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EMHJ-Eastern Mediterranean Health Journal. 2003; 9 (4): 844-855
em Inglês | IMEMR | ID: emr-158221

RESUMO

A latex agglutination test to detect urinary antigens for visceral leishmaniasis [VL] was studied. In 204 patients with suspected VL, KAtex had a sensitivity of 95.2% with good agreement with microscopy smears but poor agreement with 4 different serology tests. It was also positive in 2 confirmed VL cases co-infected with HIV. In all KAtex-positive confirmed cases actively followed up after treatment, the test became negative 1 month after completion of treatment. While KAtex had a specificity of 100% in healthy endemic and non-endemic controls, the direct agglutination test [DAT] was positive in 14% of the KAtex-negative healthy endemic controls. KAtex is a simple addition to the diagnostics of VL particularly at field level and as a complementary test for the diagnosis of VL in smear-negative cases with positive DAT results


Assuntos
Humanos , Antígenos de Protozoários/urina , Estudos de Casos e Controles , Pré-Escolar , Doenças Endêmicas/estatística & dados numéricos , Ensaio de Imunoadsorção Enzimática/normas , Técnica Indireta de Fluorescência para Anticorpo/normas , Immunoblotting/normas , Testes de Fixação do Látex/métodos , Leishmania donovani/imunologia , Parasitologia/normas
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