (ρ=-0.134), HbA1c (ρ=-0.261), and FPG (ρ=-0.198).@*Conclusion@#In this study, we found a possible association between vitamin D levels and measures of glycemic control among this group of adult Filipino patients with diabetes mellitus, but further investigations in other cohorts of individuals with diabetes are needed.


Subject(s)
Vitamin D , Diabetes Mellitus , Glycemic Control
12.
ABCD (São Paulo, Online) ; 36: e1753, 2023. tab
Article in English | LILACS | ID: biblio-1447012

ABSTRACT

ABSTRACT BACKGROUND: Vitamin, mineral, and metabolic deficiencies occur in the postoperative period of bariatric surgery, in the short and long term, and are worrisome intercurrences. AIMS: To evaluate the association of serum vitamin D levels with the lipid profile in obese patients undergoing bariatric surgery. METHODS: Case series of patients assisted from 2010 to 2018, in a private hospital of medium and high complexity, who underwent bariatric surgery using sleeve gastrectomy or Roux-en-Y gastric bypass techniques, monitored by the same surgeon. Sociodemographic, clinical, laboratory, and anthropometric data were collected preoperatively and at 6, 12, and 24 months after surgery. RESULTS: A total of 156 individuals, mostly female (75.6%) were monitored. The most frequent comorbidities were hepatic steatosis (76.3%) and hypertension (48.27). Regarding preoperative vitamin D levels, only 18.9% of the population had a satisfactory level (≥30 ng/mL). There was a reduction in weight and an improvement in the lipid profile after surgery. Significant correlations were observed between the lipid profile and vitamin D concentration only in the sample submitted to the Roux-en-Y gastric bypass technique: negative correlation between total cholesterol and vitamin D two years after surgery; positive correlation between triglycerides and vitamin D one year after surgery; and negative correlation between high-density lipoprotein and vitamin D two years post-surgery. CONCLUSIONS: It is essential to routinely monitor vitamin D levels and lipid profile pre- and postoperatively in order to avoid damage associated with this vitamin deficiency.


RESUMO RACIONAL: Deficiências vitamínicas, minerais e metabólicas ocorrem no pós-operatório de cirurgia bariátrica, a curto e longo prazo, sendo intercorrências preocupantes. OBJETIVOS: Avaliar a associação dos níveis séricos de vitamina D com o perfil lipídico, em pacientes obesos submetidos à cirurgia bariátrica. MÉTODOS: Série de casos de pacientes atendidos de 2010 até 2018, em hospital privado de média e alta complexidade, submetidos à cirurgia bariátrica pelas técnicas da gastrectomia vertical e derivação gástrica em Y de Roux, acompanhados pelo mesmo cirurgião. Foram coletados dados sociodemográficos, clínicos, dados laboratoriais e antropométricos no pré-operatório, 6 meses, 12 meses e 24 meses após cirurgia. RESULTADOS: Foram acompanhados 156 indivíduos, maioria sexo feminino (75,6%), comorbidades mais frequentes foram esteatose hepática (76,3%) e hipertensão (48,27). Em relação aos níveis de vitamina D pré-operatórios, apenas 18,9% da população apresentaram níveis satisfatórios (=30 ng/mL). Observou-se redução do peso e melhora do perfil lipídico pós-cirúrgico. Sobre as correlações entre o perfil lipídico e concentração de vitamina D foram observadas correlações significativas apenas na amostra que passou pela técnica cirúrgica derivação gástrica em Y de Roux: correlação negativa entre o colesterol total e vitamina D após 2 anos de cirurgia; correlação positiva entre triglicerídeo e vitamina D 1 ano pós-operatório; e correlação negativa entre HDL e vitamina D 2 anos pós-operatório. CONCLUSÕES: é essencial acompanhar os níveis de vitamina D e perfil lipídico no pré e pós-operatório de forma rotineira a fim de evitar danos relacionados a deficiência dessa vitamina.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Young Adult , Vitamin D Deficiency/etiology , Vitamin D Deficiency/blood , Bariatric Surgery/adverse effects , Postoperative Period , Vitamin D , Body Mass Index , Bariatric Surgery/methods , Cholesterol, HDL/blood , Cholesterol, LDL/blood , Obesity/surgery
13.
Clin. biomed. res ; 43(1): 1-8, 2023.
Article in English | LILACS | ID: biblio-1435521

