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BackgroundMobile phone addiction has attracted widespread attention in society， and psychological abuse and neglect is an important factor in predicting mobile phone addiction， whereas limited research has been done to evaluate its impact on mobile phone addiction. ObjectiveTo explore the correlation of psychological abuse and neglect with mobile phone addiction， and to test the pathway of self-esteem and interpersonal alienation， so as to provide references for preventing and curbing mobile phone addiction in junior high school students. MethodsIn May 2022， a cluster sampling was utilized to select 800 students in two middle schools in a county of Hainan Province， and all students were assessed using Child Psychological Abuse and Neglect Scale （CPANS）， Mobile Phone Addiction Index （MPAI）， Rosenberg Self-esteem Scale （SES） and Interpersonal Alienation Scale of Adolescent StudentsAlienation Scale. Pearson correlation analysis was adopted to determine the correlation among the above-mentioned scales， and Process Macro 3.5 for SPSS was used to test the mediation effect. ResultsCPANS score was negatively correlated with SES score （r=-0.278， P<0.01）， and positively correlated with Interpersonal Alienation Scale score and MPAI score （r=0.471， 0.372， P<0.01）. SES score was negatively correlated with Interpersonal Alienation Scale score and MPAI score （r=-0.438， -0.196， P<0.01）. Interpersonal Alienation Scale score was positively correlated with MPAI score （r=0.392， P<0.01）. Interpersonal alienation （indirect effect value was 0.104） played a mediation role in the relationship between psychological abuse and neglect and mobile phone addiction. Self-esteem and interpersonal alienation exhibited a chained mediation effect on the relationship between psychological abuse and neglect and mobile phone addiction （indirect effect value was 0.026）， accounting for 6.99% of the total effect. ConclusionPsychological abuse and neglect can not only directly predict mobile phone addiction， but also can indirectly affect mobile phone addiction through separate mediation of interpersonal alienation or chained mediation of self-esteem and interpersonal alienation. ［Funded by High-level Talent Project of Hainan Natural Science Foundation （number， 721RC511）］
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BACKGROUND:Currently,there are few kinds of drugs to treat kidney diseases,and many systemic drugs have some problems,such as serious side effects,rapid degradation in the body circulation and so on.At present,active targeting of nanoparticles has become a hot spot in the field of drug delivery,and the exploration of the pathological mechanism related to active targeting of nanoparticles is becoming more and more abundant. OBJECTIVE:To summarize the active targeting strategies in common renal diseases. METHODS:The first author and the second author searched CNKI,Wanfang,VIP,and PubMed databases using"nanoparticles,active targeting,target,kidney,kidney disease"as English key words and"nanoparticles,nanoparticles,targeting,active targeting,kidney disease,kidney"as Chinese key words.All relevant articles published before July 2,2023 were retrieved,screened,concluded,and summarized.Finally,62 articles were included for the summary. RESULTS AND CONCLUSION:The active targeting effect of nanoparticles has been studied in many common kidney diseases.The mechanism of active targeting is mainly the binding of ligands and receptors,by modifying the ligand on the nanoparticles to specifically target the receptor on the cells in the kidney;in which way active targeting is realized.Under different renal pathological conditions,the pathological changes of specific kidney sites may become the key breakthrough point to achieve active targeting.Although kidney-targeting nanoparticles have shown promise in the treatment of nonneoplastic kidney diseases,but it is still in the experimental phase in animals,and it is still a long way from applying these results to medical work.
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Objective To observe the efifcacy and safety of XELOX plus bevacizumab as a ifrst-ine treatment for Chinese patients with metastatic colorectal cancer. Methods In this study, we retrospectively reviewed cases in which XELOX plus bevacizumab were administered in order to evaluate its efifcacy and safety in clinical practice.In total, 40 patients with mCRC who presented at Fuchu Hospital received XELOX plus bevacizumab as a ifrst?line treatment from September, 2009 to April, 2012. Eligible patients had histologically conifrmed mCRC. XELOX consisted of a 2-h intravenous infusion of oxaliplatin 130 mg/m 2 on day 1 plus oral capecitabine 1,000 mg/m 2 twice daily for two weeks of athree?week cycle. Overall survival (OS) and survival benefit were analyzed when patients continued with XELOX plus bevacizumab beyond disease progression. Results The median progression?free survival (PFS) was 290 days [95%conif-dence interval (CI):222?409 days] and the median OS was 816 days (95%CI:490?842 days). The response rate (RR:complete plus partial response) was 67.5%, and the disease control rate (RR plus stable disease) was 90%. Conclusion XELOX plus bevacizumab may be considered a routine ifrst?line treatment option for patients with mCRC.
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@#目的观察带锁髓内钉固定结合自体骨髓移植治疗长管状骨骨折和骨折不愈合的疗效。方法对12例股骨、胫骨长管状骨骨折和骨折不愈合患者行带锁髓内钉固定、复位,同时行自体骨髓移植治疗(每2周移植1次,共移植3—6次)。结果所有病例均未出现骨折延迟愈合或不愈合,于10—18个月时取出髓内钉,未出现断钉、关节功能障碍、骨密度明显降低等。结论带锁髓内钉固定结合自体骨髓移植是一种可行的治疗长管状骨骨折与骨折不愈合的有效方法。
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Objective To develop a cutting and coagulation device with searching for surgical operation method. Methods By using the relative theory of electric technology, choice some ceramics matter and form any vibration frequency and carry out cutting biology organization and stopping blood. Results The sample instrument was made successfully, and was used in the animal experiments and clinical experiments. Conclusion This instrument has much better applying prospect and greater market demand.