Interpretation of laboratory diagnosis and molecular surveillance of Bordetella pertussis published by Euro-pean Centre for Disease Prevention and Control / 中华实用儿科临床杂志

Pertussis is a highly contagious acute respiratory infection.Although childhood vaccination has been widely practiced, it does not result in lifelong immunity.On December 21, 2022, aiming to meet the challenge of pertussis epidemic in the world, European Centre for Disease Prevention and Control published laboratory diagnosis and molecular surveillance of Bordetella pertussis, which describes in detail the protocols for laboratory diagnosis and molecular technology for pertussis, and it is worthwhile to study and learn from healthcare professionals and technicians engaged in the field of diagnosis and treatment of pertussis disease in China.This article introduces and interprets the main contents of the document.

Prevalence of hepatitis C virus genotypes and impact of T helper cytokines in achieving sustained virological response during combination therapy: A study from Central India.

Characterisation of host immune response to hepatitis C virus (HCV) genotypes may have an important prognostic and therapeutic implication. Genotype-3 was more prevalent in the examined cohort and demonstrated a significantly higher response to combination therapy than genotype-1. Sustained virological response (SVR) was 94.74% in genotype-3 and 45.45% in genotype-1. The patients who achieved SVR reported higher levels of circulating T helper 1 cytokines in comparison to subjects with no SVR in both the studied groups. Besides providing local prevalence, our study might also assist in understanding the host immune mechanisms involved to achieve SVR during combination therapy in chronic HCV patients.