ABSTRACT

Introduction: Some studies have described impairment in quality of life of vitamin-deficient subjects. However, little is known about this association in primary care. This study aimed to evaluate the association between vitamin D deficiency and quality of life in postmenopausal women attending primary care in the municipality of Santa Maria ­ Brazil. Methods: A cross-sectional study was carried out with postmenopausal women over 55 years of age, accompanied in primary care, from March to August 2014. These women were randomly selected among the participants of a cohort study in the municipality of Santa Maria ­ Brazil. Data were collected through a standardized questionnaire, quality of life was assessed using the Short Form-36 Health Survey (SF-36), and 25-hydroxyvitamin D were measured using the ALPCO® ELISA method. Results: Of the total of 78 studied women, 11.54% had vitamin D deficiency. Women with vitamin D deficiency had a poorer quality of life assessed by SF-36. In the regression analysis, both vitamin D deficiency and falls were independently associated with a lower physical component of the SF-36. Conclusion: Vitamin D deficiency is associated with poorer quality of life in the studied postmenopausal women.


Subject(s)
Humans , Female , Middle Aged , Aged , Aged, 80 and over , Quality of Life , Vitamin D , Vitamin D Deficiency , Postmenopause , Primary Health Care , Surveys and Questionnaires
14.
São Paulo; s.n; 2023. 83 p.
Thesis in Portuguese | LILACS | ID: biblio-1443812

ABSTRACT

Introdução: Associada com uma considerável quantidade de doenças crônicas, agudas e mais recentemente, a Covid 19, a deficiência de vitamina D tem se tornado cada vez mais prevalente até em regiões de baixa latitude. Objetivo geral: Identificar e caracterizar a associação entre clima, estilo de vida e áreas verdes com os status de vitamina D em mulheres. Objetivos específicos: Avaliar a associação entre concentrações séricas de 25(OH)D e fatores relacionados ao estilo de vida em uma amostra de mulheres brasileiras que vivem na latitude 21º 80' S. Analisar a associação entre verde residencial em áreas urbanas e concentrações séricas de 25(OH)D em moradoras de uma cidade brasileira interiorana de médio porte e de clima tropical. Analisar a associação entre verde residencial, estilo de vida e concentrações séricas de 25(OH)D em moradoras de cidades de clima temperado ao sul da Inglaterra. Método: Foram realizados dois estudos epidemiológicos que analisaram a influência da dieta e exposição à luz solar no status de vitamina D. Idade, variáveis antropométricas, cor da pele e estado pós-menopausa foram medidos como potenciais fatores de confusão. O estudo transversal foi realizado com 101 mulheres com 35 anos ou mais que avaliou a associação entre a concentração sérica de 25(OH)D e a exposição à radiação ultravioleta, estilo de vida e depressão. O estudo longitudinal de 1 ano avaliou o status de vitamina D em 365 mulheres caucasianas e asiáticas, na pré-menopausa e pós-menopausa, residentes na região sul do Reino Unido. Como indicador da variável áreas verdes, foi calculado o Índice de Vegetação por Diferença Normalizada. Foram usados modelos de regressão múltipla e logística para analisar a associação entre as variáveis, além de testes não paramétricos. Os estudos resultaram em três artigos que estão na presente tese. Resultados: No primeiro artigo, no estudo transversal, mulheres mais velhas tiveram uma concentração significativamente maior de 25(OH)D do que as mulheres mais jovens (p = 0,013), bem como maior exposição à RUV (p = 0,01) e menor IMC (p = 0,005). Esses achados são independentes de outros fatores de confusão medidos. No segundo artigo, observou-se uma associacao positiva estatisticamente significativa entre a exposicao ao indice de vegetacao circundante residencial abaixo da mediana e a prevalencia de niveis insuficientes de 25(HO)D (P=0,03).No terceiro artigo, no estudo de coorte, as participantes que viviam em áreas mais verdes eram mais propensas a ter status de vitamina D melhorado (RR: 1,51, IC 95%: 1,13- 2,02), assim como, as que eram mais expostas à radiação ultravioleta (RR: 2,05, IC 95%: 1,44 - 2,92). Contudo, no modelo totalmente ajustado, as variáveis etnia e hormônio paratireóideo permaneceram significantes, p < 0,001 e p = 0,003. Conclusão: Foram encontradas associações entre vitamina D, estilo de vida, saúde mental e áreas verdes importantes para um panejamento urbano e social de incentivo a atividades ao ar livre. Contudo, uma análise de mediação que elucide como as áreas verdes contribuem para maiores níveis de vitamina D através do tempo de exposição à luz solar é necessário.


