Use of ovarian reserve markers to predict ovarian response in A.R.T: a prospective study

Our study is conducted in order to evaluate the correlation between ovarian reserve markers such as antral follicular count, baseline FSH, LH, E2 as well as Inhibin-B, with the prognosis of IVF/ICSI cycles, demonstrated by the number of eggs retrieved. Through a prospective comparative study, 50 patients undergoing IVF/ICSI cycles were recruited in the study. Ovarian reserve markers, as well as the number of eggs retrieved were evaluated for all cases, and correlations were evaluated. Demonstrated that all of the ovarian reserve markers showed significant correlations with the number of eggs retrieved, duration of stimulation, rate of cancelled cycles for non response. Yet the antral follicular count showed the strongest correlation, followed by the bseline Estradiol, and baseline FSH. Antral follicular count can be used with high accuracy to evaluate and predict response to controlled ovarian stimulation in IVF/ICSI cycles, with comparable accuracy to other classic ovarian reserve markers, such as baseline hormone values

Can cervical canal length assessment by transvaginal ultrasound be used as a predictor of preterm labor in high risk patients?

To prove or disprove the efficacy of cervical canal length evaluation by Transvaginal Ultrasound in prediction of preterm labor, in patients at risk. through a Prospective study, 50 patients, pregnant 24-28 weeks, with one or more risk factors for PTL [preterm labor], but yet asymptomatic, underwent Transvaginal Ultrasound for cervical canal length assessment, then they were followed up till 37 weeks of pregnancy [fetal maturity], the length of cervical length is then correlated with the prognosis of pregnancy, and whether or not it ended in preterm labor. Showed that a cutoff value of 30 mm cervical length is a sensitive and specific value, below which, pregnant patients 24-28 weeks at high risk for preterm labor are shown to be prone to develop PTL, so that interventions such as: tocolysis, cerclage, bed rest and steroids can be advisable. Transvaginal Sonography for cervical length assessment is a safe, and effective technique to predict increased risk for preterm labor in [selectedpatients]. Normal results [length above 30 mm] can help avoid unnecessary interventions. A single transvaginal Ultrasound for cervical length assessment can be a sensitive, specific and reproducible method to detect liability for preterm labor

Value of single progesterone evaluation versus doubling of beta-hCG as predictors of unhealthy pregnancies in patients with first trimesteric threatened abortion

To assess the ability to use Progesterone as a predictor of spontaneous first trimesteric miscarriage, in patients complaining of threatened abortion, also, to compare Progesterone with Beta-hCG doubling as another predictor of unhealthy [non-viable] first trimesteric pregnancies. Fifty patients complaining of threatened abortion were recruited in this study. All of them underwent evaluation of serum Progesterone level at eight weeks of pregnancy, as well as Beta-hCG measurement two times, 48 hours apart. All the subjects were then followed up till the end of the first trimester by Ultrasound to check fetal life. showed that correlation between both parameters and prognosis of pregnancy is strong. Also, low levels of Progesterone below 15 ng/ml, were associated with increased risk of abortion, lastly, the study demonstrated that a single measurement of Progesterone can be used alone at eight weeks to evaluate the prognosis of patients with first trimesteric abortion. From the study, we can conclude that the single evaluation of serum Progesterone, in patients with first trimesteric threatened abortion, as early as 8 weeks of pregnancy, is comparably effective with Beta-hCG doubling, in predicting pregnancy outcome