Introduction: Associated with a considerable amount of chronic and acute diseases and more recently, Covid 19, vitamin D deficiency has become increasingly prevalent even in low latitude regions. General objective: To identify and characterize the association between climate, lifestyle and green areas with vitamin D status in women. Specific objectives: To evaluate the association between serum concentrations of 25(OH)D and factors related to lifestyle in a sample of Brazilian women living at latitude 21º 80' S. To analyze the association between residential green in urban areas and serum concentrations of 25(OH)D in residents of a medium-sized country town in Brazil with a tropical climate. To analyze the association between residential greenery, lifestyle and serum concentrations of 25(OH)D in residents of temperate cities in the south of England. Method: Two epidemiological studies were performed that analyzed the influence of diet and sunlight exposure on vitamin D status. Age, anthropometric variables, skin color and postmenopausal status were measured as potential confounders. A cross-sectional study was carried out with 101 women aged 35 years or older that evaluated the association between serum 25(OH)D concentration and exposure to ultraviolet radiation, lifestyle and depression. The 1-year longitudinal study assessed the vitamin D status of 365 premenopausal and postmenopausal Caucasian and Asian women residing in the southern part of the UK. As an indicator of the green areas variable, the Vegetation Index by Normalized Difference was calculated. Multiple and logistic regression models were used to analyze the association between variables, in addition to non-parametric tests. The studies resulted in three articles that are in this thesis. Results: In the first article, in the cross-sectional study, older women had a significantly higher concentration of 25(OH)D than younger women (p = 0.013), as well as greater exposure to UVR (p = 0.01) and lower BMI (p = 0.005). These findings are independent of other measured confounders. In the second article, a statistically significant positive association was observed between exposure to the surrounding residential vegetation index below the median and the prevalence of insufficient levels of 25(HO)D (P=0.03). cohort, participants who lived in greener areas were more likely to have improved vitamin D status (RR: 1.51, 95% CI: 1.13-2.02), as were those who were more exposed to ultraviolet radiation (RR: 2.05, 95% CI: 1.44 - 2.92). However, in the fully adjusted model, the variables ethnicity and parathyroid hormone remained significant, p < 0.001 and p = 0.003. Conclusion: Association was found between vitamin D, lifestyle, mental health and important green areas for urban and social planning to encourage outdoor activities. However, a mediation analysis that elucidates how green areas contribute to higher levels of vitamin D through exposure time to sunlight is needed.


Subject(s)
Humans , Female , Ultraviolet Rays , Vitamin D/radiation effects , Green Areas , Life Style
15.
REVISA (Online) ; 12(2): 250-259, 2023.
Article in Portuguese | LILACS | ID: biblio-1437599

ABSTRACT

Heródoto, do grego Ἡρόδοτος, viveu até onde se conhece entre 485 a 425 a.C., perseverando seu interesse intelectual junto as atividades de historiador e de geógrafo, sendo reconhecido enquanto "pai da história" e, tendo analisado e escrito sobre a invasão da Pérsia ao estado da Grécia.1,2,3 Em seus escritos, Heródoto pode observar que os guerreiros persas possuíam os seus "crânios moles", por conta dos mesmos, segundo suas observações, "utilizarem turbante" e, desta forma, não tendo acesso a exposição aos raios solares.


Subject(s)
Vitamin D , Research , Vitamins , Calcitriol
16.
REVISA (Online) ; 12(1): 1-12, 2023.
Article in Portuguese | LILACS | ID: biblio-1416313

ABSTRACT

Na atualidade, vasta são as produções e pesquisas, que analisam os inúmeros benefícios emanados pela vitamina D no organismo humano, se constituindo enquanto uma das principais questões na atualidade, geradora de reflexões e análises sistemáticas, em relação a este verdadeiro hormônio corporal, necessário à nossa existência e sobrevivência, com qualidade.1-10 Nesse sentido, a vitamina D se compõem enquanto constituinte, do que conhecemos enquanto "secosteroides", ou seja, compostos do tipo químico, que são derivados de um tipo de esteroide, que são provenientes de estruturas que tiveram a sua separação, desenvolvidas em suas outras ligações.


Subject(s)
Vitamin D , Calcitriol , Public Health
17.
Chinese Medical Journal ; (24): 788-798, 2023.
Article in English | WPRIM | ID: wpr-980870

ABSTRACT

BACKGROUND@#Many nutritional supplements and pharmacological agents have been reported to show preventive effects on colorectal adenoma and colorectal cancer (CRC). We performed a network meta-analysis to summarize such evidence and assess the efficacy and safety of these agents.@*METHODS@#We searched PubMed, Embase, and the Cochrane Library for studies published in English until October 31, 2021 that fit our inclusion criteria. We performed a systematic review and network meta-analysis to assess the comparative efficacy and safety of candidate agents (low-dose aspirin [Asp], high-dose Asp, cyclooxygenase-2 inhibitors [coxibs], calcium, vitamin D, folic acid, ursodeoxycholic acid [UDCA], estrogen, and progesterone, alone or in combination) for preventing colorectal adenoma and CRC. Cochrane risk-of-bias assessment tool was employed to evaluate the quality of each included study.@*RESULTS@#Thirty-two randomized controlled trials (278,694 participants) comparing 13 different interventions were included. Coxibs significantly reduced the risk of colorectal adenoma (risk ratio [RR]: 0.59, 95% confidence interval [CI]: 0.44-0.79, six trials involving 5486 participants), advanced adenoma (RR: 0.63, 95% CI: 0.43-0.92, four trials involving 4723 participants), and metachronous adenoma (RR: 0.58, 95% CI: 0.43-0.79, five trials involving 5258 participants) compared with placebo. Coxibs also significantly increased the risk of severe adverse events (RR: 1.29, 95% CI: 1.13-1.47, six trials involving 7109 participants). Other interventions, including Asp, folic acid, UDCA, vitamin D, and calcium, did not reduce the risk of colorectal adenoma in the general and high-risk populations compared with placebo.@*CONCLUSIONS@#Considering the balance between benefits and harms, regular use of coxibs for prevention of colorectal adenoma was not supported by the current evidence. Benefit of low-dose Asp for chemoprevention of colorectal adenoma still requires further evidence.@*REGISTRATION@#PROSPERO, No. CRD42022296376.


Subject(s)
Humans , Cyclooxygenase 2 Inhibitors , Calcium , Network Meta-Analysis , Vitamins , Colorectal Neoplasms/drug therapy , Chemoprevention , Aspirin , Adenoma/prevention & control , Vitamin D
18.
Article in Chinese | WPRIM | ID: wpr-981982

ABSTRACT

OBJECTIVES@#To study the correlation between 25-hydroxyvitamin D [25-(OH)D] and nephroblastoma in children and its value in assessing the prognosis of the disease.@*METHODS@#A total of 50 children with nephroblastoma who were admitted from January 2018 to December 2022 were included as the nephroblastoma group, and according to the postoperative pathological type, they were divided into a good prognosis group with 38 children and a poor prognosis group with 12 children. A total of 50 healthy children who underwent physical examination during the same period of time served as the healthy control group. The above groups were compared in terms of serum creatinine and 25-(OH)D level. A Spearman correlation analysis was used to investigate the correlation between serum 25-(OH)D level and therapeutic effect reaction. A multivariate logistic regression analysis was used to identify the risk factors affecting the prognosis of nephroblastoma in children.@*RESULTS@#The nephroblastoma group had significantly lower levels of serum creatinine and 25-(OH)D than the healthy control group (P<0.05). Compared with the good prognosis group, the poor prognosis group had a significantly larger tumor diameter, a significantly higher proportion of children with stage III-IV tumors, a significantly higher rate of tumor metastasis, and significantly lower serum levels of creatinine and 25-(OH)D (P<0.05). The Spearman correlation analysis showed that serum 25-(OH)D level was negatively correlated with therapeutic effect reaction (rs=-0.685, P<0.001). The multivariate logistic regression analysis showed that tumor diameter ≥10 cm, stage III-IV tumors, presence of tumor metastasis, and 25-(OH)D <19 ng/mL were closely associated with the poor prognosis of nephroblastoma in children (P<0.05). Serum 25-(OH)D level had an area under the curve of 0.805 (95%CI: 0.706-0.903, P<0.001) in evaluating the prognosis of nephroblastoma in children, with a Youden index of 0.512, a sensitivity of 0.938, and a specificity of 0.575 at the optimal cut-off value of 1.764 ng/mL.@*CONCLUSIONS@#There is a significant correlation between 25-(OH)D level and the prognosis of nephroblastoma in children, and 25-(OH)D can be used for prognosis prediction.


Subject(s)
Humans , Child , Creatinine , Vitamin D Deficiency/complications , Vitamin D , Calcifediol , Prognosis , Wilms Tumor , Kidney Neoplasms/complications
19.
Article in Chinese | WPRIM | ID: wpr-981872

ABSTRACT

Objective To investigate the effect of 1, 25-(OH)2-VitD3 (VitD3) on renal tubuleinterstitial fibrosis in diabetic kidney disease. Methods NRK-52E renal tubular epithelial cells were divided into control group (5.5 mmol/L glucose medium treatment), high glucose group (25 mmol/L glucose medium treatment) and high glucose with added VitD3 group (25 mmol/L glucose medium combined with 10-8 mmol/L VitD3). The mRNA and protein expression of Snail1, SMAD3, SMAD4, α-SMA and E-cadherin in NRK-52E cells were detected by real-time quantitative PCR and Western blot analysis respectively. The expression and localization of Snail1, SMAD3 and SMAD4 were detected by immunofluorescence cytochemical staining. The binding of Snail1 with SMAD3/SMAD4 complex to the promoter of Coxsackie-adenovirus receptor (CAR) was detected by chromatin immunoprecipitation. The interaction among Snail1, SMAD3/SMAD4 and E-cadherin were detected by luciferase assay. Small interfering RNA (siRNA) was used to inhibit the expression of Snail1 and SMAD4, and the expression of mRNA of E-cadherin was detected by real-time quantitative PCR. SD rats were randomly divided into control group, DKD group and VitD3-treated group. DKD model was established by injection of streptozotocin (STZ) in DKD group and VitD3-treated group. After DKD modeling, VitD3-treated group was given VitD3 (60 ng/kg) intragastric administration. Control group and DKD group were given normal saline intragastric administration. In the DKD group and VitD3-treated group, insulin (1-2 U/kg) was injected subcutaneously to control blood glucose for 8 weeks. The mRNA and protein levels of Snail1, SMAD3, SMAD4, α-SMA and E-cadherin in renal tissues were detected by real-time quantitative PCR and Western blot analysis respectively. Immunohistochemistry was used to detect the expression and localization of Snail1, SMAD3, SMAD4, α-SMA and E-cadherin in renal tissue. Results Compared with the control group, the mRNA and protein expressions of Snail1, SMAD3, SMAD4 and α-SMA in NRK-52E cells cultured with high glucose and in DKD renal tissues were up-regulated, while E-cadherin expression was down-regulated. After the intervention of VitD3, the expression levels of Snail1, SMAD3, SMAD4, α-SMA and E-cadherin in the DKD model improved to be close to those in the control group. Chromatin immunoprecipitation showed that Snail1 and SMAD3/SMAD4 bound to CAR promoter IV, while VitD3 prevented Snail1 and SMAD3/SMAD4 from binding to CAR promoter IV. Luciferase assay confirmed the interaction among Snail1, SMAD3/SMAD4 and E-cadherin. After the mRNA of Snail1 and SMAD4 was inhibited by siRNA, the expression of E-cadherin induced by high glucose was up-regulated. Conclusion VitD3 could inhibit the formation of Snail1-SMAD3/SMAD4 complex and alleviate the renal tubulointerstitial fibrosis in DKD.


Subject(s)
Animals , Rats , Cadherins/genetics , Diabetes Mellitus/pathology , Diabetic Nephropathies/pathology , Epithelial-Mesenchymal Transition , Fibrosis/pathology , Glucose/pharmacology , Kidney/pathology , Rats, Sprague-Dawley , RNA, Messenger , RNA, Small Interfering , Transforming Growth Factor beta1/metabolism , Vitamin D/pharmacology
20.
Article in Chinese | WPRIM | ID: wpr-985492

ABSTRACT

Objective: To explore the causal effects of the serum Vitamin D levels on the risk of systemic lupus erythematosus (SLE). Methods: A two-sample Mendelian randomization (MR) study was performed to infer the causality. Three Genome-wide association studies (GWAS) for circulating Vitamin D levels, including 25-hydroxyvitamin D [25(OH)D], 25-hydroxyvitamin D3 [25(OH)D3] and C3-epimer of 25-hydroxyvitamin D3 [C3-epi-25(OH)D3] published in 2020, and one GWAS for SLE published in 2015 were utilized to analyze the causal effects of the serum Vitamin D levels on the risk of SLE. MR analyses were conducted using the inverse-variance weighted method (IVW), weighted median, MR-Egger methods, MR-pleiotropy residual sum and outlier (MR-PRESSO) method. Results: 34, 29 and 6 SNPs were respectively selected as instrumental variables to analyze the causal association of total 25 (OH) D level, 25 (OH) D3 level and C3-epi-25 (OH) D3 level with the risk of SLE. The MR results showed that each standard deviation decrease in the level of 25(OH)D3 would result in 14.2% higher risk of SLE (OR, 0.858; 95%CI, 0.753-0.978; P=0.022). The levels of 25(OH)D and C3-epi-25(OH)D3 had null associations with risk of SLE (OR, 0.849; 95%CI, 0.653-1.104; P=0.222; OR, 0.904; 95%CI, 0.695-1.176; P=0.452). Conclusion: This study have identified a causal effect of 25(OH)D3 on increased risk of SLE. These findings highlighted the significance of active monitoring and prevention of SLE in population of low Vitamin D levels.


Subject(s)
Humans , Genome-Wide Association Study , Vitamin D , Lupus Erythematosus, Systemic/complications , Vitamins , Causality , Mendelian Randomization Analysis/methods , Polymorphism, Single Nucleotide
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